• Asian Pacific Journal of Cancer Prevention
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• 제16권18호
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• pp.8247-8252
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• 2016

Background: The ubiquitin-proteasome system (UPS) degrades a variety of proteins which attach to specific signals. The ubiquitination pathway facilitates degradation of damaged proteins and regulates growth and stress responses. This pathway is altered in various cancers, including acute lymphoblastic leukemia, head and neck squamous cell carcinoma and breast cancer. Recently it has been reported that expression of newly characterized human genes, UBE2Q1 and UBE2Q2, putative members of ubiquitin-conjugating enzyme family (E2), has been also changed in colorectal cancer. Epigenetics is one of the fastest-growing areas of science and nowadays has become a central issue in biological studies of diseases. According to the lack of information about the role of epigenetic changes on gene expression profiling of UBE2Q1 and UBE2Q2, and the presence of CpG islands in the promoter of these two human genes, we decided to evaluate the promoter methylation status of these genes as a first step. Materials and Methods: The promoter methylation status of UBE2Q1 and UBE2Q2 was studied by methylation-specific PCR (MSP) in tumor samples of 60 colorectal cancer patients compared to adjacent normal tissues and 20 non-malignant controls. The frequency of the methylation for each gene was analyzed by chi-square method. Results: MSP results revealed that UBE2Q2 gene promoter were more unmethylated, while a higher level of methylated allele was observed for UBE2Q1 in tumor tissues compared to the adjacent normal tissues and the non malignant controls. Conclusions: UBE2Q1 and UBE2Q2 genes show different methylation profiles in CRC cases.

• Journal of Nutrition and Health
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• 제34권3호
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• pp.322-329
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• 2001

There is growing evidence that soy isoflavones play beneficial role in the prevention of cardiovascular disease. However, current data are not sufficient to determine the effective dose of isoflavone on improving plasma lipid profiles and total antioxidant capacity in Korean menopausal women. In the present study, 24 perimenopausal and 23 postmenopausal women were divided into 3 groups and were given soy isoflavone supplements of 100, 150, 200mg/day for 12weeks. Blood samples were taken before and after 6, 12weeks of soy isoflavone supplementation for analysis of total cholesterol, LDL cholesterol, HDL cholesterol, triglyceride and total antioxidant status(TAS). In the perimenopausal women, serum total cholesterol level decreased significantly in all three groups after 12weeks of isoflavone supplementation(p< 0.05). However, serum LDL cholesterol level significantly lowered only in 150 and 200mg groups, and serum triglyceride level decreased significantly in 200mg group(p<0.05). In the postmenopausal women, the 150mg isoflavone supplementation group demonstrated significant effects on lowering serum total cholesterol, LDL cholesterol levels and raising HDL cholesterol level after 12weeks of isoflavone supplementation(p<0.05). Two hundred mg isoflavone supplementation group had a significantly higher TAS than other groups in both perimenopausal and postmenopausal women. (Korean J Nutrition 34(3) : 322∼329, 2001)

• Imaging Science in Dentistry
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• 제34권4호
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• pp.175-178
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• 2004

Purpose: Picture Archiving and Communication System (PACS) is difficult to implement in the best of situations, but evidence is growing that the benefits are significant. The aims of this study are to analyze the current status of full PACS and establish successful installation standard of dental PACS. Materials and Methods : Materials and methods were based on the investigation of current working status and installation standard of PACS, and observation of variable issues to installation of dental PACS. Results: By September 30,2004, full PACS implementations in their facilities were 88.1 % in specialized general hospitals (37 installations out of total 42 hospitals), 59.8% in general hospitals (144 installations out of total 241 hospitals), 12.3% in medical hospitals (116 installations out of total 941 hospitals) and 3.6% in dental hospitals (4 installations out of total 11 0 hospitals) Only 4 university dental hospitals currently have installed and are operating full PACS. Major obstacle to wide spread of dental PACS is initial high investments. Conclusions: Clinical environments of dental PACS differed from medical situation. Because of characteristic dental practice, the initial investments for dental PACS are generally much greater than those of medical PACS. Also new economic crisis makes users scruple. The best way to overcome these limitations is to establish an economic installation standard for dental PACS. Also the clear technical communication between the customer and the supplier before both sides are committed to the obstacles are critical to its success.

