• Title/Summary/Keyword: Gene regulation

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Polyamine Prevent Apoptotic Cell Death by Regulation of Apoptosis Related Gene Expression in Porcine Parthenotes

  • Cui, Xiang-Shun;Jin, Yong-Xun;Hwang, Kyu-Chan;Kim, Nam-Hyung
    • Proceedings of the KSAR Conference
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    • 2004.06a
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    • pp.230-230
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    • 2004
  • Polyamines, namely putrescine, spermidine, and spermine, are biogenic low-molecular-weight aliphatic amines. Polyamines play important roles in DNA stabilization, RNA and protein synthesis, membrane stabilization, modulation of ion channels, and protection against oxygen radicals and are essential for cell homeostasis, cell growth, and tumorigenesis. (omitted)

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Mechanism of E. coli RNA polymerase-promoter interactions

  • Roe, Jung-Hye;Record.Jr, M.Thomas
    • The Microorganisms and Industry
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    • v.13 no.1
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    • pp.4-9
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    • 1987
  • The regulation of gene expression in procaryotes is accomplished primarily at the level of transcription. Initiation of transcription is subject to numerous promoter-specific controls which act to ensure coordinate expression of disparate genes. The kinetics of formation of a functional("open") complex at a promoter, prior to the catalytic steps of RNA chain initiation and elongation, is thought to play a major role in controlling the efficiency of transcription of that promotor, since the subsequent processes of nucleotide binding and phosphodiester bond formation are rapid and are not promoter-specific (Mangel and Chamberlin, 1974 Shimamoto et al., 1981)

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REGULATION OF MUSCARINIC RECEPTOR-MEDIATED sAPP RELEASE BY PLA2- RELATED PATHWAYS.

  • Cho, Hye-Won;Kim, Hwa-Jung
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.198-199
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    • 2003
  • Chronic inflammatory processes are associated with pathology of Alzheimer's disease(AD). The expression of both cyclooxygenase-2(COX-2) and phospholipase A2(PLA2) appears to be strongly activated during AD, indicating the importance of inflammatory gene pathways as a response to brain injury. Stimulation of heterotrimeric G protein-coupled receptors including muscarinic receptors activates cytosolic PLA2 and receptor-mediated activation of PLA2 generates free fatty acids (i.e., arachidonic acid). (omitted)

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Control of Influenza: Live Vaccine Development

  • Seong, Baik-Lin
    • Proceedings of the PSK Conference
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    • 2002.10a
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    • pp.149-150
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    • 2002
  • Despite various efforts on improving vaccines and antivirals, influenza epidemics continue to afflict many people, causing widespread morbidity and mortality in the young and the elderly. Since the discovery of the unusual 'cap-stealing'mechanism of transcription, significant advances were made on molecular aspects of influenza gene regulation. This provides new insights for developing new antiviral compounds. Reverse genetic technologies have also been advanced for generating recombinant chimeric viruses suitable for designing live vaccine. (omitted)

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Sodium Chloride Regulation of COX-2 gene expression is independent of aldosterone activated mineralocorticoid receptor

  • Lim, Won-Chung;Park, Wan-Kyu;Lee, Young-Joo
    • Proceedings of the PSK Conference
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    • 2003.04a
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    • pp.190.2-191
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    • 2003
  • Production of prostaglandins involved in renal salt and water homeostasis is modulated by regulated expression of the inducible form of cyclooxygenase-2 (COX-2) at restricted sites in the rat kidney. COX-2 expression in the kidney is regulated by dietary salt intake, but the mechanism of its action is not fully understood. We have previously that high salt regulates COX-2 expression in rat kidney. (omitted)

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