• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.11
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• pp.5229-5252
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• 2016

With proliferation of diverse network access technologies, users demands are also increasing and service providers are offering a Quality of Service (QoS) to satisfy their customers. In roaming, a mobile node (MN) traverses number of available networks in the heterogeneous wireless networks environment and a single operator is not capable to fulfill the demands of user. It is crucial task for MN for selecting a best network from the list of networks at any time anywhere. A MN undergoes a network selection situation frequently when it is becoming away from the home network. Multiple Attribute Group Decision (MAGD) method will be one of the best ways for selecting target network in heterogeneous wireless networks (4G). MAGD network selection process is predominantly dependent on two steps, i.e., attribute weight, decision maker's (DM's) weight and aggregation of opinion of DMs. This paper proposes Multi-Attribute Intuitionistic Fuzzy Group Decision Method (MAIFGDM) using TOPSIS for the selection of the suitable candidate network. It is scalable and is able to handle any number of networks with large set of attributes. This is a method of lower complexity and is useful for real time applications. It gives more accurate result because it uses Intuitionistic Fuzzy Sets (IFS) with an additional parameter intuitionistic fuzzy index or hesitant degree. MAIFGDM is simulated in MATLAB for its evaluation. A comparative study of MAIFDGM is also made with TOPSIS and Fuzzy-TOPSIS in respect to decision delay. It is observed that MAIFDGM have low values of decision time in comparison to TOPSIS and Fuzzy-TOPSIS methods.

• Korean journal of applied entomology
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• v.59 no.4
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• pp.295-301
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• 2020

In this study, we aimed to investigate the changes in the catch rate of Monochamus saltuarius, based on sexual maturation by using aggregation-sex pheromone traps. Ovariole development of caught M. saltuarius females was compared to that of the ones not caught using traps. In a mesh cage set up at the Hongneung experimental forest, we placed a multi-funnel trap with or without an aggregation-sex pheromone lure. M. saltuarius adults, which emerged from pine logs, were grouped in four according to the emergence dates (0, 1, 7, and 10 days after emergence [DAE]). We released beetles into the mesh cage to investigate the catch rate using the traps. In each group, a total of 80 beetles (20 beetles × 4 replications) were tested, making it a total of 320 beetles. Among the four groups, M. saltuarius adults in the 7 DAE group were caught more frequently using the traps, especially with a pheromone lure; the other groups showed a low catch rate. A similar number of female and male beetles were caught using the traps. Regarding ovariole development, all the female adults in the 0 and 1 DAE groups were immature, while those in the other two groups were completely developed. Therefore, aggregation-sex pheromone traps might have a limitation in the prevention of pine wilt disease because of the transmission of pine wood nematode during maturation feeding of newly emerged M. saltuarius adults. However, aggregation-sex pheromone traps can be effective for collecting sexually mature M. saltuarius adults, for the investigation of seasonal occurrence of beetles in forests.

• Journal of Microbiology and Biotechnology
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• v.23 no.6
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• pp.818-825
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• 2013

We isolated and functionally characterized the ${\alpha}$- and ${\beta}$-subunits (ApCpnA and ApCpnB) of a chaperonin from Aeropyrum pernix K1. The constructed vectors pET3d-ApCpnA and pET21a-ApCpnB were transformed into E. coli Rosetta (DE3), BL21 (DE3), or CodonPlus (DE3) cells. The expression of ApCpnA (60.7 kDa) and ApCpnB (61.2 kDa) was confirmed by SDS-PAGE analysis. Recombinant ApCpnA and ApCpnB were purified by heat-shock treatment and anion-exchange chromatography. ApCpnA and ApCpnB were able to hydrolyze not only ATP, but also CTP, GTP, and UTP, albeit with different efficacies. Purified ApCpnA and ApCpnB showed the highest ATPase, CTPase, UTPase, and GTPase activities at $80^{\circ}C$. Furthermore, the addition of ApCpnA and ApCpnB effectively protected citrate synthase (CS) and alcohol dehydrogenase (ADH) from thermal aggregation and inactivation at $43^{\circ}C$ and $50^{\circ}C$, respectively. In particular, the addition of ATP or CTP to ApCpnA and ApCpnB resulted in the most effective prevention of thermal aggregation and inactivation of CS and ADH. The ATPase activity of the two chaperonin subunits was dependent on the salt concentration. Among the ions we examined, potassium ions were the most effective at enhancing the ATP hydrolysis activity of ApCpnA and ApCpnB.

