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Effects of Yanghyuljanggeungunbo-tang(Yangxuezhuangjinjianbu-tang) and Cervi Cornu Parvum Pharmaco-Acupuncture on the Motor Function Recovery and Nerve Regeneration in Rats Induced Spinal Cord Injury (양혈장근건보탕(養血壯筋健步湯)과 녹용약침(鹿茸藥鍼)이 척수손상 유발 흰쥐의 운동기능 회복 및 신경재생에 미치는 영향)

  • Park, Ji-Yong;Sul, Jae-Uk;Kim, Sun-Jong;Choi, Jin-Bong;Shin, Mi-Suk
    • Journal of Korean Medicine Rehabilitation
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    • v.19 no.2
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    • pp.27-49
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    • 2009
  • Objectives : The purpose of this study was to investigate the effects of Yanghyuljanggeungunbo-tang(Yangxuezhuangjinjianbu-tang) and Cervi Cornu Parvum pharmaco-acupuncture in Spinal Cord Injury(SCI)-induced rats. Methods : The subjects were divided into 5 groups ; Normal, Control no treatment after SCI, Experimental I taken with Yanghyuljanggeungunbo-tang (Yangxuezhuangjinjianbu-tang) 500 mg/kg $0.5m{\ell}$ daily after inducing SCI. Experimental II taken with Cervi Cornu Parvum pharmaco-acupuncture at Taegye(KI3) and $Yangnungch{\acute{o}}n$(GB34) after inducing SCI and Experimental III taken with Yanghyuljanggeungunbo-tang(Yangxuezhuangjinjianbu-tang) 500 mg/kg $0.5m{\ell}$ and Cervi Cornu Parvum pharmaco-acupuncture at KI3 and GB34 to SCI-induced rats. After each operation, the present author observed the motor behavior recovery and nerve regeneration by analysis of the motor behavior tests, EMG, hematological(AST, ALT, WBC), histological and immunological changes. Rats were tested at modified Tarlov test at the 1st, 2nd, 3rd, 4th day, and Motor behavior test at 1st, 3rd, 7th, 14th, 21st day. Results : Results are as follows. 1. All the experimental groups were improved compared with control group in the motor behavior tests including Tarlov test, Basso-Beattle-Bresnahan locomotor rating scale, modified inclined plane test, open field test, grid walk test and narrow beam test. Especially Experimental III was improved significantly among other groups. 2. In EMG test, H wave appeared weak only in Experimental III. And M wave was increased significantly in Experimental III. 3. All the experimental groups were significantly decreased compared with control group in serum AST, serum ALT and serum WBC tests. 4. significantly decreased in Tumor Necrosis Factor-${\alpha}$ test compared with the first day of SCI. 5. Muscle contraction and denaturation of all the experimental groups were inhibited in histological observations of gastrocnemius muscle. Especially, those of experimental III was more effective. 6. NGF and BDNF of spinal cord gray matter in all the experimental groups were increased compared with control group. Especially, those of experimental III was more effective. Conclusions : As above, it can be suggested that Yanghyuljanggeungunbo-tang(Yangxuezhuangjinjianbu-tang) and Cervi Cornu Parvum pharmaco-acupuncture may improve motor behavior, EMG, hematological, histological and immunological findings in Spinal Cord Injury(SCI)-induced rats. Especially, effects will be somewhat better in combination of these two treatments.

Fatigue Constrained Topological Structure Design Considering the Stress Correction Factor (응력 수정 계수를 고려한 피로 제약 조건 구조물의 위상최적설계)

  • Kim, Daehoon;Ahn, Kisoo;Jeong, Seunghwan;Park, Soonok;Yoo, Jeonghoon
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.31 no.2
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    • pp.97-104
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    • 2018
  • In this study, a structure satisfying the fatigue constraint is designed by applying the topology optimization based on the phase field design method. In order to predict life based on the stress value, high cycle fatigue failure theory in which stress acts within the range of elastic limit is discussed and three fatigue theories of modified-Goodman, Smith-Watson-Topper and Gerber theory are applied. To calculate the global maximum stress, a modified P-norm stress correction method is used. As a result, it is possible to obtain topology optimization results that minimize the volume while satisfying the fatigue constraints. By applying the phase field design method, a simple shape with a minimized gray scale was obtained, and the maximum stress value acting on the optimization result became very close to the allowable stress value due to the modified P-norm stress method. While previous studies does not consider the stress correction factor, this study proposes the determination method regarding the stress correction factor considering loading effects related to axial stress components.

