• Korean Journal of Fisheries and Aquatic Sciences
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• v.42 no.6
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• pp.555-560
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• 2009

To identify the food characteristics of seven melania snail species in Korea, the detailed proximate, fatty/amino acid, mineral composition and chlorophyll contents were investigated. The content ranges of moisture, crude protein, crude lipid and ash were 70.1-81.0%, 11.6-16.9%, 0.4-1.6% and 1.9-3.4%, respectively. K. nadifila showed the significant mineral contents Fe, P, Ca than other species. Total Chlorophyll level was highest in K. globus ovalis ($1.2\pm0.2$ mg/g). The major fatty acids were 16:0, 22:1, 20:1, 18:1, 20:5 and 22:6 were identified as small amounts (1.0-3.3%) of total fatty acids. Citrulline was shown to be the major free amino acids (20.4-53.1%).

• Korean Journal of Bronchoesophagology
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• v.9 no.1
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• pp.60-66
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• 2003

Although there is a wide range of diseases caused by gastric acid reflux and the number of cases is on the rise, it is difficult for the laryngologist to make the correct diagnosis. The treatment for laryngopharyngeal reflux can be grouped into 3 categories - changes in lifestyle, medication, and surgery. The medication used to treat laryngopharyngeal reflux are prokinetic agents and acid supressive agents such as antacids, H2 blockers, and PPIs(Proton pump inhibitor). Rabeprazole sodium($Pariet^{\circledR}$) is a newly developed agent belonging to the PPI group, but in contrast with the existing drugs such as omeprazole, lansoprazole, pantoprazole, has a low dependency on CYP2C19 during the metabolic cycle. Thus, it is known to have a quick but fixed antiacid effect and less individual differences. We analyzed 2166 patients from 32 hospitals who were prescribed $Pariet^{\circledR}$ from May, 2001 to April, 2002. The patients were divided into 4 groups according to the duration of treatment - Group 1: 1-14 days, Group 2: 15-28 days, group 3: 29-56 days, Group 4: more than 56 days. The cases were then analyzed for improvement of 8 symptoms(heart bum, regurgitation, chronic cough, hoarseness, globus sensation, chronic throat clearing, sore throat, and dysphagia), improvement on laryngoscope, usefulness to the doctor, and complication development. Of the total of 2116 patients, 1627(75.1%) cases showed at least 50% improvement of symptoms and the amount of improvement increased according to the duration of medical treatment. Most of the patients showed objective improvement on the laryngoscope, with 32.9% showing significant improvement and 38.7% showing moderate improvement. 37.6% of the doctors questioned replied that $Pariet^{\circledR}$ was very useful and 50.3% said it was useful, showing that most were satisfied with the treatment results. The complications known to develop after taking PPI are headache, nausea, diarrhea, abdominal pain, constipation, dizziness, fatigue, and of these, only a small percentage of the patients complained of mild headache. $Pariet^{\circledR}$ has shown to be a relatively safe and effective drug for the treatment of laryngopharyngeal reflux.

• Journal of Acupuncture Research
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• v.25 no.1
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• pp.211-219
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• 2008

