• 운동영양학회지
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• 제16권1호
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• pp.27-33
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• 2012

This study was conducted to investigate the effect of a 24-week combined exercise training program in older women with hypertension. Women with hypertension who were 70 years and older were randomized into two groups: combined exercise group (CE; n = 15) and a control group (n = 15). The CE group performed a combined exercise training program four times per week for 24 weeks and the control group did not. Five factors, including body composition (percent body fat and skeletal muscle mass), health-related physical fitness, adipocytokines (interleukin-6 [IL-6] and tumor necrosis factor-alpha [TNF-α]), kidney risk factors (glomerular filtration rate [GFR] and cystatin C), and systolic and diastolic blood pressure were measured before and after the program. The findings showed that total muscle mass, health-related physical fitness factors, and GFR increased significantly in the CE group compared to those in the control. Additionally, systolic and diastolic blood pressure and IL-6, TNF-α, and cystatin C levels in the CE group decreased significantly after the intervention. In contrast, total muscle mass decreased significantly and blood pressure remained unchanged in the control group. These results suggest that CE training may positively impact circulating levels of adipocytokines and cystatin C and improve physical fitness levels in elderly women with hypertension. Therefore, CE training helps to prevent renal disease and improve health-related physical fitness, eventually leading to a better quality of life.

• 한국노년학
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• 제27권2호
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• pp.299-322
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• 2007

본 연구에서는 노인에 대한 부정적인 스테레오타입을 전달하는 기존 노년 담론의 대안으로써 제시되고 있는, 신노년 담론이 대중매체를 통해 어떻게 구성되고 유포되는지 살펴보고자 하였다. 구체적으로 대표적인 대중매체의 하나인 신문매체의 기사들을 분석하여, 새롭게 부각되는 노년층의 문화가 어떠한 테마를 중심으로 소개되고 있으며, 이러한 테마들이 모여서 구성하는 신노년 담론의 특징과 그 의미는 무엇인가를 비판적으로 고찰하였다. 분석에 사용된 신문매체는 조선일보, 동아일보, 한겨레신문이며, 1997년부터 2006년까지 최근 10년 동안 발행된 신문 중에서, '노인' 또는 '노년'을 주제로 한 신문기사 1725건을 분석의 대상으로 선정하였다. 각 신문매체들은 신노년층 노인들의 모습을 건강과 젊음을 유지하고, 자원봉사나 유급노동, 학습 등으로 끊임없이 활동하면서 자립성을 유지하고 사회에 기여하는 모습으로 그리고 있으며, 신노인과 구노인의 대립항적인 담론구성 방식을 통해 신노년층 노인들의 라이프스타일을 고령화시대에 바람직한 삶의 모습으로 제시하고 있다. 이러한 신노년 담론이 가지고 있는 한계점들과 이데올로기적 특성을 논의하였다.

• 한국노년학
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• 제25권2호
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• pp.229-244
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• 2005

본 연구는 노년준비교육 프로그램에 대한 요구도 조사, 프로그램의 개발 및 실시 그리고 프로그램의 효과 검증을 통한 평가를 목적으로 수행하였다. 이를 위해 사회복지학, 가족학, 직업학 등의 노인 관련 전문가를 중심으로 연구진을 구성하였다. 요구도 조사는 20대 이상 남녀 560명을 대상으로 실시하였으며, 이를 바탕으로 본 연구에서는 20대와 60대 이상 두 집단을 대상으로 프로그램의 개발, 실행 및 평가가 이루어졌다. 그 결과 노년준비교육 프로그램은 생애단계와 노인의 전반적 이해, 경제적 준비, 직업, 건강증진 및 유지, 죽음과 사별대비, 심리적 관점, 자기완성의 추구, 노년기의 사회참여, 원만한 가족관계, 노인주거의 10개 영역으로 분류되었으며, 각 영역별로 교육의 효과가 유의미한 것으로 나타났다.

