• 대한본초학회지
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• 제33권4호
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• pp.53-58
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• 2018

Objectives : Kaempferia parviflora Rhizome is black ginger indigenous to Laos and Thailand. It has been used as a folk medicine to improve blood flow and promote vitality and longevity with good health and well being. For these reasons, Kaempferia parviflora Rhizome has been focused on developing it as a food or food supplement. In addition, Kaempferia parviflora Rhizome could be under consideration of new prescription based on its characteristic compounds, polymethoxyflavonoids. However, it needs to be certified as safe before it can be used. Here, a single-oral toxicity test and safety classification was carried out to identity acute information of the toxicity of Kaempferia parviflora Rhizome powder and to make sure of its safety in clinical applications. Methods : Test substance was orally administered to male and female SD-rat at dose levels of 5000 mg/kg to estimate approximate lethal dose(ALD). Based on the acute information of the toxicity, the safety classification was estimated using the HED(human equivalent dose)-based MOS(margin of safety). Results : At 14 days after treatment with test substance. there were no of test substance related with mortalities and clinical signs. In addition, no changes in the body or organ weights and no gross or histopathological findings were observed. Thus, the ALD of Kaempferia parviflora Rhizome powder was considered over 5,000 mg/kg in both female and male mice. Conclusions : Based on the single oral toxicity test using the highest and limit dose, 5,000 mg/kg and the decision guideline for safety classification based on HED-based MOS, it was estimated that Kaempferia parviflora Rhizome powder is classified as "Specified class B" indicating that clinical dose is not limited to patients as safe as food.

• Asian-Australasian Journal of Animal Sciences
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• 제7권1호
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• pp.19-29
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• 1994

The annual income (gross margin) in 1989/90 of a sample of 274 farmers in seven milk cooperatives was analyzed in the sugar cane, cassava, and horticulture areas in East Java. On average dairying contributed 42%, crops 29% and off-farm revenue 29%. Dairy income was highest in the cassava area, where it compensated for the low crop income, and lowest in the sugar cane area. Farm area and average milk yield per day per cow correlated positively with farmer's income, whereas crop income increase significantly with farm area and with the number of cows. The level of total cost per cow had a negative impact on dairy and with the number of cows. The level of total cost per cow had a negative impact on dairy and on total income. Government officials and other professionals engaged in dairying had a significantly higher total income than those with their main occupation in dairying, cropping or working as farm labourers. Uneducated farmers obtained a significantly larger income through crops, whereas farmers with tertiary education obtained more income through off-farm work, This study suggests that more attention must be paid to the actual use of labour and the improvement of the dairy output/cost ratio.

• 대한수의학회지
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• 제5권1호
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• pp.27-30
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• 1965

In a cattle which had died of extreme emaciation caused by cachexic condition, a huge cyst of $45{\times}35{\times}20$cm, in size was found at the rumen. The cyst having with the narrow stalk which ended in blind sac attached firmly to the rumen by fibrinous or fibrous adhesion and, contained the lightly yellowish, clear exudative fluid of about 20 l, in volume. Grossly, the thickness of the cyst wall was 10~14mm, and its inner portion of the half was very rigid and colored with milky white in contrast with soft and edematous outer portion of the half. Microscopically the inner portion of the cyst wall was consisted of scarred fibrous tissue and possessed at its inner margin a little amount of the muscle fibers which had degenerated passably. These were confirmed as the muscle fibers in specific staining property by Van-Gieson's and Mallory-Azan stain. On regarding to above findings of gross and microscopic pictures, it was considered to be a pseudo-diverticulous cyst composed of the serosa and the muscle layer deriving from the wall of the rumen. And it was suggested that the cyst had been growing up to big size by storage of the plenty exudate arisen from its wall and was separated from the rumen at the end of its stalk.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제18권2호
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• pp.253-260
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• 1996

The purpose of this investigation was to determine the possibility of clinical use of toothash-plaster block implant material with ratio of 2 : 1 by weight. We made 1cm diameter round partial thickness defect at both sides of calvaria. Right side was implanted with block and left side was not implanted as a control site. The following results were obtained : 1. In gross examinations, the implanted site had a hardness on palpation and the margin with host bone was not identified clearly at 12 weeks after operation. But control site contained the fibrous tissue. 2. In the light microscopic examinations, most of the implanted sites were repaired by newly-formed bone at 12 weeks postoperatively. 3. At 8 weeks postoperatively, the implanted particles were divided into small granules and the amount was decreased gradually. Some remained particles were united directly with newly-formed bone. But the implanted particles still remained partly at 24 weeks postoperatively.

• Radiation Oncology Journal
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• 제35권2호
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• pp.180-184
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• 2017

Patients with locally advanced lung cancer and very limited pulmonary function (forced expiratory volume in 1 second $[FEV1]{\leq}1L$) have dismal prognosis and undergo palliative treatment or best supportive care. We describe two cases of locally advanced node-positive non-small cell lung cancer (NSCLC) patients with very limited lung function treated with induction chemotherapy and moderate hypofractionated image-guided radiotherapy (Hypo-IGRT). Hypo-IGRT was delivered to a total dose of 45 Gy to the primary tumor and involved lymph nodes. Planning was based on positron emission tomography-computed tomography (PET/CT) and four-dimensional computed tomography (4D-CT). Internal target volume (ITV) was defined as the overlap of gross tumor volume delineated on 10 phases of 4D-CT. ITV to planning target volume margin was 5 mm in all directions. Both patients showed good clinical and radiological response. No relevant toxicity was documented. Hypo-IGRT is feasible treatment option in locally advanced node-positive NSCLC patients with very limited lung function ($FEV1{\leq}1L$).

