• 한국대기환경학회지
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• 제28권3호
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• pp.261-272
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• 2012

In this study, climate variability was predicted by the Weather Research and Forecasting (WRF) model under two different scenarios (current trends scenario; SC1 and managed scenario; SC2) for future urban growth over the Seoul metropolitan area (SMA). We used the urban growth model, SLEUTH (Slope, Land-use, Excluded, Urban, Transportation, Hill-Shade) to predict the future urban growth in SMA. As a result, the difference of urban ratio between two scenarios was the maximum up to 2.2% during 50 years (2000~2050). Also, the results of SLEUTH like this were adjusted in the Weather Research and Forecasting (WRF) model to analysis the difference of the future climate for the future urbanization effect. By scenarios of urban growth, we knew that the significant differences of surface temperature with a maximum of about 4 K and PBL height with a maximum of about 200 m appeared locally in newly urbanized area. However, wind speeds are not sensitive for the future urban growth in SMA. These results show that we need to consider the future land-use changes or future urban extension in the study for the prediction of future climate changes.

• 경영과학
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• 제34권1호
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• pp.15-25
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• 2017

We evaluated industry growth and employment effects of every possible pairs of 22 manufacturing sectors and 16 regions (i.e, 352 region-sectors). We used annual data of manufacturing sectors from 2008 to 2014 for the evaluation. The evaluation comprises of two steps; We first find several region-sectors that outperform others with respect to the effects of industry growth and employment, which are measured by location quotient analysis, shift share method, employment to GDP ratio and employment elasticity. In addition, cross-efficiency analysis follows to classify region-sector pairs into two sub-categories : efficient region-sectors that deserve to hold the current level of investments and inefficient region-sectors where we should consider efficiency improvements. To examine the efficiency, R&D investment, employment size, and capital investment were used as input factors and production volume, added value, changes in employment size, changes in annual salary per capita were used as output factors. For region-sector pairs that have outstanding growth and employment effects but are inefficient, we employed a CCR DEA model and analyzed how much to adjust the values of input and output factors to improve the efficiency scores. The analysis results showed that inefficiency is mainly due to several factors such as R&D investment, changes in employment size and changes in annual salary per capita.

• Biomolecules & Therapeutics
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• 제2권2호
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• pp.161-172
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• 1994

This study was conducted to examine DA-3002, a biosynthetic human growth hormone, for its acute and subacute toxicities in mice and rats. The drug was administered subcutaneously and orally at a dose level of 1.0, 3.0, 8.9, 26.7 or 80.0 lU/kg once for single dose toxicity and given subcutaneously at a dose level of 0.34, 1.7 or 8.4 lU/kg daily for 13 weeks to investigate repeated dose toxicity. In the acute toxicity study, doses up to 80 lU/kg had no adverse effect on the behavior or body weight gain. Pathological examinations revealed no abnormal changes which could be attributed to toxic effect of DA-3002. In the subacute toxicity study, the growth hormone was tolerated well in broth mice and rats. No drug related deaths occurred and all animals appeared to be normal throughout the dosing period. Increases in body weight gain, food utilisation and absolute organ weights were observed in the rats in the high dose group. Mild changes in the blood chemical parameters were also seen in the treated groups. Histopathologically, however, no abnormal changes were observed in any organ. The changes noted during the treatment periods presumably represent exaggerated pharmacological effects of the growth hormone, and no observed adverse effect level (NOAEL) was considered to be more than 8.4 lu/kg/day.

• 한국산림과학회지
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• 제85권3호
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• pp.462-471
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• 1996

