• 대한수의학회지
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• 제55권2호
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• pp.117-123
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• 2015

Necrotic enteritis (NE) caused by Clostridium (C.) perfringens commonly occurs in domestic broiler farms since antibiotic supplementation in poultry feed has been banned. We evaluated the antibacterial activities of medicinal plant extracts against C. perfringens isolates to select alternative compounds for preventing NE. We compared antibacterial activities using two methods and evaluated susceptibilities of the isolates based on minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Two (Fraxinus rhynchophylla Hance [FRH] and Geranium koreanum Kom. [GKK]) of the 30 plant extracts had potent antibacterial activities against C. perfringens ATCC 13124 in two assays. The MIC values for FRH and GKK against 20 C. perfringens isolates were $128{\sim}256{\mu}g/mL$ and $32{\sim}128{\mu}g/mL$, respectively. The geometric MIC mean values for the two extracts were $147.2{\mu}g/mL$ and $68.8{\mu}g/mL$, respectively. The MBCs for the two extracts against the same strains were $1,024{\sim}2,048{\mu}g/mL$ and $256{\sim}1,024{\mu}g/mL$, respectively. The geometric mean MIC and MBC for GKK were about two-fold lower than those of FRH. The modified spot-on-lawn assay may be useful for measuring primary antibacterial potential. FRH and GKK are expected to be used as feed additives to prevent or treat NE in veterinary practice.

• 한국정보과학회논문지:소프트웨어및응용
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• 제32권3호
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• pp.215-226
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• 2005

루프 불변 코드 이동(loop invariant code motion, LICM) 컴파일러 최적화는 비교적 많은 분석 작업을 필요로 하기 때문에 컴파일 시간이 수행 시간의 일부가 되는 자바 적시(Just-In-Time) 컴파일러에는 사용하기 쉽지 않다. "전통적인" LICM 기법에서는 보통 코드를 분석하여 레지스터의 정의-사용체인과 사용-정의 체인을 미리 만든 뒤 이를 바탕으로 코드 이동을 수행하는 데, 본 논문은 자바 가상 머신(Java virtual machine)이 스택 머신 (stack machine)이라서 좀 더 단순한 코드 형태를 생성한다는 특징을 이용하여 정의-사용 체인을 루프 불변 코드에 대해서만 만들고 사용-정의 체인 없이도 정확히 동작하는 알고리즘을 제시한다. 또한 기존의 방식보다 더 많은 루프 불변 코드 이동을 하게 하는 두 가지 방법을 제시한다. 우선, 간단하기 때문에 루프에 경로가 하나인 경우만 LICM을 적용하는 기존의 기법과 달리, 경로가 여러 개인 루프에서도 부분적으로 중복되는 코드에 대해서도 LICM을 안전하게 적용한다. 또한 부분적으로 중복되는 루프 불변 널(null) 포인터 체크 코드도 Itanium의 조건 수행(predication)을 이용하여 이동시키다. 제안된 기법은 Itanium 마이크로프로세서를 위한 인텔의 ORP(Open Runtime Platform) 자바 가상 머신 위의 적시 컴파일러에 구현하였다. SPECjvm98 벤치마크에 대해 실험을 수행한 결과 전체 적시 컴파일 시간을 1.3％ 정도만을 증가시켰지만 전체 수행 시간을 기하 평균으로 2.2％ 향상 시켰다.

• 지구물리와물리탐사
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• 제12권4호
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• pp.328-337
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• 2009