A Study on Motion Estimator Design Using DCT DC Value (DCT 직류 값을 이용한 움직임 추정기 설계에 관한 연구)

  • Lee, Gwon-Cheol;Park, Jong-Jin;Jo, Won-Gyeong
    • Journal of the Institute of Electronics Engineers of Korea SP
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    • v.38 no.3
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    • pp.258-268
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    • 2001
  • The compression method is necessarily used to send the high quality moving picture that contains a number of data in image processing. In the field of moving picture compression method, the motion estimation algorithm is used to reduce the temporal redundancy. Block matching algorithm to be usually used is distinguished partial search algorithm with full search algorithm. Full search algorithm be used in this paper is the method to compare the reference block with entire block in the search window. It is very efficient and has simple data flow and control circuit. But the bigger the search window, the larger hardware size, because large computational operation is needed. In this paper, we design the full search block matching motion estimator. Using the DCT DC values, we decide luminance. And we apply 3 bit compare-selector using bit plane to I(Intra coded) picture, not using 8 bit luminance signals. Also it is suggested that use the same selective bit for the P(Predicted coded) and B(Bidirectional coded) picture. We compare based full search method with PSNR(Peak Signal to Noise Ratio) for C language modeling. Its condition is the reference block 8$\times$8, the search window 24$\times$24 and 352$\times$288 gray scale standard video images. The result has small difference that we cannot see. And we design the suggested motion estimator that hardware size is proved to reduce 38.3% for structure I and 30.7% for structure II. The memory is proved to reduce 31.3% for structure I and II.

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Research Trends of Foreign Countries on Geological Evaluation of Abiotic Hydrogen Productivity: A Review (비생물기원 수소 생산성의 지질학적 평가 관련 해외 연구 동향: 리뷰 논문)

  • Jeong, Seongwoo;Kim, Taeyong;Ko, Kyoungtae;Yang, Minjune
    • The Journal of Engineering Geology
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    • v.32 no.4
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    • pp.627-642
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    • 2022
  • The world's long reliance on fossil fuels (e.g., oil, coal, and natural gas) is severely changing its environment and climate. Energy research has focused on developing hydrogen as the most promising energy carrier and a key technology for sustainable energy development. Hydrogen can be classified as gray, blue, green, and otherwise according to the raw materials and methods used for production and processing. For the development of hydrogen energy, geologists are attempting to identify the mechanism of abiotic hydrogen generation by serpentinization or hydrothermal alteration. Teams in the United States, France, and Australia have researched laboratory-scale hydrogen production through water-rock interactions under various conditions, whereas there has been almost no research on abiotic hydrogen in South Korea. This paper reviews the current state of international research on hydrothermal alteration and offers suggestions for future investigations of abiotic hydrogen production in South Korea.

Analysis of CO2 Emission and Effective CO2 Capture Technology in the Hydrogen Production Process (수소생산 공정에서의 CO2 배출처 및 유효포집기술 분석)

  • Kyung Taek Woo;Bonggyu Kim;Youngseok So;Munseok Baek;Seoungsoo Park;Hyejin Jung
    • Journal of the Korean Institute of Gas
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    • v.27 no.3
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    • pp.77-83
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    • 2023
  • Energy consumption is increased by rapid industrialization. As a result, climate change is accelerating due to the increase in CO2 concentration in the atmosphere. Therefore, a shift in the energy paradigm is required. Hydrogen is in the spotlight as a part of that. Currently 95% of hydrogen is fossil fuel-based reforming hydrogen which is accompanied by CO2 emissions. This is called gray hydrogen, if the CO2 is captured and emission of CO2 is reduced, it can be converted into blue hydrogen. There are 3 technologies to capture CO2: absorption, adsorption and membrane technology. In order to select CO2 capture technology, the analysis of the exhaust gas should be carried out. The concentration of CO2 in the flue gas from the hydrogen production process is higher than 20%if water is removed as well as the emission scale is classified as small and medium. So, the application of the membrane technology is more advantageous than the absorption. In addition, if LNG cold energy can be used for low temperature CO2 capture system, the CO2/N2 selectivity of the membrane is higher than room temperature CO2 capture and enabling an efficient CO2 capture process. In this study, we will analyze the flue gas from hydrogen production process and discuss suitable CO2 capture technology for it.