• Safety and Health at Work
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• 제14권3호
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• pp.332-339
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• 2023

Background: The aim of the study was to test the validity and reliability of the Perceived Future Decent Work Securement Scale for Turkish nursing students. Methods: A cross-sectional, methodological study design was used. The study was carried out at three nursing undergraduate programs in Turkey during the academic year of 2020-2021 with 336 senior nursing students. Language validity and content validity analyses were performed for the scale adaptation, followed by confirmatory factor analysis (CFA) for construct validity. The reliability of the scale was determined using the test-retest and Cronbach's alpha internal consistency coefficient. Results: The scale-content validity index score was 0.988. In CFA, all goodness-of-fit indices verified the acceptable fit of the model; its root mean square error of approximation was 0.076; the normed fit index was 0.909; the standardized mean square residual was 0.097; the relative fit index was 0.881; the goodness-of-fit index was 0.915; the adjusted goodness-of-fit index was 0.872 and χ²/df = 2.932. The overall reliability was α = 0.86. The item-total correlations of the scale were above the acceptable level, and the test-retest analysis had a high correlation. The access to healthcare (14.68, SD 3.53) obtained the highest average score, and the adequate compensation (8.52, SD 3.76) was the lowest rated by the senior nursing students. Conclusion: The Perceived Future Decent Work Securement Scale is a valid and reliable scale to assess nursing students' future decent work securement.

• Journal of Ginseng Research
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• 제48권1호
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• pp.40-51
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• 2024

Background: Ginsenoside 20(S)-Rg3 shows promising tumor-suppressive effects in ovarian cancer via inhibiting NF-kB signaling. This study aimed to explore the downstream tumor suppressive mechanisms of ginsenoside Rg3 via this signaling pathway. Materials and methods: A systematical screening was applied to examine the expression profile of 41 kinesin family member genes in ovarian cancer. The regulatory effect of ginsenoside Rg3 on KIF20A expression was studied. In addition, we explored interacting proteins of KIF20A and their molecular regulations in ovarian cancer. RNA-seq data from The Cancer Genome Atlas (TCGA) was used for bioinformatic analysis. Epithelial ovarian cancer cell lines SKOV3 and A2780 were used as in vitro and in vivo cell models. Commercial human ovarian cancer tissue arrays were used for immunohistochemistry staining. Results: KIF20A is a biomarker of poor prognosis among the kinesin genes. It promotes ovarian cancer cell growth in vitro and in vivo. Ginsenoside Rg3 can suppress the transcription of KIF20A. GST pull-down and co-immunoprecipitation (IP) assays confirmed that KIF20A physically interacts with BTRC (β-TrCP1), a substrate recognition subunit for SCF^β-TrCP E3 ubiquitin ligase. In vitro ubiquitination and cycloheximide (CHX) chase assays showed that via interacting with BTRC, KIF20A reduces BTRC-mediated CDC25A poly-ubiquitination and enhances its stability. Ginsenoside Rg3 treatment partly abrogates KIF20A overexpression-induced CDC25A upregulation. Conclusion: This study revealed a novel anti-tumor mechanism of ginsenoside Rg3. It can inhibit KIF20A transcription and promote CDC25A proteasomal degradation in epithelial ovarian cancer.

• Nutrition Research and Practice
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• 제18권2호
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• pp.223-238
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• 2024

