• Asian Pacific Journal of Cancer Prevention
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• 제17권7호
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• pp.3213-3222
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• 2016

Background: Methyl donor status influences DNA stability and DNA methylation although little is known about effects on DNA methyltransferases. The aim of this study was to determine whether methyl-donor status influences DNA methyltransferase (Dnmt) gene expression in cervical cancer cells, and if so, whether there are associated effects on global DNA methylation. Materials and Methods: The human cervical cancer cell line, C4-II, was grown in complete medium and medium depleted of folate (F-M+) and folate and methionine (F-M-). Growth rate, intracellular folate, intracellular methionine and homocysteine in the extracellular medium were measured to validate the cancer cell model of methyl donor depletion. Dnmt expression was measured by qRT-PCR using relative quantification and global DNA methylation was measured using a flow cytometric method. Results: Intracellular folate and methionine concentrations were significantly reduced after growth in depleted media. Growth rate was also reduced in response to methyl donor depletion. Extracellular homocysteine was raised compared with controls, indicating disturbance to the methyl cycle. Combined folate and methionine depletion led to a significant down-regulation of Dnmt3a and Dnmt3b; this was associated with an 18% reduction in global DNA methylation compared with controls. Effects of folate and methionine depletion on Dnmt3a and 3b expression were reversed by transferring depleted cells to complete medium. Conclusions: Methyl donor status can evidently influence expression of Dnmts in cervical cancer cells, which is associated with DNA global hypomethylation. Effects on Dnmt expression are reversible, suggesting reversible modulating effects of dietary methyl donor intake on gene expression, which may be relevant for cancer progression.

• Journal of Preventive Medicine and Public Health
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• 제43권6호
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• pp.472-478
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• 2010

Cancer is a leading cause of death around the world. Education is at the core of cancer prevention activities, especially programs targeting empowering existing public health workforce. In the past 10 years, researchers at the University of Pittsburgh have been building the Global Health Network Supercourse project, a library of over 4500 online lectures and a network of nearly 50000 public health professionals in 174 countries. As of November 2010, the overall number of Supercourse participants from Asia exceeds 7000 participants. The Supercourse network has been investigating methods for Internet based recruitment of cancer prevention professionals in order to network cancer experts locally and globally, including the use of mHealth technologies for cancer research education and for NCD registries. Supercourse is a tool that can offer a solution to the challenges of information sharing, especially in the field of NCDs and cancer. In this paper, we highlight the need for the development of Cancer Supercourse with Satellite in Asia and encourage faculty members from Asia to join the network.

• Asian Pacific Journal of Cancer Prevention
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• 제17권sup1호
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• pp.11-15
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• 2016

Viet Nam is a country with the highest rate of adult male smokers in the world. In 2010, the percentage of adult male smokers was 47.4%. Each year in Viet Nam, there are 40,000 lives lost from tobacco-related diseases. The Global Tobacco Youth Survey is an international standardized survey that has been conducted in more than 140 countries. To provide evidence for tobacco control, Viet Nam already conducted two rounds of GYTS in 2003 and 2007. The GYTS in 2014 is the survey's third iteration. This paper aims to document key methodological details and socio-demographic characteristics of the respondents included in the 2014 GYTS in Viet Nam. This survey followed international protocol and was conducted in 13 provinces representative of 6 geographical regions. A total of 3,430 school children, aged 13 to 15 years used a standardized answer sheet to answer 76 questions about seven tobacco-related topics, including prevalence of tobacco use, environmental tobacco smoke, access and availability, media and advertisement, cessation, knowledge and attitudes, tobacco-related school curriculum. This GYTS provides valid and reliable data for monitoring tobacco use among youth in Vietnam and is recommended to be regularly repeated.

• Asian Pacific Journal of Cancer Prevention
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• 제15권13호
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• pp.5283-5286
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• 2014

Stage of cervical cancer may adversely affect the quality of life (QOL) among patients. The objective of this study was to predict the QOL among cervical cancer patients by the stage of their cancer. A cross-sectional study from September 2012 until January 2013 was conducted among cervical cancer patients who completed treatment. All patients completed a interviewer-guided questionnaire comprising four sections: (A) socio-demographic data, (B) medical history, (C) QOL measured by general health status questionnaire (QLQ-30) and (D) cervical cancer specific module CX-24 (EORTC) was used to measured patient's functional, symptom scale and their global health status. Results showed that global health status, emotional functioning and pain score were higher in stage III cervical cancer patients while role functioning was higher in stage I cervical cancer patients. Patients with stage IV cancer have a lower mean score in global health status (adjusted b-22.0, 95 CI% -35.6, -8.49) and emotional functioning (adjusted b -22.5, 95CI% -38.1, -6.69) while stage III had lower mean score in role functioning (adjusted b -14.3, 95CI% -25.4, -3.21) but higher mean score in pain (adjusted b 22.1, 95 CI% 8.56, 35.7). In conclusion, stage III and IV cervical cancers mainly affect the QOL of cervical cancer patients. Focus should be given to these subgroups to help in improving the QOL.