Research on Characterizing Urban Color Analysis based on Tourists-Shared Photos and Machine Learning - Focused on Dali City, China - (관광객 공유한 사진 및 머신 러닝을 활용한 도시 색채 특성 분석 연구 - 중국 대리시를 대상으로 -)

  • Yin, Xiaoyan;Jung, Taeyeol
    • Journal of the Korean Institute of Landscape Architecture
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    • v.52 no.2
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    • pp.39-50
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    • 2024
  • Color is an essential visual element that has a significant impact on the formation of a city's image and people's perceptions. Quantitative analysis of color in urban environments is a complex process that has been difficult to implement in the past. However, with recent rapid advances in Machine Learning, it has become possible to analyze city colors using photos shared by tourists. This study selected Dali City, a popular tourist destination in China, as a case study. Photos of Dali City shared by tourists were collected, and a method to measure large-scale city colors was explored by combining machine learning techniques. Specifically, the DeepLabv3+ model was first applied to perform a semantic segmentation of tourist sharing photos based on the ADE20k dataset, thereby separating artificial elements in the photos. Next, the K-means clustering algorithm was used to extract colors from the artificial elements in Dali City, and an adjacency matrix was constructed to analyze the correlations between the dominant colors. The research results indicate that the main color of the artificial elements in Dali City has the highest percentage of orange-grey. Furthermore, gray tones are often used in combination with other colors. The results indicated that local ethnic and Buddhist cultures influence the color characteristics of artificial elements in Dali City. This research provides a new method of color analysis, and the results not only help Dali City to shape an urban color image that meets the expectations of tourists but also provide reference materials for future urban color planning in Dali City.

Clinical Implications of Focal Mineral Deposition in the Globus Pallidus on CT and Quantitative Susceptibility Mapping of MRI

  • Hyojin Kim;Jinhee Jang;Junghwa Kang;Seungun Jang;Yoonho Nam;Yangsean Choi;Na-young Shin;Kook-Jin Ahn;Bum-soo Kim
    • Korean Journal of Radiology
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    • v.23 no.7
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    • pp.742-751
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    • 2022
  • Objective: To assess focal mineral deposition in the globus pallidus (GP) by CT and quantitative susceptibility mapping (QSM) of MRI scans and evaluate its clinical significance, particularly cerebrovascular degeneration. Materials and Methods: This study included 105 patients (66.1 ± 13.7 years; 40 male and 65 female) who underwent both CT and MRI with available QSM data between January 2017 and December 2019. The presence of focal mineral deposition in the GP on QSM (GPQSM) and CT (GPCT) was assessed visually using a three-point scale. Cerebrovascular risk factors and small vessel disease (SVD) imaging markers were also assessed. The clinical and radiological findings were compared between the different grades of GPQSM and GPCT. The relationship between GP grades and cerebrovascular risk factors and SVD imaging markers was assessed using univariable and multivariable linear regression analyses. Results: GPCT and GPQSM were significantly associated (p < 0.001) but were not identical. Higher GPCT and GPQSM grades showed smaller gray matter (p = 0.030 and p = 0.025, respectively) and white matter (p = 0.013 and p = 0.019, respectively) volumes, as well as larger GP volumes (p < 0.001 for both). Among SVD markers, white matter hyperintensity was significantly associated with GPCT (p = 0.006) and brain atrophy was significantly associated with GPQSM (p = 0.032) in at univariable analysis. In multivariable analysis, the normalized volume of the GP was independently positively associated with GPCT (p < 0.001) and GPQSM (p = 0.002), while the normalized volume of the GM was independently negatively associated with GPCT (p = 0.040) and GPQSM (p = 0.035). Conclusion: Focal mineral deposition in the GP on CT and QSM might be a potential imaging marker of cerebral vascular degeneration. Both were associated with increased GP volume.

