• 청정기술
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• 제26권4호
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• pp.251-256
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• 2020

The biocompatibility and plasmonic properties of Au nanoparticles make them useful for photothermal therapy, drug delivery, imaging, and many other fields. This study demonstrated a novel, facile, economic, and green synthetic method to produce gold nanoparticles. Gold nanoparticles (AuNPs) with spherical and triangular shapes were effectively synthesized using only Schisandra chenesis fruit extract as the capping and reducing agent. The shape of the AuNPs could be engineered simply by adjusting the molar concentration of HAuCl4 in the reaction mixture. The as-synthesized AuNPs were characterized using UV-VIS spectroscopy, transmission electron microscopy (TEM), X-ray diffraction (XRD), dynamic light scattering (DLS), and energy dispersive X-ray analysis (EDXA). This study revealed that by using the HAuCl4 concentration in the AuNP synthesis, the shape and size of the AuNPs could be controlled by the concentration of HAuCl4 and Schisandra chinensis fruit extract as a surfactant. The as-synthesized AuNPs samples had sufficient colloidal stability without noticeable aggregation and showed the predominant growth of the (111) plane of face-centered cubic gold during the crystal growth. The catalytic efficiency of the AuNPs synthesized using Schisandra chenesis fruit extract was examined by monitoring the catalytic reduction of 4-nitrophenol to 4-aminophenol using Ultraviolet-visible spectroscopy (UV-Vis spectroscopy). The synthesized AuNPs showed good catalytic activity to reduce 4-nitrophenol to 4-aminophenol, revealing their practical usefulness.

• 한국방사선학회논문지
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• 제18권1호
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• pp.1-9
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• 2024

양성자 치료는 브래그 피크로 인해 우수한 치료 기법으로 알려져 있다. 양성자의 치료 효과를 높이기 위해 금 나노입자를 종양에 분포시켜 흡수선량을 높이는 방법이 연구되고 있다. 마이크로미터와 나노미터 범위에서 금 나노입자를 다루었던 것을 밀리미터 범위에서 금 나노입자를 전산모사 할 수 있는 방법을 제시하였다. 전산모사를 위해 Geant4 툴킷을 사용하였다. 인체와 유사한 물과 금 나노입자가 균일하게 분포되어 있다는 것을 가정하고 밀도비를 통해 금 나노입자의 개수 또는 농도를 조절하였다. 브래그 피크 위치에서 밀도비가 5%일 때 금 나노입자로 인해 순수 물 팬텀에 비해 흡수 에너지의 이득이 거의 2배로 나타났다. 밀도비가 증가할수록 흡수 에너지의 이득은 선형적으로 증가하였다. 브래그 피크 위치에서 금 나노입자가 하나의 복셀에만 분포하고 있을 때 양성자의 에너지는 자신 주변의 복셀에만 영향을 미치지만, 넓은 영역에 금 나노입자가 분포하는 경우 순수 물 팬텀에서 최고 흡수 에너지 (9.95 keV)의 95% 흡수 에너지 (9.46 keV)를 나타내는 부피는 16배 큰 영역에서 흡수 에너지의 이득이 나타났다. 그리고 이 영역은 밀도비가 증가할수록 증가하였다. 밀리미터 범위에서 금 나노입자의 밀도비와 RBE의 관계를 정량화하는 등 추가적인 연구가 필요하다.

• 한국콘텐츠학회논문지
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• 제16권8호
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• pp.477-483
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• 2016

두부 모의피폭체를 활용하여 MV X, ${\gamma}$선에서의 선량증가 효과와 금 나노입자의 크기, 물질의 농도에 대한 의존성을 평가하였다. MCNPX code를 이용하여 Monte Carlo 시뮬레이션 기법을 적용하였으며, 입사 에너지는 4, 6, 10, 15 MV X선, Co60 ${\gamma}$선을 사용하였다. 두부 모의피폭체 내에 종양을 묘사하고 내부에 25, 75, 125 nm 직경의 금 나노입자를 삽입하였다. 나노입자의 농도는 5, 15, 25 mg/g을 적용하였으며, 선량 증가 물질이 없을 때를 기준으로 하여 선량증가비를 산출하였다. 입사 에너지가 낮을수록, 선량증가 물질의 농도가 높을수록 높은 선량증가비를 나타내었다. 나노입자의 크기는 입사 에너지가 낮고, 물질의 농도가 높을수록 상대적으로 높은 의존성을 보였다. 금 나노입자를 이용한 선량증가 효과를 나타내는데 기초자료로 활용할 수 있을 것으로 사료된다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권1호
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• pp.169-174
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• 2015