목적 : 전통적으로 태충($LR_3$)과 양릉천($GB_{34}$)은 운동기능과 관련된 질환에 사용되어 왔다. 우리는 두뇌에 신경독을 주입하여 파킨슨병 쥐모델을 제작하였고, 쥐는 운동기능이 손상되고 도파민성 신경세포가 선택적으로 소멸하였다. 병증 모델 쥐에게 태충과 양릉천에 자침한 결과 운동기능이 개선되고 신경세포보호효과가 나타남을 관찰한 바 있다. 이에 실제로 태충과 양릉천에 자침하여 운동기능과 관련된 추체외로 영역에서 신경의 활성화가 나타나는지를 fMRI를 통하여 관찰하였다. 방법 : 자침은 수기침을 선택하였으며, 혈위는 (1) 태충, (2) 양릉천, (3) 태충+양릉천의 세군데를 설정하였고, 자침에 대한 대조자극으로 피부자극을 채택하였다. fMRI 스캐너는 3T를 사용하였고 뇌신경 활성화의 신호는 BOLD(blood-oxygen-level dependant)를 관찰하였다. 두뇌에서 관찰부위는 중뇌를 중심으로 추체외로로 한정하였다. 결과 : 태충에 자침하였을 때 두뇌의 substantia nigra, subthalamic nucleus, red nucleus, pons 등이 활성화 되었다. 양릉천에 자침하였을 때 substantia nigra, subthalamic nucleus, caudate nucleus, thalamus가 활성화 되었다. 태충과 양릉천에 동시에 자침하였을 때는 substantia nigra, subthalamic nucleus, red nucleus, globus pallidus가 활성화되었다. 대조자극에 의해서는 위의 영역들이 활성화되지 않았다. 결론 : 태충, 양릉천, 태충+양릉천 자극은 대뇌에서 추체외로 영역을 활성화시키며 특히 substantia nigra의 활성화는 파킨슨병과 같은 질환의 조절가능성을 시사한다.

• The Korea Journal of Herbology
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• v.27 no.4
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• pp.81-88
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• 2012

Objective : Banhahubak-tang is indicated for globus hystericus, marked by a subjective sensation as if something stuffed in the throat, chest distress, cough or vomiting, greasy whitish, taut and smooth pulse. In this study, the effects of Banhahubak-Tang extract (BHTe) were tested for anti-stress action. Methods : BHTe was extracted by pure water using electronic extractor and then fed to ICR male mice ($20{\pm}2g$) orally with the dose of 100mg/kg/day for five days. Mice were exposed to sociopsychological stress by restraining and seeing foot shock stressed mice for one hour for five days. Results : BHTe administered group showed a tendency of decreasing of serum corticosterone secretion when compared with control group, and BHTe administration also significantly up-regulated noradrenaline secretions in the dorsal cortex of brain. Lipid peroxidation of the brain tissues of mice were tested by measuring malondialdehyde, but BHTe showed no significant change. The elevated plus-maze test was designed to detect the effect of anxiolytic drugs, and BHTe administered group showed a significant increase of latency time. Conclusions : These results suggest that BHTe can effectively rid the psychological stress and it's related diseases.

• Herbal Formula Science
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• v.14 no.2
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• pp.97-108
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• 2006

Objective: Functional dyspepsia refers to sustainable or repetitive pain at upper stomach related with food intake. This research was intended to observe the improvement of the symptom by administering Bowhatang to a number of functional dyspepsia patients and to clarify its clinical effects. Method: The research was performed upon the appropriate 36 patients conforming to the criteria after being diagnosed with functional dyspepsia among the 87 patients who visited the department of internal medicine at Gumi Oriental Hospital of Daegu Haany University for digestive diseases and were administered with Bowhatang. Result: 91.8% of the patients had upper stomach globus symptoms. which is of the largest percentage. and 13.5% had hunger pain. which is of the least percentage. After administering Bowhatang. by and large Likert scale was significantly reduced. According to the subjective improvement evaluation by the patients. 32 patients(86%) were improved. and 3 patients(8%) had neither improvement nor relapse. while 2 patients ( 6%) were relapsed. Conclusion: Bowhatang has shown significant improvement about the symptoms for functional dyspepsia patients. It is predicted when more outcomes become available from researches on side effects or toxicity of Bowhatang later on. it will be more often used in the clinic.

