• Biomolecules & Therapeutics
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• v.4 no.4
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• pp.301-309
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• 1996

LBD-001, a recombinant human interferon ${\gamma}$ produced by genetically engineered yeast as a host system, was intravenously administered to pregnant female rats (Sprague-Dawley) from day 7 to 17 of gestation at dose levels of 0.35$\times$10$^{6}$ , 0.69$\times$10$^{6}$ , and 1.38$\times$10$^{6}$ I.U./kg/day. As the control groups, hydrocortisone sodium succinate (5 or 10 mg/kg/day) was also similarly administered. Teratological effects of the test agents on fetuses and development of offsprings (F1 rats) were investigated. (1) No significant changes by the treatment of LBD-001 were observed in body weight, food and water consumption, feeding and nursing behaviors, and autopsy of pregnant or lactating mother rats. However, in hydrocortisone sodium succinate (10 mg/kg/day)-treated group, significant decreases of body weight on day 16, 18, and 20 of gestation and food consumption on day 20 of gestation and outstanding atrophy of thymus and adrenals were observed in two rats autopsied on day 20 of gestation. (2) No significant changes in resorption rate, skeletal or visceral development of fetuses, and physical or sensory development of offsprings (Fl) by the treatment of LBD-001 were detected. In hydrocortisone sodium succinate (10 mg/kg/day)-treated group, however, there were significant decreases of body weight of fetuses, delay of ossification, temporary delay of body weights of offsprings (F1) on day 1 and 3 of lactation, and increased tendency of stillborn rate and malformation rate of bone. The results show that LBD-001 at the dose of 1.38$\times$10$^{6}$ I.U./kg/day or less is not teratogenic in organogenesis of fetuses and the development of offsprings (F1). Meanwhile, hydrocortisone sodium succinate (10 mg/kg/day) seems to delay ossification of fetuses and temporarily retard the development of offsprings (Fl).

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.12 no.1
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• pp.17-27
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• 2012

Broadcast-based data dissemination has become a widely accepted approach of communication in the mobile computing environment. However, with a large set of data items, the expected delay of receiving a desired data increases due to the sequential nature of the broadcast channel. This paper explores the issue of designing proper data allocation on multiple broadcast channels to reduce this wait time, and proposes a new data allocation scheme named near optimal data allocation(NODA). The proposed scheme first partitions all data items in K group based on the theoretical lower-bound of the average expected delay to determine data items which each broadcast channel has to broadcast. Then, NODA further partitions each group of data items in B groups using extended dynamic programming algorithm to broadcast data items allocated on the same broadcast channel in different frequencies. The proposed scheme is capable of minimizing the average expected delay time since it can broadcast data items allocated on the same channel reflecting their popularities.

• The KIPS Transactions:PartC
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• v.16C no.6
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• pp.791-800
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• 2009

Multicasting is fundamental to many ad hoc network applications requiring collaboration of multiple nodes in a group. A general approach is to construct an overlay tree and to deliver a multicast packet to multiple receivers over the tree. This paper proposes adaptive overlay trees (AOTs) on wireless ad hoc networks of static nodes for delay- and energy-efficient multicast. A tradeoff function is derived, and an algorithm for AOT construction is developed. Note here that the requirements of delay and energy consumption may vary with different classes of applications. By adjusting parameters in the tradeoff function, different AOTs can be adaptively chosen for different classes of applications. An AOT is constructed in O(ke) time where e is the number of wireless links in a network and k is the number of member nodes in a multicast group. The simulation study shows that AOT adaptively provides tradeoffs between the fastest multicast (which is the choice if delay is the most important factor) and the most energy efficient multicast (which is used when energy consumption is the primary concern). In other words, one of AOTs can be appropriately chosen in accordance with the operation requirement.

