• 대한전기학회:학술대회논문집
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• 대한전기학회 1999년도 하계학술대회 논문집 F
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• pp.2742-2744
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• 1999

In this paper, an auto-tuning method for fuzzy logic controller based on the genetic algorithm is presented. In the proposed method, normalization parameters and membership function parameters of fuzzy controller are translated into binary bit-strings, which are processed by the genetic algorithm in order to be optimized for the well-chosen objective function (i.e. fitness function). To examine the validity of the proposed method. a genetic algorithm based fuzzy controller for an indirect vector control of induction motors is simulated and experiment is carried out. The simulation and experimental results show a significant enhancement in shortening development time and improving system performance over a traditional manually tuned fuzzy logic controller.

• International Journal of Computer Science & Network Security
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• 제22권4호
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• pp.131-138
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• 2022

A Mobile Ad-hoc Network (MANET) is a collection of moving nodes that communicate and collaborate without relying on a pre-existing infrastructure. In this type of network, nodes can freely move in any direction. Routing in this sort of network has always been problematic because of the mobility of nodes. Most existing protocols use simple routing algorithms and criteria, while another important criterion is path selection. The existing protocols should be optimized to resolve these deficiencies. 'Particle Swarm Optimization (PSO)' is an influenced method as it resembles the social behavior of a flock of birds. Genetic algorithms (GA) are search algorithms that use natural selection and genetic principles. This paper applies these optimization models to the OLSR routing protocol and compares their performances across different metrics and varying node sizes. The experimental analysis shows that the Genetic Algorithm is better compared to PSO. The comparison was carried out with the help of the simulation tool NS2, NAM (Network Animator), and xgraph, which was used to create the graphs from the trace files.

• 한국정보통신학회논문지
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• 제10권1호
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• pp.212-219
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• 2006

퍼지 논리 제어기(FLC : Fuzzy Logic Controller)를 사용할 때, 가장 중요한 것은 소속 함수의 범위를 정하는 것과 규칙의 형태를 결정하는 것이다. 소속 함수의 범위나 규칙의 형태는 자금까지 전문가가 임의로 정하는 방법을 사용하였다. 그러나 기존의 방법을 사용하면, 전문가의 주관적인 규칙과 소속 함수가 생성될 수 있고, 소속함수의 경우 최적의 범위를 정확히 예측하기 어려운 단점이 있다. 본 논문에서는 이런 단점을 보완하기 위해, 유전자 알고리즘을 사용함으로써 최적의 소속 함수와 규칙의 형태를 구하려 하였다. 제시하는 방법의 타당성을 검증하기 위해 자동차 주행 제어 문제에 적용시켜 보았다.

• Journal of Audiology & Otology
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• 제25권4호
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• pp.230-234
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• 2021

Otosclerosis, a hereditary disorder characterized by disordered resorption and deposition of bone, results in progressive hearing loss. Osteogenesis imperfecta (OI) is a genetic disorder characterized by recurrent fractures, blue sclera, and varying degrees of hearing impairment; and is a known risk factor for otosclerosis. After adolescence, the risk of fracture decreases, reducing the need for follow-up in OI. However, otosclerosis is a progressive disorder. In this report, we discuss two cases of familial otosclerosis with different clinical features. We hypothesize that the difference in hearing level correlates with the difference in computed tomography findings. The mother, whose case was considered severe, was prescribed hearing aids, while the daughter, who had normal hearing level, was regularly followed up.

• 대한청각학회지
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• 제25권4호
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• pp.230-234
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• 2021

Otosclerosis, a hereditary disorder characterized by disordered resorption and deposition of bone, results in progressive hearing loss. Osteogenesis imperfecta (OI) is a genetic disorder characterized by recurrent fractures, blue sclera, and varying degrees of hearing impairment; and is a known risk factor for otosclerosis. After adolescence, the risk of fracture decreases, reducing the need for follow-up in OI. However, otosclerosis is a progressive disorder. In this report, we discuss two cases of familial otosclerosis with different clinical features. We hypothesize that the difference in hearing level correlates with the difference in computed tomography findings. The mother, whose case was considered severe, was prescribed hearing aids, while the daughter, who had normal hearing level, was regularly followed up.

• Molecules and Cells
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• 제46권1호
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• pp.4-9
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• 2023

The advent of the CRISPR-Cas genome editing platform has greatly enhanced the capabilities of researchers in many areas of biology. Its use has also been turned to the development of therapies for genetic diseases and to the enhancement of cell therapies. This review describes some recent advances in these areas.

