• Biomolecules & Therapeutics
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• 제3권4호
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• pp.251-255
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• 1995

DA-3002 is a genuine human growth hormone produced by Dong-A Pharm. Co. Ltd. research laboratory using recombinant DNA technic. In this study, antigenic potential of DA-3002 was examined by active systemic anaphyaxis(ASA) in guinea pigs, mouse-rat passive cutaneous anaphylaxis(PCA) and passive hemagglutination(PHA) test as a part of safety research. DA-3002 induced anaphylactic shock in ASA test using guinea pigs Immunized with DA-3002 alone or DA-3002 incoporated into Freund's complete adjutant(FCA) when challenged with 10 times higher dose of anticipated clinical dose of DA-3002. In the mouse-rat PCA and PHA test, DA-3002 also showed positive results. DA-3002, therfore, was considered to produce IgE, IgG, and/or IgM in mice. The results of this study were similar to those of the other human growth hormones and these positive results were thought to be caused due to the fact that both DA-3002 and the other human growth hormones were heterogenous proteins to guinea pigs and mice. Considering the fact that DA-3002 is a genuine human growth hormone of which structure is identical with indigenous human growth hormone, DA-3002 is thought not to cause immunological problems in clinical use.

• 벤처창업연구
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• 제1권1호
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• pp.1-21
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• 2006

본 논문은 1999년과 2005년 두시점 간에 코스닥시장과 코스닥상장기업간의 진성성장 상관패턴을 분석하여 코스닥시장의 진성성장에 코스닥상장기업의 재무우량화가 기여한 정도를 평가하는 것에 초점을 두었다. 특히 본 연구는 진성성장 개념을 통해 코스닥시장과 코스닥상장기업의 단순한 외형성장만이 아닌 질적 성장까지를 포함하는 성장도를 평가하였으며 이에는 유동성, 공정성, 변동성, 건전성 등의 지표와 1999년 말과 2005년 말 기준 코스닥 시가총액 30위 기업으로 대상으로 한 외형재무(매출액, 이익 및 이익률) 등을 비교하였으며 질적 재무로 지속적 이익의 규모 변화를 측정하였다. 이러한 분석을 통해, 본 논문은 크게 세 가지의 연구결과를 도출하였다. 첫째, 상장기업수와 거래량 및 거래규모가 증가하는 가운데서도 코스닥시장이 질적으로 성장할 수 있었던 동인인 기업의 수만 양적으로 증가한 것이 아닌 재무적 성과가 질적으로 우수한 상장기업들이 늘어났기 때문이다. 둘째, 시장의 변동성이 낮아지며 시장이 안정성을 이루는 동인은 상장기업의 이익의 질이 우수하였기 때문이여 특히 지속적 이익의 증가는 기업의 미래성장성을 높이며 단기적 투자보다는 중장기적인 미래 가치투자를 가능하게 하였기 때문이다. 셋째, 코스닥시장이 시장과 재무지표 중심의 상장폐지제도를 운영하며 시장의 투명성을 제고하고 이를 통해 진성성장을 이룬 것은 상장기업들이 시장중심의 지표를 적용해도 충분히 소화해 낼 수 있는 진성 재무성과를 보였기 때문이다.

• 한국표면공학회지
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• 제24권1호
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• pp.1-17
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• 1991

Understanding of the detailed reaction mechanisms during MOVPE and ALE is essential to further improve the properties of the grown crystals and the controllability of the growth parameters. The unified models for the detailed reaction paths are not available at this stage. The study, however, has been advanced to the extent that consensus on some of the reaction paths can be drawn from the scattered data. Metalakyls such as TMGa and TMIn seem to nearly fully decompose in the gas phase through homogeneous reaction at the typical MOVPE growth temperature. Hydrides such as AsH3 and PH3, on the contrary. seem to decompose heterogeneously onthe substrate surfaces as well as homogeneously in the gas phase. However, at lower temperatures, where ALE crystals are typically grown, the growth process is strongly dependent on the surface reactions. It seems that steric hindrance effects which the radicals reaching the substrate exhibit on the surface the growth rate a function of the metalalkyle supply durations. In addition, dydrogens released from hydrides seem to play an essential role in removing carbons leberated from the metalalkyls. High growth temperatures also seem to be effective in desorbing carbons from surface. The understanding of the reaction mechanisms was possible though diverse appraaches utilizing many ex-situ and in-situ diagnostic techniques and genuine experimental designs. It is the purpose of this paper to review and discuss many of these efforts and to draw some possible conclusions from them.