BACKGROUND/OBJECTIVES: The purpose of this study was to establish a fruit-cooking method suitable for older adults with masticatory dysfunction. MATERIALS/METHODS: Five types of fruits were selected to make fruit jelly and puree: apple, sweet persimmon, mandarin, Korean melon, and watermelon. Recipes were selected based on the Korean Industrial Standard (KS) for senior-friendly foods (KS H 4897), which classifies foods into 3 levels (L1-L3) based on their hardness and viscosity. RESULTS: In South Korea, senior-friendly foods are classified into 3 stages based on their hardness. Stage 1 is for foods that are able to eat with teeth (hardness greater than 50,000 N and less than 500,000 N), Stage 2 is for foods that are able to eat with gums (hardness greater than 20,000 N and less than 50,000 N), and Stage 3 is for foods that are able to eat with the tongue (hardness less than 20,000 N). As a result of measuring the hardness by varying the shape of the fruit, it was found that nearly all fruits could be eaten fresh by chewing with the teeth (L1) but did not meet the KS for mastication using the gums (L2) or tongue (L3), so the cooking method was selected as fruit jelly and fruit puree. Only sweet persimmon, which had a hardness of 61,624-496,393 N, was not suitable for consumption in fresh fruit, unprocessed form. Based on their hardness measurements, fruit jellies (27,869 to 36,343 N) and fruit purees (315 to 1,156 N) met the L2 and L3 requirements, respectively. The viscosity results of all fruit purees met the L3 requirement. CONCLUSION: These results offer a simple cooking method to prepare texture-modified fruits suitable for safe consumption by older adults living with masticatory difficulties in general households and nursing facilities.

• Clinical Nutrition Research
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• 제13권2호
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• pp.108-120
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• 2024

The study aimed to investigate the basic data to derive plans for snack provision to improve the nutritional status of older adults living in long-term care facilities (LFs) or long-term care hospitals (LHs). The 252 respondents (118 from LHs and 134 from LFs) were included in the study. The questionnaire of nationwide cross-sectional survey was developed by the authors and registered dietitians. The written questionnaire was sent to the food service managers across 800 LFs or LHs. The online survey was introduced using the online platform and network site for dietitians. More than 70% of live-in and non-live-in LFs provided snacks, which were mainly provided one to two times a day. Most institutions provided fruits one to three times a week. The main considerations when providing fruit were in the order of residents' preference, cost, and ease of consumption. The reasons for not serving fruit included cost and differences in the residents' eating and mastication abilities. Most institutions also provided dairy products at a frequency of one to three times a week. The reasons for not serving dairy products included cost and the lack of awareness of the need to provide them. To improve the quality of life and the offer benefits of fruits and dairy products to older people, efforts are needed to propose a plan to expand the provision of snacks in appropriate quantities and varieties.

• Journal of Veterinary Science
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• 제25권4호
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• pp.49.1-49.15
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• 2024

Importance: Endochondral ossification plays an important role in skeletal development. Recent studies have suggested a link between increased intracellular reactive oxygen species (ROS) and skeletal disorders. Moreover, previous studies have revealed that increasing the levels of myeloperoxidase (MPO) and osteopontin (OPN) while inhibiting NADPH oxidase 4 (NOX4) can enhance bone growth. This investigation provides further evidence by showing a direct link between NOX4 and MPO, OPN in bone function. Objective: This study investigates NOX4, an enzyme producing hydrogen peroxide, in endochondral ossification and bone remodeling. NOX4's role in osteoblast formation and osteogenic signaling pathways is explored. Methods: Using NOX4-deficient (NOX4^-/-) and ovariectomized (OVX) mice, we identify NOX4's potential mediators in bone maturation. Results: NOX4^-/- mice displayed significant differences in bone mass and structure. Compared to the normal Control and OVX groups. Hematoxylin and eosin staining showed NOX4^-/- mice had the highest trabecular bone volume, while OVX had the lowest. Proteomic analysis revealed significantly elevated MPO and OPN levels in bone marrow-derived cells in NOX4^-/- mice. Immunohistochemistry confirmed increased MPO, OPN, and collagen II (COLII) near the epiphyseal plate. Collagen and chondrogenesis analysis supported enhanced bone development in NOX4^-/- mice. Conclusions and Relevance: Our results emphasize NOX4's significance in bone morphology, mesenchymal stem cell proteomics, immunohistochemistry, collagen levels, and chondrogenesis. NOX4 deficiency enhances bone development and endochondral ossification, potentially through increased MPO, OPN, and COLII expression. These findings suggest therapeutic implications for skeletal disorders.

