• 한국태양에너지학회 논문집
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• 제24권2호
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• pp.83-88
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• 2004

Since the solar radiation is the main input for sizing any solar photovoltaic system, it will be necessary to understand and evaluate the insolation data. The Korea Institute of Energy Research(KIER) has begun collecting horizontal global insolation data since May, 1982 at 16 different locations. Because of a poor reliability of existing data, KIER's new data will be extensively used by solar photovoltaic system users as well as by research institutes From the results, we can conclude that 1) The yearly averaged horizontal global insolation of Korea was turned out $3.57kWh/m^2.day$ in the periods of $1982\sim2001$. 2) Horizontal global insolation of spring and summer was respectively 24 % and 21 % higher than the yearly average value, and that of fall and winter was respectively 12 % and 34 % lower than the yearly average value.

• 대한기계학회논문집B
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• 제30권4호
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• pp.343-349
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• 2006

Systematic experiments in $CH_4/Air$ counterflow diffusion flames diluted with He have been undertaken to study the oscillatory instability in which lateral flame size was less than burner nozzle diameter and thus lateral heat loss could be remarkable at low global strain rate. The oscillatory instability arises for Lewis numbers greater than unity and occurs near extinction condition. The oscillation is the direct outcome from the advancing and retreating edge flame. The dynamic behaviors of extinction in this configuration can be classified into three modes; growing, harmonic and decaying oscillation mode near extinction. As the global strain rate decreases, the amplitude of the oscillation becomes larger. This is caused by the increase of lateral heat loss which can be confirmed by the reduction of lateral flame size. Oscillatory edge flame instabilities at low global strain rate are shown to be closely associated with not only Lewis number but also heat loss (radiation and lateral heat loss).

• 태양에너지
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• 제20권2호
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• pp.19-30
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• 2000

Since the solar radiation is the main input for sizing any solar system, it will be necessary to understand and evaluate the insolation data. The Korea Institute of Energy Research(KIER) has began collecting horizontal global insolation data since May, 1982 at 16 different locations. Because of a poor reliability of existing data, KIER's new data will be extensively used by solar system users as well as by research institutes. From the results, we can conclude that 1) The yearly averaged horizontal global insolation of Korea was turned out $3,042kcal/m^2.day$ in the periods of $1982\sim1999$. 2) Horizontal global insolation of spring and summer were 24 % and 21 %, higher than the yearly average value, respectively, and for fall and winter, their values were 12 % and 34 % lower than the yearly average value, respectively.

• Nuclear Engineering and Technology
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• 제46권1호
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• pp.73-80
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• 2014

A concrete cask is an option for spent nuclear fuel interim storage. A concrete cask usually consists of a metallic canister which confines the spent nuclear fuel assemblies and a concrete overpack. When the overpack undergoes a missile impact, which might be caused by a tornado or an aircraft crash, it should sustain an acceptable level of structural integrity so that its radiation shielding capability and the retrievability of the canister are maintained. A missile impact against a concrete overpack produces two damage modes, local damage and global damage. In conventional approaches [1], those two damage modes are decoupled and evaluated separately. The local damage of concrete is usually evaluated by empirical formulas, while the global damage is evaluated by finite element analysis. However, this decoupled approach may lead to a very conservative estimation of both damages. In this research, finite element analysis with material failure models and element erosion is applied to the evaluation of local and global damage of concrete overpacks under high speed missile impacts. Two types of concrete overpacks with different configurations are considered. The numerical simulation results are compared with test results, and it is shown that the finite element analysis predicts both local and global damage qualitatively well, but the quantitative accuracy of the results are highly dependent on the fine-tuning of material and failure parameters.