• 한국표면공학회지
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• 제24권1호
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• pp.1.1-1.1
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• 1991

Understanding of the detailed reaction mechanisms during MOVPE and ALE is essential to further improve the properties of the grown crystals and the controllability of the growth parameters. The unified models for the detailed reaction paths are not available at this stage. The study, however, has been advanced to the extent that consensus on some of the reaction paths can be drawn from the scattered data. Metalakyls such as TMGa and TMIn seem to nearly fully decompose in the gas phase through homogeneous reaction at the typical MOVPE growth temperature. Hydrides such as AsH3 and PH3, on the contrary. seem to decompose heterogeneously onthe substrate surfaces as well as homogeneously in the gas phase. However, at lower temperatures, where ALE crystals are typically grown, the growth process is strongly dependent on the surface reactions. It seems that steric hindrance effects which the radicals reaching the substrate exhibit on the surface the growth rate a function of the metalalkyle supply durations. In addition, dydrogens released from hydrides seem to play an essential role in removing carbons leberated from the metalalkyls. High growth temperatures also seem to be effective in desorbing carbons from surface. The understanding of the reaction mechanisms was possible though diverse appraaches utilizing many ex-situ and in-situ diagnostic techniques and genuine experimental designs. It is the purpose of this paper to review and discuss many of these efforts and to draw some possible conclusions from them.

• 인간행동과 음악연구
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• 제5권2호
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• pp.93-102
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• 2008

융의 발달이론에 따르면, 인생은 만 35에서 40세를 전후로 페르소나가 형성되어가는 전반기와 참자기를 찾아 나서게 되는 후반기의 두 단계로 나누어진다. 이러한 관점에서, 나는 발달적으로 개성화에 대한 고민을 하지 않을 수 없는 역치점에 서 있으며, 음악-중심 음악치료사라는 페르소나를 가지고 있는 한 인간으로서 나의 개성화 과정은 음악적 참자기와 음악 안에서의 자기실현을 찾아나서는 과정에서부터 시작되어야 한다고 생각하였다. 나는 이러한 과정을 음악적 개성화(musical individuation)라 명명하고자 하며, 음악적 성장과 변화가 곧 음악 외적 성장과 변화를 상징한다는 음악-중심 음악치료 철학의 기본전제를 바탕으로, 나는 내 자신의 음악적 개성화 과정이 곧 나의 음악 외적 개성화 과정을 대변하리라 믿는다. 이 글은 아직도 많은 여정이 남아있고, 어쩌면 참된 완성이 가능하지 않을 수도 있는 음악적 개성화 과정에 대한 나의 개인적 기록이며 진솔한 고백이다.

• 한국가스학회지
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• 제4권1호
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• pp.9-15
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• 2000

원통형 톨루엔 저장탱크의 구조결함을 조사하기 위하여 음향방출시험을 수행하였다. 원통형 저장탱크는 고장력강으로 제작되었으며, 최근에 저장탱크의 하부 1 및 2단은 전면 보수되었다. 음향방출은 최대설계하중의 $75{\~}84\%$ 레벨영역에서 하중절차에 따라 실시간으로 모니터링 되었다. 시험결과는 순수 음향방출뿐만 아니라 유사 음향방출특성도 보여준다. 밸브잡음으로 판단되는 유사 방출들은 하중과는 무관하게 밸브잠금과정에서 과도적으로 발생되었다. 충수과정에서 발생된 순수 음향방출들은 결함에 기인하며, $75{\~}84\%$의 시험하중영역에서는 성장을 하지 않는 것으로 평가되었다. 이 결함들은 활성센서들을 중심으로 수행된 방사선시험을 통하여 용접균열과 기공인 것으로 밝혀졌다.

• 한방안이비인후피부과학회지
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• 제17권1호
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• pp.1-15
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• 2004

The different growth steps of human show the different energetic phenomenon such as the strength of triple energizer, the sale of extra meridian, and the stability of 12 meridians. So we have to understand the physiological and pathological phenomena on this point of view. Especially atopic dermatitis means the loss of adaptability under the lack of genuine energy. If you approach to this disease not with any perception of excess or deficiency of the human genuine energy but with simple symptom enumeration or partial diagnosis, it will be dangerous. So we must approach to this disease with more concrete and objective body-centered standard. Thus when we cure and diagnose infants with this disease, we should focus on stablizing the "Energy of Earth(土)" digestive ability, under the consideration of inducement to the enough "Byun-Jeung-Hu(變蒸候)" and the function of Triple Energizer. Through this process we can lead infants to the beginning equipment state(始全). Until 7 years old, we should stabilize the Link Vessel(維脈) by clarifying interior and exterior classification of Nutritive Element and Defensive Energy to control the child's energy of metal(金), water(水), wood(木) and fire(火) in the basis of the energy of earth(土). And also we should stabilize the Heel Vessel(？脈) through the Water and Fire complement each other to control the movements and to control sleep and awakening. Through this process, we can lead children to the basal equipment state(本全). After then, until adolescent phase, we should control 12 meridian and 8 extra meridian by leading vital function to be harmonized and prosperous on the basis of the meridian to reach the mature equipment state(旣全). Adult atopic dermatitis should be controlled through conciliation between meridian and internal organs by differentiating male from female.

