• Korean Journal of Clinical Pharmacy
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• v.26 no.3
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• pp.254-263
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• 2016

Objective: Written information could be helpful for senior population to adhere to complex medication therapies, but must be well prepared and empirically assessed to achieve such end. We purposed to develop a drug information leaflet for senior citizens by applying 'performance-based user-testing.' Methods: We employed a user-testing, a mixed method to figure difficulties out with patients' leaflets from the user perspective. The cycle made of test and revision can be repeated as necessary. We recruited senior citizens with age of 65 or above who were taking antihypertensive medications at the point of participating and excluded the elderly who suffered illiteracy. We firstly rectified a drug information leaflet of antihypertensive medications for the general public distributed by the Korean authority based on focus group interviews (9 participants). The revised leaflets were tested four times with 8~12 participants in each round (40 seniors in total). We targeted to develop a leaflet which more than 80% of participants understood 10 key information. Main outcomes measures were to be able to find information and be able to understand information. This study was approved by the Yeungnam University Research Ethics Committee. Results: Focus group interviews identified difficulties with small font of words, professional language, long information, and a poor structure. The leaflet was revised and in the first round questionnaire found problems with 4/10 information points; interviews disclosed all but one (normal blood pressure range) were ill-understood. The second round questionnaire and interview found fewer problems but the comprehensiveness of participants was still poor in several points. For the third and fourth rounds we revised the leaflets in the individual-targeted manner. Finally, the fourth round showed all key information found and understood by at least 80% of participants except one question about drug name. Conclusion: The drug leaflets need to be developed in a personalized mode for the seniors. There was a limit for Korean seniors to understand nonproprietary name of their drugs because they used to producers' trade names which the Korean health system predominantly works with.

• Journal of Genetic Medicine
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• v.15 no.2
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• pp.79-86
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• 2018

Purpose: This study aimed to evaluate the clinical usefulness of non-invasive prenatal testing (NIPT) as an alternative testing of invasive diagnostic testing in pregnancies with ultrasound abnormalities. Materials and Methods: This was a retrospective study of pregnant women with abnormal ultrasound findings before 24 weeks of gestation between April 2016 and March 2017. Abnormal ultrasound findings included isolated increased nuchal translucency, structural anomalies, and soft markers. The NIPT or diagnostic test was conducted and NIPT detected trisomy 21 (T21), T18, T13 and sex chromosomal abnormalities. We analyzed the false positive and residual risks of NIPT based on the ultrasound findings. Results: During the study period, 824 pregnant women had abnormal ultrasound findings. Among the study population, 139 patients (16.9%) underwent NIPT. When NIPT was solely performed in the patients with abnormal ultrasound findings, overall false positive risk was 2.2% and this study found residual risks of NIPT. However, the discordant results of NIPT differed according to the type of abnormal ultrasound findings. Discordant results were significant in the group with structural anomalies with 4.4% false positive rate. However, no discordant results were found in the group with single soft markers. Conclusion: This study found different efficacy of NIPT according to the ultrasound findings. The results emphasize the importance of individualized counseling for prenatal screening or diagnostic test based on the type of abnormal ultrasound.

• Journal of the Korean Society of Physical Medicine
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• v.5 no.2
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• pp.233-243
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• 2010

Purpose : This study aimed to examine the effects of sling exercise therapy on the relief of low back pain and the cross-sectional area change of lumbar muscles by CT analysis for chronic low back pain patients. Methods : Forty-one patients with diagnosis of chronic low back pain was divided sling exercise therapy group(SEG) 19 subjects and conservative physical therapy group(CPG) 22 subjects. we randomized and treated them(subjects) for 12 weeks. As using visual analogue scale(VAS), we evaluated recovery accuracy of pain, and for investigating cross-section area change of lumbar muscles for before and after treatment we used computed tomography(CT). Results : This study were summarized as follows : 1) As treatment period, in each compared testing on VAS of SEG and CPG, the both group was significantly different(p<.05). 2) Compared testing on VAS of between-subject groups(SEG and CPG) were not significantly different(p>.05). 3) At SEG of before and after treatment, in compared testing on cross-section area size of lumbar muscles, All muscles of psoas major, quadratus lumborum, erector spinae and multifidus were significantly different(p<.05). At CPG, psoas major was significantly different(p<.05). But other muscles were not significantly different(p>.05). Conclusion : From this result, both sling exercise therapy and the conservative physical therapy are effect on decrease of pain for chronic low back pain patients. but Increasing of the cross-section area being proportioned with muscular strengthening of low back muscle is noticeable difference in SEG. Therefore, sling exercise therapy have affect both decreasing of pain for chronic low back pain patients and lumbar muscles strengthening.