• Journal of Microbiology and Biotechnology
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• 제15권4호
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• pp.756-766
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• 2005

The signaling mechanism underlying aburatubolactam C-induced FasL upregulation was investigated in human Jurkat T cells. After treatment with aburatubolactam C, the src-family PTKs $p56^{lck}\;and\;p59^{fyn}$, and MAP kinases ERK2 and JNK1, were activated prior to FasL upregulation; Both $p56^{lck}\;and\;p59^{fyn}$ were directly activated 2.4- and 2.2-fold, respectively, in vitro by aburatubolactam C. The aburatubolactam C-induced cellular changes, including the activation of ERK2 and INK1, and FasL upregulation, were completely prevented by the PTK inhibitor genistein. The activation of protein kinase C (PKC$\delta,\;\epsilon\;and\;\mu$ was also induced following aburatubolactam C treatment. Although the activation of $p56^{lck}$ and tyrosine phosphorylation of the cellular proteins were not blocked by the PKC inhibitor GFl09203X, the activation of ERK2 was completely abrogated, along with a detectably enhanced JNK1 activation; FasL upregulation, and apoptosis. However, the FasL upregulation and apoptosis were significantly inhibited by the PKC activator PMA, with a remarkable increase in the ERK2 activation. The cytotoxic effect of aburatubolactam C was reduced in the presence of the anti-Fas neutralizing antibody ZB-4. Although ectopic expression of Bcl-2 failed to completely block the cytotoxicity of aburatubolactam C, it was clearly suppressed. The c-Fos mRNA expression was upregulated in a biphasic manner, where the second phasic expression overlapped with the FasL upregulation. Accordingly, these results demonstrate that aburatubolactam C-induced apoptosis is exerted, at least in part, by FasL upregulation dictated by activation of the PTK ($p56^{lck}\;and\;p59^{fyn}$) /JNKI pathway, which is negatively affected by the concurrent activation of the PKC/ERK2 pathway proximal to PTK activation.

• 한국산학기술학회논문지
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• 제21권7호
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• pp.146-155
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• 2020

본 연구는 간호사가 지각하는 병원내부마케팅이 직무수행 및 충성도에 미치는 영향을 분석하기 위하여 경기도에 소재한 종합병원 간호사 250명을 대상으로 2018년 12월 26일부터 2019년 1월 4일까지 실시하였다. 본 연구의 결과는 첫째, 병원 내부마케팅이 직무수행에 조직비전 및 미래상, 교육훈련제도, 커뮤니케이션, 조직속성 및 체계에 통계적으로 유의미한 영향을 미치는 것으로 나타났고(F=29.118, p<.001), 충성도는 교육훈련제도, 조직비전 및 미래상, 보상 및 복리후생제도, 근무환경 관리에 통계적으로 유의미한 영향을 미치는 것으로 나타났고(F=38.671, p<.001), 직무수행이 충성도에 미치는 영향은 통계적으로 유의미한 영향을 미치는 것으로 나타났다(F=87.324, p<.001). 둘째, 간호사가 지각하는 병원 내부마케팅과 충성도의 관계에서 1단계 직무수행에 통계적으로 유의미한 정(+)의 영향을 미치는 것으로 나타났고(p<.001), 2단계 충성도에 통계적으로 유의미한 정(+)의 영향을 미치는 것으로 나타났으며(p<.001), 3단계 내부마케팅 회귀계수가 유의미하였고, 직무수행도 유의미하게 나타났다(p<.001). 병원의 내부고객인 간호사가 만족을 하여야 직무수행 및 충성도가 높아질 것이다. 내부직원이 직무만족과 충성도가 높아야 외부고객에게 보다 나은 의료서비스를 제공할 수 있기 때문에 병원 경영진에서는 간호사의 직무수행 및 충성도를 높이기 위해서 내부마케팅을 강화해야 할 필요가 있다고 사료된다.