• Journal of Gastric Cancer
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• 제23권2호
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• pp.315-327
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• 2023

Purpose: Oxaliplatin, a component of the capecitabine plus oxaliplatin (XELOX) regimen, has a more favorable toxicity profile than cisplatin in patients with advanced gastric cancer (GC). However, oxaliplatin can induce sensory neuropathy and cumulative, dose-related toxicities. Thus, the capecitabine maintenance regimen may achieve the maximum treatment effect while reducing the cumulative neurotoxicity of oxaliplatin. This study aimed to compare the survival of patients with advanced GC between capecitabine maintenance and observation after 1st line XELOX chemotherapy. Materials and Methods: Sixty-three patients treated with six cycles of XELOX for advanced GC in six hospitals of the Catholic University of Korea were randomized 1:1 to receive capecitabine maintenance or observation. The primary endpoint was progression-free survival (PFS), analyzed using a two-sided log-rank test stratified at a 5% significance level. Results: Between 2015 and 2020, 32 and 31 patients were randomized into the maintenance and observation groups, respectively. After randomization, the median number of capecitabine maintenance cycles was 6. The PFS was significantly higher in the maintenance group than the observation group (6.3 vs. 4.1 months, P=0.010). Overall survival was not significantly different between the 2 groups (18.2 vs. 16.5 months, P=0.624). Toxicities, such as hand-foot syndrome, were reported in some maintenance group patients. Maintenance treatment was a significant factor associated with PFS in multivariate analysis (hazard ratio, 0.472; 95% confidence interval, 0.250-0.890; P=0.020). Conclusions: After 6 cycles of XELOX chemotherapy, capecitabine maintenance significantly prolonged PFS compared with observation, and toxicity was manageable. Maintenance treatment was a significant prognostic factor associated with PFS.

• Journal of Chest Surgery
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• 제24권12호
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• pp.1167-1172
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• 1991

Since March 1988 we have performed 133 arteriovenous fistulae for hemodialysis in 121 patients with chronic renal failure. Of the 133 cases of arteriovenous fistulae, follow-up evaluation was possible for 80 cases which performed in 69 patients. The relation between blood flow and patency rate and duration of arteriovenous fistula was examined. The overall 6 - 12 - 18 -, and 24 - month patency rates of arteriovenous fistulae were 82%, 64%a, 62%, and 57%, respectively. The maximum blood flow was 150 ~ 350ml /min[mean 217.1$\pm$44.27]. The patency duration was evaluated in patients divided into three groups owing to maximum blood flow through the fistulae. The range of maximum blood flow was 150 ~ 200ml /min for group A, 200 ~ 250ml /min for group B, and above 250ml /min for group C. The mean duration of the patency was 10.7$\pm$7.60 months in group A, 14.9$\pm$9.82 months in group B, and 21.6$\pm$11.16 months in group C[p<0 05]. With increased maximum blood flow, the duration of the patency was longer in group A than group B and C [r=0.39, p<0. 05]. The maintenance blood flow was 100 ~ 250ml /min[mean 179.2$\pm$37.26 ml/min]. When the maintenance blood flow was above 200ml /min, long-term patency rate was higher than the group below 200ml /min[r=0.48, p<0.01]. In the same range of blood flow, patency duration of the patients with using their own blood vessels were longer than the patients with using vascular graft for A-V fistula. We concluded that the patency of the arteriovenous fistulae was closely correlated with the blood flow through the fistulae.

• Journal of Periodontal and Implant Science
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• 제52권4호
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• pp.312-324
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• 2022

Purpose: The role of hard-type crosslinked hyaluronic acid (HA) with particulate bone substitutes in bone regeneration for combined inlay-onlay grafts has not been fully investigated. We aimed to evaluate the effect of hard-type crosslinked HA used with bone substitute in terms of new bone formation and space maintenance. Methods: A 15-mm-diameter round defect was formed in the calvaria of 30 New Zealand White rabbits. All animals were randomly assigned to 1 of 3 groups: the control group (spontaneous healing without material, n=10), the biphasic calcium phosphate (BCP) graft group (BCP, n=10), and the BCP graft with HA group (BCP/HA, n=10). The animals were evaluated 4 and 12 weeks after surgery. Half of the animals from each group were sacrificed at 4 and 12 weeks after surgery. Samples were evaluated using micro-computed tomography, histology, and histomorphometry. Results: The BCP group showed higher bone volume/tissue volume (BV/TV) values than the control and BCP/HA groups at both 4 and 12 weeks. The BCP and BCP/HA groups showed higher bone surface/tissue volume (BS/TV) values than the control group at both 4 and 12 weeks. The BCP group showed higher BS/TV values than the control and BCP/HA groups at both 4 and 12 weeks. No statistically significant difference in newly formed bone was found among the 3 groups at 4 weeks. The BCP group showed significantly higher new bone formation than the BCP/HA group at 12 weeks. Conclusions: Hard-type crosslinked HA did not show a positive effect on new bone formation and space maintenance. The negative effect of hard-type crosslinked HA may be due to the physical properties of HA that impede osteogenic potential.