• Radiation Oncology Journal
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• 제18권3호
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• pp.167-176
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• 2000

최근의 방사선치료는 치료의 질을 향상시켜서 치료 후의 삶의 질을 높이는 것을 목표로 하고 있다. 국내에서도 방사선치료 환자와 치료 시설의 빠른 증가로 방사선종양학 분야는 많은 발전이 되고 있으며, 치료기술 또한 3-dimensional conformal radiotherapy의 보편화, liuac based stereotactlc radiosurgery의 활발한 적용과 luteuslty modulated radiation tferapy (IMRT)의 도입 준비 등 고난도의 치료 기술도입이 시도되고 있다. 저자는 최근 20년간 한국에서의 방사선 종양학의 발전을 조망하고 최근 발전되는 4차원적 방사선치료, IMRT의 현황, blologlcai conformailty치료의 개념, 항암제와 방사선치료의 병용에 대하여 살펴보고 최근 정보기술 혁명에 따른 인터넷과 방사선종양학 분야의 정보관리 시스템의 중요성 및 원격진료의 세계적 현황 등에 대해서 알아보고, 21 세기 한국에서의 방사선치료의 질을 올리기 위한 방법들을 제시하였다. 이들은 1) OA (qualify assurance) 향상, 2) 공동 프로토콜에 의한 3상 임상 연구의 필요성, 3) 특정 암에 대한 통일된 치료 프로토콜 또는 가 이드라인, 4) 전국적인 방사선종양학 관련 자료의 광역 data base구축과 중요 암에 대한 patterns of care study 등 시행의 필요성이다

• Journal of Microbiology and Biotechnology
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• 제21권4호
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• pp.438-447
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• 2011

Deinococcus radiodurans is extremely resistant to various genotoxic conditions and chemicals. In this study, we characterized the effect of a sublethal concentration (100 ${\mu}M$) of cadmium (Cd) on D. radiodurans using a whole-genome DNA microarray. Time-course global gene expression profiling showed that 1,505 genes out of 3,116 total ORFs were differentially expressed more than 2-fold in response to Cd treatment for at least one timepoint. The majority of the upregulated genes are related to iron uptake, cysteine biosynthesis, protein disulfide stress, and various types of DNA repair systems. The enhanced upregulation of genes involved in cysteine biosynthesis and disulfide stress indicate that Cd has a high affinity for sulfur compounds. Provocation of iron deficiency and growth resumption of Cd-treated cells by iron supplementation also indicates that CdS forms in iron-sulfur-containing proteins such as the [Fe-S] cluster. Induction of base excision, mismatch, and recombinational repair systems indicates that various types of DNA damage, especially base excision, were enhanced by Cd. Exposure to sublethal Cd stress reduces the growth rate, and many of the downregulated genes are related to cell growth, including biosynthesis of cell membrane, translation, and transcription. The differential expression of 52 regulatory genes suggests a dynamic operation of complex regulatory networks by Cd-induced stress. These results demonstrate the effect of Cd exposure on D. radiodurans and how the related genes are expressed by this stress.

• 한국태양에너지학회 논문집
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• 제31권1호
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• pp.51-58
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• 2011

The energy makes the basic element which improves the quality of life with motive power of industry and life. However, using the fossil fuel resources was restricted through it's abuse and exhaustion, and that cause a global warming resultingly. According to the reason, the world increased the interest that are stability and use of new and renewable energy which is clean energy with environment. Therefore, the property data of new and renewable is needed for developing and supplying the energy. In other words, the data of new and renewable energy becomes the standards for supply and evaluation of new and renewable energy with development of industry and technology. Also, the necessity came to the fore as the reference and standards of new and renewable energy data. Therefore, in this study, we evaluate and collect the solar radiation data as the new and renewable data and process the collected data through the standards for valuation. We evaluate uncertainty with standards which are NREL, WMO, and GUM. Whereby the data becomes reference standards data and gains the credibility. For the reliability data, we correct the measuring instrument with correction period. Using the DQMS and SERI QC, we efficiently manage and evaluate the solar radiation data. As a result, we evaluate uncertainty as 1,120 case about 16 area. we achieve credibility of data from evaluated solar radiation data and provide an accurate information to user. The annual average of horizontal radiation presents between 1,484 and 4,577, then the uncertainty evaluates from 163 to 453. The error of uncertainty presents smaller than the measurement values. So, we judge a credibility of data by expression of reliability quantitatively. In additional, the reference standards data which is possible to approach anywhere will be used for the supporting related industry and policy making.

