• Journal of Periodontal and Implant Science
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• 제25권3호
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• pp.518-528
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• 1995

The immunohistochemical study has been performed on the distribution of receptors for various growth factors in the newly forming granulation tissues following the guided tissue regeneration procedures. Two specimens from 2 different patients were collected from the newly forming granulation tissues at 2 weeks following GTR procedures using Gore-tex menbrane and rubber dam, respectively. For immunohistochemical localization of each recptor, anti-platelet-derived growth factor $receptor-{\alpha}$, anti-platelet-derived growth factor $receptor-{\beta}$. anti-insulin-like growth factor receptor, anti-basic fibroblast growth factor receptor, anti-transforming growth $factor-{\beta}$ receptor and anti-fibronectin receptor were incubated onto the specimens as primary antibodies. After the reaction, FITC-conjugated second antibodies have been applied. When the total numbers of immunoreactive cells and the true positive cells were counted, there were high variability among receptors tested in the present study. The mean number of immunoreactive cells were highest in the case for anti-IFG-1 receptor. However the number of true positive cells were highest in the case for $TGF-{\beta}$ receptor. The present investigation indicated that the receptor for $TGF-{\beta}$ were stongly expressed in the newly forming granulation tissues following the guided tissue regeneration therapy.

• Bulletin of the Korean Chemical Society
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• 제35권7호
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• pp.1939-1943
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• 2014

Solid dispersion (SD) system of everolimus (EVR) with Gelucire 50/13 (Stearoyl polyoxyl-32 glycerides) was prepared using melt granulation technique with the aim of improving the physicochemical properties and dissolution rate. The solid state characterization using scanning electron microscopy and X-ray powder diffraction, indicated that the drug was homogeneously distributed in the surfactant carrier in a stable amorphous form. The dissolution rate of EVR from the optimized SD composed of the drug, Gelucire 50/13 and microcrystalline cellulose in a weight ratio of 1:5:10, was markedly rapid and higher than that from the drug powder and the market product (Afinitor$^{(R)}$, Novartis Pharmaceuticals) in all dissolution mediums tested from pH 3.0 to pH 6.8. The results of this study suggest that formulation of SD with Gelucire 50/13 using melt granulation procedure may be a simple and promising approach for improving the dissolution rate and oral absorption of the anti-cancer agent without the need for using an organic solvent.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2007년도 심포지엄 논문집 정보 및 제어부문
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• pp.201-203
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• 2007

The paper concerns the successive optimization for structure and parameters of fuzzy inference systems that is based on parallel Genetic Algorithms (PGA) and information data granulation (IG). PGA is multi, population based genetic algorithms, and it is used tu optimize structure and parameters of fuzzy model simultaneously, The granulation is realized with the aid of the C-means clustering. The concept of information granulation was applied to the fuzzy model in order to enhance the abilities of structural optimization. By doing that, we divide the input space to form the premise part of the fuzzy rules and the consequence part of each fuzzy rule is newly' organized based on center points of data group extracted by the C-Means clustering, It concerns the fuzzy model related parameters such as the number of input variables to be used in fuzzy model. a collection of specific subset of input variables, the number of membership functions according to used variables, and the polynomial type of the consequence part of fuzzy rules, The simultaneous optimization mechanism is explored. It can find optimal values related to structure and parameter of fuzzy model via PGA, the C-means clustering and standard least square method at once. A comparative analysis demonstrates that the Dnmosed algorithm is superior to the conventional methods.

• ETRI Journal
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• 제37권6호
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• pp.1231-1241
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• 2015

In this study, we investigate the relationship between emotions and the physiological responses, with emotion recognition, using the proposed fuzzy information granulation-based neural network (FIGNN) for boredom, pain, and surprise emotions. For an analysis of the physiological responses, three emotions are induced through emotional stimuli, and the physiological signals are obtained from the evoked emotions. To recognize the emotions, we design an FIGNN recognizer and deal with the feature selection through an analysis of the physiological signals. The proposed method is accomplished in premise, consequence, and aggregation design phases. The premise phase takes information granulation using fuzzy c-means clustering, the consequence phase adopts a polynomial function, and the aggregation phase resorts to a general fuzzy inference. Experiments show that a suitable methodology and a substantial reduction of the feature space can be accomplished, and that the proposed FIGNN has a high recognition accuracy for the three emotions using physiological signals.