Characteristics and Distribution Pattern of Carbonate Rock Resources in Kangwon Area: The Gabsan Formation around the Mt. Gachang Area, Chungbuk, Korea (강원 지역에 분포하는 석회석 자원의 특성과 부존환경: 충북 가창산 지역의 갑산층을 중심으로)

  • Park, Soo-In;Lee, Hee-Kwon;Lee, Sang-Hun
    • Journal of the Korean earth science society
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    • v.21 no.4
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    • pp.437-448
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    • 2000
  • The Middle Carboniferous Gabsan Formation is distributed in the Cheongrim area of southern Yeongwol and the Mt. Gachang area of Chungbuk Province. This study was carried out to investigate the lithological characters and geochemical composition of the limestones and to find out controlling structures of the limestones of the formation. The limestones of the Gabsan Formation are characterized by the light gray to light brown in color and fine and dense textures. The limestone grains are composed of crinoid fragments, small foraminfers, fusulinids, gastropods, ostracods, etc. Due to the recrystallization, some limestones consist of fine crystalline calcites. The chemical analysis of limestones of the formation was conducted to find out the contents of CaO, MgO, Al$_2$O$_3$, Fe$_2$O$_3$ and SiO$_2$. The content of CaO ranges from 49.78-60.63% and the content of MgO ranges from 0.74 to 4.63% The contents of Al$_2$O$_3$ and Fe$_2$O$_3$ are 0.02-0.55% and 0.02${\sim}$0.84% , respectively. The content of SiO$_2$ varies from 1.55 to 4.80%, but some samples contain more than 6.0%. The limestones of the formation can be grouped into two according to the CaO content: One is a group of which CaO content ranges from 49.78 to 56.26% and the other is a group of which CaO content varies from 59.36 to 60.38%. In the first group, the contents of Al$_2$O$_3$, Fe$_2$O$_3$ and SiO$_2$ range very irregularly according to the CaO content. In the second group, the values of MgO, Al$_2$O$_3$, Fe$_2$O$_3$ and SiO$_2$ are nearly same. Detailed structural analysis of mesoscopic structures and microstructures indicates the five phase of deformation in the study area. The first phase of deformation(D$_1$) is characterized by regional scale isoclinal folds, and bedding parallel S$_1$ axial plane foliation which is locally developed in the mudstone and sandstone. Based on the observations of microstructures, S$_1$ foliations appear to be developed by grain preferred orientation accompanying pressure-solution. During second phase of deformation, outcrop scale E-W trending folds with associated foliations and lineations are developed. Microstructural observations indicate that crenulation foliations were formed by pressure-solution, grain boundary sliding and grain rotation. NNW and SSE trending outcrop scale folds, axial plane foliations, crenulation foliations, crenulation lineations, intersection lineations are developed during the third phase of deformation. On the microscale F$_3$ fold, axial plane foliations which are formed by pressure solution are well developed. Fourth phase of deformation is characterized by map scale NNW trending folds. The pre-existing planar and linear structures are reoriented by F$_4$ folds. Fifth phase of deformation developed joints and faults. The distribution pattern of the limestones is mostly controlled by F$_1$ and F$_4$ folds.

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The effect of silk fibroin and rhBMP-2 on bone regeneration in rat calvarial defect model (백서 두개골결손모델에서 실크단백과 골형성단백 이식체가 골재생에 미치는 영향)