• 한국발생생물학회:학술대회논문집
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• 한국발생생물학회 2003년도 제3회 국제심포지움 및 학술대회
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• pp.3-6
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• 2003

The birth of the clone animals is influencing the frontier of research of animal biotechnology. It has effects on research of animal biotechnology itself by necessitating setting of new research subjects, modifications of the strategy of ongoing research projects, and challenges to schemes formerly considered impossible. In my talk, such topics including mass production of fertile ova and oocyte maturation will be discussed. (1) Oocytes are needed for the production of a clone by nuclear transplantation. Mitochondrial DNA inherited via the oocyte are involved also in the morphogenesis. Therefore, oocytes from the same animal must be used as recipients to produce genuine clones by nuclear transplantation. Experimenting on the assumption that selective oogenesis can be avoided, and apoptosis of oocytes can be prevented, by using ovarian angiogenic factos will be introduced. (2) It is important to clarify the factors of oocytes involving in reprogramming of somatic cells. Such factors are thought to be expressed in oocytes during oogenesis and oocyte maturation. Therefore, molecular mechanisms of oogenesis and oocyte maturation must be clarified extensively. Topics in this field including our recent advances will be discussed. (중략)

• Biomolecules & Therapeutics
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• 제7권1호
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• pp.14-21
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• 1999

The immunogenicity of the recombinant human basic fibroblast growth factor (rh-bFGF) was investigated by tests for active systemic anaphylaxis (ASA), passive cutaneous anaphylaxis (PCA), passive hemagglutination (PHA) and guinea pig maximization test (GPMT) in mice or guinea pigs. Guinea pigs were sensitized with rh-bFGF ($100-1000\;\mu\textrm{g}/kg$) or rh-bFGF-CFA mixture ($1000\;\mu\textrm{g}/kg$). All animals sensitized with rh-bFGF alone or mixture with CFA showed symptoms of anaphylactic shock. IgE antibodies to rh-bFGF were detected in sera obtained from rh-bFGF and rh-bFGF-Alum ($1000\;\mu\textrm{g}/kg$) sensitized mice, indicating that rh-bFGF has immunogenicity eliciting potential. IgG and/or IgM antibodies to rh-bFGF were also detected in all the sera obtained from sensitized mice by PHA. In the GPMT for delayed type skin reaction, no skin reaction was observed in sensitized guinea pigs after intradermal injection and dermal application of 0.01% rh- bFGF. However, these positive reactions were consistent with the results of another rh-bFGF, showing that rh- bFGF is a heterogenous protein to rodents. Considering the fact that rh-bFGF is a genuine human protein of which structure is identical to the endogenous human bFGF, it is thought that rh-bFGF is rarely associated with immunological problems in clinical use.

• 항공우주정책ㆍ법학회지
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• 제spc호
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• pp.247-270
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• 2007

Space development and utilization must be conducted within a framework of "peaceful uses" principle under Space Treaty. Japan ratified the treaty in 1967, and interpreted "peaceful uses" as "non-military uses" then. A ghost of "peaceful uses" principle has been hung over Japan up to the moment. Japan's space development and utilization has been conducted with genuine academic interest, and therefore Japan did not introduce space infrastructures to national security policy and did not facilitate growth of space industry. When the Cold War ended, Northeast Asian security environment makes Japan difficult to maintain an interpretation as "non-military uses". Besides the change of external security environment, the domestic industry situation and a series of rocket launching failure needed reexamination of Japan's space policy. Japan is gradually changing its space policy, and introducing space infrastructure in a national security policy under a "generalization" theory that gave a broad interpretation of "peaceful uses" principle. Council for Science and Technology Policy (CSTP) adopted a basic strategy of Japan's space policy in 2004. Since then, a long-term report of Japan Aerospace Exploration Agency (JAXA), an investigation report of Society of Japanese Aerospace Companies (SJAC) and a proposal of Japan Business Federation (JSF) were followed. Japan will promote space development and utilization in national security policy with a "strictly defensive defense" strategy and "non-aggressive uses"principle for protection of life and property of Japanese people and stabilization of East Asian countries.