• 한국학교ㆍ지역보건교육학회지
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• 제18권2호
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• pp.1-25
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• 2017

Objectives: There is higher rates of experience of suicide ideation and suicide attempt of adolescents in the Lima and Callao region compared with the results of the epidemiological study (2013) conducted by Peru National Institute of Mental Health and the Global School-based Student Health Survey (2010) which is was conducted among adolescents across all regions of Peru. Based on the PRECEDE model, this study analyzed the prevalence and the factor associated with the suicide attempt among the adolescent in a poor urban area in Peru. Methods: A stratified random sampling was used for the survey to select study participants from the 6 secondary schools based in Comas or Callao. The survey was conducted November 25th and December 4th in 2015 and a total of 738 individuals included in the analysis. In order to analyze factors influencing suicide attempt, comparison of predisposing factor, reinforcing factor, enabling factor, behavioral factor, environmental factor, psychological factors by suicide attempt and suicide risk group were identified through the chi-square test and hierarchical logistic regression. Results: Results showed that those who reported having less parental understanding, less time spent with parents, and 'almost none/none' for parental affection had more experience of suicide attempt and were more likely to sort into the high suicide risk group. Also, a greater proportion of those with the experience of suicide attempt had more experience of smoking and alcohol consumption, and experience of physical abuse and feeling insulted and depression in comparison to that of those without experience of suicide attempt. Variables that had a significant effect on suicide attempt included depression, subjective happiness, smoking experience, sexual intercourse, involvement in fight, parental affection, and gender (male). Conclusions: The results of the current study can serve as grounds for the necessity of acknowledging that adolescent suicide does not simply depend on a couple of factors, but arises from situations in which individual, home, school, social factors influence one another, and therefore adolescent suicide should be prevented and addressed through a multi-dimensional and integrated approach.

• 한국전자통신학회논문지
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• 제18권3호
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• pp.545-554
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• 2023

현대 산업에서 위성항법시스템(Global Navigation Satellite System : GNSS)은 PNT 정보(측위(P : Positioning), 항법(N : Navigation), 시각동기(T : Timing))가 항상 제공되어야 하고, 그 정보를 기반으로 정밀한 위치추정이 요구되는 다양한 분야에 활용되고 있다. 특히, 2019년부터 시작된 COVID-19 펜데믹 상황에 대한 감염 예방 및 확산 방지를 위해 정밀한 위성항법시스템 기술과 이를 보조하는 다양한 기술들이 사용되어 왔고, 전 세계의 적극적인 방역과 감염 확산 억제 노력으로 엔데믹 상황으로의 전환을 앞두고 있다. 질병, E-health 분야는 감염병의 추적 및 감시와 더불어 원격 의료 서비스 제공을 위해 이용자의 위치정보가 반드시 필요한데, 위성항법시스템이 정확한 위치정보 제공에 주도적인 역할을 하고 있다. 본 논문은 이러한 위성항법시스템 기술이 질병 및 E-health 분야에 활용된 최신 연구 동향에 대해 조사한 결과를 제시하고 그 결과를 분석한다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권2호
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• pp.421-425
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• 2012

Cancer can be a major cause of poverty. This may be due either to the costs of treating and managing the illness as well as its impact upon people's ability to work. This is a concern that particularly affects countries that lack comprehensive social health insurance systems and other types of social safety nets. The ACTION study is a longitudinal cohort study of 10,000 hospital patients with a first time diagnosis of cancer. It aims to assess the impact of cancer on the economic circumstances of patients and their households, patients' quality of life, costs of treatment and survival. Patients will be followed throughout the first year after their cancer diagnosis, with interviews conducted at baseline (after diagnosis), three and 12 months. A cross-section of public and private hospitals as well as cancer centers across eight member countries of the Association of Southeast Asian Nations (ASEAN) will invite patients to participate. The primary outcome is incidence of financial catastrophe following treatment for cancer, defined as out-of-pocket health care expenditure at 12 months exceeding 30% of household income. Secondary outcomes include illness induced poverty, quality of life, psychological distress, economic hardship, survival and disease status. The findings can raise awareness of the extent of the cancer problem in South East Asia and its breadth in terms of its implications for households and the communities in which cancer patients live, identify priorities for further research and catalyze political action to put in place effective cancer control policies.

• Asian Pacific Journal of Cancer Prevention
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• 제13권9호
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• pp.4839-4842
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• 2012

The recent policy statement by the Cancer Council of Australia on infant circumcision and cancer prevention and the announcement that the quadrivalent human papillomavirus (HPV) vaccine will be made available for boys in Australia prompted us to provide an assessment of genital cancer prevention. While HPV vaccination of boys should help reduce anal cancer in homosexual men and cervical cancer in women, it will have little or no impact on penile or prostate cancer. Male circumcision can reduce cervical, penile and possibly prostate cancer. Promotion of both HPV vaccination and male circumcision will synergistically maximize genital cancer prevention.

• 보건행정학회지
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• 제28권3호
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• pp.288-293
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• 2018

In 1994 Korea government began to develop the healthcare industry, since then the government has tried to create opportunities to promote the industry through various political efforts and policies. The biggest achievement was attracting foreign patients from 2009 to 2016 with a cumulative 1.56 million and total revenue of 3 trillion won. But Korea still loses the opportunity to become a global leader in the health care industry due to regulations and various ideological disputes. Accordingly, it is necessary to facilitate policy understanding and present a practical road map so that Korea's healthcare industry become a new growth engine that will lead the trend of global market in the future. It also suggests a national economic development paradigm, the health economy as health and economic value are rotated through a shift in view of health care. At this point, 20 years after the beginning of the healthcare industry development, it is necessary to evaluate the related policies and discuss effective future directions. In this sense, the purpose of this study is to examine the policies and limitations of the healthcare industry by each government division, and based on it, to propose political tasks for the future.

• 지식경영연구
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• 제19권4호
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• pp.187-201
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• 2018

This paper explores the potential of Blockchain technology in enabling a panacea for health equity. Since Satoshi Nakamoto first described Blockchain technology in 2008 pseudonymous paper, that distributed ledger system is empowered and ranging from finance to law to another sector and beyond. Also impacting healthcare sector and life science. In other words, there are many usage cases being researched in healthcare and Blockchain has shown its considerable special side in recent years. But this paper aims to the distributed ledger that is the special side of Blockchain technology is potentially can panacea for some global health equity issues such as patient data, counterfeit drug and hospital payment management.