Cervical cancer (CxCa) is the most common cancer in women and a prominent cause of cancer mortality worldwide. The primary cause of CxCa is human papillomavirus (HPV). Radiation therapy and chemotherapy have been used as standard treatments, but they have undesirable side effects for patients. It was reported that gallic acid has antioxidant, antimicrobial, and anticancer activities. Gold nanoparticles are currently being used in medicine as biosensors and drug delivery agents. This study aimed to develop a drug delivery agent using gold nanoparticles conjugated with gallic acid. The study was performed in uninfected (C33A) cervical cancer cells, cervical cancer cells infected with HPV type 16 (CaSki) or 18 (HeLa), and normal Vero kidney cells. The results showed that GA inhibited the proliferation of cancer cells by inducing apoptosis. To enhance the efficacy of this anticancer activity, 15-nm spherical gold nanoparticles (GNPs) were used to deliver GA to cancer cells. The GNPs-GA complex had a reduced ability compared to unmodified GA to inhibit the growth of CxCa cells. It was interesting that high-concentration ($150{\mu}M$) GNPs-GA was not toxic to normal cells, whereas GA alone was cytotoxic. In conclusion, GNPs-GA could inhibit CxCa cell proliferation less efficiently than GA, but it was not cytotoxic to normal cells. Thus, gold nanoparticles have the potential to be used as phytochemical delivery agents for alternative cancer treatment to reduce the side effects of radiotherapy and chemotherapy.

• Biomolecules & Therapeutics
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• 제23권2호
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• pp.99-109
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• 2015

Drug development groups are close to discovering another pot of gold-a therapeutic target-similar to the success of imatinib (Gleevec) in the field of cancer biology. Modern molecular biology has improved cancer therapy through the identification of more pharmaceutically viable targets, and yet major problems and risks associated with late-phase cancer therapy remain. Presently, a growing number of reports have initiated a discussion about the benefits of metabolic regulation in cancers. The Warburg effect, a great discovery approximately 70 years ago, addresses the "universality" of cancer characteristics. For instance, most cancer cells prefer aerobic glycolysis instead of mitochondrial respiration. Recently, cancer metabolism has been explained not only by metabolites but also through modern molecular and chemical biological techniques. Scientists are seeking context-dependent universality among cancer types according to metabolic and enzymatic pathway signatures. This review presents current cancer metabolism studies and discusses future directions in cancer therapy targeting bio-energetics, bio-anabolism, and autophagy, emphasizing the important contribution of cancer metabolism in cancer therapy.

• 대한정형도수물리치료학회지
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• 제18권1호
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• pp.1-10
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• 2012

Thoracic kyphosis is occasionally used to describe someone with accentuated thoracic curvature, hyperkyphosis is preferred since kyphosis itself refers to the normal sagittal angle of thoracic curvature. The angle of thoracic kyphosis tends to increase with age resulting in hyperkyphosis in some individuals. The persons who suffer from hyperkyphosis are at increased risk for a variety of adverse health outcomes that include musculoskeletal alteration, physical functional limitations, poor quality of life, falls, and even earlier mortality. Hyperkyphosis may develop from vertebral fractures, degenerative disc disease, either muscle weakness, decreased mobility and sensory deficits. The gold-standard orthopaedic technique for assessment of thoracic kyphosis is standing lateral spine radiographs. Other clinical measures are Debrunner kyphometer, inclinometer, flexicurve ruler, arcometer, flexible electrogoniometer and spinal mouse.

