• The Korean Journal of Physiology
• /
• 제26권1호
• /
• pp.89-97
• /
• 1992

In hypoxic tissue conditions, pyruvate can not enter the Krebs cycle and lactic acid, produced from pyruvate, accumulates to induce lactic acidosis. Pyruvate, However, can also be converted to alanine by glutamate pyruvate transaminase, that could be enhanced by glutamate. Therefore, it would be a fundamental measure to treat the lactic acidosis in tissue hypoxic conditions when one can convert the accumulated lactic acid, through pyruvate, to alanine. To test the above hypothesis, we induced a lactic acidosis in cats and the effect of glutamate on recovery of acid base state and removal of the lactic acid from blood were assessed and the results were compared with those of bicarbonate administration, which is one of the most frequently used conventional measure for correction of the acid base state during lactic acidosis. The results were that glutamate and combined glutamate bicarbonate solutions not only restored the acid base status completely from the lactic acidosis in an hour or two, but also restored the blood level of lactate partially. We concluded that administration of glutamate solution to convert pyruvate into alanine is effective in preventing lactic acid accumulation and treating lactic acidosis.

• 한국식품영양과학회지
• /
• 제13권4호
• /
• pp.437-443
• /
• 1984

포도당으로 perfusion한 쥐의 뒷다리 근육에 전기자극으로 근육운동을 유도하여 대사물의 농도변화를 측정한 결과는 아래와 같다. 근육내의 구연산회로대사물, 피루빅산, 젖산등의 농도가 상당히 증가하였고 알라닌, 글루타믹산, 아스파틱산등의 아미노산은 약간 증가하였고, 크레아틴 포스페이트, ATP의 농도가 급강하 한데 반하여 AMP와 암모니아의 농도가 증가하였다. 이 결과는 운동시에 에너지대사를 촉진시키는 구연산회로 대사물 일부는 아미노산으로부터 transamination 반응을 통하여 공급되고, 일부는 purine nucleotidecycle반응을 통하여 아스파틱산으로 공급되고 있음을 밝혔다.