• The Journal of Korean Medicine
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• v.25 no.1
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• pp.129-141
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• 2004

Objective: The purpose of this clinical observation was to estimate the efficacy of Quetong & Voice on the abatement of subjective symptoms related nose & pharynx. Methods: We observed 46 patients who visited Kang-Nam oriental hospital with subjective symptoms related nose & pharynx that were prescribed Quetong or Voice. We made an inquiry into the inconvenience, side effect, abatement of subjective symptoms, etc. We used the Wilcoxon signed rank test. Results and Conclusions: 1. The distribution of age & sex was as fallows: 21-30 years(34.8%) were the most, 31-40 years(26.1 %) were the second, 1-10 years(24.0%) were the third. Total patient numbers for men and women were 15 men(32.6%), 31 women(67.4%). 2. The distribution of prescribed aerosols for 46 patients: 5 cases(10.9%) prescribed Quetong, 22 cases(47.9%) prescribed Voice, and 19 cases(41.3%) prescribed Quetong & Voice. 3. The duration of use: 12 cases(26.1 %) used 1 week, 19 cases(41.3%) used 1-2 weeks, 9 cases(19.6%) used 2-4 weeks, 4 cases(8.7%) used 4-8 weeks, and 2 cases(4.3%) used above 8 weeks. 4. The frequency of use: The most patients used 1-5 times(69.6%) or 5-10 times(21.7%) for a day. 5. Quetong & Voice were effective on abatement of subjective symptoms(rhinorrhea, nasal obstruction, pharyngalgia, sneeze or cough, post nasal drip, pharyngeal pruritus, pharyngeal dryness, nasal dryness, and globus hystericus). 6. We must prescribe Quetong to the child or the sensitive patients with discretion becouse of the sting. 7. The side effect was not occurred in all of 46 patients.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.2
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• pp.539-542
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• 2007

After analyzing the cases of treating female patients troubled with morbid leukorrhea, the writer drew the conclusions as follows. The shapes of patients with morbid leukorrhea show a large number of shapes of Gi type, Sin type or being inclined to be vigorous Gi, to have depressive syndrome due to disorder of Gi, to be Fire's nature flared upward, to become retention of phlegm and fluid, to become retention of Gi or to become retention of heat, or San syndromes. Accompanied syndromes of morbid leukorrhea appear over the body of upper, middle or lowe portion. In lower cho, the symptoms are menopathy, menstrual irregularities, menstrual irregularities, oligomenorrhea, itching of external genitals, San syndromes, infertility, lumbago which are connected with uterus. And in the middle cho, those are indigestion, nausea, distress in the stomach, vomiting, swallowing acid connected with digestive organs. And also in the upper cho, globus hystericus, chest distress, headache, dizziness, neck stiffness, heat in the upper, pimples connected with upper cho are appeared. Among the prescriptions of treatment for morbid leukorrhea, Ijintang was applied with the widest range of all. Besides that there were mainly prescribed for symptoms such as Gamisachil-tang, Haenggihyangso-san, Gamigwibi-tang, hyangsapyeongwi-san, Onkyung-tang, Banchong-san, Yongdamsagan-tang, Sogampaedok-san, Ojeok-etc.

• Journal of The Korean Society of Clinical Toxicology
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• v.11 no.1
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• pp.41-45
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• 2013

Following are brief statements about the delayed encephalopathy of a patient who recovered without disturbance of consciousness after acute carbon monoxide poisoning. A 72-year-old male was found without consciousness at home and then visited the ER center. Later we learned that the patient was using briquettes as a household heating source. Blood carbon monoxide hemoglobin level was 17.5%. As carbon monoxide poisoning was uncertain after the first interview with the patient, hyperbaric oxygen therapy was not administered at the early stage. After supplying 100% oxygen, the patient recovered consciousness, however, the strength of the lower limb muscle had decreased to class II. The patient showed continued weakening of the lower limb muscle and an increase of CPK; therefore, he was diagnosed as carbon monoxide intoxication and rhabdomyolysis and then admitted to the intensive care unit (ICU) for conservative treatment. During the hospitalization period, continued weakening of the lower limb muscle was observed and he was diagnosed as myopathy after EMG/MCV. However, he suddenly showed altered mentality on the 20th day of hospitalization, and underwent brain MRI. T2 weighted MRI showed typically high signal intensity of both globus pallidus and periventricular white matter; therefore, he was diagnosed as delayed carbon monoxide encephalopathy. This case showed delayed encephalopathy accompanied by rhabdomyolysis and myopathy of a patient who recovered without disturbance of consciousness.

