• ETRI Journal
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• 제44권4호
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• pp.641-653
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• 2022

In the process of autonomous vehicle motion planning and to create comfort for vehicle occupants, factors that must be considered are the vehicle's safety features and the road's slipperiness and smoothness. In this paper, we build a mathematical model based on the combination of a genetic algorithm and a neural network to offer lane-change solutions of autonomous vehicles, focusing on human vehicle control skills. Traditional moving planning methods often use vehicle kinematic and dynamic constraints when creating lane-change trajectories for autonomous vehicles. When comparing this generated trajectory with a man-generated moving trajectory, however, there is in fact a significant difference. Therefore, to draw the optimal factors from the actual driver's lane-change operations, the solution in this paper builds the training data set for the moving planning process with lane change operation by humans with optimal elements. The simulation results are performed in a MATLAB simulation environment to demonstrate that the proposed solution operates effectively with optimal points such as operator maneuvers and improved comfort for passengers as well as creating a smooth and slippery lane-change trajectory.

• 국제학술발표논문집
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• The 2th International Conference on Construction Engineering and Project Management
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• pp.509-519
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• 2007

Private financing is playing an increasing role in public infrastructure construction projects worldwide. However, private investors/operators are exposed to the financial risk of low profitability due to the inaccurate estimation of facility demand, operation income, maintenance costs, etc. From the operator's perspective, a sound and thorough financial feasibility study is required to establish the appropriate capital structure of a project. Operators tend to reduce the equity amount to minimize the level of risk exposure, while creditors persist to raise it, in an attempt to secure a sufficient level of financial involvement from the operators. Therefore, it is important for creditors and operators to reach an agreement for a balanced capital structure that synthetically considers both profitability and repayment capacity. This paper presents an optimal capital structure model for successful private infrastructure investment. This model finds the optimized point where the profitability is balanced with the repayment capacity, with the use of the concept of utility function and multi-objective GA (Generic Algorithm)-based optimization. A case study is presented to show the validity of the model and its verification. The research conclusions provide a proper capital structure for privately-financed infrastructure projects through a proposed multi-objective model.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2021년도 학술발표회
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• pp.206-206
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• 2021

The necessity for appropriate management of water resources infrastructures such as reservoirs, levees, and dikes is increasing due to unexpected hydro-climate irregularities and rising water demands. To meet this need, past studies have focused on advancing theoretical optimization algorithms such as nonlinear programming, dynamic programming (DP), and genetic programming. Yet, the optimally derived theoretical solutions are limited to be directly implemented in making release decisions in the real-world systems for a variety of reasons. This study first aims to comparatively analyze the two prominent optimization methods, DP and evolutionary multi-objective direct policy search (EMODPS), under historical inflow series using K-fold cross validation. A total of six optimization models are formed each with a specific formulation. Then, one of the optimization models was coupled with the actual zone-based hedging rule that has been adopted in practice. The proposed methodology was applied to Boryeong Dam located in South Korea with conflicting objectives between supply and demand. As a result, the EMODPS models demonstrated a better performance than the DP models in terms of proximity to the ideal. Moreover, the incorporation of the real-world policy with the optimal solutions improved in all indices in terms of the supply side, while widening the range of the trade-off between frequency and magnitude measured in the sides of demand. The results from this study once again highlight the necessity of closing the gap between the theoretical solutions with the real-world implementable policies.

• 한국농림기상학회지
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• 제14권1호
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• pp.19-27
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• 2012

