• 대한기관식도과학회지
• /
• 제1권1호
• /
• pp.146-150
• /
• 1995

Esophageal manometry and Bernstein acid perfusion test were performed in 39 patients with globus sensation and 30 controls without experiencing a lump sensation in the throat. Globus patients also underwent physical examination, paranasal sinus x-ray, laryngoscopy and esophagogram. Nine of 39 patients were excluded from the study because local reasons for a lump sensation in the throat were found. Globus group showed significant elevation in upper esophageal sphinter pressure(P=0.0001) and six patients(20%) had evidence of nonspecific esophageal motility disorders, which suggested that hypertonicity of the upper esophageal sphinter and esophageal motility disorders could be the cause of globus syndrome.

• 사상체질의학회지
• /
• 제24권3호
• /
• pp.93-103
• /
• 2012

Objectives Rate of gastroesophageal reflux disease accompanied by irritable bowel syndrome is on the increase. This case study reports significant improvement of patients with gastroesophageal reflux disease and irritable bowel syndrome who had suffered from chest pain, globus pharyngis and diarrhea after taking Sasang constitutional treatment. Methods This patient was diagnosed as Large Yin type Esophagus Cold pattern(Taeeumin Wiwanhanjeung). Herb medicine(Jowiseungcheong-tang) was taken by the patient, three or two times per day during treatment periods. We assessed the changes of the main symptoms such as chest pain, globus pharyngis, defecation discomfort, insomnia et al. using visual analogue scale(VAS). Results The symptoms of chest pain, globus pharyngis, defecation discomfort, insomnia decreased from VAS 7~8 to VAS 0~1 for about three months. Conclusions This case shows that Sasang constitutional medicine treatment can be effective treatment method for gastroesophageal reflux disease accompanied by irritable bowel syndrome.

• Medical Lasers
• /
• 제9권1호
• /
• pp.71-75
• /
• 2020

Eagle syndrome is relatively uncommon with an incidence of abnormal stylohyoid length being 4% to 7.3%. A vast majority of individuals with elongation of the styloid process are asymptomatic. It is a syndrome marked by the clinical signs and symptoms of facial pain, ear pain, throat pain, dysphagia and a globus sensation in the throat. The cause of Eagle syndrome is believed to be a congenital or hormonal change and reactive osseus hyperplasia of the styloid process in response to pharyngeal trauma or surgical intervention, such as tonsillectomy. We present here a case of a 37-year-old female with a twelve-month history of both sided oropharyngeal pain and globus sensation which has no trauma or surgical intervention. The patient presented with a long, slender, bony intraoral projection that was found to be an elongated styloid process. We removed this elongated styloid process with a CO₂ laser, and her symptoms disappeared.

• 대한한방내과학회지
• /
• 제43권6호
• /
• pp.1301-1310
• /
• 2022

Objective: The purpose of this case study was to report the effects of Korean medicine treatment on a patient diagnosed with postgastrectomy syndrome (PGS). Methods: The patient was treated with herbal medicine, acupuncture, and moxibustion in combination with Western medicine for 3 months. Results: Though abdominal tenderness was maintained at a similar level, other clinical symptoms (epigastric pain, globus pharyngis, and epigastric pain) were improved after Korean medicine treatment. Conclusions: These results suggest that the need to promote practical research on PGS, should receive greater attention in the Korean medical community.

• Journal of Korean Neurosurgical Society
• /
• 제48권2호
• /
• pp.134-138
• /
• 2010

