• Radiation Oncology Journal
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• v.18 no.4
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• pp.226-232
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• 2000

Purpose :This study was performed to find out the prognostic factors affecting local control in early glottic cancer treated with radiation therapy alone. Materials and Methods :We analysed 37 patients of histologically confirmed early glottic cancer treated at Chonnam National University Hospital between July Im and December 1995, retrospectively. Age of patients ranged from 30 to 73 years (median; 59 years). Thirty-five (95$\%$) patients were male. Histological type was all squamous cell carcinoma. According to the staging system of 1997 American Joint Committee on Cancer, 37 patients were restaged as follows: Tla; U (73$\%$), Tlb; 3 (8$\%$), 72: 7 (19$\%$). Radiation therapy was done using 6 MV X-ray of linear accelerator The range of total radiation dose delivered to the glottic lesion was between 5,040 cGy and 7,020 cGy (median; 6,600 cGy). Median follow-up period was U months. local control rates were calculated by Kaplan-Meier method. Generalized Wilcoxon test was used to evaluate the difference of control rates between comparable groups. Multivariate analysis using Cox proportional hazard model was done to find out prognostic factors affecting local control. Results:5 year survival rate of 37 patients was 89$\%$. Local control rate of 37 patients was 74$\%$ in 5 years. We included age, 7-stage, anterior commissure involvement, fraction size, total radiation dose, treatment time of radiotherapy as potential prognostic factors in univariate and multivariate analysis. As a result, treatment time had statistical significance in local control rate in both univariate (p=0.026) and multivariate (p=0.017) analysis. Complication was not recorded except one patient with hypothyroidism. Conclusion :This study revealed that overall treatment time of radiation was a significant factor affecting local control rate.

• Radiation Oncology Journal
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• v.3 no.2
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• pp.131-136
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• 1985

A retrospective analysis of 29 patients with glottic cancer, treated at the Department of Therapeutic Radiology, Seoul National University Hospital. $97\%$ of the patients was male. Of the 29 patients, stage $T_1N_0M_0$ comprised $31\%$, $T_2N_0M_0\;52\%$, and stage $T_3N_0M_0\;14\%$. Local control rate with radical readiotherapy was $78\%$ for stage $T_1N_0M_0,\;60\%$, for stage $T_2N_0M_0$, and $50\%$ for stage $T_3N_0M_),\;57\%$ of the patients with the radiation failure was salvaged by surgery. The overall 3 year survival rate was $89\%$ for the $T_1N_0M_0,\;80\%$ for stage $T_2N_0M_0$, and $50\%$ for stage $T_3N_0M_0$. Among the survivors: $88\%$ of $T_1N_0M_0\;75\%$ of $T_2N_0M_0,\;and\;50\%$ $T_3N_0M_0$ had an intact larynx and natural voice. It is concluded that radiotherapy is a highly effective method as the primary treatment of the early glottic cancer, emphasized on preserving of the larynx and natural voice.

• Radiation Oncology Journal
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• v.10 no.2
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• pp.181-186
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• 1992

A retrospective analysis was undertaken for 22 patients with early glottic cancer ($T_1N_0M_0$; 17, $T_2N_0M_0$; 5) who completed curative radiotherapy at the Department of Therapeutic Radiology, Chonnam University Hospital between November 1985 and December 1990. Median follow-up period was 39 months. The 3 year actuarial survival rate of T1, T2 was $81\%$ and $80\%$. respectively. Three patients ($13\%$) showed second malignant tumors and the site of the new primary was esophagus in two patients and lung in the other one. They were excluded from the local control analysis. The local control rate of T1. T2 group was $66\%$ and $50\%$. respectively. The surgical salvage rate and the ultimate local control rate of T1 group was $80\%$ (4/5) and $93\%$. and that of T2 group was $100\%\;(2/2)\;and\;75\%$. respectively. The local control rates of T1 stage were evaluated according to the various parameters. The local control rate of the superficial and exophytic lesion was better than that of the ulcerative and infiltrative one, and the involvement of anterior commissure was not seemed to be adverse prognostic factor. But the protracted treatment time showed the adverse effect on the local control of the disease. All of the eleven patients controlled by primary radiation therapy have maintained their voice well without any significant complication.