암석 시료의 전기비저항과 공극수의 전기비저항의 관계를 고찰하기 위한 실험에 있어서 일반적으로 코어의 유효공극 내의 공극수를 포화시키고자 하는 전해질 용액이 완전히 치환하였다고 가정한다. 이 연구에서는 용액의 전기전도 도가 8, 160, 3200, 64000 ${\mu}S$/cm인 4종류의 소금물을 동일한 시멘트 시험편에 각각 4회씩 포화과정을 반복하며 함수율의 변화에 따른 전기비저항을 측정하고, 그 변화로부터 포화과정의 반복에 의해 공극수가 치환되는 정도에 대한 고찰하였다. 용액의 전기전도도를 높여가며 각각 4회씩 반복하고 다시 낮춰가면서 4회씩 포화과정을 반복하였다. 반복 횟수가 많아질수록 용액이 공극수를 더 많이 치환할 것이다. 따라서 용액의 전기전도도를 높여가며 측정한 전기비저항과 낮춰가며 측정한 전기비저항의 기하평균을 용액이 공극수를 완전히 치환하였을 때의 전기비저항으로 간주하고 비교의 기준으로 삼았다. 포화과정을 4회 반복함으로써 공극수가 치환하고자 하는 용액으로 치환되어 이전 공극수의 전기전도도와는 상관없이 암석의 전기비저항을 10% 이내의 편차로 측정할 수 있었다. 반면, 전기전도도가 낮은 용액으로부터 높은 용액으로 순차적으로 포화과정을 1회만 수행했을 경우에는 측정되는 암석의 전기비저항에 있어서 최대 40%의 오차를 보였다. 측정된 시료의 전기비저항과 공극수의 전기비저항의 관계는 변형된 병렬저항모델로 대체적으로 설명되어지나, 이를 일반화하기 위해서는 다양한 공극율을 가지는 암석 시료에 대해 다양한 공극수의 전기비저항에 대한 자료의 축적이 필요하다.

• 한국항만경제학회지
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• 제39권2호
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• pp.1-13
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• 2023

이 연구는 IMO의 환경규제와 4차산업 혁명 기술의 확산에 따라 그중요성과 비중이 확대되고 있는 친환경 스마트 선박의 성장에 필요한 인력 수요를 통계청의 2000년~2020년의 조선산업 인력자료를 기반으로 예측하였다. 추세분석과 시계열분석의 다양한 모델을 적용하여 조선산업의 인력 수요를 예측하고 최근 5년간의 실적치와 비교하여 기하평균을 적용한 단순평균법이 예측 오차가 유의적으로 가장 적은 것으로 평가되었다. 그리고 산업통상자원부의 친환경 스마트 선박 분야의 2018년과 2020년의 인력현황 설문조사 결과를 바탕으로 조선산업 인력 증가추이를 반영하여 인력 수요를 예측하였다. 조선산업의 인력수요 예측치에 친환경 스마트 선박부분의 인력 증가수치를 반영하여 인력 수요를 예측한 결과, 2025년 62,001명, 2030년 85,035명으로 증가하는 것으로 예측되었다. 본 연구는 고부가가치 친환경 스마트 선박 분야에 필요한 인력 수요를 통계자료에 기반하여 객관적으로 예측함으로써, 향후의 인력 수요에 대응한 적절한 전문인력의 양성 및 공급 방안 수립에 기여하게 될 것으로 평가된다.

• Toxicological Research
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• 제32권1호
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• pp.57-64
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• 2016

Recently several studies reported that the renal toxicity of lead (Pb) and cadmium (Cd) may exist in even a low level exposure. In terms of the deterioration of tubular function, it affects the loss of divalent metals and leads to other complications, so renal tubular effect of heavy metals should be well managed. Considering the exposure to heavy metals in reality, it is hard to find the case that human is exposed to only one heavy metal. We designed a cross-sectional study using Korean Research Project on the Integrated Exposure Assessment (KRIEFS) data to investigate the renal effects of multiple metal exposure in general population. We used blood Pb and urinary Cd as exposure measures, and urinary N-acetyl-${\beta}$-D-glucosaminidase (NAG) and ${\beta}_2$-microglobulin (${\beta}_2$-MG) as renal tubular impairment outcome. We conducted linear regression to identify the association between each heavy metal and urinary NAG and ${\beta}_2$-MG. And then, we conducted linear regression including the interaction term. Of 1953 adults in KRIEFS (2010~2011), the geometric mean of blood Pb and urinary Cd concentration was $2.21{\mu}g/dL$ (geometric $SD=1.49{\mu}g/dL$) and $1.08{\mu}g/g\;cr$ (geometric $SD=1.98{\mu}g/g\;cr$), respectively. In urinary Cd, the strength of the association was also high after adjusting (urinary NAG: ${\beta}=0.44$, p < 0.001; urinary ${\beta}_2$-MG: ${\beta}=0.13$, p = 0.002). Finally, we identified the positive interactions for the two renal biomarkers. The interaction effect of the two heavy metals of ${\beta}_2$-MG was greater than that of NAG. It is very important in public health perspective if the low level exposure to multiple heavy metals has an interaction effect on kidney. More epidemiological studies for the interaction and toxicological studies on the mechanism are needed.