• Journal of the Korean Society of Radiology
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• v.15 no.2
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• pp.93-100
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• 2021

The purpose of this study is to find out the factors that affect the patient's exposure dose during the abdominal CT scan using the bolus tracking technique, and reducing the radiation exposure to the patient during the abdominal CT scan using the bolus tracking technique by adjusting the delay time according to the corresponding factor. The experiment was divided into two parts, and the first experiment was conducted with 300 patients There were 188 males and 112 females, and their average age was 58±12.18(19~85). In the second experiment, 150 subjects (100 males and 50 females) who were undergoing their follow-up examination among the first experiment subjects, and the difference in dose before and after was compared by applying the delay time according to the influencing factor. As a result of the first experiment, there was a relationship between the arrival time of the contrast media and the heart rate, and it was found that the arrival time decreased as the heart rate increased for both men and women. As a result of the second experiment, the average dose of CTDIvol and DLP before/after applying the delay time according to the heart rate decreased 4.98 mGy and 5.33 mGy·cm in the male group, and 3.54 mGy and 3.88 mGy·cm in the female group. By applying proper delay time according to the patient's heart rate during abdominal CT scan with the bolus tracking technique, the radiation exposure dose of the patient can be reduced.

• Radiation Oncology Journal
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• v.18 no.2
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• pp.133-137
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• 2000

Purpose :To investigate whether combined beta-carotene with X-Irradiation has more enhanced radition response than X-irradiation or not, we peformed a experiment about in vitro cytotoxlcity of beta-carotene and/or X-irradiation in the fibrosarcoma cells, tumor growth delay of combined beta-caroten with/or X-irradiation in the mouse fibrosarcoma. Materials and Methods : 2$\%$ emulsion of beta-carotene was serially diluted and used. X-Irradiation was given by 6 MeV linear accelerator. The cytotoxicity of beta-carotene in vitro was evaluated from clonogenic assay. To compare the cytotoxiclty between combined beta-carotene with X-irradiation and X-irradiation group, 2 mg/ml of beta-carotene was contacted to fibrosarcoma (FSall) cells for 1 hour before X-irradiation. For the tumor growth delay, single 20 Gy was given to FSall tumor hearing C3H/N mice whic was classified as beta-crotene with X-irradiation group (n=5) and X-irradiation alone group (n=5). 0.2 ml of 20 mg/kg of beta-carotene were i.p. injected to mice 30 minute before X-irradiation in the beta-crotene with X-irradiation group. The tumor growth delay defined as the time which reach to 1,000 mm$^{3}$ of tumor volume. Results : (1) Cytotoxicity in vitro: 1) survival fraction at beta-carotene concentration of 0.002,0.02,0.2 and 2 mg/ml were 0.69$\pm$0.07, 0.59$\pm$0.08, 0.08$\pm$0.008 and 0.02$\pm$0.006, respectively. 2) each survival fraction at 2, 4, 6 and 8 Gy in the 2 mg/ml of beta-carotene + X-irradiation group were 0.13$\pm$0.05, 0.03$\pm$0.005, 0.01 $\pm$0.002 and 0.009$\pm$0.0008, respectively. But each survival fraction at same irradiation dose in the X-irradiation group were 0.66$\pm$0.05, 0.40$\pm$0.04, 0.11$\pm$0.01 and 0.03$\pm$0.006, respectively(p<0.05). (2) The time which reach to 1,000 mm$^{3}$ of tumor volume of beta-carotene + X-irradiation group and X-irradiation alone group were 18, 19 days, respectively(p>0.05) Conclusion : The contact of beta-caroten to Fsall cells showed mild cytotoxicity which 띤as increased according to concentration. The cytotoxicity of combined beta-carotene with X-irradiation more increased than that of X-irradiation, additionally, And there was significant difference of cytotoxicity between two groups. But there were no significant difference of the growth delay of fibrosarcoma between two groups.

• Journal of electromagnetic engineering and science
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• v.10 no.2
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• pp.73-77
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• 2010

This paper proposes a novel memory effect measurement technique in RF power amplifiers(PAs) using a two-tone intermodulation distortion(IMD) signal with a very simple and intuitive algorithm. Based on the proposed predistortive tone cancellation technique, the proposed measurement method is capable of measuring the relative phase and magnitude of the third-order and fifth-order IMDs, as well as the fundamental signal. The measured relative phase between the higher and lower IMD signal for specific tone spacing can be interpreted as the group delay(GD) information of the IMD signal concerned. From the group delay analysis, we can conclude that an adaptive control of GD as well as the magnitude and phase is a key function in increasing the linearization bandwidth and the dynamic range in a predistortion(PD) technique.