Objective : Meige syndrome is the combination of blepharospasm and oromandibular dystonia. We assessed the surgical results of bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) in patients with medically refractory Meige syndrome. Methods : Eleven patients were retrospectively analyzed with follow-ups of more than 12 months. The mean follow-up period was $23.1{\pm}6.4$ months. The mean age at time of surgery was $58.0{\pm}7.8$ years. The mean duration of symptoms was $8.7 {\pm}7.6$ years. DBS electrodes were placed under local anesthesia using microelectrode recording and stimulation. After $2.4{\pm}1.3$ days of trial tests, the stimulation device was implanted under general anesthesia. Patients were evaluated using the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS). Results : BFMDRS total movement scores improved by 59.8%, 63.5%, 74.1%, 74.5%, and 85.5% during the immediate postoperative period of test stimulation, 3, 6, 12, and 24 months (n = 5) after surgery, respectively. The BFMDRS total movement scores were reduced gradually and the results reached statistical significance in the postoperative period (test period, p < 0.001; 3 months, p < 0.001; 6 months, p = 0.003; 12 months, p < 0.001; 24 months, p = 0.042). There was no statistical difference between 12 months and 24 months. BFM subscores improved by 63.3% for the eyes, 80.9% for the mouth, 68.4% for speech/swallowing, and 87.9% for the neck at 12 months after surgery. The adverse effects were insignificant. Conclusion : The bilateral GPi-DBS can be effective for the treatment of intractable Meige syndrome without significant side effects.

• 동의생리병리학회지
• /
• 제20권3호
• /
• pp.516-521
• /
• 2006

The following conclusions are drawn from Hyungsang medicinal review on th globs hystericus through Donguibogam and other literatures. The globs hystericus appears in the throat and the epigastric region. It is a subjective sensation as if a plum pit is stick in the throat and is compressed, usually ac companied by stuffiness in chest, depression, nausea, and hiccup. But the throat is not marked with redness and swelling. Because Gi stagnation due to seven emotions is the main cause, the globs hystericus is usually followed by Seven Gi injuries, Pain and depressive syndrome due to disorder of Gi, palpitation due to fright, continuous violent palpitation, Gi phlegm, precordial pain with palpitation, epigastric pain due to seven emotions, cough and dyspnea due to disorder of Gi, and six kinds of stagnations. When head and body or chest and abdomen is compared to heaven and earth, the blockage of Gi between heaven and earth is common to the persons with the following charcteristics in Hyungsang; Dam type rather than Bankwang type, Gi type and Shin type rather than deer type and fish type, Taeum and Yangmyeong meridian types out of six meridian types, manly women, womanly man, too long or short neck, and signs of stagnation between the eyebrows. The globus hystericus needs, distinguishing from aphonia, acute tonsilitis, goiter, and pectorial pain with stuffiness. The affected area of aphonia and acute tonsilitis is the throat but they are not cause by the disturbance of seven emotions. Goiter can be distinguished by the changes in the appearance of neck. Even though the symptoms are similar, globus hystericus is caused by the stagnation of Gi, but the pectorial pain with stuffiness, by the insufficiency of the Heart blood. The general prescriptions are Chilgitang, Sachiltang, Gamisachiltang, Gamiijintang, and Sinihwan.

• 대한후두음성언어의학회지
• /
• 제11권1호
• /
• pp.87-97
• /
• 2000

1999년 4월 일주일간 전국 101개 병의원의 이비인후과 외래를 방문한 신환을 대상으로 설문을 실시하고 이비인후과 전문의의 진찰을 통하여 인.후두 위산역류중(LPR)의 발병빈도와 그와 관련된 사항들을 조사하여 다음과 같은 결과를 얻었다. 1) 이비인후과 신환 전체 진단 병명의 24%, 이비인후과 신환 환자 중 25%에서 LPR 관련 증상 또는 진찰소견이 확인되었다. 2) LPR 관련 진단명으로는 인두이물감증후군(Glo-bus syndrome)이 27%로 가장 많았으며, 역류성후두염, 만성후두염 등의 순이었다. 3) 여성에서 남성보다 많았으며, 40, 50, 60대에 흔하여 노인성 변화와의 관련이 의심되었다. 4) 비만도와는 큰 상관관계가 없었음. 5) LPR의 3대 주증상은 인두이물감, 만성적 목청소, 원인모를 쉰 목소리였음. 6) LPR을 악화시키는 요인으로는 피곤함, 정신적 스트레스, 술, 담배, 자극성있는 음식, 커피 등이었음. 7) 목소리를 직업적으로 쓰는 사람에서 LPR 증상의 발현이 높았음. 8) 과거 병력상 위질환과 잦은 편도염이 많았음.

