• Advances in pediatric surgery
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• 제17권2호
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• pp.179-187
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• 2011

Experimental tracheal ligation (TL) has been shown to reverse the pulmonary hypoplasia associated with congenital diaphragmatic hernia (CDH) and to normalize gas exchange. The purpose of this study was to determine whether the TL would correct the surfactant deficiency present in the fetal rabbit model of CDH by using lamellar body count. Lamellar bodies are synthesized and secreted by the type II pneumocytes of fetal lung. The phospholipids present in these bodies constitute the major component of pulmonary surfactant. Twenty-one pregnant New Zealand rabbits underwent hysterotomy and fetal surgery on gestational day 24. Two fetuses of each pregnant rabbit were operated. In the fetus of one end of bicornuate uterus, left DH was created by excision of fetal diaphragm through open thoracotomy (DH Group). In the fetus of the other end of bicornuate uterus, left DH and TL were created (TL Group). The fetuses were delivered by Cesarean section on gestational day 31. Fourteen in control group, 12 in the DH group and 13 in TL group were born alive. En bloc excision of lungs, bronchi and trachea was done in all newborn rabbits. A five Fr catheter was inserted through trachea and repeated irrigations with 10 cc normal saline were done. The irrigated fluid was centrifuged at $280{\times}g$ for 5 minutes and the lamellar bodies were counted with the upper level fluid in platelet channel of electronic cell counter. The average lamellar body counts were $37.1{\pm}14.2{\times}10^3/{\mu}L$ in control group, $11.5{\pm}4.4 {\times}10^3/{\mu}L$ in DH group, and $6.5{\pm}0.9{\times}10^3/{\mu}L$ in TL group. Lamellar body count in DH group was lower than in control group and did not increase after TL. This study shows TL has no therapeutic effect on decreased surfactant level of CDH and the pregnant rabbit is appropriate for the animal model of CDH.

• 한국발생생물학회지:발생과생식
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• 제17권4호
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• pp.435-440
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• 2013

Previous studies, including our own, have demonstrated that the intratesticular injection of hypertonic saline (20%) decreased serum testosterone level which was similar to the surgical castration in the rat, showing the state of chemical castration. In the present study, we further verify the efficacy of this less invasive method as an alternative of surgical orchidectomy in the andrological field. Sterilized 20% saline was directly injected into the adult male rats (750 ${\mu}l$ per testis). The tested rats were divided into 3 groups including intact group (intact), orchidectomy group (ORX) and saline injection group (SAL) after bilateral orchidectomy was performed at the same day of injection. All rats were sacrificed at 4 weeks after injection. The reproductive organs (testes, epididymis, seminal vesicles and prostates) were collected and used for DNA and protein pattern analyses. Also, patho-histological studies on the testes were performed. In contrast to the intact group, similar DNA damages of testis and seminal vesicle were appeared in ORX group and SAL group. The DNA degradations seemed to be the results of necrosis rather than apoptosis. In the protein pattern analysis, all the testing tissues exerted similar patterns in the ORX group and the SAL group compared to the those of intact group. Patho-histological studies revealed that severe degenerative changes in testicular seminiferous tubules and massive infiltration of immune cells in SAL group. The present study confirmed that direct injection of hypertonic saline into the testis caused the equivalent biochemical changes in the accessory sex organs as shown in the orchidectomized animals. These results suggest that hypertonic saline injection model could be a useful castration model which can substitute for surgical castration when its safety is secured through further study in the future.

• 대한치과보철학회지
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• 제27권2호
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• pp.79-100
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• 1989

The Purpose of this study was to investigate material differences in stress transmission among various artificial teeth and denture base materials. For this study, a two-dimensional finite element model and a two-dimensional photoelastic model of a mandible with complete denture were made. A resin tooth and a porcelain tooth were used as artificial teeth, and a resin base, a metal lined base, and a soft-liner lined base were used as denture bases. An occlusal load was applied and principal stresses generated in the supporting tissues were compared. To test the impact stress transmission, strain gauge attached to the denture base specimens made of the different materials were made in thick and thin groups. Voltage outputs from hitting the specimen with a steel ball were compared. The results were as follows : 1. In FEM, increasing the mucosal thickness reduced the maximum principal stresses in the supporting tissues, but altering the tooth materials and the base materials induced no difference in the stresses. 2. In photoelastic model study, no difference in fringe order among the specimens were observed, but the thick mucosa group and the soft-liner lined group revealed a more uniform distribution of the load. 3. In strain measuring, the impact force transmission was highest in the soft-liner lined group, and was the lowest in the metal lined group(p<0.01). 4. In the thin group using the resin base, the porcelain tooth showed higher impact stress transmission than the resin tooth(p<0.01), but no difference was observed between them in the thick group. In the soft-liner lined group, the porcelain tooth showed higher impact stress transmission than the resin tooth(p<0.01), but no difference was observed between them in the metal lined group. 5. The thick group showed lower impact stress transmission than the thin group(p<0.01).

• 대한한의학회지
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• 제44권4호
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• pp.136-149
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• 2023

Objectives: Facial diagnosis is an important part of clinical diagnosis in traditional East Asian Medicine. In this paper, we proposed a model to quantitatively classify cold sensitivity using a fully automated facial image analysis system. Methods: We investigated cold sensitivity in 452 subjects. Cold sensitivity was determined using a questionnaire and the Cold Pattern Score (CPS) was used for analysis. Subjects with a CPS score below the first quartile (low CPS group) belonged to the cold non-sensitivity group, and subjects with a CPS score above the third quartile (high CPS group) belonged to the cold sensitivity group. After splitting the facial images into train/validation/test sets, the train and validation set were input into a convolutional neural network to learn the model, and then the classification accuracy was calculated for the test set. Results: The classification accuracy of the low CPS group and high CPS group using facial images in all subjects was 76.17%. The classification accuracy by sex was 69.91% for female and 62.86% for male. It is presumed that the deep learning model used facial color or facial shape to classify the low CPS group and the high CPS group, but it is difficult to specifically determine which feature was more important. Conclusions: The experimental results of this study showed that the low CPS group and the high CPS group can be classified with a modest level of accuracy using only facial images. There was a need to develop more advanced models to increase classification accuracy.