• 한국물환경학회지
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• 제27권6호
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• pp.754-759
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• 2011

A sequencing batch reactor (SBR) was operated under different pH conditions to better understand the influence of pH to granulation in enhanced biological phosphorus removal systems. Granules from the SBR were also investigated using scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX). Considerable decreases in the amount of phosphorus released per substrate provided under anaerobic conditions and the content of biomass polyphosphate under aerobic conditions were observed when pH was changed from 7.5 to 7.0, followed by 6.5. Aerobic granulation was also observed at pH 7.0. A number of bacteria with the typical morphological traits of tetrad-forming organisms (TFOs) were observed at pH 7.0, including large members of cluster. Filamentous bacteria were also there in large numbers. The occurrence and growth of granules were further enhanced at pH 6.5. A SEM analysis showed that the aerobic granules had a compact microbial structure with shaperical shape and morphologically consisted of aggregates of small coccoid bacteria and filamentous bacteria encapsulated by extracellular polymeric substance. The main material ions identified by EDX moreover revealed that the structural materials for polyphosphate in the granules include phosphorus, potassium and calcium. Therefore, these results strongly suggested that PAOs are a dominant population in the microbial community of the aerobic granules.

• 한국임상수의학회지
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• 제38권1호
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• pp.32-35
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• 2021

Three dogs (a 30-month-old spayed female English bulldog; a 12-month-old castrated male English bulldog; a 19-month-old castrated male Shar-pei dog) were presented to the Dana Animal Hospital Eye Center with clinical signs of blepharospasm, epiphora, and ocular discharge (serous to mucopurulent) in one or both eyes. Through ophthalmic examination, the dogs (5 eyes) were diagnosed with trichiasis caused by upper and lower eyelid entropion, including the lateral canthus. To correct upper and lower eyelid entropion, modification using a combination of the Stades forced granulation method for upper eyelid entropion and Hotz-Celsus procedure for lower eyelid entropion was performed in all cases. At the last follow-up, mean 274 days after surgery, clinical signs disappeared and no recurrences of entropion were observed in any of the 3 dogs (5 eyes). Therefore, the combination of the Stades forced granulation method and Hotz-Celsus procedure may be an effective treatment for trichiasis caused by upper and lower eyelid entropion in dogs.

• Advances in Traditional Medicine
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• 제7권3호
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• pp.254-260
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• 2007

Alstonia scholaris (Family: Apocynaceae) has been indicated for the treatment of various diseases, one among which is wound healing. The purpose of this study is to investigate the wound healing effect and antioxidant role of Alstonia scholaris leaves in animal models. The ethanol and aqueous extracts of Alstonia scholaris (EEAS, AEAS respectively) were tested against excision, incision and dead space wound models to evaluate the wound healing activity. In excision wound model, treatment was continued till the complete healing of wound, in incision and dead space wound models, the treatment was continued for 10 days. For topical application, 5% w/w ointment of EEAS and AEAS were prepared in 2% sodium alginate. For oral administration, EEAS was suspended in distilled water using Tween 80 and AEAS was dissolved in distilled water. The wound healing was assessed by the rate of wound contraction, period of epithelialisation, skin breaking strength, granulation strength, dry granulation tissue weight, hydroxyproline, collagen and histopathology of granulation tissue. Malondialdehyde level was also estimated to evaluate the extent of lipid peroxidation. AEAS and EEAS significantly promoted wound healing activity in all the wound models studied. Increase in the rate of wound contraction, skin breaking strength, granulation strength, dry granulation tissue weight, hydroxyproline and collagen, decrease in the period for epithelialisation and increased collagenation in histopathological section were observed with EEAS and AEAS treated groups. EEAS and AEAS also significantly decreased the levels of lipid peroxidation. The present study is suggestive that EEAS and AEAS promote wound healing activity.