• Bulletin of the Korean Chemical Society
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• v.31 no.6
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• pp.1519-1526
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• 2010

The behavior of peptide or protein solutes in saline aqueous solution is a fundamental topic in physical chemistry. Addition of ions can strongly alter the thermodynamic and physical properties of peptide molecules in solution. In order to study the effects of added ionic salts on protein conformation and dynamics, we have used the molecular dynamics (MD) simulations to investigate the behavior of Staphylococcus aureus Hfq protein under two different ionic concentrations: 0.1 M NaCl and 1.0 M NaCl in presence and absence of RNA (a hepta-oligoribonucleotide AU5G). Hfq, a global regulator of gene expression is highly conserved and abundant RNA-binding protein. It is already reported that in vivo the increase of ionic strength results in a drastic reduction of Hfq affinity for $Q{\beta}$ RNA and reduces the tendency of aggregation of Escherichia coli host factor hexamers. Our results revealed the crucial role of 0.1 M NaCl Hfq system on the bases with strong hydrogen bonding interactions and by stabilizing the aromatic stacking of Tyr42 residue of the adjacent subunits/monomers with the adenine and uridine nucleobases. An increase in RNA pore diameter and weakened compactness of the Hfq-RNA complex was clearly observed in 1.0 M NaCl Hfq system with bound RNA. Aggregation of monomers in Hfq and the interaction of Hfq with RNA are greatly affected due to the presence of high ionic strength. Higher the ionic concentration, weaker is the aggregation and interaction. Our results were compatible with the experimental data and this is the first theoretical report for the experimental study done in 1980 by Uhlenbeck group for the present system.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.20 no.1
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• pp.107-112
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• 2020

We analyze the flow aggregate (FA) based network delay guarantee framework, with generalized minimal interleaved regulator (IR) initially suggested by IEEE 802.1 time sensitive network (TSN) task group (TG). The framework has multiple networks with minimal IRs attached at their output ports for suppressing the burst cascades, with FAs within a network for alleviating the scheduling complexity. We analyze the framework with various topology and parameter sets with the conclusion that the FA-based framework with low complexity can yield better performance than the integrated services (IntServ) system with high complexity, especially with large network size and large FA size.

• Macromolecular Research
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• v.17 no.4
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• pp.265-270
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• 2009

Noble thermosensitive nanoparticles, based on a PNIPAAm-co-AA core and a chitosan shell structure, were designed and synthesized for the controlled release of the loaded drug. PNIPAAm nanoparticles containing a carboxylic group on their surface were synthesized using emulsion polymerization. The carboxylic groups were conjugated with the amino group of a low molecular weight, water soluble chitosan. The particle size of the synthesized nanoparticles was decreased from 380 to 25 nm as the temperature of the dispersed medium was increased. Chitosan-conjugated nanoparticles with $2{\sim}5$ wt% MBA, a crosslinking monomer, induced a stable aqueous dispersion at a concentration of 1mg/1mL. The chitosan-conjugated nanoparticles showed thermo sensitive behaviors such as LCST and size shrinkage that were affected by the PNIPAAm core and induced some particle aggregation around LCST, which was not shown in the NIPAAm-co-AA nanoparticles. These chitosan-conjugated nanoparticles are also expected to be more biocompatible than the PNIPAAm core itself through the chitosan shell structures.