• Restorative Dentistry and Endodontics
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• 제25권3호
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• pp.321-337
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• 2000

Dental caries, one of the most frequent dental disease, become larger because it can be thought as a simple disease. Further more, it can progress to unexpected root canal therapy with fabrication of crown that needs reduction of tooth structure. Base is required in a large caries and ZOE, ZPC, glass ionomer are used frequently as base material. They, with restorative material, can affect the longevity of the restoration. In this study, we assume that the mandibular 1st molar has deep class I cavity. So, installing the 3 base material, 3 kinds of fillings were restored over the base as follows; 1) amalgam only, 2) amalgam with ZPC, 3) amalgam with ZOE, 4) amalgam with GI cement, 5) gold inlay with ZPC, 6) gold inlay with GI cement, 7) composite resin only, 8) composite resin with GI cement. After develop the 3-dimensional model for finite element analysis, we observe the distribution of stress and temperature with force of 500N to apical direction at 3 point on occlusal surface and temperature of 55 degree, 15 degree on entire surface. The analyzed results were as follow : 1. Principal stress produced at the interface of base, dentin, cavity wall was smallest in case of using GI cement as base material under the amalgam. 2. Principal stress produced at the interface of base, dentin, cavity wall was smaller in case of using GI cement as a base material than ZPC under gold inlay. 3. Composite resin-filled tooth showed stress distributed over entire tooth structure. In other words, there was little concentration of stress. 4. ZOE was the most effective base material against hot stimuli under the amalgam and GI cement was the next. In case of gold inlay, GI cement was more effective than ZPC. 5. Composite resin has the small coefficient of thermal conductivity. So, composite resin filling is the most effective insulating material.

• Bulletin of the Korean Chemical Society
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• 제34권9호
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• pp.2795-2799
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• 2013

Irradiation of gold nanorods (GNRs) with laser light corresponding to the longitudinal surface plasmon oscillation results in rapid conversion of electromagnetic energy into heat, a phenomenon commonly known as the photothermal effect of GNRs. Herein, we propose a facile strategy for increasing the photothermal conversion efficiency of GNRs by integration to form graphene oxide (GO) nanocomposites. Moreover, conjugation of iron oxide (IO) with the GO-GNR nanohybrid allowed magnetic enrichment at a specific target site and the separated GO-IO-GNR assembly was rapidly heated by laser irradiation. The present GO-IO-GNR nanocomposites hold great promise for application in various biomedical fields, including surface enhanced Raman spectroscopy imaging, photoacoustic tomography imaging, magnetic resonance imaging, and photothermal cancer therapy.

• Medical Lasers
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• 제10권1호
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• pp.7-14
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• 2021

In cancer therapy, it is often desirable to use precision medicine that involves treatments of high specificity. One such treatment is the use of photo-triggered theranostic nanoparticles. These nanoparticles make it possible to visualize and treat tumors specifically in a controlled manner with a single injection. Several novel and powerful photo-triggered theranostic nanoparticles have been developed. These range from small organic dyes, semiconducting and biopolymers, to inorganic nanomaterials such as iron-oxide or gold nanoparticles, carbon nanotubes, and upconversion nanoparticles. Using photo-triggered theranostic nanoparticles and localized irradiation, complete tumor ablation can be achieved without causing significant toxicity to normal tissue. Given the great advances and promising future of theranostic nanoparticles, this review highlights the progress that has been made in the past couple of years, the current challenges faced and offers a future perspective.

• 대한소아치과학회지
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• 제7권1호
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• pp.7-11
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• 1980

6877 children who visited to pedodontic department from 1976 to 1979, were surveyed on the state of dental caries, therapic inclination a year and yearly tendency of treatment. The results were as follows ; 1. The prevalence of dental caries tended to show the increase in general year by year. 2. Girls had higher d.e.f. T. & S. index and D.M.F. T. & S. index than boys generally. 3. Distribution of therapy a year. (1979) Amalgam Filling 4464 Pulpotomy 952 S.P.-Crown 1538 Gold Inlay 250 Space Maintainer 341 Extraction 1313 Orthodontic Appliance 206 4. Tendency of treatment in 1979 (compared with 1976) No. of new patients 87.5% increased Amalgam Filling 50.0% increased Extraction 31.4% increased Orthodontic Appliance 267.9% increased S.P.-Crown 225.8% increased Gold Inlay 27.8% decreased Space Maintainer 2.3% decreased Pulpotomy 20.5% decreased.