• Journal of Korean Neurosurgical Society
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• v.53 no.2
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• pp.65-71
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• 2013

Objective : In order to develop a novel nerve guidance channel using porcine small intestinal submucosa (SIS) for nerve regeneration, we investigated the possibility of SIS, a tissue consisting of acellular collagen material without cellular immunogenicity, and containing many kinds of growth factors, as a natural material with a new bioactive functionality. Methods : Left sciatic nerves were cut 5 mm in length, in 14 Sprague-Dawley rats. Grafts between the cut nerve ends were performed with a silicone tube (Silicon group, n=7) and rolled porcine SIS (SIS group, n=7). All rats underwent a motor function test and an electromyography (EMG) study on 4 and 10 weeks after grafting. After last EMG studies, the grafts, including proximal and distal nerve segments, were retrieved for histological analysis. Results : Foot ulcers, due to hypesthesia, were fewer in SIS group than in Silicon group. The run time tests for motor function study were 2.67 seconds in Silicon group and 5.92 seconds in SIS group. Rats in SIS group showed a better EMG response for distal motor latency and amplitude than in Silicon group. Histologically, all grafts contained some axons and myelination. However, the number of axons and the degree of myelination were significantly higher in SIS group than Silicon group. Conclusion : These results show that the porcine SIS was an excellent option as a natural biomaterial for peripheral nerve regeneration since this material contains many kinds of nerve growth factors. Furthermore, it could be used as a biocompatible barrier covering neural tissue.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.8B
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• pp.721-729
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• 2004

In this paper, we applied a group scheduling algorithm to core nodes in an optical burst switching (OBS) network and measured its performance by simulation. For the case of core nodes with multi-channel input/output ports, performance of the group scheduling has been compared to that of the immediate scheduling. Since the group scheduling has a characteristic of scheduling a group of bursts simultaneously in a time window using information collected from corresponding burst header packets arrived earlier to a core node, simulation results show that the group scheduling outperforms the immediate scheduling in terms of both burst loss probability and channel utilization and the difference gets larger as the load increases. Another node configuration in which wavelength converters are equipped at the output ports has also been considered. In this case, even though both performance metrics of the group scheduling are almost the same as those of the immediate scheduling in the offered load range between 0.1 and 0.9, the group scheduling has lower wavelength conversion rate than the immediate scheduling by at least a factor of seven. This fact leads us to the conclusion that the group scheduling makes it possible to implement more economical OBS core nodes.

• 전자공학회논문지 IE
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• v.45 no.1
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• pp.44-49
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• 2008

In this paper, the performance for the non-linear satellite channel including the characteristics of group delay and gain ripple of transponder is analyzed with multi-level QAM-OFDM schemes. Comparing the BER performances between general OFDM and CI(Carrier Interferometry)-OFDM for various QAM schemes, the degree of performance improvement is presented in AWGN environments for specified nonlinear characteristics. The simulations are performed with the 36MHz bandwidth of transponder channel and 120Mbps transmission rate for QPSK, 8QAM, 16QAM, 32QAM, 64QAM schemes between normal and worst case condition. It is shown that the improvement measure by the CI-OFDM for the group delay of channel and nonlinear characteristic of HPA outperforms that for the gain ripple in the case of higher level QAM scheme in normal condition. And the simulation results show that the additional techniques like the channel coding and compensation scheme against the nonlinear characteristic are required for 32QAM and higher level QAM in worst case condition.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.9 no.6
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• pp.2014-2034
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• 2015

This paper focuses on solving co-channel interference (CCI) issues arising in the open subscriber group (OSG) mode of heterogeneous networks (HetNets). Considering a general framework consisting of arbitrary number of picocells within a macro cell, where the inter-user interference (IUI) is the main CCI to macro user equipments (UEs), while the the inter-cell interference (ICI) is the major CCI to pico UEs. In this paper, three IA based transceiver design schemes are proposed. For macro cell, we uniformly use block diagonalization (BD) scheme to eliminate the IUI. And for picocells, three IA schemes are proposed to mitigate the ICI. The first scheme, named as zero forcing IA (ZF-IA) scheme, aligns the inter picocell interference onto an arbitrary sub-space of the cross-tier interference using ZF scheme. Considering the channel state information (CSI) of the desired channel of pico UEs, the second scheme, named as optimal desired sub-channel selected IA (ODC-IA) scheme, aligns the inter picocell interference onto a certain sub-space of the cross-tier interference, which guarantees the largest channel gain of the desired signal of pico UEs. The third IA scheme, named as maximum cross-tier interference selected IA (MI-IA) scheme, is designed for the system with less receive antennas. The inter picocell interference is aligned onto the space of the strongest cross-tier interference and only the interference on this space is nullified. The complexity analysis and simulations show that the proposed transceiver design schemes outperform the existing IA schemes in the OSG mode of HetNets, and the MI-IA scheme reduces the requirement of the receive antennas number with lower complexity.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.12 no.1
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• pp.17-27
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• 2012

Broadcast-based data dissemination has become a widely accepted approach of communication in the mobile computing environment. However, with a large set of data items, the expected delay of receiving a desired data increases due to the sequential nature of the broadcast channel. This paper explores the issue of designing proper data allocation on multiple broadcast channels to reduce this wait time, and proposes a new data allocation scheme named near optimal data allocation(NODA). The proposed scheme first partitions all data items in K group based on the theoretical lower-bound of the average expected delay to determine data items which each broadcast channel has to broadcast. Then, NODA further partitions each group of data items in B groups using extended dynamic programming algorithm to broadcast data items allocated on the same broadcast channel in different frequencies. The proposed scheme is capable of minimizing the average expected delay time since it can broadcast data items allocated on the same channel reflecting their popularities.