• Transactions of the Korean Society of Mechanical Engineers
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• v.16 no.12
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• pp.2376-2384
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• 1992

A theoretical analysis is carried out to predict the characteristics of transient ignition phenomena for the spherical fuel droplets cloud with non-uniform droplet size and number density distribution. Numerical calculations are performed for various cases depending on the combinations of the major parameters such as ambient temperature and initial distributions of droplet size and number density. The results of present study show that the ignition delay decreases for higher ambient temperature and smaller droplet size. Droplets cloud of hollow type with outer concentrated distribution ignites most rapidly.

• The Journal of Asian Finance, Economics and Business
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• v.5 no.4
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• pp.45-56
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• 2018

The paper aims to examine relationships between search-based sentiment and stock market reactions in Vietnam. This study constructs an internet search-based measure of sentiment and examines its relationship with Vietnamese stock market returns. The sentiment index is derived from Google Trends' Search Volume Index of financial and economic terms that Vietnamese searched from January 2011 to June 2018. Consistent with prediction from sentiment theories, the study documents significant short-term reversals across three major stock indices. The difference from previous literature is that Vietnam stock market absorbs the contemporaneous decline slower while the subsequent rebound happens within a day. The results of the study suggest that the sentiment-induced effect is mainly driven by pessimism. On the other hand, optimistic investors seem to delay in taking their investment action until the market corrects. The study proposes a unified explanation for our findings based on the overreaction hypothesis of the bearish group and the strategic delay of the optimistic group. The findings of the study contribute to the behavioral finance strand that studies the role of sentiment in emerging financial markets, where noise traders and limits to arbitrage are more obvious. They also encourage the continuous application of search data to explore other investor behaviors in securities markets.

• Journal of the Optical Society of Korea
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• v.16 no.3
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• pp.288-291
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• 2012

We designed an ultra-wide band-pass filter applicable to microwave reflectometry for KSTAR (Korea Superconducting Tokamak Advanced Research) and to microwave photonics. The proposed ultra-wide band-pass filter exhibits a metamaterial structure characterized by a wide band, low insertion loss, and high skirt selectivity. The proposed filter is applied to enhance the linearity of reflectometry at the output of a VCO (voltage controlled oscillator). The pass-band of the proposed filter is observed at 18~28 GHz, and the out-of-band rejection is below 20 dB. Further, we constructed an unwrapped negative phase of S(2, 1) to verify the characteristics of the metamaterial. The under- and upper-band at lower limits of the pass-band are left- and right-handed, respectively. The group delay of the filter is less than 0.5 ns.

• Journal of Information Processing Systems
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• v.11 no.3
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• pp.483-494
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• 2015

High Efficiency Video Coding (HEVC) is the most recent video codec standard of the ITU-T Video Coding Experts Group and the ISO/IEC Moving Picture Experts Group. The main goal of this newly introduced standard is for catering to high-resolution video in low bandwidth environments with a higher compression ratio. This paper provides a performance comparison between HEVC and H.264/AVC video compression standards in terms of objective quality, delay, and complexity in the broadcasting environment. The experimental investigation was carried out using six test sequences in the random access configuration of the HEVC test model (HM), the HEVC reference software. This was also carried out in similar configuration settings of the Joint Scalable Video Module (JSVM), the official scalable H.264/AVC reference implementation, running on a single layer mode. According to the results obtained, the HM achieves more than double the compression ratio compared to that of JSVM and delivers the same video quality at half the bitrate. Yet, the HM encodes two times slower (at most) than JSVM. Hence, it can be concluded that the application scenarios of HM and JSVM should be judiciously selected considering the availability of system resources. For instance, HM is not suitable for low delay applications, but it can be used effectively in low bandwidth environments.