• Investigative Magnetic Resonance Imaging
• /
• 제21권3호
• /
• pp.125-130
• /
• 2017

Purpose: To evaluate the clinical significance of T1 high signal intensity on the globus pallidus as a predictor of severe hepatic encephalopathy in patients with acute-on-chronic liver failure (ACLF), which is a distinct syndrome characterized by multi-organ dysfunction including cerebral failure. Materials and Methods: From January 2002 to April 2014, we retrospectively reviewed the magnetic resonance imaging (MRI) findings and clinical and magnetic resonance (MR) features of 74 consecutive patients (44 men and 30 women; mean age, 59.5 years) with liver cirrhosis. The chronic liver failure-sequential organ failure assessment score was used to diagnose ACLF. The pallidal index (PI), calculated by dividing the mean signal intensity of the globus pallidus by that of the subcortical frontal white matter were compared according to ACLF. The PI was compared with the Model for End-Stage Liver Disease (MELD) score in predicting the development of ACLF. Results: Fifteen patients who were diagnosed with ACLF had higher hepatic encephalopathy grades (initial, P = 0.024; follow-up, P = 0.002), MELD scores (P < 0.001), and PI (P = 0.048). In the ACLF group, the mean PI in patients with cerebral failure was significantly higher than that in the patients without cerebral failure (1.33 vs. 1.20, P = 0.039). In patients with ACLF, the area under the curve (AUC) for PI was 0.680 (95% confidence intervals [CI], 0.52-0.85), which was significantly lower than that for the MELD score (AUC, 0.88; 95% CI, 0.77-0.99) (P = 0.04). Conclusion: The PI can be an ancillary biomarker for predicting the development of ACLF and severe hepatic encephalopathy.

• 한국독성학회:학술대회논문집
• /
• 한국독성학회 2001년도 International Symposium on Dietary and Medicinal Antimutgens and Anticarcinogens
• /
• pp.164-164
• /
• 2001

Manganese (Mn) intoxication causes a parkinsonian syndrome. It may be difficult to distinguish Mn-induced parkinsonism from idiopathic Parkinson disease (IPD). Neuropathological descriptions on the brains with Mn intoxication showed the preferential damage in the globus pallidus and substantia nigra pars reticularis.(omitted)

• 동의생리병리학회지
• /
• 제18권5호
• /
• pp.1285-1290
• /
• 2004

From a view point of Hyungsang medicine a study is made on depressive syndromes through 'Donguibogam(東醫寶鑑)' ,'Clinical lectures by Mr. Jeesan(芝山先生 臨床學特講)' and other literature. Depressed energy(?) originally meant the disorder of vital energy in the circulation of nature with the lapse of time. In later, it has been changed to mean the disease of man, especially related to the mind. Depressive syndromes come from the stagnation of the Ki or the abnormal circulation(rising, falling, coming and going), which happens when man cannot adjust oneself to the circumstances due to the disharmony between internal and external conditions. Depressive syndrome easily attacks the following types of persons; Dam type person with excessive Ki and deficient Hyung(形), manly woman, womanly man, Bird type person who shows a great variety of emotion, Turtle type person declined to melancholy, Ki type person apt to be depressive, and Shin type person with upward gush of the fire. It also attacks the persons who have smudgy face with the scar between eyebrows, those whose pulses are mixture of two different kinds and those whose pulses extend on two ranges in Jeesan's diagram. Depressive syndromes recorded in 'Donguibogam' are globus hystericus, chest congestion, gastric discomfort, cough and asthma caused by depressed Ki, abdominal mass, edema, and tympanites. The most effective prescriptions for depressive syndromes are Eajintang(二陳湯), Guibitang(歸脾湯), Hyangsosan(香蘇散), and Gamisachiltang(加味四七湯).