• 생물정신의학
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• 제18권4호
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• pp.225-231
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• 2011

Objectives Atypical antipsychotics show better treatment efficacy, safety and tolerability than typical antipsychotics. Among the adverse events observed during treatment with antipsychotics, extrapyramidal syndrome (EPS) and negative symptoms has been greatly reduced. But still, weight gain is receiving growing attention. The aim of this study was to investigate the association between therapeutic response to atypical antipsychotics and weight gain in admission status. Methods The study was conducted for Korean inpatients with schizophrenia in a university hospital in Seoul, between Jan 2006 and Dec 2010. Data was collected by reviewing the medical record of 39 consecutively hospitalized patients with Schizophrenia (DSM-IV) at a university hospital. Positive and Negative Symptom Scale (PANSS), Body Mass Index (BMI) and body weights were measured. Results No significant difference was observed for sex, age, illness onset age, family history of schizophrenia, numbers of hospitalization before treatment, educational years, marriage status, occupational status and subtype of schizophrenia between weight gainers and non-weight gainers. Regarding treatment response to atypical antipsychotics, weight gainers show significantly more PANSS decrease than non-weight gainers during admission period. Conclusions Our findings suggest that it appears to be more likely to respond to atypical antipsychotics in weight gainers than non-weight gainers (that weght gainers appear to be more likely to respond to atypical antipsychotics than non-weight gainers). These results show that the antipsychotic-induced body weight gain is associated with therapeutic response of antipsychotics in Korean inpatients with schizophrenia.

• 한국정보통신학회논문지
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• 제10권11호
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• pp.2107-2112
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• 2006

노년층의 인구비율이 늘어나면서 IT 기술을 활용한 상시 건강관리 시스템에 관한 관심과 연구가 크게 증가하고 있다. 본 연구에서는 소형 저 전력 센서 노드와 핸드폰을 이용한 유비쿼터스 헬스케어 시스템을 설계하고 구현하였다. 본 연구에서 제안하는 시스템은 소형 저전력 센서노드간의 네트워크가 가능하며 핸드폰과의 인터페이스로 장소에 구애받지 않고 자신의 현재 건강상태를 확인해 볼 수 있다. WIPI기반으로 만들어진 휴대폰 어플리케이션을 통해 간단한 건강상태 확인이 가능하고 또한 웹과의 연동을 통해 의료서비스 서버에서 자신의 생체신호에 대한 좀 더 자세하고 정확하게 분석 된 결과를 받아볼 수 있도록 하며 검사된 생체신호 데이터는 DB에 저장이 가능하도록 하여 전문의료진을 통해 확인이 가능하도록 하였다. 본 논문에서는 IEEE 802.11b/g 방식과 IEEE 802.15.4 방식을 선택사용 할 수 있는 센서 노드 및 베이스 스테이션을 제안하였으며 또한 휴대폰을 통한 데이터통신 및 모니터링을 위한 WIPI기반의 휴대폰 어플리케이션을 구현하였다. 또한 웹서버에서의 생체신호 분석 및 모니터링 프로그램, 데이터베이스관리 프로그램이 구동되어 핸드폰과 연동되어 동작하는 전체 서비스모델을 구현하였다.

• Neurospine
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• 제15권4호
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• pp.329-337
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• 2018

Objective: Machine learning algorithms excel at leveraging big data to identify complex patterns that can be used to aid in clinical decision-making. The objective of this study is to demonstrate the performance of machine learning models in predicting postoperative complications following anterior cervical discectomy and fusion (ACDF). Methods: Artificial neural network (ANN), logistic regression (LR), support vector machine (SVM), and random forest decision tree (RF) models were trained on a multicenter data set of patients undergoing ACDF to predict surgical complications based on readily available patient data. Following training, these models were compared to the predictive capability of American Society of Anesthesiologists (ASA) physical status classification. Results: A total of 20,879 patients were identified as having undergone ACDF. Following exclusion criteria, patients were divided into 14,615 patients for training and 6,264 for testing data sets. ANN and LR consistently outperformed ASA physical status classification in predicting every complication (p < 0.05). The ANN outperformed LR in predicting venous thromboembolism, wound complication, and mortality (p < 0.05). The SVM and RF models were no better than random chance at predicting any of the postoperative complications (p < 0.05). Conclusion: ANN and LR algorithms outperform ASA physical status classification for predicting individual postoperative complications. Additionally, neural networks have greater sensitivity than LR when predicting mortality and wound complications. With the growing size of medical data, the training of machine learning on these large datasets promises to improve risk prognostication, with the ability of continuously learning making them excellent tools in complex clinical scenarios.