• Radiation Oncology Journal
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• v.37 no.4
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• pp.271-278
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• 2019

Purpose: To investigate the differences in treatment outcomes between two radiation techniques, intensity-modulated radiotherapy (IMRT) and three-dimensional conformal radiotherapy (3DCRT). Materials and Methods: We retrospectively analyzed 160 (IMRT = 23, 3DCRT = 137) patients with stage I glottic cancer treated from January 2005 through December 2016. The IMRT was performed with TomoTherapy (16 patients), volumetric-modulated arc therapy (6 patients), and step-and-shoot technique (1 patient), respectively. The 3DCRT was performed with bilateral parallel opposing fields. The median follow-up duration was 30 months (range, 31 to 42 months) in the IMRT group and 65 months (range, 20 to 143 months) in the 3DCRT group. Results: The 5-year overall survival and 3-year local control rates of the 160 patients were 95.7% and 91.4%, respectively. There was no significant difference in 3-year local control rates between the IMRT and 3DCRT groups (94.4% vs. 91.0%; p = 0.587). Thirteen of 137 patients in the 3DCRT group had recurrences. In the IMRT group, one patient had a recurrence at the true vocal cord. Patients treated with IMRT had less grade 2 skin reaction than the 3DCRT group, but this had no statistical significance (4.3% vs. 21.2%; p = 0.080). Conclusion: IMRT had comparable outcomes with 3DCRT, and a trend of less acute skin reaction in stage I glottic cancer patients.

• Proceedings of the KSLP Conference
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• 2006.12a
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• pp.158-158
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• 2006

• Proceedings of the KSLP Conference
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• 1993.12a
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• pp.18-18
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• 1993

성문폐쇄부전의 개선을 위해 후두내에 주입하여온 여러 재료 중 현재에는 teflon만이 가장 흔히 사용되어지고 있다. 그러나 teflon은 점막하와 가동성 성대 내에 주입할 수 없어 경도 성문 폐쇄부전의 미세 조정과 성대의 작은 결손에는 부적합하다. 성문폐쇄부전을 개선하기 위하여 9명의 환자에서 17회 cross-linked collagen을 주입한 결과 이 방법은 환자의 음성을 개선하고 성문폐쇄부전을 교정하는데 성공적이었다. (중략)

• Proceedings of the KSLP Conference
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• 1993.12a
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• pp.21-21
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• 1993

발성장애와 호흡곤란을 주소로 하는 성대 전연부 격막은 후두병변의 부적절한 치료, 만성염증 또는 외상 등의 후천적인 원인으로 발생하는 경우가 많다. 성문중 가장 협소한 부위인 전연부에 발생한 격막에 대하여는 여러 가지 다양한 치료방법이 보고되고 있지만, 재협착의 가능성이 높고, 치료후 반흔 조직에 의하여 음성의 질을 높이는데 한계점이 있다. (중략)

• Proceedings of the KSLP Conference
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• 1994.06a
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• pp.117-127
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• 1994

사람의 성대는 일상회화중 1초에 100∼300번 진동하며 노래를 부를 때에는 100번 이하 또는 1,000번 이상까지 진동하게되므로 우리의 육안으로는 그 자세한 진동상태를 관찰할 수 가 없다. 따라서 이런 경우의 성대 진동상태를 관찰하려면 특수한 검사기기를 사용해야한다. 현재 사용되고 있는 검사법으로는 후두스트로보스코피(laryngostroboscopy), 초고속영화촬영(ultra high speed cinematography), 그로토그라피(glottoraphy) 및 카이모그라피(kymography) 등이 있다. (중략)

• 대한미세수술학회:학술대회논문집
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• 1995.11a
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• pp.72.1-72.1
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• 1995

• 대한두경부종양학회:학술대회논문집
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• 1990.11a
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• pp.24.1-24.1
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• 1990