• 수면정신생리
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• 제18권1호
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• pp.35-39
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• 2011

목 적: 일중선호도는 하루 중 어느 시간대에 각성도가 높고 활기찬 지에 대한 경향으로 아침형-저녁형이라고도 알려져있다. PER3 유전자는 일중선호도에 영향을 주는 것으로 알려져 왔다. 본 연구에서 우리는 젊고 건강한 피험자들에서 환경과 혼란요인들을 통제하고 PER3 유전자 다형성과 일중선호도간에 연관을 연구하였다. 방 법: 연구에 참여한 대상자는 299명의 의과대학생들(남자 299, 여자 191명)이며 평균연령은 22.9세였다. 일중선호도는 13개 문항의 Composite Scale for Morningness (CSM)로 측정하였다. PER3 VNTR(rs57875989)의 유전자형분석은 중합효소연쇄반응법을 사용하여 이루어졌다. 양측검정으로 유의수준은 p<0.05로 하였다. 결 과: 전체 대상자에 대한 CSM 점수는 31.90${\pm}$6.39 (평균${\pm}$표준편차)였다. 남녀간에 CSM 총점에 유의한 차이는 없었다. PER3 5R/5R에서 CSM 점수가 높은 경향을 보였으나, PER3 VNTR(rs57875989) 유전자형과 대립유전자에 따른 CSM 점수의 유의한 차이는 없었다. 결 론: 본 연구는 젊은 건강한 한국인에서 PER3 V- NTR과 일중선호도간의 연관을 입증하지 못했다. 향후 보다 대규모의 피험자들을 대상으로 PER3의 여러 유전자들에 대해 다형성과 일중선호도간의 연관에 대한 연구가 필요할 것으로 생각된다.

• Asian Pacific Journal of Cancer Prevention
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• 제14권10호
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• pp.6165-6171
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• 2013

This study aimed to analyze the expression and clinical significance of cyclin G2 (CCNG2) in thyroid carcinoma and the biological effects of CCNG2 overexpression in a cell line. Immunohistochemistry and Western blotting were used to analyze CCNG2 protein expression in 63 cases of thyroid cancer and normal tissues to allow the relationship with clinical factors to be assessed. CCNG2 lentiviral and empty vectors were transfected into the thyroid cancer K1 cell line. Reverse transcription-polymerase chain reaction (RT-PCR) and Western blotting were applied to detect the mRNA and protein levels of CCNG2. MTT assay and cell cycle were also conducted to assess the influence of up-regulated expression of CCNG2 on K1 cell biology. The level of CCNG2 protein expression was found to be significantly lower in thyroid cancer tissue than normal tissues (P<0.05). Western blot: The relative amount of CCNG2 protein in thyroid cancer tissue was respectively found to be significantly lower than in normal tissues (P<0.05), correlating with lymph node metastasis, clinic stage and histological grade (P<0.05), but not gender, age or tumor size (P>0.05). Loss of CCNG2 expression correlated significantly with poor overall survival time on Kaplan-Meier analysis (P<0.05). The results for biological functions showed that K1 cell transfected CCNG2 had a lower survival fraction, a greater percentage in the G0/G1 phases, and lower cyclin-dependent kinase 2 (CDK2) protein expression compared with K1 cells non-transfected with CCNG2 (P<0.05). CCNG2 expression decreased in thyroid cancer and correlated significantly lymph node metastasis, clinic stage, histological grade and poor overall survival, suggesting that CCNG2 may play important roles as a negative regulator in thyroid cancer K1 cells by promoting degradation of CDK2.