• BMB Reports
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• 제50권1호
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• pp.3-4
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• 2017

Recent advances in genome sequencing technologies have enabled humans to generate and investigate the genomes of wild species. This includes the big cat family, such as tigers, lions, and leopards. Adding the first high quality leopard genome, we have performed an in-depth comparative analysis to identify the genomic signatures in the evolution of felid to become the top predators on land. Our study focused on how the carnivore genomes, as compared to the omnivore or herbivore genomes, shared evolutionary adaptations in genes associated with nutrient metabolism, muscle strength, agility, and other traits responsible for hunting and meat digestion. We found genetic evidence that genomes represent what animals eat through modifying genes. Highly conserved genetically relevant regions were discovered in genomes at the family level. Also, the Felidae family genomes exhibited low levels of genetic diversity associated with decreased population sizes, presumably because of their strict diet, suggesting their vulnerability and critical conservation status. Our findings can be used for human health enhancement, since we share the same genes as cats with some variation. This is an example how wildlife genomes can be a critical resource for human evolution, providing key genetic marker information for disease treatment.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2002년도 춘계 학술대회지
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• pp.48-50
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• 2002

A strategy for development of a functional rice in proved with human lactoferrin and enhancement of nutrient compounds was planned. For the purposes we have cloned and characterized a human lactoferrin cDNA from human mammary gland cDNA library A endosperm storage vacuole targeting sequence and the cDNA fragment was linked to endosperm specific glutelin promoter. The fusion gene fragment was inserted into a binary vector containing MAR gene. In addition a new ${\beta}$-galactosidase gene from Bifidobacterium of human was used as a reporter gene in the vector system, Rice plants showing a high concentration of amino acids in the endosperm cells were developed by using a biochemical mutation and bred for the transformation with the binary vector system Finally we have established a transformation method for the rice endosperm cells.

• 대한교통학회지
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• 제26권5호
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• pp.175-184
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• 2008

도로용량 증대를 위한 소요예산 추정문제는 관련주체인 이용자와 공급자의 입장을 모두 반영할 필요가 있다. 본 연구에서는 총통행시간, 형평성, 환경비용을 평가지표로 설정하고, 3가지 평가지표에 대한 관련주체의 요구사항이 만족되는 대안 중 소요예산을 최소화하는 최적 도로용량 증대 대안을 선정하는 문제를 모형화하였다. 일반적으로 도로용량 증대를 위한 소요예산 추정문제는 Network Design Problem(NDP)로 다루어지며, 이용자와 공급자의 다른 입장을 고려하기 위해 Bi-level 최적화문제로 모형화된다. 본 연구에서는 장래 교통수요의 불확실성을 반영하기 위해 확률모형(Stochastic model)을 적용하고, 평가지표별 신뢰도를 차별화하기 위해 Chance-constrained model(CCM)를 적용하였으며, 3가지 평가지표의 제약식을 만족하면서 소요예산을 최소화하는 목적함수를 만족하는 최적대안을 선정하기 위해 렉시코그라픽(Lexicographic) 최적화문제로 접근하였다. 예제 네트워크를 통하여 분석한 결과, 평가지표별 신뢰도 및 교통수요 변화율이 클수록 더욱 많은 소요예산이 요구되며, 평가지표별 신뢰도가 클수록 장래 교통수요의 변화에 더욱 탄력적으로 대응할 수 있는 대안이 선정되었다. 제안된 모델은 다양한 관련주체의 입장을 모두 고려한 최적 도로용량 증대 대안과 소요예산을 선정함과 동시에, 도로용량 증대량의 변화에 따른 평가지표간 상쇄관계(Tradeoff)와 도로 네트워크 개선을 위한 예산 배분의 포트폴리오를 정책결정자에게 제공 가능하다.

• Ecology and Resilient Infrastructure
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• 제2권1호
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• pp.33-41
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• 2015

본 연구는 어류서식적합도 향상을 위해 유전자알고리즘을 이용한 하천의 구조개선 방안을 제시하였다. 하천구조 개선에 의한 수리특성의 변화에 따른 어류 서식적합도와 물리적 교란양상과의 상관특성을 분석하였다. 원주천의 하천 환경조사와 어류의 군집특성을 이용하여 수중 생태계를 대표할 수 있는 복원 목표어종으로 참갈겨니를 선택하였다. 참갈겨니의 서식적합지수를 사용한 서식적합도 분석은 PHABSIM 모형을 이용하였다. HEC-RAS를 이용한 수리특성 분석과 하천교란 평가방법을 이용하여 물리적 교란평가를 수행하였다. 서식적합도 향상을 위한 최적의 저수로 폭의 개선방안을 제시하였다. 하천구조의 개선에 의한 수리특성의 변화에 따른 서식적합도와 물리적 교란의 상관성을 분석하여 어류 서식적합도와 물리적 교란 평가점수의 향상이 있음을 확인하였다. 서식적합도 향상을 위한 하천의 구조 개선은 물리적 교란의 평가점수의 향상을 가져옴을 확인하였다.