• 한국의상디자인학회지
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• 제25권2호
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• pp.111-122
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• 2023

This study aims to collect Big Data related to DIY clothing, analyze the results on a year-by-year basis, understand consumers' perceptions, the status, and reality of DIY clothing. The reference period for the evaluation of DIY clothing trends was set from 2012 to 2022. The data in this study was collected and analyzed using Textom, a Big Data solution program certified as a Good Software by the Telecommunications Technology Association (TTA). For the analysis of fabric-related DIY products, the keyword was set to "DIY clothing", and for data cleansing following collection, the "Espresso K" module was employed. Also, via data collection on a year-by-year basis, a total of 11 lists were generated and the collected data was analyzed by period. The following are the findings of this study's data collection on DIY clothing. The total number of keywords collected over a period of ten years on search engines "Naver" and "Google" between January 1, 2012 and December 31, 2022 was 16,315, and data trends by period indicate a continuous upward trend. In addition, a keyword analysis was conducted to analyze TF-IDF (Term Frequency-Inverse Document Frequency), a statistical measure that reflects the importance of a word within data, and the relationship with N-gram, an analysis of the correlation concerning the relationship between words. Using these results, it was possible to evaluate the popularity and growing tendency of DIY clothing products in conjunction with the evolving social environment, as well as the desire to explore DIY trends among consumers. Therefore, this study is valuable in that it provides preliminary data for DIY clothing research by analyzing the status and reality of DIY products, and furthermore, contributes to the development and production of DIY clothing.

• 한국토양비료학회지
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• 제19권2호
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• pp.153-156
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• 1986

수온 및 지온변화에 단독(單獨) 또는 혼합(混合) 서식(棲息)하는 좀개구리밥, 붕어마름 및 조류등(藻類等)이 미치는 영향(影響)을 구명(究明)코자 1/200a 대형무저토관(大型無底土管)에서 조사연구(調査硏究)한 결과(結果)는 다음과 같았다. 1. 담수토양(湛水土壤)의 일중(日中) 최고수온 및 지온은 좀개구리밥 서식지(棲息地)가 무서식지(無棲息地)보다 $1{\sim}3^{\circ}C$정도(程度) 낮았으나 최저수온 및 지온은 같거나 $0.5^{\circ}C$정도(程度) 높았다. 2. 담수토양(湛水土壤)의 천기별(天氣別) 수온 및 지온은 좀개구리밥 서식지(棲息地)가 무서식지(無棲息地)보다 맑은 날은 $0.1{\sim}0.3^{\circ}C$ 낮았으나 구름 강우(降雨) 개임시(時)는 $0.1{\sim}0.4^{\circ}C$정도(程度) 높았다. 3. 조류서식(藻類棲息) 담수토양(湛水土壤)의 수온 및 지온은 무서식지(無棲息地)보다 $0.3{\sim}1.0^{\circ}C$ 높아 조류(藻類)에 의한 보온효과가 認定되었다. 4. 잡초서식(雜草棲息) 형태별(形態別) 수온 및 지온 보존(保存) 효과는 붕어마름 단독서식(單獨棲息)>혼합서식(混合棲息)>분개구리밥 단독서식(單獨棲息)>무서식(無棲息) 순(順)으로 높았다.

• 한국임상수의학회지
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• 제27권1호
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• pp.17-22
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• 2010

천연물 유래 항생제 대체 사료첨가제 Flavo-$SK^{TM}$은 원광대학교 인수공통감염병연구센터에서 1,000종 이상의 천연물로부터 효능평가를 거쳐 개발되었다. 본 연구는 육계 농장에서 대규모 임상 효능평가를 통한 Flavo-$SK^{TM}$의 항균 효과 규명과 항생제 대체 효과를 알아보고자 수행되었다. 20,000 마리의 병아리를 Flavo-$SK^{TM}$ 투여군과 비투여군 2 그룹으로 나누어 31일 동안 육계농장에서 연구가 수행되었다. Flavo-$SK^{TM}$ 투여군에는 항생제가 없는 사료에 Flavo-$SK^{TM}$를 0.29% 배합하여 급여하였고 비투여군은 항생제 포함된 일반 사료를 급여하였다. 연구기간 동안 사료섭취량, 체중, 임상증상을 분석하고 시험종료일에 부검하여 육안검사와 미생물학적 검사 및 병리조직학적 검사를 수행하였다. 연구결과 천연물 유래 항생제 대체 사료첨가제 Flavo-$SK^{TM}$은 육계에 항균효과를 가진 항생제 대체 사료첨가제로서 효과적인 것을 확인할 수 있었다.

• 한국학교보건학회지
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• 제11권2호
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• pp.271-277
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• 1998

Gradually computerized information systems have become increasingly important in the management of health service and management, The purpose of this study is to develop information system of school health care. This study identified the soureses of health information produced in elementary school environment and classified them into four different categories such as physical information, health status and disease information, school environment information, and health education and school health services information, Those information are analyzed and categorized as one of the element of information system for the development of school health information system. To manage and improve the health of school population and to meet the need of fast growing health information, unit model of evaluation system of school of health and components of constructing school health information system are suggested.