• Bulletin of the Korean Chemical Society
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• v.30 no.11
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• pp.2707-2712
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• 2009

5-$HT_{3}$ receptor;5-$HT_{3A}$ receptor channel activity;Novel 5-$HT_{3}$ receptor channel current blockers;Chlorophenyl substituted piperazinylethylaminomethylpyrazoles; The 5-$HT_{3A}$ receptors are one of ligand-gated ion channels and are known to be involved in visceral pain, anxiety, or anticancer agent-induced nausea and vomiting. In present study, we designed novel skeletons based on the developed 5-$HT_{3}$ receptor antagonists and evaluated their effects on 5-$HT_{3A}$ receptor channel currents ($I_{5-HT}$) of a series of pyrazole derivatives having N-chlorophenylpiperazine functionality (6-9). We found that most of N-p-chlorophenyl substituted piperazinyl-pyrazole derivatives (7b, 7c, 7e and 7h) exhibited the high potency for the inhibition of $I_{5-HT}$, whereas the compound without chloride (6) or with m-chlorophenyl group (a serious of 8 and 9) showed the low potency. These result indicate that p-chlorophenyl group is might play an important role for increasing the inhibitory potency on $I_{5-HT}$.

• Journal of Digital Convergence
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• v.18 no.6
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• pp.255-269
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• 2020

This paper aims to analyze the factors influencing consumer's choice of smartphone purchase channel in multichannel environments. Recently, smartphone purchase channels are becoming more complex and diverse. A smartphone with a short purchase cycle is a product applying advanced technology, the research of this topic would be significant. The major findings of this study are as follows. First, depending on the consumer's shopping orientation, the consumer group was classified into three groups of preference 1. Active shopping, 2. Convenient shopping, and 3. Rational shopping. Second, it was analyzed that the consumer's shopping orientation influenced the decisions of the information search channel and the purchase channel. Third, there was a significant difference between the search and purchase channels in the three groups. Finally, in the channel experience, there was a significant difference in price satisfaction by group. The results of these studies are expected to provide practical implications for establishing a customized multi-channel strategy. This study provides a desirable model for research on smartphone purchase channels.

• Biomolecules & Therapeutics
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• v.15 no.3
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• pp.156-161
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• 2007

Rapid advances in pharmacogenomic research have provided important information to improve drug selection, to maximize drug efficacy, and to minimize drug adverse reaction. The SNPs that are the most abundant type of genetic variants have been proven as valid biomarkers to give information on the prediction of pharmacokinetic/pharmacodynamic properties of drugs based on genotype. In order to elucidate a correlation between SNPs of calcium channel encoding gene and adverse reactions of calcium channel blockers, we investigated SNPs in CACNA1C gene known as a binding site of calcium channel blocker. 96 patients with hypertension who had taken or are taking an antihypertensive drug, 1,4-dihydropyridine (DHP) were included for analysis. These patients were composed of 47 patients with adverse drug reactions (ADR) such as edema from calcium channel blockers and 49 patients without ADR as a control group. The exons encoding the drug binding sites were amplified by PCR using specific primers, and SNPs were analyzed by direct sequencing. We found that there was no SNP in the exons encoding DHP binding site, but four novel SNPs in the exon-intron junction region. However, four novel SNPs were not associated with the ADR of calcium channel blockers. In conclusion, this study showed that ADR from calcium channel blockers may not be caused by SNPs of the binding sites of calcium channel blockers in CACNA1C gene.

• Journal of Advanced Navigation Technology
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• v.11 no.4
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• pp.415-422
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• 2007

In this paper, we proposed a new dynamic channel allocation algorithm for TD-SCDMA with cross time slots. In order to reduce the interference in cross time slot, the mobile stations (MSs) are divided into two groups: the Near Group consisting of MSs near by the base station(BS) and the Far Group including the MSs far from the BS. The reverse link for MSs in the Near Group and forward link for MSs in the Far Group are allocated to the cross time slot. In cellular systems, a BS has multiple neighbor BSs. Some of neighbor BSs can operate in the same direction link while the others have cross time slot. Thus, it is required to determine which BS has the most significant impact in terms of interference. We divide each cell into 6 areas based on the direction of arrival of smart antenna and the most significant neighbor sector is determined with this division. The proposed allocation method and area division method can avoid the severe interference in cross time slots and increase the system capacity about 2%~9% compared to FCA, and 0.5%~1.3% compared to RCA.

• Journal of Welding and Joining
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• v.32 no.4
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• pp.10-14
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• 2014

Laser aided Direct Metal Tooling(DMT) process is a kind of Additive Manufacturing processes (or 3D-Printing processes), which is developed for using various commercial steel powders such as P20, P21, SUS420, H13, D2 and other non-ferrous metal powders, aluminum alloys, titanium alloys, copper alloys and so on. The DMT process is a versatile process which can be applied to various fields like the mold industry, the medical industry, and the defense industry. Among of them, the application of DMT process to the mold industry is one of the most attractive and practical applications since the conformal cooling channel core of injection molds can be fabricated at the slightly expensive cost by using the hybrid fabrication method of DMT technology compared to the part fabricated with the machining technology. The main objectives of this study are to provide various characteristics of the parts made by DMT process compared to the same parts machined from bulk materials and prove the performance of the injection mold equipped with the conformal cooling channel core which is fabricated by the hybrid method of DMT process.