• Asian-Australasian Journal of Animal Sciences
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• 제21권6호
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• pp.861-867
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• 2008

The objective of this study was to evaluate the effect of exogenous ghrelin on the behaviors, weight gain, and feed intakes of weanling piglets. A total of 25 pairs of Duroc$\times$Landrace$\times$Large White piglets weaned at 21 days of age were used in this experiment which finished on day 36. Each pair of healthy piglets from the same litter with similar body weight and of the same gender were selected and randomly arranged to ghrelin or control groups. Thus, there were 50 piglets (ghrelin 25; control 25) kept in 10 pens (ghrelin 5; control 5) and 5 piglets per pen. Initial body weight of the pigs did not differ between the control and ghrelin treatment ($7.43{\pm}0.17kg$; p = 0.81). Experimental pigs were infused with ghrelin ($1{\mu}g/d$ pig) via the marginal ear vein between 0750 and 0800 h at 22, 23, 24 days of age. Control pigs were infused with 0.9% saline. Feed consumption was measured on days 23, 24, 25, 29 and 36. Body weight was measured on days 22, 23, 24, 25, 29 and 36. Behavior data of individual piglets were collected by real-time observation from 0800-1500 h through remote supervisory equipment at 22, 23 and 24 days of age. The results indicated that ghrelin infusion could increase drinking (p<0.05) and lying behaviors (p<0.01) and decrease mounting behaviors (p<0.05). No significant influence of ghrelin was found on average daily weight gain (ADG) and average daily feed intake (ADFI) in this experiment (p>0.05). In conclusion, exogenous ghrelin by the method above and at the dosage of $1{\mu}g/d$ pig could cause a variety of behavioral effects, but not improve performance of weanling piglets.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.717-723
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• 2014

Background: This study was carried out to investigate the interaction of p53 codon 72 polymorphism, dietary and tobacco habits with reference to risk of stomach cancer in Mizoram, India. A total of 105 histologically confirmed stomach cancer cases and 210 age, sex and ethnicity matched healthy population controls were included in this study. Materials and Methods: The p53 codon 72 polymorphism was detected by PCR-RFLP and sequencing. H. pylori infection status was determined by ELISA. Information on various dietary and tobacco related habits was recorded with a standard questionnaire. Results: This study revealed that overall, the Pro/Pro genotype was significantly associated with a higher risk of stomach cancer (OR, 2.54; 95%CI, 1.01-6.40) as compared to the Arg/Arg genotype. In gender stratified analysis, the Pro/Pro genotype showed higher risk (OR, 7.50; 95%CI, 1.20-47.0) than the Arg/Arg genotype among females. Similarly, the Pro/Pro genotype demonstrated higher risk of stomach cancer (OR, 6.30; 95%CI, 1.41-28.2) among older people (>60 years). However, no such associations were observed in males and in individuals <60 years of age. Smoke dried fish and preserved meat (smoke dried/sun dried) consumers were at increased risk of stomach cancer (OR, 4.85; 95%CI, 1.91-12.3 and OR, 4.22; 95%CI, 1.46-12.2 respectively) as compared to non-consumers. Significant gene-environment interactions exist in terms of p53 codon 72 polymorphism and stomach cancer in Mizoram. Tobacco smokers with Pro/Pro and Arg/Pro genotypes were at higher risk of stomach cancer (OR, 16.2; 95%CI, 1.72-153.4 and OR, 9.45; 95%CI, 1.09-81.7 respectively) than the non-smokers Arg/Arg genotype carriers. The combination of tuibur user and Arg/Pro genotype also demonstrated an elevated risk association (OR, 4.76; 95%CI, 1.40-16.21). Conclusions: In conclusion, this study revealed that p53 codon 72 polymorphism and dietary and tobacco habit interactions influence stomach cancer development in Mizoram, India.