본 연구는 인공호수(人工湖水) 조성에 의한 기상환경(氣象環境) 변화(變化)가 주변지역의 수목생장(樹木生長)에 어떻게 작용하는지 밝히기 위하여 수행되었다. 이를 위하여 먼저 지형기후학적(地形氣候學的)인 방법에 의하여 임하댐 주변지역의 담수전(湛水前)과 담수후(湛水後)의 기후값을 추정(推定)하고, 그 편차(偏差)에 의하여 담수에 의한 기상환경 변화를 정량화(定量化)하였다. 또한 임하댐 주변에 생육하고 있는 소나무를 대상으로 거리별(距離別)로 30m에서 5km까지 6단계로 나누어 생장(生長)을 분석(分析)하고 기상변화와 비교함으로써 댐 건설에 의한 기상환경 변화가 주변지역의 수목생장에 미치는 영향(影響)을 정량적으로 분석하였다. 댐이 건설된 이후의 수목생장(樹木生長)은 댐으로부터 1km 이내의 가까운 거리에 있는 수목은 생장이 증가(增加)고 있었지만, 1km 이상 떨어진 지역에 생육(生育)하는 임목은 기상환경 변화와 무관(無關)함을 알 수 있었다. 댐에서 가까운 지역에 생육(生育)하는 수목의 생장 증가는 주로 봄철의 강수량(降水量) 증가와 생육기간 동안의 일사량(日射量) 총량이 담수전에 비하여 늘어난 것에 기인(起因)한 것으로 판단된다. 그러나 월평균기온(月平均氣溫)의 변화량(變化量) 소나무 생장에 큰 영향을 미치지 못한 것으로 추측(推測)되는데 이는 변화량 자체가 크지 않았기 때문으로 생각된다.

• 대한의생명과학회지
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• 제16권4호
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• pp.349-357
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• 2010

We have examined the histological changes of skin during hair follicle growth after depilation in C57BL/6N mice. We first studied on histological changes of number of mast cells and thickness of skin during hair follicle growth periods (telogen, 1 day, 3 day, 5 day, 10 day, 14 day, 17 day and 21 day after depilation) by toluidine blue, Giemsa and H&E staining methods. We second studied immunoreactive density of cytokines and Brdu labeled cells in skin during hair follicle growth periods after depilation in C57BL/6N mice by immunohistochemical methods. The histological changes on skin thickness was increased from telogen to 14 day. The number of mast cells was decreased in 3,5 and 10 day and increased in 14, 17 and 20 day after depilation. Immunoreactive density of cytokines [protein kinase C-${\alpha}$ (PKC-${\alpha}$), c-kit, and vascular endothelial growth factor (VEGF)] in 1, 3, 5, 10, and 14 day after depilation was mildly stained in bulge and cutaneous trunci m., but immunoreactive density of cytokines in 17 and 21 day was heavily stained in epidermis, bulge, outer root sheath (ORS), inner root sheath (IRS) and cutaneous trunci m.. Immunoreactive density of Brdu labeled cells in skin in 1 and 3 day was heavily stained in bulge, epidermis and connective tissue under the cutaneous trunci m.. In all periods, immunoreactive density of Brdu labeled cells in skin was heavily stained in bulge, subcutaneous tissue, cutaneous trunci m, ORS and IRS. These experiments suggest that histological changes related to hair follicle growth elevated mast cell counts, skin thickness and epidermis thickness and heavily stained immunoreactive density of cytokines and Brdu labeled cutaneous trunci m. and connective tissue under the cutaneous trunci m. after depilation in C57BL/6N mice.

• Clinical and Experimental Pediatrics
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• 제61권7호
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• pp.226-230
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• 2018

Purpose: This pilot study assessed changes in the growth plate and growth rates in children during a 6-month period. Methods: The study included 31 healthy children (17 boys, 14 girls) under evaluation for growth retardation. Height, weight, bone age, insulin like growth factor-1 (IGF-1), and insulin like growth factor binding protein 3 (IGF-BP3) were measured at baseline and after 6 months. In addition, the diameter, thickness, and volume of the femoral and tibial growth plates were measured using magnetic resonance imaging. Results: The mean bone age in boys and girls was 11.7 and 10.7 years, respectively. In boys, height (z score) (-0.2 vs. 0.0), weight (z score) (0.8 vs. 1.1), body mass index (BMI) (z score) (1.27 vs. 1.5), IGF-1 (ng/mL) (343.6 vs. 501.8), and IGF-BP3 (ng/mL) (5,088.5 vs. 5,620.0) were significantly higher after 6 months. In girls, height (z score) (-1.0 vs. -0.7), weight (z score) (-0.5 vs. 0.1), BMI (z score) (-0.02 vs. 0.3), IGF-1 (ng/mL) (329.3 vs. 524.6), and IGF-BP3 (ng/mL) (4,644.4 vs. 5,593.6) were also significantly higher after 6 months. In both sexes, the mean diameter and volume of the femoral and tibial growth plates were significantly increased 6 months later. Conclusion: No significant correlation was found between changes in the growth plate and clinical parameters in children with growth retardation in this study, other than correlations of change in femoral diameter with weight and BMI. A larger, long-term study is needed to precisely evaluate the correlation between change in the growth plate and growth.

