• 동의생리병리학회지
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• 제21권2호
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• pp.399-403
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• 2007

In order to obtain practical application of Daehwangmokdan-tang gout disease, water extract of Gami-daehwangmokdan-tang(GDMT) added with Lonicera japonica is prepared through decoction and freeze drying. The effects were evaluated with blood sample from ICR mice treated with MSU intra-peritoneal injection 1 time a day, 3 days consecutively. The results were as follows. GDMT decreased BUN, creatinine and C-reactive protein level in serum significantly. But the HDL and LDL cholesterol levels were not changed in spite of positive tendency in HDL cholesterol. Triglyceride and uric acid levels were decreased significantly too. These results show that GDMT can be used effectively against the urate-related gout disease.

• Journal of Oral Medicine and Pain
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• 제23권3호
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• pp.257-261
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• 1998

Angiokeratoma is a cutaneous vascular disorder that occurs at any sites as trunk,extremities, fingers and toes etc. Although solitary or multiple cutaneous lesions have been reported, oral lesions have been very care. A 72-year-old man who had an exophtic, essile mass with dark red, black colored which located on buccal mucosa, was treated with excisional biopsy. He had no specific systemic history except for the medication of allopurinol, for treatment of gout since 10 years. Final diagnosis was determined as angiokeratoma by evaluation of clinical and histopathological finding, and the lesion has not been recurred for two months by decrease of allopurinol. It has been emphasized that the relationship between oral mucosal disease and the complication of allopurinol. Allopurinol is widely used for gout treatment, which we will report a case on the allopurinol-associated angiokeratoma in the oral mucosa.

• 약학회지
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• 제47권5호
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• pp.307-310
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• 2003

Ethanol extract of Actinidia polygama Max. (AP) was examined for hypouricemic activity in potassium oxonateinduced hyperuricemic animal model. Ethanol extract of AP lowered the plasma uric acid level by 20％ when compared to the hyperuricemic control group. AP ether fraction at a dose of 100 mg/kg showed 27％ reduction, whose efficacy was comparable to the probenecid-treated group. AP ether fraction-treated group also showed 23％ reduction of urate in urine and this result suggests that AP ether fraction has anti-gout activity probably due to xanthine oxidase inhibition.

• 대한간호학회지
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• 제43권4호
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• pp.547-556
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• 2013

Purpose: This study was conducted to examine the changing patterns of knowledge related to disease, medication adherence, and self-management and to determine if outcomes were more favorable in the experimental group than in the comparison group through 6 months after providing a web-based self-management intervention. Methods: A non-equivalent control group quasi-experimental design was used and 65 patients with gout, 34 in experimental group and 31 in comparison group, were selected from the rheumatic clinics of two university hospitals. Data were collected four times, at baseline, at 1 month, 3 months, and 6 months after the intervention. Results: According to the study results, the changing patterns of knowledge and self-management were more positive in the experimental group than in the control group, whereas difference in the changing pattern of medication adherence between two groups was not significant. Conclusion: The results indicate that the web-based self-management program has significant effect on improving knowledge and self-management for middle aged male patients with gout. However, in order to enhance medication adherence, the web-based intervention might not be sufficient and other strategies need to be added.

• 혜화의학회지
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• 제17권1호
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• pp.95-104
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• 2008

This study was designed to investigate the Effects of Smilacis Glabrae Rhizoma(SGR) on the gout. After pretreatment of SGR(50, 500mg/kg) for 5days, the Effects of SGR was evaluated on changes Joint value increase ratio, Serum albumin, Serum globulin, glutamate dxalacetate transminase(AST), glutanate pyruvate transminase(ALT), blood urea nitrogen(BUN), Serum creatitine, Serum uric acid, xanthine oxidase activity, WBC, Erythrocyte Sedimentation Rate(ESR), platelet. The results were obtained as follows ; Joint valueincrease ratio was decreased in 50mg/kg, 500mg/kg SGR taken group, but changes were not significantly different with the control group. AST, ALT were not significantly different in all SGR taken groups compared with the control group. Serum BUN, creatinine were significantly decreased in 500mg/kg SGR taken group compared with control group. ESR was significantly decreased in all SGR taken groups compared with the control group. WBC, platelet were significantly decreased in 500mg/kg SGR taken group compared with control group. Serum uric acid was not significantly different in all SGR taken groups compared with the control group. Xanthine oxidase activity was significantly decreased in 500mg/kg SGR taken group compared with control group. From above results, it may be concluded that SGR can be used for treatment and prevention of gout.