본 연구는 외국에서 이용해 왔던 기존의 상부 개방형 온실의 단점을 보완하여, 장기적인 연구가 요구되는 수목을 대상으로 설치한 상부 개방형 온실의 운영결과를 제공하고자 하는 것이다. 이 자료에는 이산화탄소의 농도 조절 능력 및 안정성을 비롯하여, 대기와 OTC 내부 간의 미세환경 차이에 대한 정보를 포함하고 있다. OTC 시설은 대조구인 OTC 외부 시험구, 대기와 동일 $CO_2$ 농도의 OTC 시험구, 대기 $CO_2$ 농도의 1.4배 증가시킨 OTC 시험구, 대기 $CO_2$ 농도의 1.8배 증가시킨 OTC 시험구로 구성되어 있다. 이시설은 온실 6기, $CO_2$ 폭로장치 6기, $CO_2$ 제어장치 6기, 액화탄산가스 탱크 1기, 제어감시실 1실로 구성되어 있다. 온실 6기는 직경 10m, 높이 7m의 10각형 구조물로 제작되었으며, 상부 개구율은 75% 이상을 유지하고 있다. $CO_2$ 폭로를 위해 16개 원통형 토출배관을 도입하였다. OTC의 평균 가동률은 2010년 6월에 94.2%로 가장 낮았으나, 7월 이후부터는 98% 이상의 가동률을 나타냈고, 2011년에는 100% 가동률을 보였다. 2010년과 2011년 모두 $CO_2$ 농도 조절 결과는 목표 값에 도달하였으며, 2011년이 보다 안정된 값을 나타냈다. 2011년 무처리 OTC의 $CO_2$ 농도는 목표 값의 106%였으며, 1.4배 OTC는 목표 값의 100%, 1.8배 OTC는 목표 값의 94%였다. 대기와 OTC 내부의 온도는 오전 10시부터 오후 2시 사이에 차이가 가장 컸는데, 편차는 $1.2{\sim}2.0^{\circ}C$를 기록했으나, OTC간 온도 차이는 크지 않았다. 대기와 OTC 내부간 상대 습도의 차이는 0.1~1% 사이로 매우 적었다. OTC를 운영하는데 사용된 $CO_2$ 가스 소비량은 2010년과 2011년 6월에 가장 많은 11.33톤과 17.04톤을 기록했다.

• Journal of Advanced Marine Engineering and Technology
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• 제39권6호
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• pp.633-641
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• 2015

선박, 발전소, 석유화학 등의 분야에서 운전되고 있는 많은 프로세스들은 강한 비선형성을 보일 뿐만 아니라 동시에 시변 특성도 가지고 있다. 이런 프로세스에 기존의 고정-파라미터 PID 제어기를 적용하면 성능이 나빠지고 경우에 따라서는 불안정해질 수도 있다. 따라서 본 연구에서는 복잡한 프로세스를 제어하기 위한 비선형 PID 제어기를 제안한다. 제안되는 제어기의 이득은 오차와 오차의 변화율의 비선형 함수로 기술되며, 사용자 파라미터들은 ITAE를 최소로 하는 관점에서 유전알고리즘으로 동조된다. 제안된 방법은 열분해반응 또는 촉매를 이용한 고분자합성에 널리 사용되는 연속 교반탱크반응기를 대상으로 시뮬레이션을 실시하며, 그 유효성을 보이기 위해 다른 두 비선형/적응 제어법과 비교한다.

• Clinical and Experimental Pediatrics
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• 제59권sup1호
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• pp.25-28
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• 2016

Phelan-McDermid syndrome is a rare genetic disorder caused by the terminal or interstitial deletion of the chromosome 22q13.3. Patients with this syndrome usually have global developmental delay, hypotonia, and speech delays. Several putative genes such as the SHANK3, RAB, RABL2B, and IB2 are responsible for the neurological features. This study describes the clinical features and outcomes of Korean patients with Phelan-McDermid syndrome. Two patients showing global developmental delay, hypotonia, and speech delay were diagnosed with Phelan-McDermid syndrome via chromosome analysis, fluorescent in situ hybridization, and multiplex ligation-dependent probe amplification analysis. Brain magnetic resonance imaging of Patients 1 and 2 showed delayed myelination and severe communicating hydrocephalus, respectively. Electroencephalography in patient 2 showed high amplitude spike discharges from the left frontotemporoparietal area, but neither patient developed seizures. Kidney ultrasonography of both the patients revealed multicystic kidney disease and pelviectasis, respectively. Patient 2 experienced recurrent respiratory infections, and chest computed tomography findings demonstrated laryngotracheomalacia and bronchial narrowing. He subsequently died because of heart failure after a ventriculoperitoneal shunt operation at 5 months of age. Patient 1, who is currently 20 months old, has been undergoing rehabilitation therapy. However, global developmental delay was noted, as determines using the Korean Infant and Child Development test, the Denver developmental test, and the Bayley developmental test. This report describes the clinical features, outcomes, and molecular genetic characteristics of two Korean patients with Phelan-McDermid syndrome.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2013년도 제45회 하계 정기학술대회 초록집
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• pp.273-273
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• 2013

