• Title/Summary/Keyword: Glycoprotein

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Anti-aging Effects of Rosa damascena Extract Containing Low Molecular Glycoprotein (저분자 당단백을 함유하는 다마스크 장미추출물의 항노화 효과)

  • Han, Jeung Hi;Song, Ji Hoon;Kim, Young Eun;Lee, Yu Hee;Lee, Jung Min;Lee, Ji Ean
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.44 no.1
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    • pp.49-57
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    • 2018
  • In this study, we investigated the anti-aging effect of Rosa damascena extract containing low molecular glycoprotein (RELG) converted from the high molecular glycoprotein by bioconversion. Free radical scavenging activities were performed by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. Antioxidant activities ($IC_{50}$) of RELG and the positive control ascorbic acid were $22.6{\mu}g/mL$ and $21.1{\mu}g/mL$, respectively. For skin cells, $15{\mu}g/mL$ RELG showed 28% antioxidant activity by inhibiting the production of active oxygen species induced by ultraviolet ray and hydrogen peroxide. $15{\mu}g/mL$ RELG prevented 10% the cell death caused by stress in human hair follicle dermal papilla cells (HDPC) and reduced 90% the production of active oxygen species. In addition, the glycoprotein showed not only anti-wrinkle effect but also moisturizing effect by 48% inhibition of matrix metallo proteinase-1 (MMP-1) production by ultraviolet stress and $10{\mu}g/mL$ RELG enhanced 10% neutral lipid synthesis with 44% aquaporin 3 (AQP3) expression, which is moisture factor. In conclusion, the RELG can be used as an anti-aging cosmetic material.