• Journal of Korean Neurosurgical Society
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• 제62권4호
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• pp.476-486
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• 2019

Objective : The functional information of $^{11}C$-methionine positron emission tomography (MET-PET) images can be applied for Gamma knife radiosurgery (GKR) and its image quality may affect defining the tumor. This study conducted the phantom-based evaluation for geometric accuracy and functional characteristic of diagnostic MET-PET image co-registered with stereotactic image in Leksell $GammaPlan^{(R)}$ (LGP) and also investigated clinical application of these images in metastatic brain tumors. Methods : Two types of cylindrical acrylic phantoms fabricated in-house were used for this study : the phantom with an array-shaped axial rod insert and the phantom with different sized tube indicators. The phantoms were mounted on the stereotactic frame and scanned using computed tomography (CT), magnetic resonance imaging (MRI), and PET system. Three-dimensional coordinate values on co-registered MET-PET images were compared with those on stereotactic CT image in LGP. MET uptake values of different sized indicators inside phantom were evaluated. We also evaluated the CT and MRI co-registered stereotactic MET-PET images with MR-enhancing volume and PET-metabolic tumor volume (MTV) in 14 metastatic brain tumors. Results : Imaging distortion of MET-PET was maintained stable at less than approximately 3% on mean value. There was no statistical difference in the geometric accuracy according to co-registered reference stereotactic images. In functional characteristic study for MET-PET image, the indicator on the lateral side of the phantom exhibited higher uptake than that on the medial side. This effect decreased as the size of the object increased. In 14 metastatic tumors, the median matching percentage between MR-enhancing volume and PET-MTV was 36.8% on PET/MR fusion images and 39.9% on PET/CT fusion images. Conclusion : The geometric accuracy of the diagnostic MET-PET co-registered with stereotactic MR in LGP is acceptable on phantom-based study. However, the MET-PET images could the limitations in providing exact stereotactic information in clinical study.

• 대한원격탐사학회지
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• 제38권6_4호
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• pp.1901-1910
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• 2022

뉴스페이스(new space) 시대가 도래함에 따라 국내 KOMPSAT-3·3A 위성영상과 해외 위성영상과의 글로벌 융합활용 기술확보가 대두되고 있다. 일반적으로 다중센서 위성영상은 취득 당시의 다양한 외부요소로 인해 영상 간 상대적인 기하오차(relative geometric error)가 발생하며, 이로 인해 위성영상 산출물의 품질이 저하된다. 따라서 본 연구에서는 KOMPSAT-3·3A 위성영상과 해외 위성영상 간 존재하는 상대기하오차를 최소화하기 위한 정밀영상정합(fine-image registration) 방법론을 제안한다. KOMPSAT-3·3A 위성영상과 해외 위성영상 간 중첩영역을 선정한 후 두 영상 간 공간해상도를 통일한다. 이어서, 특징 및 영역 기반 정합기법을 결합한 형태의 하이브리드(hybrid) 정합기법을 이용하여 정합점(tie-point)을 추출한다. 그리고 피라미드(pyramid) 영상 기반의 반복적 정합을 수행하여 정밀영상정합을 수행한다. KOMPSAT-3·3A 위성영상과 Sentinel-2A 및 PlanetScope 영상을 이용하여 제안기법의 정확도 및 성능을 평가하였다. 그 결과, Sentienl-2A 영상 기준 평균 Root Mean Square Error (RMSE) 1.2 pixels, PlanetScope 영상 기준 평균 RMSE 3.59 pixels의 정확도가 도출되었다. 이를 통해 제안기법을 이용하여 효과적으로 정밀영상정합을 수행할 수 있을 것으로 사료된다.