  • Nam, Jeong-Hun;Noh, Kyung-Lok;Pang, Eun-O;Yu, Woo-Geun;Kang, Eung-Sun;Kweon, Hae-Yong;Kim, Seong-Gon;Park, Young-Ju
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.36 no.5
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    • pp.366-374
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    • 2010
  • Introduction: This study evaluated the capability of silk fibroin (SF) and recombinant human bone morphogenetic protein-2 loaded SF (SF-BMP) as a bone defect replacement matrix when grafted in a calvarial bone defect of rats in vivo. Materials and Methods: A total 70 calvarial critical size defects (5.0 mm in diameter) made on 35 adult female Sprague-Dawley rats were used in this study. The defects were transplanted with (1) rhBMP-2 loaded silk fibroin graft (SF-BMP: 0.8+$10\;{\mu}g$), (2) Silk fibroin (SF: $10\;{\mu}g$), and (3) no graft material (Raw). The samples were evaluated with soft x-rays, alkaline phosphatase activity, calcium/phosphate quantification, histological and histomorphometric analysis at postoperative 4 and 8 weeks. Results: The SF-BMP group ($48.86{\pm}14.92%$) had a significantly higher mean percentage bone area than the SF group ($24.96{\pm}11.01%$) at postoperative 4 weeks.(P<0.05) In addition, the SF-BMP group ($40.01{\pm}12.43%$) had a higher % bone area at postoperative 8 weeks than the SF group ($33.26{\pm}5.15%$). The mean ratio of gray scale levels to the host bone showed that the SF-BMP group ($0.67{\pm}0.08$) had a higher mean ratio level than the SF group ($0.61{\pm}0.09$) at postoperative 8 weeks. These differences were not statistically significant.(P=0.168 and P=0.243, respectively) The ratio of the calcium and phosphate contents of the SF-BMP ($0.93{\pm}0.22$) group was lower than that of the SF ($1.90{\pm}1.42$) group at postoperative 4 weeks. However, the SF-BMP group ($0.75{\pm}0.31$) had a higher Ca/$PO_4$ ratio than the SF ($0.68{\pm}0.04$) at postoperative 8 weeks. These differences were not statistically significant.(P=0.126 and P=0.627, respectively) For the bone-specific alkaline phosphatase (ALP) activity, which is recognized as a reliable indicator of the osteoblast function, the SF-BMP ($23.71{\pm}8.60\;U/L$) groups had a significantly higher value than the SF group ($12.65{\pm}6.47\;U/L$) at postoperative 4 weeks.(P<0.05) At postoperative 8 weeks, the SF-BMP ($21.65{\pm}10.02\;U/L$) group had a lower bone-specific ALP activity than the SF group ($16.72{\pm}7.35\;U/L$). This difference was not statistically significant.(P=0.263) For the histological evaluation, the SF-BMP group revealed less inflammation, lower foreign body reactions and higher bone healing than the SF group at postoperative 4 and 8 weeks. The SF group revealed more foreign body reactions at postoperative 4 weeks. However, this immunogenic reaction decreased and the remnant of grafted material was observed at postoperative 8 weeks. For histomorphometric analysis, the SF-BMP group had a significantly longer bone length to total length ratio than those of the SF group at postoperative 4 and 8 weeks.(P<0.05) Conclusion: The rhBMP-2 loaded silk fibroin graft revealed fewer immunoreactions and inflammation as well as more new bone formation than the pure silk fibroin graft. Therefore, silk fibroin may be a candidate scaffold for tissue engineered bone regeneration.

A Survey on Diseases and Insect Pests in Sweet Persimmon Export Complexes and Fruit for Export in Korea (단감수출단지 과원과 수출단감 병해충 조사)

  • Jung, Young Hak;You, Eun Ju;Son, Daeyoung;Kwon, Jin Hyeuk;Lee, Dong Woon;Lee, Sang Myeong;Choo, Ho Yul
    • Korean journal of applied entomology
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    • v.53 no.2
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    • pp.157-169
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    • 2014
  • Between 2010 and 2012, diseases and insect pests of sweet persimmon were surveyed at sweet persimmon export complexes and non-export orchards in Suncheon, Jeonnam Province; Jinju, Changwon (Dongeup and Bukmyeon), and Gimhae, Gyeongnam Province; and Ulzu, Ulsan. The following diseases were found in the sweet persimmon orchards: angular leaf spot (Cercospora kaki), anthracnose (Colletotrichum gloeosporioides and Colletotrichum acutatum), circular leaf spot (Mycosphaerella nawae), powdery mildew (Phyllactinia kakicola), and gray mold (Botrytis cinerea). Circular leaf spot was the most frequent and serious disease, and C. gloeosporioides and C. acutatum were found on fruits. Thirty-three insect pest species that belonged to 32 genera of 20 families in 5 orders were found in the sweet persimmon orchards; the two-spotted spider mite, Tetranychus urticae, was also found in the surveyed orchards. Apolygus spinolae, Pseudaulacaspis cockerelli, and Adoxophyes orana were widely found in the surveyed orchards; Spodoptera litura and Homona magnanima were also recorded. Damage by insect pests was low, and the quarantine insect pests peach pyralid moth (Dichocrocis punctiferalis) and persimmon fruit moth (Stathmopoda masinissa) were rarely or not found in the sweet persimmon export complexes. In addition, other quarantine insect pests, such as persimmon false spider mite (Tenuipalpus zhizhilashviliae) and Japanese mealybug (Planococcus kraunhiae), were not detected. These quarantine insect pests were also not found in the sorting places, storage houses, and fruits for export; however, scale insects and two-spotted spider mites were found at a low rate. Although anthracnose (C. acutatum) infested fruit was found in the storage houses, only one in Jinju and Gimhae.