• 대한치과교정학회지
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• 제30권6호
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• pp.699-712
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• 2000

림프조직은 비인두 부위에서 Waldeyer's ring의 일부조직으로 tonsil을 이루며 정상적으로 존재한다. 이러한 림프조직이 임상적인 증상을 나타낼 정도로 과증식한 것을 'Adenoid vegetation or Adenoids'라고 이른다. 아데노이드는 일반적으로 유년기에 발생하며 $2\~12$세때 특징적인 증상을 보인다. 사춘기시기에 이르면 절대적인 아데노이드 크기 감소와 주변의 비인두의 성장으로 인한 상대적 크기 감소가 나타난다. 그리하여 성인이 되면 아데노이드는 퇴화된 상태로 변하게 된다. 아데노이드는 구호흡의 주요한 원인 중 하나이며, '아데노이드 얼굴'이라는 특징적인 안면형태를 야기한다고 알려져 있다. 아데노이드에 의한 구호흡이 안면 형태와 치열에 영향을 미칠 수 있다는 주장은 오래 전부터 제기되고 있으나, 여러 가지 복합적인 원인으로 이들간의 상호연관정도를 정확히 알기가 어려웠다. 이에 본 연구에서는 정상 교합 아동에서의 골 연령에 따라 아데노이드와 악골 크기의 정상치와 성장변화량을 제시하고 이들간의 상관관계를 알아보았으며 다음과 같은 결과를 얻었다. 1. 골 연령에 따른 남녀별 계측항목의 평균과 표준편차를 얻었다. 2. 같은 골연령을 비교시 남자는 여자보다 약 2년 가량 성장속도가 느렸다. 3. 비인두의 height과 depth는 남자에서는 CVMI 1과 2 때 많은 성장을 보이고, CVMI 4 이후에서는 성장을 보이지 않았으며, 여자에서는 모든 골 연령에서 유사한 정도의 성장이 나타났다. 4. 비인두의 상대적 면적은 남자에서 CVMI 1에서 2로 이행되는 시기에 유의한 증가를 보였다. 5. 비기도의 상대적 면적과의 상관분석에서 남녀 모두에서 아데노이드 항목중에서는 Ad2와 관련된 항목과 uppe pharynx가 높은 상관관계를 보였으며, 치열궁과 관련된 항목중에는 상$\cdot$하악의 견치간 너비, 상악의 대구치간 너비, 구개정 높이가 상관관계가 있었다.

• 대한간호
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• 제36권2호
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• pp.73-83
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• 1997

Bed rest is recommended to prevent postlumbar puncture headaches(PLPHA), but the period of bed rest varies in the literature from 6 hours to 24 hours. In clinical practice the period of bed rest varies but nursing methods for adults and children have little difference. In Seoul National University Hospital, children have been given at least 6 hours bed rest after a lumbar puncture. Pediatric oncology patients require a lumbar puncture for an initial diagnosis, follow up treatment or administration of chemotherapeutic agent. But it is difficult for young children to lie supine or to refrain from their usual activities in any way, and unpleasant problems related to a shortage of beds often occurs during discharge or in an outpatient setting. The purpose of this study is to substantiate the preventive effect of PLPHA by the period of bed rest, to identify the other factors that influence PLPHA, and to use the nursing methods proper to children. The subjects were 65 children, ages 1-17, undergoing treatment in the children's cancer center at SNUCH during the period June 1, 1995, to Aug. 31, 1995. The team nurses asked questions about PLPHA of the parents and children in order to fill out a questionnaire. The data were evaluated by percent, t-test, Chi-square test and Mann-Whitney U test. Result; 1. There was no significant difference relating the bed rest time spent to the occurrence of postspinal headaches (t-test). 2. There was a significant risk of PLPHA in the children who were irritable before procedure and/or had experienced previous PLPHA(p<0.05, ${x^2}-test$). 3. The following factors were not found to be associated with increased risk of PLPHA: previous puncture experience, giving analgesics, the choice of puncturist, inpatient/outpatient status, gauge of needle, purpose, the amount of CSF removed, gender, diagnosis, the number of peripheral WBCs, previous lumbago experience after LP, position after bed rest, age, the number of aural puncture at the time. A longer period of bed rest is unlikely to be more effective to prevent PLPHA and seems impractical. A shorter period will save time and effort. Perhaps it will also allay some of the fears which surround LP. So 1 hour bed rest after LP is suggested and nursing methods for emotional support should be investigated to reduce PLPH.