• 산업경영시스템학회지
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• 제13권22호
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• pp.99-111
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• 1990

The first national QC Circle Convention sponsored by Industry Advancement Administration in 1975 was the beginning of employees group activity from a national point view. Subsequently some events such as the first nationwide Factory Seamaul activity small Group Convention, which was supervised by the ministry of Trading and Industry and Factory Seamanulundong promotion Center, paved the way for proliferation of the group activity through all kinds of manufacturing. Although since November 1982 these two conventions has been united, many problem have been disclosed that are against the basic principle more or less. Worker's small group activity is, essentially, a trouble shooting oriented voluntary small group within their working place to improve the surroundings creatively. In practice, however, many groups are so typical and so impetuous of the material effect that it is worried to be inclined to outform rather than contents. Effective small group activities are presumed to he successful only with labor management cooperation on the basis of human-oriented management philosophy. The small group activities are also prevalent in service sector. More derivative methods have been developed and more members are willingly participating in training programs. The small group which is basically a horizontal organization unit, promotes communication within the whole organization. In consideration of the social circumstances and traditions, the flexible model of the small group activities suitable to the corporate environment, will contribute to industrial development.

• 품질경영학회지
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• 제19권1호
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• pp.115-128
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• 1991

In korea, since November 1982 these two small group actvity convension (QC circle convension and Factory Saemaul activity small group convension) has been united, many problem have been disclosed that are against the basic principle more or less. Worker's small group activity is essentially, a trouble shooting oriented voluntary small group within their working place to improve the surroundings creatively. In practice. however, many group are so typical and so impetuous of the material effect that it is worried to be inclined to outform rather than contents. Effective small group activities are presumed to be successful only with labor management cooperation on the basis of human-orient management philosophy. The small group activities are also prevalent in service sector. More derivative methods have been developed and more members are willingly participating in training programs. The small group which is basically a horizontal organization unit, promptes communication within the whole organization. In consideration of the social circumstances and traditions, the flexible model of the small group activities suitable to the corporate environment, will contribute industrial development.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2002년도 기초기술학술발표회
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• pp.11-29
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• 2002

Current design of pile group is based on the estimation of the overall bearing capacity of a pile group from that of a single pile using a group efficiency. However, the behaviors of a pile group are influenced by various factors such as method of pile installation, pile-soil-pile interaction, cap-soil-pile interaction, etc. Thus it is practically impossible to take into account these factors reasonably with the only group efficiency, In this paper, a new method for the design of pile groups is proposed, where the significant factors affecting the behavior of a pile group are considered separately by adopting several efficiencies. Furthermore, in the proposed method, the load transfer characteristics of piles and the difference of pile behaviors with respect to the pile locations in group can be taken into account. The efficiencies for the method are determined using the settlement failure criterion, which is consistent with the concept of allowable settlement for structures. The efficiencies calculated from the results of existing model tests are presented, and the bearing capacity of a pile group in the other model test is calculated and compared with that from the test result, to verify the validity of the proposed method.

• 마케팅과학연구
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• 제17권3호
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• pp.1-19
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• 2007

본 연구에서는 농촌관광 방문객에게 제공되는 편의시설을 유형화하고 어떤 특징을 가진 방문객이 어떤 편의시설을 선호하는지를 규명하기 위한 방법과 그 분석결과를 제시하였다. 이를 위하여 우선 2단계 군집분석법을 사용하여 농촌관광 편의시설을 유형화하였다. 그 다음으로 군집분석에 사용되는 변인이 범주형 변인이 있을 경우 전통적인 군집분석 방법을 적용할 수 없기 때문에 2단계 군집분석을 하였다. 본 연구는 2단계 군집분석법이 범주형 변인으로 측정된 농촌관광의 편의시설을 유형화하는 데 매우 유용하다는 것을 보여 주고 있다. 다중로짓 모형을 사용하여 특정 편의시설 유형을 선호할 확률에 영향을 미치는 농촌관광 방문자의 사회인구학적 특성과 여행특성을 규명하였다. 즉, 다중로짓 모형을 통해 참조항(일반농가형)으로 설정된 편의시설 유형에 비해 특정 편의시설을 선호할 확률에 영향을 미치는 소비자의 특성을 규명할 수 있다는 것이 본 연구의 특징이다.

• 산업경영시스템학회지
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• 제16권27호
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• pp.83-89
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• 1993

In order to model the Group Technology Problem three formulations are used, that is, generally the following formulations are used: (1) Matrix formulation, (2) Mathematical programming formulation, (3) Graph formulation. In the case of Matrix formulation, it is difficult to discribe the situation using the multi-job machine. But this paper proposed the model of Group Technology using the multi-job machin, taking the method of making practical application of principle of similarity coefficient.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2002년도 ICCAS
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• pp.93.6-93
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• 2002

Many livings form groups that we consider as collective systems. Their collective behaviors are good model for the development of useful distributed systems. In this paper, We discussed the group of motile elements that is described by simple model. The dynamics of each element is described by simple kinematics, but the group shows various types of motions. In addition, we found out the formation of the group changes by modifying rc which is an optimum distance between each element. This modification shows us to observe close-packed structure, face-centered lattice, sim pie lattice and double file.