• 한국융합학회논문지
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• 제7권1호
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• pp.31-36
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• 2016

최근들어 스마트 단말의 급속한 보급과 업무 방식의 변화에 따른 재택근무 등 근무형태의 유연화로 인하여 다양한 정보를 제공받고 있다. 아기를 둔 엄마들은 유아가 먹는 음식, 건강, 성장 등에 관심을 갖게 되었고, 육아라는 새로운 환경은 가족을 위해 완벽히 잘 해야 한다는 부담감과 동시에 훌륭한 엄마가 되어야 한다는 강박장애로 이어져 많은 엄마들이 육아 스트레스로 고통을 호소하고 있다. 또한, 모바일 환경에서의 일과 삶의 조화가 중요하게 대두됨에 따라 초보엄마들을 위한 육아관리에 도움을 줄 수 있는 통합적 육아정보 관리 애플리케이션의 필요성이 증대되었다. 본 연구에서는 육아정보 관련 앱의 선호도를 분석하여 실질적으로 필요한 맞춤형 통합 육아정보를 제공할 수 있는 육아정보관리 프로토타입 앱을 개발하였다.

• 대한소아치과학회지
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• 제26권1호
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• pp.151-156
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• 1999

1. 하순에 심한 self-mutilation wound를 야기한 Lesch-Nyhan syndrome 환아에서 상하악 유전치에 치관부 절단 및 치수 절제술을 시행하여 치아에 의한 자해를 방지하였다. 2. 장치를 이용한 치료가 어려운 경우 발치가 고려되기도 하나 본 증례에서는 발치보다 보존적인 술식으로 만족할 만한 결과를 얻었다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제20권2호
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• pp.97-100
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• 1998

Systemic lupus erythematosus is a severe cutaneous-systemic disorder of unknown etiology, It is represented with erythematous patches on the face in a so-called butterfly distribution, and characteristically classified as an autoimmune disease with antinuclear antibodies. The autoimmune diseases such as systemic lupus erythematosus, $Sj{\ddot{o}}gren$ syndrome, rheumatoid arthritis have been associated with lymphoid malignancy - leukemia, malignant lymphoma - which could involve various organs(spleen, liver, brain, mediastinal lymph node, supraclavicular lymph node, inguinal lymph node, cervical lymph node etc.). Many authors have studied about the association of systemic lupus erythematosus and malignant lymphoma, but exact etiology is still unknown. A common viral etioloty for systemic lupus erythematosus has been suggested since virus-like particles have been found in the glomerular endothelium of patients with systemic lupus erythematosus. These oncogenic viruses may be responsible for the higher frequency of malignant lymphoma in patients with systemic lupus erythematosus. In the other theory, the causes of malignant lymphoma are the defect of immune system due to systemic lupus erythematosus and the long-term use of therapeutics for treatment of systemic lupus erythematosus. When the cellular immune system(delayed hypersensitivity) is impaired by immunosuppressive drugs, it is likely that the body is no longer able to recognize and reject malignant cells as they arise; they continue to grow and divide unhindered. The impairment of the cellular immune system may allow growth of oncogenic virus or the survival of neoplatic tissues. 47-year old female patient treated systemic lupus erythematosus with steroid and immunosuppressive drugs for 5 years visited to our hospital due to elevated mass on left upper anterior maxilla area. By performing biopsy, we diagnosed this lesion as malignant lymphoma and referred to oncologist for chemotherapy. So we report a case of malignant lymphoma due to systemic lupus erythematosus with review of literatures.

• 대한두개안면성형외과학회지
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• 제14권2호
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• pp.115-118
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• 2013

Craniosynostosis is a congenital anomaly in which cranial sutures close prematurely and restrict skull growth. In this paper, the case of two siblings, a male and a female, who were both diagnosed as craniosynostosis is reported. They underwent corrective osteotomy for cranial vault remodeling. A 22-month-old female infant who was brought to the department of plastic and reconstructive surgery of the authors' hospital was diagnosed with plagiocephaly. At the same time, her 7-month-old brother was diagnosed with brachycephaly. In the case of the female infant, corrective coronal osteotomy and supraorbital bar advancement were performed. Her brother underwent frontal advancement osteotomy using Tessier's tongue in the groove procedure. After the correction of the craniosynostosis, the two patients recovered in several days later, and the results were good in both cases cosmetically and functionally. They showed normal head circumference increasing curves and no symptom of functional disorder in their last follow-up. Isolated or nonsyndromic craniosynostosis is sporadic but mostly autosomal dominant. This paper presents a case of craniosynostosis with a genetic tendency; and although it occurred between siblings, the affected lesions differed. Thus, appropriate diagnosis and management in patients are needed.

• Neonatal Medicine
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• 제18권2호
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• pp.370-373
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• 2011

Citrin deficiency는 염색체 7q21.3의 SLC25A13 유전자 돌연변이에 의해 발생하는 상염색체 열성질환으로 neonatal-onset type II citrullinemia (CTLN2) 및 adult-onset CTLN2로 분류된다. 생후 16일된 여아가 신생아 대사 검사에서 citrullinemia (CTLN)가 의심되었고 혈중 아미노산 분석에서 CTLN 및 고암모니아혈증을 보였고, SLC25A13 유전자 분석 결과 c.221C>T in exon4 and c.1645C in exon16 (p.[Ser74Phe]+[Gln549X]) 의 새로운 돌연변이가 발견되어 neonatal-onset CTLN2로 진단되었다. 저자들은 신생아 대사 검사에서 citrullinemia를 보이는 영아들에서 확진을 위한 유전자 검사 및 혈중 아미노산 분석이 필요하다고 생각한다.