• 한국균학회지
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• 제38권1호
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• pp.85-87
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• 2010

버섯으로부터 새로운 항통풍성 소재를 개발하여 이를 대체의약의 소재나 건강 기능성 제품 개발에 응용할 수 있는 자료를 얻고자 12종의 국내 버섯 자실체들의 물 추출물을 제조하여 이들의 항통풍성 xanthine oxidase 저해 활성을 측정하였다. 시료 버섯 가운데 신령 버섯 자실체의 물 추출물이 가장 높은 72.9%의 저해 활성을 보였고 이 저해 물질은$30^{\circ}C$에서 24시간 추출하였을 때 가장 많이 용출 되었다.

• Journal of Acupuncture Research
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• 제40권2호
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• pp.135-142
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• 2023

Background: This study aimed to investigate hyperuricemia, renal inflammation, and xanthine oxidase (XO) activity improvement in a rat model treated with Scutellaria baicalensis extract (SBE). Methods: The rats were divided into 4 groups (n = 5 each), including sham, potassium oxonate (PO) injected hyperuricemia (control group), PO + 10 mg/kg allopurinol administrated (allopurinol group), and a PO + 50 mg/kg SBE administrated (SBE group), to investigate the effectiveness and molecular mechanisms of SBE. The effects of SBE on PO-induced hyperuricemia rats, renal inflammation, and XO activity were measured. Body weight and organ index of the kidney and liver were measured in PO-induced hyperuricemia rats, and serum uric acid level was extracted from whole blood and was measured. Renal inflammation was observed under a microscope after sections. XO activity was measured by liver tissue and serum XO levels. Results: Organ indexes of the kidney and liver in rats were significantly decreased in the allopurinol group than in the control group and with no significant difference in the SBE group. A PO injection for 5 days significantly increased serum uric acid levels in the control group compared to the sham group. Meanwhile, the SBE and allopurinol groups have significantly decreased serum uric acid levels compared to the control group. The SBE group revealed effectively improved renal histopathological changes compared to the control group. The XO inhibitor, allopurinol, significantly decreased XO activity. Additionally, SBE significantly lowered XO activity in rats. Conclusion: SBE can be used as an effective treatment for gout in the future.

• 디지털융복합연구
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• 제11권12호
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• pp.615-620
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• 2013

이 연구은 2012년 인구보건복지협회가 검진한 일개도 통풍검사 결과를 성별을 구분하여 자료를 분석한 결과로 추후 통풍환자관리에 있어 기초 자료로 활용하기 위해 실시되었다. 분석은 SPSS 18.0을 이용하여 빈도분석, 카이제곱 분석 및 로지스틱 회귀분석을 실시하였다. 그 결과, 고요산혈증으로 정밀검사를 요하는 수진자는 남자가 월등히 많았고, 저요산혈증은 여자가 유의하게 많게 나타났다(p<0.001). 연령별 정밀검사를 요하는 수진자 및 저요산혈증은 70세 이상이 유의하게 가장 많았다(p<0.001). 고요산혈증으로 정밀검사를 요하는 수진자는 시지역이 저요산혈증은 군지역이 약간 높았으며, 고요산혈증은 내륙지역이 저요산혈증은 해안지역 약간 높은 비율이 나타났다. 이 조사를 토대로 하여 연도별, 연령별, 성별 통풍 유병률을 지속적으로 관찰한다면 통풍의 유병률 변화추세를 판단하기에는 상당히 유용할 것이며, 유소견자로 판정된 사람에 대한 추후관리 서비스 제공 및 폐경 후 여성에서 증가하는 고요산혈증 연구뿐만 아니라 저요산혈증의 원인에 대한 연구가 필요하다.

• 대한수의사회지
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• 제16권8_10호
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• pp.305-307
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• 1980

• 대한족부족관절학회지
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• 제16권4호
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• pp.280-285
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• 2012

Osteochondroma, which is an osteocartilaginous exostosis, is essentially the most common primary bone tumor. These benign neoplasms are generally asymptomatic and have a relatively small potential for adverse effects. Calcaneal osteochondroma is rare, furthermore osteochondroma accompanying with gouty arthritis is very rare. Also, the subtalar joint is not a classic site of acute gout. In this report, we report the case of a patient who experienced an unusual calcaneal osteochondroma with undiagnosed gouty arthritis of the subtalar joint.