• 한국산학기술학회논문지
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• 제19권9호
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• pp.156-165
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• 2018

본 연구는 전문대학생의 셀프리더십과 거부민감성이 주관적 삶의 질에 미치는 영향을 파악하여 기초자료를 제공하고자 한다. 일개 대학 전문대학생에게 2016년 11월 14일부터 11월 30일까지 기혼자와 간호학과 학생을 제외하고 설문 조사를 실시한 결과, 불성실한 응답을 제외하고 총 607명 응답을 분석하였다. 자료는 SPSS 18.0 버전으로 t-test, ANOVA, Pearson 상관계수와 단계적 다중회귀분석으로 분석하였다. 전문대학생의 주관적 삶의 질 정도는 4.1점(7점 기준)으로 여학생에 비해 남학생의 주관적 삶의 질이 높고(p=.021), 1학년인 경우가 그렇지 않은 경우보다 삶의 질이 낮았다(p<.001). 셀프리더십과 양의 상관관계(r=.279)를 보이고, 거부민감성과는 음의 상관관계 (r=-.224)를 나타내었다. 전문대학생의 주관적 삶의 질에 대한 회귀분석 결과, 전공만족도(${\beta}=32$, p<.001), 자연적 보상전략(${\beta}=23$, p<.001), 성별(${\beta}=.17$, p<.001), 예기불안(${\beta}=-.15$, p<.001) 및 학년(${\beta}=.14$, p<.001)순으로 통계적으로 유의하였으며, 이에 대한 설명력은 27.6%이었다. 추후 전문대학생의 주관적인 삶의 질을 향상시키기 위해 셀프리더십과 거부민감성에 대한 교육프로그램을 개발하여 적용하는 것이 필요할 것이다. 또한, 신입생과 여학생의 경우에 삶의 질을 향상시키기 위해 보다 각별한 관심이 요구되는 바이다.

• 한국산학기술학회논문지
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• 제21권4호
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• pp.109-116
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• 2020

본 연구는 간호대학생의 진로동기, 유머감각, 문제해결능력이 정신건강에 미치는 영향을 확인하여 정신건강을 향상시키기 위한 기초자료를 제공하기 위하여 시도되었다. 연구대상자는 B, Y시의 간호대학생 253명을 대상으로 하였다. 자료수집은 2018년 10월 22일부터 10월 31일까지 였다. 수집된 자료는 SPSS 22.0 program을 이용하여 실수, 백분율, 평균, 표준편차, t-검증, 일원분산분석, 피어슨 상관계수, 다중회귀분석으로 분석하였다. 연구결과 대상자의 정신건강은 평균 2.19±0.77점으로 나타났다. 대상자의 일반적 특성에 따른 정신건강의 차이는 성별(F=2.219, p=.027), 학년(F=7.142, p<.001), 용돈(F=5.055, p=.007), 학교 성적(F=4.322, p=.014), 동료와의 관계(F=23.561, p<.001), 건강상태(F=21.555, p<.001)에서 유의한 차이가 나타났다. 대상자의 정신건강은 진로동기(r=-.443, p<.001), 유머감각(r=-.400, p<.001), 문제해결능력(r=-.465, p<.001)와 부적 상관관계를 나타냈다. 대상자의 정신건강에 영향을 미치는 요인은 성별(β=-.121, p=.033), 용돈(β=.123, p=.028), 동료와의 관계(β=.165, p=.004), 유머감각(β=-.168, p=.012), 문제해결능력(β=-.186, p=.006)으로 나타났고, 설명력은 33.6%로 나타났다. 본 연구결과를 통하여 간호대학생의 정신건강에 영향을 미치는 다양한 요인을 확인하는 연구가 필요하다. 또한 일반적 특성, 자신을 조절할 수 있는 심리적 요인, 학습을 통해 획득할 수 있는 기술적인 요인을 확인하는 반복연구를 통해 정신건강을 향상시킬 수 있는 중재방안을 개발하는 것이 필요하다.