• 대한치과교정학회지
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• 제22권3호
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• pp.491-507
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• 1992

경북대학교 치과대학에서 두개 안면골 성장에 관한 누년적 연구의 일환으로 남자 26명 여자 21명을 대상으로 평균 연령 8.5세에서 16.5세까지 격년 간격으로 활용한 두부X선 규격사진 235매를 분석하여 이 기간동안 나타난 안면각 부의 성장 변화를 분석하여 다음과 같은 결론을 얻었다. 1. 이 기간동안 두개저에 대하여 하악골이 상악골보다 전방 성장량이 많았다. 2. 하악골은 두개저에 대해 전상방으로 닫히는 방향으로 회전되었다. 3. 전체 하악골 길이(Ar-Gn)에서 뚜렷한 사춘기 급성장을 보였으며 그 시기는 남자 12-14세 여자 10-12세로 신장에서 급성장 시기와 일치하였다. 4. 전체 두개저 길이 (Ba-Na)에서도 사춘기 급성장을 보였고 그 시기는 남자 10-12세 여자는 8-10세로 신장 및 하악골 길이에 비해 2년 정도 빠른 시기에 나타났다. 5. 전${\cdot}$후방 안면 높이(AFH, PFH) 모두에서 최대 성장 시기는 남녀 모두 신장에서 최대 성장 시기와 일치하였다. 6. 남녀별로 각 연령에서 각 계측치의 평균치를 이용하여 전반적 평균 성장 변화도 및 진단용 profilogram을 작성하였다.

• The Korean Journal of Ecology
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• 제15권4호
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• pp.377-386
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• 1992

Seasonal changes of symbiotic nitrogen-fixation activity and growth characteristics of four different natural populations of kummerowia striata were quantitatively analyzed during the growing period. the nitrogen-fixation activity of root nodules attained the maximum rates of 148, 132, 102 and 100$\muM\;C_2H_4\;\cdot\;g\;fw\;nodule^{-1}\;\cdot\;hr^{-1}$, respectively for sunny, multibranched, shade and unibranched populations at the optimum growth conditions. and the seasonal changes showed fluctuations by environmental conditions such as light, temperature, nutrient contents, water stress and plant ages, etc. The multibranched plant showed the greater amount of leaf and root nodule biomass, and the higher nitrogenase activity than the unibranched plant. the optimum conditions of leaf chloropht11 and water content of each organ indicated the active growth and the maximum fresh biomass of 4 different populations were 1.92, 1.85, 0.97 and 0.56 g $fw\cdotplant^{-1}$ for shade multibranched, sunny and unibranched populations, respectively.

• International Journal of Human Ecology
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• 제14권1호
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• pp.29-39
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• 2013

The study examined how changes in time invested in private tutoring and academic achievement influenced each other through a multivariate latent growth model by using the data from the first to the third year presented in the KYPS. This study identifies not only how changes in the private tutoring experience exerted a direct influence on changes in academic achievement, but also measures what kind of changes in private tutoring and academic achievement had emerged over time. The detailed study results are as follows. First, the analysis of time invested in private tutoring showed that the higher the grades, the greater were the amount of time invested in private tutoring in the case of Korean language study. On the other hand, the results showed that in the case of English and mathematics, the higher the grades, the lesser was the amount of time invested in private tutoring. Second, private tutoring and academic achievement were all in a linear relationship. Third, it was shown that the time invested in private tutoring and academic achievement exerted a negative influence on each other according to the passage of time.

• 아동학회지
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• 제31권3호
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• pp.83-97
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• 2010

Growth mixture modeling was used to identify types of changes in overt aggression from Grades 4 to 7 among a sample from the Korean Youth Panel Survey. Three discrete patterns were found to adequately explain changes of overt aggression in both boys and girls : Persistent intermediate aggression; Increasing aggression; and Decreasing aggression. Most boys (93%) fell into the Persistent intermediate aggression group and 49% of girls were found to fall into the Increasing aggression group. This suggests that prevention programs should recognize that girls are at risk of increasing aggression in their early adolescence. Multinomial logistic regression analysis shows that self-control, child abuse, peer support, and involvement with deviant peers at Grades 4 were all strongly associated with trajectory class membership. These associations did not differ by gender. These findings suggest that prevention programs should focus on the multiple risk factors of both boys and girls.