Recently, Point-of-care (POC) testing microdevices enable to do the patient monitoring, drug screening, pathogen detection in the outside of hospital. Immunochromatographic strip (ICS) is one of the diagnostic technologies which are widely applied to POC detection. Relatively low cost, simplicity to use, easy interpretations of the diagnostic results and high stability under any circumstances are representative advantages of POC diagnosis. It would provide colorimetric results more conveniently, if the genetic analysis microsystem incorporates the ICS as a detector part. In this work, we develop a reverse transcriptase-polymerase chain reaction (RT-PCR) microfluidic device integrated with a ROSGENE strip for colorimetric influenza H1N1 virus detection. The integrated RT-PCR- ROSGENE device is consist of four functional units which are a pneumatic micropump for sample loading, 2 ${\mu}L$ volume RT-PCR chamber for target gene amplification, a resistance temperature detector (RTD) electrode for temperature control, and a ROSGENE strip for target gene detection. The device was fabricated by combining four layers: First wafer is for RTD microfabrication, the second wafer is for PCR chamber at the bottom and micropump channel on the top, the third is the monolithic PDMS, and the fourth is the manifold for micropump operation. The RT-PCR was performed with subtype specific forward and reverse primers which were labeled with Texas-red, serving as a fluorescent hapten. A biotin-dUTP was used to insert biotin moieties in the PCR amplicons, during the RT-PCR. The RT-PCR amplicons were loaded in the sample application area, and they were conjugated with Au NP-labeled hapten-antibody. The test band embedded with streptavidins captures the biotin labeled amplicons and we can see violet colorimetric signals if the target gene was amplified with the control line. The off-chip RT-PCR amplicons of the influenza H1N1 virus were analyzed with a ROSGENE strip in comparison with an agarose gel electrophoresis. The intensities of test line was proportional to the template quantity and the detection sensitivity of the strip was better than that of the agarose gel. The test band of the ROSGENE strip could be observed with only 10 copies of a RNA template by the naked eyes. For the on-chip RT-PCR-ROSGENE experiments, a RT-PCR cocktail was injected into the chamber from the inlet reservoir to the waste outlet by the micro-pump actuation. After filling without bubbles inside the chamber, a RT-PCR thermal cycling was executed for 2 hours with all the microvalves closed to isolate the PCR chamber. After thermal cycling, the RT-PCR product was delivered to the attached ROSGENE strip through the outlet reservoir. After dropping 40 ${\mu}L$ of an eluant buffer at the end of the strip, the violet test line was detected as a H1N1 virus indicator, while the negative experiment only revealed a control line and while the positive experiment a control and a test line was appeared.

• 대한토목학회논문집
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• 제28권1D호
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• pp.107-117
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• 2008

민간투자사업의 자본구조는 사업시행자가 출자한 자기자본과 대출금융기관으로부터 조달한 타인자본으로 구성된다. 민간투자사업 기본계획에서는 사업시행자의 최소 자기자본비율을 25%로 규정하고 있으며, 일반적으로 정부와 사업시행자 간의 실시협약을 통하여 자본구조를 결정하게 된다. 그러나 민간투자사업의 자본구조는 사업의 수익률과 재무적 안정성을 결정하는 중요한 기준이기 때문에 자금조달계획 수립 시 자본구조에 따른 수익률의 변동성을 파악하고 적정 수익률과 재무적 안정성을 고려하여 자본구조를 최적화할 필요가 있다. 본 연구는 민간투자사업의 수익률과 재무적 안정성을 동시에 극대화할 수 있도록 자본구조를 최적화하기 위한 방법론을 제시하는데 그 목적이 있다. 이를 위하여 기존 민간투자사업들의 자본구조를 고찰하고 민간투자사업 재무모델을 분석하였다. 재무분석을 바탕으로 최적 자본구조를 결정하기 위해 효용함수 개념과 다목적 유전자 알고리즘을 이용한 자본구조 최적화모델을 제시하였다. 제시된 최적화 모델을 인천공항철도 민간투자사업에 적용하여 최적 자본구조를 도출하였고 민감도 분석과 시나리오 분석을 통해 그 활용성을 검증하였다. 사례분석 결과, 최적 자기자본비율은 실시협약에서 결정된 30%보다 낮은 22.3%에서 결정되었으며 이는 자기자본비율을 더 낮추어도 수익률과 재무적 안정성을 유지할 수 있다는 것을 시사한다. 본 연구는 수익률과 재무적 안정성을 동시에 고려하여 최적 자본구조를 결정함으로써 민간투자사업의 사업시행자에 적합한 자본구성과 자금조달을 위한 합리적인 의사판단 기준을 제시하였으며 사업시행자의 수익률 향상에 기여할 것으로 기대된다.