• Biomedical Science Letters
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• v.8 no.1
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• pp.13-20
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• 2002

Asadisulphide were purified from Ferrula assafoetida by organic solvent extraction and chromatography. Since ethyl acetate extracts of F. assafoetida has the strongest inhibitory effects on adherence of HL-60 cells, it was reextracted with ethyl acetate, hexane, and ethyl ether and chromatographed three times to isolate asadisulphide. HL-60 cells were grouped into untreated control, TPA-treated, asadisulphide-teated and TPA＋asadisulphide-treated groups, and structural changes of these cells were observed using light microscope, scanning electron microscope and transmission electron microscope to examine the inhibitory effects of asadisulfide on the TPA-induced adherence of HL-60 cells. Light microscopic observations showed that asadisulphide has inhibitory effects on the cell aggregation, extention of cytoplasmic processes and inhibition of substrate adhesion of HL-60 cells. Using scanning and transmission electron microscope, it was observed that cell surfaces and several ultrastructures of TPA-treated HL-60 cell were different from control group, while there were no remarkable differences between asadisulphide-treated and TPA＋asadisulphide-treated group. These results could suggest that asadisulphide has the inhibitory effects on the TPA-induced structural changes of HL-60 cells.

• Textile Coloration and Finishing
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• v.27 no.4
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• pp.245-260
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• 2015

The effect of salt milling process on the crystal size, morphology, and color characteristics of C.I. Pigment Red 57:1 was studied. The primitive morphology and color properties of the pigment after synthesis were studied in the former series work. The size and morphology of primary particles and the second aggregation features should be considered because they are very important to determine pigment quality. We compared the primary morphology of pigment particles before drying with the secondary aggregated morphology of pigment particles after drying and salt milling process. Morphological properties were investigated by particle size analysis, X-ray diffraction, and scanning electron microscopy and color measurement was carried out. Significant reduction in particle size as well as enhanced crystallite size after salt milling process was observed. This result might give a difference in color of the pigment, turning into brighter and more blue-toned red color. It was revealed that synthesis condition affect the morphology and color of the pigment even after milling. Increase in HCl concentration in the synthesis process enhanced crystal size and quality forming bluer-red pigments but an increase in $CaCl_2$ concentration resulted in more amorphous crystals forming darker-red pigments after salt milling.

• Journal of Korean Foot and Ankle Society
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• v.18 no.4
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• pp.159-164
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• 2014

Purpose: The purpose of this study is to confirm the effect of antiplatelet drugs in diabetic peripheral vasculopathy in diabetic foot patients. Materials and Methods: We designed a retrospective study in diabetic foot patients with diabetic peripheral vasculopathy. From October 2007 to December 2013, 278 cases in 139 patients who took antiplatelet drugs over at least a six-month period were included in this study. We categorized these patients according to the type of drug used. The efficacy of antiplatelet drugs was evaluated using anklebrachial index (ABI) and pulse wave velocity (PWV). Results: Only the aspirin group showed a statistically significant increase of ABI after antiplatelet therapy ($1.10{\pm}0.12$ to $1.12{\pm}0.11$). In addition, only the cilostazol group showed a statistically significant decrease of PWV after antiplatelet therapy ($1,701.20{\pm}396.56$ to $1,627.42{\pm}324.98$). Conclusion: Aspirin and cilostazol may be used in treatment of diabetic peripheral vasculopathy, whereas dual antiplatelet therapy with aspirin and clopidogrel has no specific benefits in diabetic peripheral vasculopathy.

• Journal of Ginseng Research
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• v.47 no.2
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• pp.283-290
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• 2023

Hypercoagulability is frequently observed in patients with severe coronavirus disease-2019 (COVID-19). Platelets are a favorable target for effectively treating hypercoagulability in COVID-19 patients as platelet hyperactivity has also been observed. It is difficult to develop a treatment for COVID-19 that will be effective against all variants and the use of antivirals may not be fully effective against COVID-19 as activated platelets have been detected in patients with COVID-19. Therefore, patients with less severe side effects often turn toward natural remedies. Numerous phytochemicals are being investigated for their potential to treat a variety of illnesses, including cancer and bacterial and viral infections. Natural products have been used to alleviate COVID-19 symptoms. Panax ginseng has potential for managing cardiovascular diseases and could be a treatment for COVID-19 by targeting the coagulation cascade and platelet activation. Using molecular docking, we analyzed the interactions of bioactive chemicals in P. ginseng with important proteins and receptors involved in platelet activation. Furthermore, the SwissADME online tool was used to calculate the pharmacokinetics and drug-likeness properties of the lead compounds of P. ginseng. Dianthramine, deoxyharrtingtonine, and suchilactone were determined to have favorable pharmacokinetic profiles.