• Journal of Preventive Medicine and Public Health
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• 제29권4호
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• pp.747-764
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• 1996

This study intended to obtain an useful information for health management of lead exposed workers and determine biological monitoring interval in early period of exposure by measuring the lead exposure indices and work duration in all male workers (n=433 persons) exposed less than 1 year in 6 storage battery industries and in 49 males who are not exposed to lead as control. The examined variables were blood lead concentration (PBB), Zinc-protoporphyrin concentration (ZPP), Hemoglobin (HB) and personal history; also measured lead concentration in air (PBA) in the workplace. According to the geometric mean of lead concentration in the air, the factories were grouped into three categories: A; When it is below $0.05mg/m^3$, B; When it is between 0.05 and $0.10mg/m^3$, and C; When it is above $0.10mg/m^3$. The results obtained were as follows: 1. The means of blood lead concentration (PBB), ZPP concentration and hemoglobin(HB) in all male workers exposed to lead less than 1 year in storage battery industries were $29.5{\pm}12.4{\mu}g/100ml,\;52.9{\pm}30.0{\mu}g/100ml\;and\;15.2{\pm}1.1\;gm/100ml$. 2. The means of blood lead concentration (PBB), ZPP concentration and hemoglobin(HB) in control group were $5.8{\pm}1.6{\mu}g/100ml,\;30.8{\pm}12.7{\mu}g/100ml\;and\;15.7{\pm}1.6{\mu}g/100ml$, being much lower than that of study group exposed to lead. 3. The means of blood lead concentration and ZPP concentration among group A were $21.9{\pm}7.6{\mu}g/100,\;41.4{\pm}12.6{\mu}g/100ml$ ; those of group B were $29.8{\pm}11.6{\mu}g/100,\;52.6{\pm}27.9{\mu}g/100ml$ ; those of group C were $37.2{\pm}13.5{\mu}g/100,\;66.3{\pm}40.7{\mu}g/100ml$. Significant differences were found among three factory group(P<0.01) that was classified by the geometric mean of lead concentration in the air, group A being the lowest. 4. The mean of blood lead concentration of workers who have different work duration (month) was as follows ; When the work duration was $1\sim2$ month, it was $24.1{\pm}12.4{\mu}g/100ml$, ; When the work duration was $3\sim4$ month, it was $29.2{\pm}13.4{\mu}g/100ml$ ; and it was $28.9\sim34.5{\mu}g/100ml$ for the workers who had longer work duration than other. Significant differences were found among work duration group(P<0.05). 5. The mean of ZPP concentration of workers who have different work duration (month) was as follows ; When the work duration was $1\sim2$ month, it was $40.6{\pm}18.0{\mu}g/100ml$, ; When the work duration was $3\sim4$ month, it was $53.4{\pm}38.4{\mu}g/100ml$ ; and it was $51.5\sim60.4{\mu}g/100ml$ for the workers who had longer work duration than other. Significant differences were found among work duration group(P<0.05). 6. Among total workers(433 person), 18.2% had PBB concentration higher than $40{\mu}g/100ml$ and 7.1% had ZPP concentration higher than $100{\mu}g/100ml$ ; In workers of factory group A, those were 0.9% and 0.0% ; In workers of factory group B, those were 17.1% and 6.9% ; In workers of factory group C, those were 39.4% and 15.4%. 7. The proportions of total workers(433 person) with blood lead concentration lower than $25{\mu}g/100ml$ and ZPP concentration lower than $50{\mu}g/100ml$ were 39.7% and 61.9%, respectively ; In workers of factory group A, those were 65.5% and 82.3% : In workers of factory group B, those were 36.1% and 60.2% ; In workers of factory group C, those were 19.2% and 43.3%. 8. Blood lead concentration (r=0.177, P<0.01), ZPP concentration (r=0.135, P<0.01), log ZPP (r=0.170, P<0.01) and hemoglobin (r=0.096, P<0.05) showed statistically significant correlation with work duration (month). ZPP concentration (r=0.612, P<0.01) and log ZPP (r=0.614, P<0.01) showed statistically significant correlation with blood lead concentration 9. The slopes of simple linear regression between work duration(month, independent variable) and blood lead concentration (dependent variable) in workplace with low air concentration of lead was less steeper than that of poor working condition with high geometric mean air concentration of lead. The study result indicates that new employees should be provided with biological monitoring including blood lead concentration test and education about personal hygiene and work place management within $3\sim4$ month.