• Asian-Australasian Journal of Animal Sciences
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• 제14권8호
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• pp.1098-1105
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• 2001

There is little information on smallholder dairy farming in Zimbabwe. With such inadequate knowledge, no meaningful decisions on how to improve these systems can be made. A study was, therefore, carried out in Nharira communal area and Lancashire small-scale commercial area to provide information on the viability of dairy farms. This paper is based on data obtained through participatory monitoring of 13 smallholder dairy farms in 1996 and 1997. All the four farms in Lancashire were found to be viable in both years. In Nharira, two out of the nine farms in 1996 and three farms in 1997 failed to break even. There were considerable inter-farm differences in the contribution of milk sales towards total income from dairy farming, ranging from 41% to 99% in Nharira and 71% to 81% in Lancashire in 1996. Corresponding estimates in 1997 were 51-95% and 72-78%, respectively. Expenses on cattle feeds contributed 36-84% in 1996 and 37-80% in 1997 towards total variable costs in Nharira. In Lancashire, the respective estimates were 15-33% and 22-36%. Seven out of the nine studied farms in Nharira and three out of four in Lancashire realized higher gross margin (GM) in 1997 than in 1996. All these farming households had conserved considerable amounts of farm-grown feeds. It was concluded that feed costs, number of cows and sizes of land holdings were the main factors determining viability of smallholder dairy farming. The major challenge to smallholder dairy farming in Nharira, in particular, was to develop low-cost feeding strategies.

• The Journal of Asian Finance, Economics and Business
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• 제7권9호
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• pp.105-115
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• 2020

The study empirically examines the effects of loan portfolio diversification on bank risk and return in the nascent banking market of Vietnam. Loan portfolio diversification is captured through the Hirschman-Herfindahl index and the Shannon Entropy with sectoral exposures. We access each bank's financial reports to collect the required data, especially the breakdown of sectoral loan portfolios, thus constituting a unique dataset. To compute bank return, we use the traditional accounting indicators, including return-on-assets, return-on-equity, and net-interest margin. For bank risk, we utilize the loan-loss provisions and non-performing loans relative to gross customer loans. Using a sample of 30 commercial banks over the period from 2008 to 2019 and the system generalized method of moments estimator for the dynamic panel, we indicate the downsides of portfolio diversification. Concretely, we observe that all diversification measures exhibit significantly negative signs in all regressions across different bank return proxies. At the same time, the estimates display the significant and positive impact of diversification on the non-performing loan ratio. Hence, sectoral loan portfolio diversification significantly hampers bank performance in both aspects of lower return and higher credit risk. The results are robust across a rich set of bank performance and portfolio diversification measures.

• 보험의학회지
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• 제3권1호
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• pp.233-244
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• 1986

We'd experienced a case of primary hepatoma at medical department, Dae han Kyoyuk Ins. Company January 1985. As it was found very early stage, we made out the case long term-survival possibility unexpectedly. The conclusions we gained, making comparative-analysis of ultrasonic view and operation's view are as follows; 1. By ultrasonography, echogenicity of tumor was increased type as compared with liver parenchyme. 2. The margin of the primary hepatoma by ultrasonography encapsulated well and the extraction after operation was same. 3. The boundary of tumor was clear. 4. The space-occupying lesion in liver was solitary. 5. The affected site was left lobe of the liver. 6. We couldn't discover a little fluid echo in upper abdomen on the ultrasonography, but could see in the cul-de-sac area and it accorded with the gross finding during laparotomy. 7. The case was cholangiocarcinoma in view of pathologic histology. 8. After the operation of lobectomy. the prognosis which was passed a months was very satisfactory and she exists until present.

• Nuclear Engineering and Technology
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• 제48권1호
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• pp.236-245
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• 2016

In a reactor coolant system of a nuclear power plant (NPP), an overpressure protection system keeps pressure in the loop within 110% of design pressure. However if the system does not work properly, pressure in the loop could elevate hugely in a short time. It would be seriously disastrous if a weak point in the pressure boundary component bursts and releases radioactive material within the containment; and it may lead to a leak outside the containment. In this study, a gross deformation that leads to a burst of pressure boundary components was investigated. Major components in the primary pressure boundary that is structurally important were selected based on structural mechanics, then, they were used to study the burst pressure of components by finite element method (FEM) analysis and by number of closed forms of theoretical relations. The burst pressure was also used as a metric of design optimization. It revealed which component was the weakest and which component had the highest margin to bursting failure. This information is valuable in severe accident progression prediction. The burst pressures of APR-1400, AP1000 and VVER-1000 reactor coolant systems were evaluated and compared to give relative margins of safety.

• 한국임상수의학회지
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• 제36권5호
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• pp.266-270
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• 2019

A 13-year-old spayed female American cocker spaniel dog was submitted to an animal hospital with a mass from left ear canal and enlarged left parotid lymph node. Given one-year history of odorous exudates and chronic otitis externa, total ear canal ablation was performed. Grossly, because of the neoplastic mass in both inner and outside of annular cartilage in external ear, vertical ear canal was severely narrowed. Histologically, there were numerous proliferated glands in the ear canal mass. Many neoplastic glands contained secretory vesicles on the free margin and necrotic cellular debris. Severe multifocal necrosis and strong invasion were also observed throughout the mass. Massive metastatic foci of glandular structures originated from ceruminous gland were presented in the enlarged parotid lymph node. Neoplastic glandular epithelia contained PAS-positive diastase-resistant eosinophilic cytoplasmic granules. Immunohistochemically, the neoplastic cells showed positive reactions for cytokeratin (CK) 7 and negative for CK 5/6. Based on the clinical implication and gross findings, histopathology and immunohistochemistry, this case was diagnosed as metastatic ceruminous gland adenocarcinoma in the American cocker spaniel.