• 대한관절경학회지
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• 제7권1호
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• pp.87-91
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• 2003

건막 거대세포종은 관절내에 드물게 발생하는 병변으로 이를 보고하는 문헌도 제한되어 있으며 특히 후방십자인 대에 발생한 거대세포종의 국내 보고는 없었다. 저자들은 슬관절 후방십자인대에 발생한 거대세포종 2례를 관절경하에서 절제 후 병리학적으로 확진 하였으며 임상적으로 좋은 결과를 보였기에 문헌고찰과 항께 보고하고자 한다.

• 대한두개안면성형외과학회지
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• 제11권2호
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• pp.103-106
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• 2010

Purpose: Giant cell tumors of the bone are rare, locally aggressive lesions that primarily affect the epiphysis of the long bones in young adults. These tumors occur very rarely on the skull, principally in the sphenoid and temporal bones. The occipital bone is an unusual site. We report a rare case of a giant cell tumor of the occipital bone with a review of the relevant literature. Methods: A 7-year-old boy presented with a mass of the right occipital area, which was accompanied by localized tenderness and mild swelling. The mass was first recognized approximately 1 year earlier and grew slowly. There was no significant history of trauma. The physical examination revealed a nonmobile and non-tender bony swelling on the occipital region. The neurological evaluation was normal. The serial skull radiography and CT scan showed focal osteolytic bone destruction with a bulged soft tissue mass in the right occipital bone. The patient underwent a suboccipital craniectomy and a complete resection of the epidural mass. The lesion was firm and cystic. The mass adhered firmly to the dura mater. Results: The postoperative clinical course was uneventful, and the patient was discharged 5 days later. The histopathology report revealed scattered multinucleated giant cells and mononuclear stromal cells at the tumor section, and the giant cells were distributed evenly in the specimen, indicating a giant cell tumor. Conclusion: Giant cell tumors are generally benign, locally aggressive lesions. In our case, the lesion was resected completely but a persistent long term follow up will be needed because of the high recurrence rate and the possible transformation to a malignancy.

• 대한세포병리학회지
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• 제10권1호
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• pp.79-84
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• 1999

Osteoclast-like giant cell tumor of the liver is an extremely rare malignancy with poor prognosis. To our knowledge, 5 cases have been reported in English literatures, but there was no report about fine needle aspiration cytologic(FNAC) features. We experienced a case of osteoclast-like giant cell tumor of the liver obtained by computed tomography(CT)-guided FNAC and needle biopsy. The cytologic findings mimicked slant cell tumor of the bone. A large hepatic mass of the left lobe with abdominal wall invasion was found by CT in a 46- year-old female complaining of epigastric pain. The FNAC showed moderately cellular smears consisting of osteoclast-like giant cells and mononuclear cells, which were individually scattered or intermingled in clusters. The osteoclast-like giant cells had abundant cytoplasms and multiple small round nuclei with fine chromatin and distinct nucleoli. The mononuclear cells had moderate amount of cytoplasm and relatively bland-looking oval nuclei with single small nucleoli. All of the cytologic features recapitulated the histologic findings of bland-looking osteoclast-like multinucleated giant cells evenly dispersed throughout the background of mononuclear cell. The immunohistochemical study showed positive reaction for CD68 and vimentin, but negative for cytokeratin in both osteoclast-like slant cells and mononuclear cells.

• Journal of Chest Surgery
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• 제35권3호
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• pp.251-253
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• 2002

거대세포종은 늑골에 매우 드물게 발생하는 종양으로, 원발성 늑골 종양일 때는 주로 후방궁에 위치한다. 저자들은 늑골의 전방궁에 발생한 원발성 거대세포종 1례를 치험하였기에 문헌 고찰과 함께 보고하는 바이다.

• Journal of Chest Surgery
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• 제24권10호
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• pp.1024-1027
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• 1991

We experienced a case of giant cell tumor arising from the right 2nd rib in the diagnostic and therapeutic thoracotomy at our department of Thoracic and Cardiovascular Surgery, Chungnam Univ. Hospital in May 3rd, 1991. The reports of this tumor are very rare and are known to have the incidence of 1 percent or less of all giant cell bone tumor. The tumor of the right 2nd rib, infant head-sized, covered with parietal pleura was invaded into the vertebra on operation finding. The tumor was resected partially[three fourths] and revealed to be the giant cell tumor on pathologic finding. At now, the patient is taking the radiotherapy to achieve the therapeutic goal to the remnant tumor.

• Journal of Chest Surgery
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• 제40권7호
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• pp.526-528
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• 2007

골조직에 발생하는 거대세포종은 국소적으로는 양성이지만 재발률이 매우 높고, 아주 드물게 원격전이를 일으킬 수 있다. 우측 요골에 발생한 거대세포종이 치료 후 재발되어, 요골을 제거한 후, 다시 동측 흉벽 연부조직에 전이된 29세의 남자환자를 보고하는 바이다. 종양은 흉벽의 골조직과는 연관이 없었다. 수술은 주위 연부조직과 함께 광범위 절제하였으며, 조직학적 검사상 악성 종양을 시사하는 소견은 없었다.

• 대한골관절종양학회지
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• 제1권1호
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• pp.1-6
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• 1995

Giant cell tumors are primary bone tumors originating from non-osteoblastic connective tissue. The sites of involvement were commonly distal femur, proximal tibia, proximal humerus, distal radius and others (including os calcis, ilium and sacrum). Giant cell tumor located around knee joint has been difficult to treat because of local recurrence following curettage with or without bone graft. Although primary resections reduce recurrence of the lesion, the joint function will be markedly impaired. Marginal excision was very often complicated by a loss of joint integrity since all the giant cell tumors occupy juxtaarticular positions. Techniques involving physical adjuncts(high speed burr and electric cauterization) have been used in the hope of decreasing the rate of local recurrence and avoiding the morbidity of primary resection. A meticulous clinical, radiological and histological evaluation is needed to choose the correct treatment, keeping in mind the possibility of recurrence after each treatment modality.

• 대한골관절종양학회지
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• 제10권1호
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• pp.39-44
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• 2004

거대 세포종은 일반적으로 양성 골종양이지만 드물게 폐로 전이하는 특성이 있다. 임상적으로 거대 세포종의 폐 전이는 지속적으로 진행하기도 하지만 종종 스스로 성장이 정지하거나 또는 자연 소실되는 경우도 있는 것으로 알려져 있다. 저자들은 거대 세포종의 광범위한 폐전이가 자연 소실된 예를 경험하여 보고하고자 한다.

• 대한골관절종양학회지
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• 제9권2호
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• pp.217-222
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• 2003

거대세포종은 주로 대퇴골 원위단, 경골 근위단, 요골 원위단등 장관골의 골간단부를 침범하여 팽창되는 골붕해성 병변을 일으키며 또한 그 치료 방법에 대해서도 골소파, 골소파 및 골이식 절제, 방사선조사, 절단, 한냉수술등 아직 특별한 원칙이 없는 상태이다. 본 교실에서 는 19세 남자의 슬개골에 발생한 거대세포종에 대해서 골 소파술후 자가골 이식술을 시행하였으며 이 결과를 문헌고찰과 함께 보고하는 바이다.

• 대한골관절종양학회지
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• 제5권4호
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• pp.229-234
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• 1999

Giant cell tumor of the talus is an extremely rare condition and therapeutic options are ill defined. Recently we experienced a case of giant cell tumor of the talar body in a 20-year-old male treated by curettage and bone graft. There was no recurrence at 1year follow-up. A case report and review of the literature are presented.