• The Korean Journal of Food And Nutrition
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• v.28 no.2
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• pp.320-327
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• 2015

Since Korean ancient times, powder of Rosa rugosa Thunberg has been used as a folk remedy. This study was conducted to verify the effects of Rosa rugosa Thunberg powder on in vitro antioxidant properties and serum lipid levels of high-fat diet-induced mice from a nutritional viewpoint. In the case of Rosa rugosa Thunberg powders, measurement of TPC, ABTS radical scavenging activity of trolox, DPPH radical scavenging activity, and measured value of FRAP were higher in ethanol extract than water extracts. For LDL-cholesterol concentration, mice fed 10% powder of Rosa rugosa Thunberg with high-fat diets showed a high numerical value compared with other groups (p<0.05). When testing for triglyceride concentrations in blood, mice fed 10% and 20% powder of Rosa rugosa Thunberg with high-fat diets showed the lowest numerical values (p<0.05). When testing for blood insulin concentrations, the high-fat diet group showed higher levels than compared to the control group (p<0.05). When testing for blood leptin concentrations, the high-fat diet group was $5.88{\pm}3.53ng/dL$, whereas mice fed 10% powder of Rosa rugosa Thunberg with high-fat diets showed a blood leptin level of $10.36{\pm}5.96ng/dL$ (p<0.05). Therefore, results prove that powder of Rosa rugosa Thunberg reduces triglyceride concentrations in the blood, and could be used as an excellent natural antioxidant in the future.

• Journal of Applied Reliability
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• v.6 no.3
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• pp.205-212
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• 2006

The purpose of this article is about the accelerated product-reliability-test method of the changing colors of mobile products, which are majorly from the frequent touching of sweating fingers. Such problems of changing colors of mobile products have found mostly In metallic paint containing aluminum paste pigments. Also we found that the color of Al Paste is changed by human sweat. Therefore, the accelerated experimental method has been tested as follow: applying the various concentration of lactic acid, which is the changing color components from human sweat, and deeping the testing sample under temperature of $60^{\circ}C$ in dilutelactic acid with water. From the series of tests, the most optimum concentration of lacticacid has been obtained in 10wt% and the sample is observed to be almost same effect as natural changing of colors by human touching after the test. It has been also confirmed from the cross-sectional analysis. In detail, the testing sample has changed its color in 48hr by changing color effect of Alpaste with 10 wt% of lactic acid, and the digit of $\Delta$ E has measured 10.9 after the test.

• Journal of the Korean Society for Nondestructive Testing
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• v.23 no.5
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• pp.520-525
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• 2003

Fast Breeder Test Reactor (FBTR) is a 40MW (thermal) / 13.2MW (electrical), Plutonium - Uranium mixed carbide fuelled, sodium cooled, loop type nuclear reactor operating at Indira Gandhi Centre for Atomic Research (IGCAR), Kalpakkam. Its main aim is to generate experience in operation of fast reactors and sodium systems and to serve as an irradiation facility for development of fuels and structural materials fur fast reactors. Nuclear reactors pose difficulties to the NDT techniques used to monitor the conditions of the internal components. Sodium cooled fast breeder reactors have their own typical difficulties in using the NDT techniques. These are due to the need for operation in aggressive environment of nuclear radiation and sodium (molten/vapour), as well as the need to maintain leak tightness of a very high order during all states of reactor operation and shutdown for fuel handling, maintenance and remote inspection. This paper discusses the following NDT techniques, which have been successfully used for the past 15 years in FBTR: (i) Periscope and Projector, (ii) Core Co-ordinate Measuring Device and, (iii) Optical fiberscope. The inspection using these techniques have given confidence for further reactor operation at high power by giving useful data on the conditions of the components inside the reactor vessel.