• Genomics & Informatics
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• 제11권4호
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• pp.245-253
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• 2013

A radioresistant cell line was established by fractionated ionizing radiation (IR) and assessed by a clonogenic assay, flow cytometry, and Western blot analysis, as well as zymography and a wound healing assay. Microarray was performed to profile global expression and to search for differentially expressed genes (DEGs) in response to IR. H460R cells demonstrated increased cell scattering and acidic vesicular organelles compared with parental cells. Concomitantly, H460R cells showed characteristics of increased migration and matrix metalloproteinase activity. In addition, H460R cells were resistant to IR, exhibiting reduced expression levels of ionizing responsive proteins (p-p53 and ${\gamma}$-H2AX); apoptosis-related molecules, such as cleaved poly(ADP ribose) polymerase; and endoplasmic reticulum stress-related molecules, such as glucose-regulated protein (GRP78) and C/EBP-homologous protein compared with parental cells, whereas the expression of anti-apoptotic X-linked inhibitor of apoptosis protein was increased. Among DEGs, syntrophin beta 2 (SNTB2) significantly increased in H460R cells in response to IR. Knockdown of SNTB2 by siRNA was more sensitive than the control after IR exposure in H460, H460R, and H1299 cells. Our study suggests that H460R cells have differential properties, including cell morphology, potential for metastasis, and resistance to IR, compared with parental cells. In addition, SNTB2 may play an important role in radioresistance. H460R cells could be helpful in in vitro systems for elucidating the molecular mechanisms of and discovering drugs to overcome radioresistance in lung cancer therapy.

• 대한방사성의약품학회지
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• 제1권2호
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• pp.137-144
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• 2015

Hypoxia is an important adverse prognostic factor for tumor progression and is a major cause of failure of radiation therapy. In case of short-term hypoxia, the metabolism can recover to normal, but if hypoxia persists, it causes irreversible cell damage and finally leads to death. So a hypoxia marker would be very useful in oncology. In particular, 2-nitroimidazole can be reduced to form a reactive chemical species, which can bind irreversibly to cell components in the absence of sufficient oxygen, thus, the development of radiolabeled nitroimidazole derivatives for the imaging of hypoxia remains an active field of research to improve cancer therapy result. 2-nitroimidazole based hypoxia marker, [$^{18}F$]FMISO holds promise for the evaluation of tumor hypoxia by Positron emission tomography (PET), at both global and local levels. In the present study, [$^{18}F$]FMISO was synthesized using an automatic synthesis module with high radiochemical purity (>99%) in 60 min. Immunohistochemical analysis using pimonidazole confirmed the presence of hypoxia in xenografted CT-26 tumor tissue. A biodistribution study in CT-26 xenografted mice showed that the increased tumor-to-muscle ratio and tumor-to-blood ratios from 10 to 120 min post-injection. In the PET study, [$^{18}F$]FMISO also showed increased tumor-to-muscle ratios from 10 to 120 min post-injection. In conclusion, this study demonstrates the feasibility and utility of [$^{18}F$]FMISO for imaging hypoxiain mouse colon cancer model using small animal PET.

• 한국기후변화학회지
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• 제7권4호
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• pp.433-442
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• 2016

In this study, we examine future changes in surface radiation associated with cloud amount and aerosol emission over East Asia. Data in this study is HadGEM2-CC (Hadley Centre Global Environmental Model version 2, Carbon Cycle) simulations of the Representative Concentration Pathways (RCPs) 2.6/4.5/8.5. Results show that temperature and precipitation increase with rising of the atmosphere $CO_2$. At the end of $21^{st}$ century (2070~2099) relative to the end of $20^{st}$ century (1981~2005), changes in temperature and precipitation rate are expected to increase by $+1.85^{\circ}C/+6.6%$ for RCP2.6, $+3.09^{\circ}C/+8.5%$ for RCP4.5, $+5.49^{\circ}C/10%$ for RCP8.5. The warming results from increasing Net Down Surface Long Wave Radiation Flux (LW) and Net Down Surface Short Wave Radiation Flux (SW) as well. SW change increases mainly from reduced total Aerosol Optical Depth (AOD) and low-level cloud amount. LW change is associated with increasing of atmospheric $CO_2$ and total cloud amount, since increasing cloud amounts are related to absorb LW radiation and remit the energy toward the surface. The enhancement of precipitation is attributed by increasing of high-level cloud amount. Such climate conditions are favorable for vegetation growth and extension. Expansion of C3 grass and shrub is distinct over East Asia, inducing large latent heat flux increment.