• 한국물환경학회지
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• 제28권2호
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• pp.202-212
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• 2012

Due to the deterioration of water supply network and the deficiency of raw water, the water utility of local governments have performed various projects to improve their revenue water ratio. However, it is very difficult to estimate the cost for maintaining the revenue water ratio at higher level after completing the project, because local governments have different conditions affecting the operating and maintenance cost of water supply network. The purpose of this study is to present a procedure to estimate the operating and maintenance cost required to maintain the target revenue water ratio of the water supply network. For this purpose, we estimated the cost used only for operation and maintenance of water supply network of 164 local governments with the aid of K-Mean Clustering Analysis and the data from 40 representative local governments. Then, the regression analysis was performed to find relationship between revenue water ratio and the operating and maintenance cost with two different data sets generated by two classification methods; the first method classifies the local governments by means of k-means clustering, and the other classifies the local governments according to the index standardized by the operating and maintenance cost per unit length of water mains per revenue water ratio. The results shows that the method based on the index standardized by the cost and revenue water ratio of each government produces more reliable results for finding regression equations between revenue water ratio and the operating and maintenance cost only for water supply network. The estimated regression equations for each group can be used to estimate the cost required to keep the target revenue water ratio of the local government.

• 한국멀티미디어학회논문지
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• 제6권4호
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• pp.668-675
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• 2003

Now a days many industries and bigger organisation (Indian Railways, Bharat Heavy Electricals Ltd.) are facing difficulties in implementing the new technology because of non-availability of fully trained staff. Also for the employed technical and other staff lot of resistance management has to face to get them trained for adoption of new technology. There are also very less organisations who can design effective training programmes and at the same time develop course material specially multimedia packages and computer base training (CBT) which can satisfy the need of different target groups of industries. Indian Railways was also facing similar situation while implementing the Air Brake System technology In Indian Railways. TTTI Bhopal took that challenge and designed, developed and trained Indian Railways trainer for implementation of the package on different target group. The present paper offers a case study on the same.

• 한국의류학회지
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• 제27권7호
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• pp.809-818
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• 2003

The purpose of this study was to identify importance of gender in dynamic relationship structure in fashion internet shopping mall and to provide marketers e-CRM marketing strategy. Out of 473 customers, 470 who had purchased fashion products in fashion Internet shopping mall were surveyed for this study. The data was analyzed by factor analysis, 1-test, correlation analysis, Structural Equation Model(SEM) using AMOS program. As the results, both men and women had ‘relationship maintenance intention’ in e-CRM. However, only women had ‘intention to discontinue relationship’, when shopping mall made mistakes to them. Also, in men's group, ‘service’ only had effect on ‘Trust’, while ‘service’and ‘financial benefit’ had effects on‘Trust’ in women's group. If women would be dissatisfied with a shopping mall, they have a strong intention to disconnect with it. Based on these results, it could be concluded that men have more tolerance for shopping mall's mistakes than women have. Therefore, the results of this study provide e-CRM marketing strategy for fashion internet marketers.

• 대한임상전기생리학회지
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• 제2권3호
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• pp.1-12
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• 2004

Estrogens are critical to the functioning and maintenance of a diverse array of tissues and physiological systems in mammals. The actions of estrogen on such classical targets as the reproductive tract, gonads, mamary tissue, and hypothalamic/pituitary axis have been well characterized. A role in nonreproductive tissues, such as maintenance of bone mineral density and cardiovascular health in woman, as has been described. There were ne significant differences in the average of body weights, testis weights, among the experimental groups. The lumen of rate testis began to dilate from the day 8 and continued to the 59 post-treatment. The average diameter of dilate of rate testis in ICI 182,780 treated group increased 2.3-fold compared to the control group. Epithelical cell height in the rate testis of the treated mice decreased all the time periods, compared to the control.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2016년도 춘계 학술논문 발표대회
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• pp.89-90
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• 2016

Despite the rise of importance of Facility Management(FM), relatively little attention was paid to evaluate FM efficiency and drive for greater FM efficiency. The purpose of the present paper is to offer a quantitative analysis of 14 Key Success Factors(KSF) and 22 detailed maintenance practices in order to develop FM evaluation system. In addition, from survey with Owner/Property Manager group and Facility Manager group, the present paper measures both importance of detailed maintenance practices and performance satisfaction. It is expected that by using the result of this survey, this paper helps increase efficiency in FM. Moreover, It is expected that this paper will be used as base line data in developing FM practice evaluation system.

• 대한산업공학회지
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• 제40권4호
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• pp.428-434
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• 2014

Dry docks are used to repair warships or Merchant ships based on their life cycles. There are the certain number of dry docks in the ROK Navy, However, the ROK Navy force structure has been changing a lot since the Korean War. The focus of this study is to analyze the queueing problem regarding present dry docks capacities and to forecast the appropriate number of dry docks based on future naval ship structure. The study proposes to obtain an efficient dry dock size using queueing problem and simulation.

• 한국통신학회:학술대회논문집
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• 한국통신학회 2006년도 하계종합학술발표회 논문 초록집
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• pp.615-615
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• 2006