• 대한토목학회논문집
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• 제26권3D호
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• pp.409-416
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• 2006

VMS를 통해 제공되는 실시간 교통정보는 운전자의 통행경로선택에 영향을 주는 것으로 알려져 있으며, 이에 따라 VMS 정보를 이용한 운전자 통행경로 제어를 통해 도로망 전체의 운영효율을 최적화하고자하는 다양한 연구들이 이루어져 왔다. 본 연구에서는 실시간으로 주기별로 최적화된 메시지의 내용을 VMS에 표출할 때 도로망 전체의 총 통행시간을 최소화할 수 있는 운전자 경로선택행태 모형을 개발하였다. 우선 운전자의 경로선택을 현실감 있게 반영하기 위해 Stated Preference(SP) 조사를 바탕으로 하여 개발하였다. VMS를 통해 제공되는 메시지 내용과 표출주기가 주어졌을 때 최적의 VMS 정보제공 조합은 유전자 알고리즘을 이용하여 구했으며, 최적해 산출과정에서 필요한 교통분석은 미시적 교통시뮬레이션인 파라믹스를 이용하였다. 실험결과를 살펴보면 모든 시나리오에서 본 모형이 효과적으로 최적해를 찾아가는 것으로 나타났다. VMS 설치 전후를 비교하면 VMS를 운영하였을 때 도로망의 총 통행시간을 줄일 수 있는 것으로 나타났으며, VMS 정보의 표출주기가 짧을수록 VMS 메시지 내용의 개수가 작은 것이 총 통행시간을 감소시키는데 유리한 것으로 분석되었다.

• 보험의학회지
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• 제29권2호
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• pp.29-32
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• 2010

Moyamoya disease (MMD) is a progressive occlusive disease of the cerebral vasculature with particular involvement of the circle of Willis and the arteries that feed it. MMD is one of cerebrovacular accident,which is treated with sugical maeuver in pediatic neurosurgery. Moyamoya (ie, Japanese for "puff of smoke") characterizes the appearance on angiography of abnormal vascular collateral networks that develop adjacent to the stenotic vessels. The steno-occlusive areas are usually bilateral, but unilateral involvement does not exclude the diagnosis. The exact etiology of moyamoya disease is unknown. Some genetic predisposition is apparent because it is familial 10% of the time. The disease may be hereditary and multifactorial. It may occur by itself in a previously healthy individual. However, many disease states have been reported in association with moyamoya disease, including the following: 1) Immunological - Graves disease/thyrotoxicosis 2) Infections - Leptospirosis and tuberculosis 3) Hematologic disorders - Aplastic anemia, Fanconi anemia, sickle cell anemia, and lupus 4) Congenital syndromes - Apert syndrome, Down syndrome, Marfan syndrome, tuberous sclerosis, Turner syndrome, von Recklinghausen disease, and Hirschsprung disease 5) Vascular diseases - Atherosclerotic disease, coarctation of the aorta and fibromuscular dysplasia, 6)cranial trauma, radiation injury, parasellar tumors, and hypertension etc. These associations may not necessarily be causative but do warrant consideration due to impact on treatment.(Mainly neurosurgical operation.) The incidence of moyamoya disease is highest in Japan. The prevalence of MMD is 1 person per 100,000 population. The prevalence and incidence of moyamoya disease in Japan has been reported to be 3.16 cases and 0.35 case per 100,000 people, respectively. With regard to sex, the female-to-male ratio is 1.4:1. A bimodal peak of incidence is noted, with symptoms occurring either in the first decade(5-10yr) or in the third and fourth decades (30-40yr)of life. Mortality rates of moyamoya disease are approximately 10% in adults and 4.3% in children. Death is usually from hemorrhage. In aspect of life insurance, MR is 1700%, EDR is 16 per 1000 persons. Children and adults with moyamoya disease (MMD) may have different clinical presentations. The symptoms and clinical course vary widely from asymptomatic to transient events to severe neurologic deficits. Adults experience hemorrhage more commonly; cerebral ischemic events are more common in children. Children may have hemiparesis, monoparesis, sensory impairment, involuntary movements, headaches, dizziness, or seizures. Mental retardation or persistent neurologic deficits may be present. Adults may have symptoms and signs similar to those in children, but intraventricular, subarachnoid, or intracerebral hemorrhage of sudden onset is more common in adults. Recently increasing diagnosis of MMD with MRI, followed by surgical operation is noted. MMD needs to be considered as the "CI" state now in life insurance fields.