• Journal of the Korean Society for Nondestructive Testing
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• v.27 no.4
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• pp.321-327
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• 2007

In lock-in thermography, a phase difference between the defect area and the healthy area indicates the qualitative location and size of the defect. To accurately estimate these parameters, the shearing-phase technique has been employed which gives the shearing-phase distribution. The shearing-phase distribution has maximum, minimum, and zero points that help determine quantitatively the size and location of the subsurface defect. In experiment, the proposed technique is verified with artificial specimen and these related factors are analyzed.

• Analytical Science and Technology
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• v.27 no.6
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• pp.284-291
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• 2014

The handling process of car indoor air quality is composed of 2 steps of testing. First, assambly part is tested to find a source of car indoor VOCs. Second, cut sample of unit component is tested to find a source material of VOCs emission. If the source material of VOCs emission is found, it can reduce car and assembly part of VOCs by improving material. As cut sample testing has problem of emission from cut surface to find the source of VOCs, it needs to apply unit components testing method. The aim of study is to evaluate VOCs impact factor of unit components in assembly parts. ISO 12219-5 test method reflects not only material effect but also surface area effect by testing unit component without cutting. The unit components of doortrim and console, were tested by ISO12219-5. And it could figure what unit component is main source of VOCs in assembly. And quantity conversion Factor which gets by testing assembly and unit components can be used to make guideline of ISO 12219-5.

• Journal of the military operations research society of Korea
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• v.28 no.1
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• pp.83-96
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• 2002

The Analytic Hierarchy Process (AHP) is well suited to group decision making and offers numerous benefits as a synthesizing mechanism in group decisions. To date, the majority of AHP applications have been in group settings. One reason for this may be that groups often have an advantage over individual when there exists a significant difference between the importance of quality in the decision and the importance of time in which to obtain the decision. Another reason may be the best alternative is selected by comparing alternative solutions, testing against selected criteria, a task ideally suited for AHP. In general, aggregation methods employed in group AHP can be largely classified into two methods: geometric mean method and (weighted) arithmetic mean method. In a situation where there do not exist clear guidelines for selection between them, two methods do not always guarantee the same group decision result. We propose a simulation approach for building group consensus without efforts to make point estimates from individual diverse preference judgments, displaying possible disagreements as is natural in group members'different viewpoints.

• Journal of the Korean Society for Nondestructive Testing
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• v.24 no.3
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• pp.275-281
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• 2004

Socket weldment used to change the flow direction of fluid nay have flaws such as lack of fusion and cracks. Liquid penetrant testing or Radiography testing have been applied as NDT methods for flaw detection of the socket weldment. But it is difficult to detect the flaw inside of the socket weldment with these methods. In order to inspect the flaws inside the socket weldment, a ultrasonic testing method is established and a ultrasonic transducer and automated ultrasonic testing system are developed for the inspection. The automated ultrasonic testing system is based on the portable personal computer and operated by the program based Windows 98 or 2000. The system has a pulser/receiver, 100MHz high speed A/D board, and basic functions of ultrasonic flaw detector using the program. For the automated testing, motion controller board of ISA interface type is developed to control the 4-axis scanner and a real time iC-scan image of the automated testing is displayed on the monitor. A flaws with the size of less than 1mm in depth are evaluated smaller than its actual site in the testing, but the flaws larger than 1mm appear larger than its actual size on the contrary. This tendency is shown to be increasing as the flaw size increases. h reliable and objective testing results are obtained with the developed system, so that it is expected that it can contribute to safety management and detection of repair position of pipe lines of nuclear power plants and chemical plants.