• Proceedings of the KOR-BRONCHOESO Conference
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• 2002.12a
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• pp.9-9
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• 2002

이비인후과 영역에 있어서 위산 역류에 의한 질환의 진단은 쉽지 않고 분명하지 않은 점이 많지만, 병변의 영향은 광범위하며, 실제로 역류에 의한 증상을 가지고 내원하는 환자도 증가하는 추세이다. 인후두역류질환의 치료는 크게 생활습관의 변경, 약물복용, 항역류수술로 나눌 수 있으며, 사용약제는 크게 두 부류로 나누는데, 제산제, H2 수용체 차단제, PPI(Proton Pump Inhibitor) 제제와 같은 산억제 약물군과 Prokinetic 약물군이다. Rabeprazole sodium(Pariet(R))은 PPI 제제에 해당하는 약제로 기존의 omeprazole, lansoprazole, pantoprazole과는 달리 대사 과정 중 CYP2C19에 대한 의존도가 낮아, 개체 간 차이가 적고 빠르고 일정하게 산분비 억제 효과를 나타내는 것으로 알려져 있은 약물이다. 2001년 5월부터 2002년 4월까지 32개 병원에서 Pariet(R) 를 복용한 2166명의 환자를 대상으로 분석하였다. 복용기간에 따라 4군(1군;1-14일, 2군;15-28일, 3군;29-56일, 4군:57일 이상)으로 나누었으며, 8가지 증상(Heart burn, Regurgitation, Chronic cough, Hoarseness, Globus sensation, Chronic throat clearing, Sore throat, Dysphagia)에 대한 호전 여부 및 후두내시경상 개선 정도, 의사에 의한 유용도 평가, 부작용 발생 여부에 대해 연구하였다. 증상개선율 50%이상을 치료 반응군으로 했을때 전체 2166명중 1627명(75.1%)에서 증상의 호전을 보았으며, 이는 복용기간이 길수록 증가하였다. 후두 내시경상 개선 정도는 현저한 개선이 32.9%, 중등도 개선이 38.7%로 대부분 환자에서 객관적인 병변의 호전을 보였으며, 유용도 평가에서는 매우 유용이 37.6%, 유용이 50.3%로 치료효과에 대한 만족도도 높은 것을 알수 있었다. PPI 제제의 부작용으로 보고되고 있는 두통, 오심, 설사, 복통. 변비, 어지럼증. 피곤 중. 소수의 환자가 두통을 호소하였으나, 그다지 심각한 정도는 아니었다. 인후두역류증 치료제로서 Pariet(R) 는 비교적 안전하고 효과가 높은 약물임이 임상 연구 결과 밝혀졌기에 보고하는 바이다.

• Journal of the Korea Society of Computer and Information
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• v.10 no.4 s.36
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• pp.165-171
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• 2005

High speed computer, large scale storage device and high speed computer network are computing infrastructure which we can easily access to in these days. However, many computer simulations in natural or applied science such as molecular simulation require more computing power as well as larger scale of storage. Grid computing which is a next generation of distributed computing environment, is one of solution for the new requirements. Even though many researches have been going on Grid computing, those are oriented to communication interface and protocols, and middleware like globus tool kits[2, 3]. Therefore research on application level platform or application itself is yet premature and it makes real users be difficult to utilize Grid system for their research. In this paper, we suggest a new user environment and an abstract job model for simulation experiments on MGrid(Molecular Simulation Grid). It will make users be able to utilize Grid resources efficiently and reliably.