• Pediatric Infection and Vaccine
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• 제23권1호
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• pp.72-76
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• 2016

골화석증은 골격의 경화증이 특징적으로 나타나는 드문 유전 질환으로 뼈 흡수 기전에 손상이 오며 조기 사망하는 질환이다. 반면 거대세포바이러스 감염은 가장 흔한 선천성 감염 중 하나로 빈혈, 혈소판 감소증과 간비장종대, 뇌 석회화 등이 나타날 수 있다. 심한 간비비대, 혈소판 감소증 및 저칼슘혈증과 발달지연으로 내원한 환자에서 두 가지 질환이 함께 있어 항바이러스제 치료 및 대증치료를 시행하였고, 치료 반응이 빠르게 나타나지는 않았으나 지속적인 치료 결과 대부분의 수치가 정상화 되는 것을 확인하였다. 본 증례는 골화석증 신생아에게 동반된 거대세포바이러스 감염의 첫 증례 보고로, 거대세포바이러스 감염에 대한 항바이러스제의 장기 치료로 호전된 사례이다.

• 한국지능정보시스템학회:학술대회논문집
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• 한국지능정보시스템학회 2001년도 The Pacific Aisan Confrence On Intelligent Systems 2001
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• pp.330-335
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• 2001

The occurrences of occupational illness and injury have been seriously underestimated in Korea. Surveillance systems for occupational diseases have recently emerged as important strategies for the control of occupational hazards and the implementation of intervention programs to protect workers. However, health service providers do not actively diagnose occupational diseases and are unwilling to report occupational diseases. With the rapid growth of Internet usage in Korea, the computer network has become the predominant means of communicating and sharing information. Therefore, we developed a web-based updated information and education network to assist the health services providers in reporting occupational diseases. Information systems for occupational disease surveillance were also designed to support occupational disease reporting. Commonly available database systems, such as web databases, are useful to manage occupational diseases data efficiently. Standardized case definitions and report guidelines were also established, which included cumulative trauma disorder, occupational asthma, occupational contact dermatitis, and occupational cancer. This system may provide the basis of an efficient and continuously updated source of educational information and provide specific information concerning the occurrence of occupational diseases in specific areas. Background information on occupational diseases obtained in this way will be invaluable for preventing hazards and enforcing occupational disease prevention programs. Moreover, our experiences in establishing these information systems will be of great use in other countries and settings.

• Clinical and Experimental Pediatrics
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• 제45권4호
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• pp.540-544
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• 2002

저자들은 임상적으로 Rett 증후군이 의심된 2세 환아에서 MECP2 유전자의 직접 염기 서열 분석을 통해 P152R 돌연변이를 확인하였다. 이에 대한 문헌 고찰과 함께 보고하는 바이다.

• 대한소아치과학회지
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• 제31권1호
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• pp.120-125
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• 2004

Cornelia de Lange Syndrome은 이형성적 특징들에 의해 특징 지워지는 증후군으로서 정확히 알려지지 않은 원인을 가진 이상증이다. 이 증후군은 이형성적 임상증상에 의거하여 진단되기 때문에 염색체 검사, 유전자 검사 등의 진단 목적의 다른 검사들은 유효하지 않다고 할 수 있다. 임상증상으로는 전반적 발육 장애 정신지체, 외소증 다모증(hypertrichosis), 갈매기 모양의 눈썹(confluent eye brows), 낮은 헤어라인, 낮고 평평한 코, 위로 들린 코끝, 사지 기형, 발가락의 합지증(webbing), 심장기형, 위식도 역류 질환, 청력 이상, 그리고 안 질환 등이 나타나며 구강관련 증상으로는 왜소악 치아 맹출 지연, 구순 구개열, 높은 구개궁, 얇은 상순, 그리고 처진 구각 등이 나타난다. 본 증례에서는 전북대학교병원 소아치과에 치아 우식증을 주소로 내원한 Cornelia do Lange Syndrome을 가진 3세 및 4세 여환의 치료 예를 보고하는 바이다.

• Journal of Periodontal and Implant Science
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• 제34권2호
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• pp.357-366
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• 2004

Chronic exposure to high levels of manganese leads a pronounce and debilitating disorder known as manganism. Research on the toxic manifestation of manganese have focused primarily on its neurological effects because exposure to high levels of the metal produces a distinct and irreversible extrapyramidal dysfunction resembling the dystonic movements associated with Parkinson's physiological and biochemical systems in the body. The purpose of this study was to evaluate the effect of manganeses on primary rat calvarial cell growth and toxicity. The experimental groups were in concentration of 0, 10, 30, 60, 100, 300 ${\mu}M$. Cell activity was assessed at day 1 and day 3 using a fluorescent molecular probe. Cell proliferation was evaluated at day 1 and day 3 by MTT assay. The amount of total protein synthesis was measured at day 3 and day 7. The results were as follows: The proliferation of primary rat calvarial cells were inhibited by $MnCl_2$ in the concentration exceeding $100{\mu}M$. The primary rat calvarial cells treated with $MnCl_2$ showed similar protein synthesis to the control group except in 100 ${\mu}M$. These result suggest that manganese suppress the viability and protein synthesis of primary rat calvarial cells in concentration exceeding $100{\mu}M$.