• 한국산업보건학회지
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• 제10권1호
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• pp.160-169
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• 2000

Daily indoor and outdoor nitrogen dioxide ($NO_2$) concentration for 30 days were measured in 28 houses with questionnaire of housing characteristics in Brisbane, Australia. Using mass balance equation and regression analysis, penetration factors and source strength factors were calculated. The penetration factors of 27 houses except one house were between zero and 1, though penetration factor should be between zero and 1 by means of mass balance equation. Relationship between indoor and outdoor concentrations in each 27 house was calculated using regression analysis. According to the obtained linear regression equation, the slope means penetration factor and the intercept means source strength factor. Calculated mean and standard deviation of coefficients of determination ($R^2$) in electric and gas range houses were $0.70{\pm}0.13$ and $0.57{\pm}0.21$, respectively. The source strength factors were more than zero in 27 houses. Mean and standard deviation of slopes in electric and gas range houses were $0.65{\pm}0.18$ and $0.56{\pm}0.12$, respectively. Mean and standard deviation of intercepts in electric and gas range houses were $1.49{\pm}1.25$ and $5.77{\pm}3.55$, respectively. Air exchange rate and source strength were calculated from penetration factor and source strength factor, respectively. Geometric mean and standard deviation of calculated air exchange rates in 27 houses were $1.1/hr{\pm}1.5$. Presence of gas range was the most significant factor contributing to indoor $NO_2$ level in house characteristics (p=0.003). In gas range houses, source strengths ranged from 4.1 to $33.1cm^3/hr{\cdot}m^3$ with a mean $12.7cm^3/hr{\cdot}m^3$ and a standard deviation 9.8. The source strengths of gas range houses were significantly different from those of electric range houses by t-test (p<0.001)

• 한국환경보건학회지
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• 제46권4호
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• pp.359-367
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• 2020

Objectives: Exposure to mold is strongly associated with adverse health effects (development or exacerbation of allergic diseases). We reviewed the health effects of mold exposure and explored to determine the annual distribution of indoor mold in facilities with susceptible populations. Methods: The health effects of mold exposure were mainly summarized by reviewing related papers and WHO research reports. We selected 10 facilities, including daycare centers, postpartum care centers, medical institutions, and elderly care facilities within the Seoul Metropolitan. Mold sampling was performed once every week or once every quarter from February 2016 to 2017. In addition, fungal species analyses was performed, and distribution status by month and facility was analyzed in the same manner as concentration. Results: Adverse health effects attributed to fungal exposure are largely divided into allergic symptoms, toxic effects, and infectious effects. Monthly mean concentrations of mold indoors and outdoors was 368.8 CFU/㎥ (geometric mean 213.4 CFU/㎥) and 496.0 CFU/㎥ (327.9 CFU/㎥), respectively. The indoor concentration has begun to increase in February, peaked in July, declined in August, increased again until October, and then decreased in November. About 36 genera of indoor fungal species were found in each facility. Cladosporium sp., Penicillium sp., Fusarium sp., Aspergillus sp., Alternaria sp., and Arthrinium sp. were observed as the dominant species. Conclusions: Our findings showed that the overall level of indoor mold was below the 500 CFU/㎥ level recommended by the Ministry of Environment. The development of DNA-based assessment and expanding facilities to be monitored for mold would be necessary for preventive aspects.