• 재활간호학회지
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• 제6권1호
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• pp.51-60
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• 2003

This study was a descriptive research in search of a nursing intervention scheme to improve stroke patients' quality of life by understanding the relationship of stroke patients' ADL, depression, self-efficacy and quality of life with various variables and identifying factors that affect their quality of life. Each subject was interviewed one to one based on a structured questionnaire. With regard to research tools, Modified Barthel Index (MBI: Fortinsky et al., 1981), which was translated by Choi, Hye-sook (1996), was used in measuring ADL, Randloff's (1977) tool, which was translated by Choi, Soon-hee, was used in measuring depression, and the tool developed by Sherer et al. (1982), which is to measures self-efficacy under general conditions not limited to specific conditions, and modified by O, Bok-ja (1994) was used in measuring self-efficacy. The quality of life was measured using the scale of satisfaction of life developed by Diener et al. (1985). The results of this study were as follows: 1. The means of ADL of the subjects was $79.5{\pm}31.9$, depression $26.8{\pm}10.4$, self-efficacy $47.1{\pm}25.7$, and the quality of life $12.3{\pm}4.9$. 2. The subjects' quality of life showed a statistically significant difference according to gender (t=7.9, p= .006), satisfaction with income (F=5.8, p= .004), the burden of medical fee (F=3.7, p= .028) and the period of disease (F=2.8, p= .042). 3. With regard to relationship among ADL, depression, self-efficacy and the quality of life, ADL was in a relatively low positive correlation (r= .293, p= .003) with and the quality of life, depression in a high negative correlation (r=- .634, p= .000) with the quality of life, and self-efficacy in a positive correlation with the quality of life (r= .388, p= .000). 4. Factors that made a significant influence on the quality of life were depression (B=- .309, p= .001) and satisfaction with income (B=-2.611, p= .001). Based on these results, this study made following suggestions: 1. It is necessary to run rehabilitation programs to improve stroke patients' ADL, depression and self-efficacy. 2. It is necessary to perform research of monitoring stroke patients' quality of life in various areas using measuring tools.

• 한국치위생학회지
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• 제9권3호
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• pp.426-438
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• 2009

The purpose of this study was to examine the relationship of the general characteristics of dental patients to their total O'Leary index and individual plaque indexes in a bid to check the oral hygiene state of citizens and evaluate their plaque management ability. The subjects in this study were 288 patients at dental hospitals and clinics in Busan and South Gyeongsang Province. A survey was conducted from September to November 2008. The findings of the study were as follows: 1. Overall, the O'Leary index of the patients investigated stood at 72 percent. By age and gender, the O'Leary index was highest among those in their 30s(83%) and among the women(75%)(p<.05). As to the influence of toothbrushing frequency, the patients who did it twice or more a day had the highest O'Leary index(75%)(p<.001). By the use of oral hygiene supplies, the patients who used oral hygiene supplies had a higher O'Leary index(76%) than the others who didn't(p<.01). 2. As for plaque index for each tooth, 28 percent of their teeth were given zero point, and 52 percent were given one mark. 13 percent were given two marks, and 6.3 percent were given three marks. Thus, the teeth that were given one mark were largest in number(p<.001). 3. As for plaque index for labial posterior mandibular, 43 percent of their teeth were given one point, and 36 percent were given zero mark. 14 percent were given three mark, and 5 percent were given three marks(p<.01). 4. As for plaque index for buccal posterior maxilla, 57 percent of their teeth were given one point, and 20 percent were given zero mark. 16 percent were given two mark, and 6.3 percent were given three marks(p<.01). 5. As for plaque index for lingual posterior mandibular, 56 percent of their teeth were given one point, and 27.8 percent were given zero mark. 9 percent were given three mark and 6 percent were given three mark(p<.001).