• Tuberculosis and Respiratory Diseases
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• 제78권1호
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• pp.31-35
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• 2015

An 18-year-old woman was evaluated for a chronic productive cough and dyspnea. She was subsequently diagnosed with mediastinal non-Hodgkin lymphoma (NHL). A covered self-expandable metallic stent (SEMS) was implanted to relieve narrowing in for both main bronchi. The NHL went into complete remission after six chemotherapy cycles, but atelectasis developed in the left lower lobe 18 months after SEMS insertion. The left main bronchus was completely occluded by granulation tissue. However, the right main bronchus and intermedius bronchus were patent. Granulation tissue was observed adjacent to the SEMS. The granulation tissue and the SEMS were excised, and a silicone stent was successfully implanted using a rigid bronchoscope. SEMS is advantageous owing to its easy implantation, but there are considerable potential complications such as severe reactive granulation, stent rupture, and ventilation failure in serious cases. Therefore, SEMS should be avoided whenever possible in patients with benign airway disease. This case highlights that SEMS implantation should be avoided even in malignant airway obstruction cases if the underlying malignancy is curable.

• 한국인터넷방송통신학회논문지
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• 제21권3호
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• pp.67-72
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• 2021

연관규칙 마이닝은 여러 테이블에 숨겨진 패턴들의 관계를 나타내주는 방법이다. 요즈음에는 연관규칙 마이닝에 보다 세부적인 의미를 추가하기 위하여 과립화 논리를 이용하고 있다. 또한 기존의 데이터를 이용하여 추천하는 기존의 시스템과는 달리 과립화 연관규칙에서는 신규 가입자나 신규상품에 대한 추천의 경우도 가능하다. 따라서 연관규칙의 과립화의 정성적인 크기를 결정하는 것이 추천 시스템의 성능을 좌우한다. 본 논문에서는 관람자가 평가한 영화에 대한 관계를 파악하기 위하여 퍼지논리와 샤논 엔트로피 개념을 이용하여 관람자와 영화데이터에 대한 과립화 방법을 제안한다. 연구는 관람자와 영화간의 연관규칙의 함의에 결정적인 역할을 하는 데이터의 과립화의 크기를 결정하는 부분과 이러한 과립화를 이용하여 관람자와 영화간의 연관규칙을 추출하는 두 번째 부분으로 구성되어 있으며 넷플릭스의 MovieLens데이터를 이용하여 분석하였다. 최종적으로 도출된 연관규칙의 의미와 추천의 정확도 및 고려해야하는 함의를 제시하였다.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2006년 학술대회 논문집 정보 및 제어부문
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• pp.217-219
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• 2006

본 연구는 정보입자와 유전알고리즘의 기호코딩을 통해 퍼지집합 기반 다항식 뉴럴네트워크(IG based gFSPNN)의 최적 설계 제안한다. 기존의 Furry Srt-based Polynomial Neural Networks의 최적설계를 위해 유전자 알고리즘의 이진코딩을 사용하였다. 이지코딩은 스티링 길이 때문에 연산시간이 급격히 증가되는 현상과 해밍절벽(Hamming Cliff)에 따른 급격한 비트변환이 힘들다는 단점이 내제 하였다. 이에 본 논문에서는 스티링 길이와 해밍절벽에 따른 문제를 해결 하기위해 기호코딩을 사용하였다._데이터들의 특성을 모델에 반영하기 위해 Hard C-Means(HCM)을 결합한 Information Granulation(IG)을 사용하여 최적모델 구축 속도를 빠르게 하였다. 실험적 예제를 통하여 제안된 모델의 성능을 평가한다.