• 한국연초학회지
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• 제35권1호
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• pp.56-61
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• 2013

Bryonia alba L. belongs to the Cucurbitaceae family and grows in Europe, Asia, America, Africa, Russia, Ukraina and Armenia. The root of Bryonia alba has been used for neuropsychical diseases, psychosis, hysteria, paralysis, epilepsy, vertigo, headache, migrain, melancholia, forgetfulness, sadness, absent mindedness, delirium, cardiovascular disease, ischemia, gastrointestinal diseases, gastric ulcer and respiratory diseases. The root of Bryonia alba contains an oxidized tetra cyclic triterpens, cucurbitaceous, polyunsaturated hydrocarbons, phospholipids, phosphatidylcholines, ethereal oils, fatty acids, a great amount of amino acids, alcohol soluble enzymes, sugar, carotene, vitamin C and E. Bryonia alba increases coronary blood-flow and the amplitude of cardiac contractions. Bryonia alba has an antistressor action and increases the working capacity. Bryonia alba activates connective tissue cells. Bryonia alba markedly increases the oxygen consumption by young and senescent rat brain, liver as well as heart mitochondrial fraction as Korean Ginseng. Bryonia alba decreases lipid peroxidation after immobilization stress. In conclusion, Bryonia alba like Ginseng used in traditional medicine came from ancient time has a good perspective administration as prophylactic and medical remedy, as remedy of lot of diseases in modern medicine.

• Journal of Acupuncture Research
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• 제25권1호
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• pp.169-178
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• 2008

Objectives : Dong-si acupuncture therapy is being widely used because of good clinical result. The purpose of this study was to compare the location and efficacy of Dong-si acupoints and 14 meridian acupoints. Conclusions : 1. Dong-si acupoints on the lower extremity total 83. Among them, 16 acupoints are the same as 14 meridian acupoints. 2. Between the same location points, the efficacy of each Dong-si acupoints is similar to that of each of the 14 meridian acupoints in cases of musculoskeletal pain diseases, paralytic diseases, urogenital diseases, and gastrointestinal diseases. 3. Dr. Dong studied deeply into the 14 meridian acupoints and created Dong-si acupuncture therapy. He said that the distribution of acupuncture points was closely related to the 14 meridians. 4. I think that we are able to apply Dong-si acupuncture therapy to clinical use widely by comprehending the character of the 14 meridian acupoints and each meridians.

• Clinical and Experimental Pediatrics
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• 제50권5호
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• pp.416-421
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• 2007

Many previous studies have proved that human allergic disease resulted from the formation of antibodies belonging to a unique immunoglobulin isotype termed immunoglobulin E (IgE). Most of IgE-producing plasma cells are found in the lymphoid tissue associated with the gastrointestinal and respiratory tracts. IgE may be found free in the mucosal secretions of these tissues, bound to local mast cells, or distributed by the systemic circulation to mast cells and basophils throughout the body. Total serum IgE concentrations tend to be higher in allergic adults and children compared with non-allergic individuals, but the value of total serum IgE as a screening test for allergic disease is limited. Total serum IgE levels are related to the probability of an individual having detectable allergen-specific IgE. Allergen-specific IgE concentrations vary with a person's age, the degree and duration of the recent allergen or cross-reactive allergen exposure. The value of quantitative assays for allergen-specific IgE has been suggested in recent studies. Serum IgE increases in many non-allergic diseases, including infectious and parasitic diseases. The IgE changes appear to be specific to the infectious agents, whereas non-specific in other diseases. The increased serum IgE in some of these conditions probably results from alterations in immune function. This review summarizes the clinical significance of total and allergen-specific IgE examinations in allergic diseases.

• Allergy, Asthma & Immunology Research
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• 제10권6호
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• pp.575-590
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• 2018

The prevalence of allergic disorders has dramatically increased over the past decade, particularly in developed countries. Apart from gastrointestinal disorders, neoplasia, genital and dermatological diseases etc., dysregulation of gut microbiota (dysbiosis) has also been found to be associated with increased risk of allergies. Probiotics are increasingly being employed to correct dysbiosis and, in turn, to modulate allergic diseases. However, several factors like strain variations and effector metabolites or component of them in a bacterial species can affect the efficacy of those as probiotics. On the other hand, host variations like geographical locations, food habits etc. could also affect the expected results from probiotic usage. Thus, there is a glaring deficiency in our approach to establish probiotics as an irrefutable treatment avenue for suitable disorders. In this review, we explicate on the reported probiotics and their effects on certain allergic diseases like atopic dermatitis, food allergy and asthma to establish their utility. We propose possible measures like elucidation of effector molecules and functional mechanisms of probiotics towards establishing probiotics for therapeutic use. Certain probiotics studies have led to very alarming outcomes which could have been precluded, had effective guidelines been in place. Thus, we also propose ways to secure the safety of probiotics. Overall, our efforts tend to propose necessary discovery and quality assurance guidelines for developing probiotics as potential immunomodulatory 'Pharmabiotics.'

• 대한의생명과학회지
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• 제26권4호
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• pp.327-335
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• 2020

As the interest in oral health is increasing with quality of life. The most representative oral diseases include dental caries, periodontal disease, and malocclusion, as well as dry mouth and oral mucosa. Cinnamaldehyde have an antioxidant effect that has been studied not only to treat rheumatism and hypertension, but also to protect liver, and gastrointestinal tract, but there are few studies related to the control of oral diseases. The purpose of this study was the effect of enhanced orofacial pain when oral administration of cinnamaldehyde in the oral diseases. Cinnamaldehyde (5, 12.5, 25, and 50 mg/kg) orally administered at a dose of 1 mL, and the change in biological response was confirmed after a week. In addition, 5% formalin (30, 50 μL) was injected into TMJ and subcutaneous areas of the whiskers of rats to observe the change in the threshold of the improved orofacial pain model. As a result of the experiment, in the xerostomia model, drinking water was decreased in the cinnamaldehyde-administered group, feed intake and weight increased, and saliva was also increased compared to the naïve group. In particular, the most significant increase trend was observed at the concentrations of 25 and 50 mg/kg. In addition, it was confirmed that the pain behavioral response of the orofacial area improved by oral diseases decreased depending on the concentration of cinnamaldehyde. Based on these results, cinnamaldehyde effectively reduced symptoms related to xerostomia and showed improved pain relief in the orofacial areas.

• Clinical Endoscopy
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• 제57권1호
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• pp.1-10
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• 2024

Barrett's esophagus (BE) is the precursor to esophageal adenocarcinoma (EAC), and is caused by chronic gastroesophageal reflux. BE can progress over time from metaplasia to dysplasia, and eventually to EAC. EAC is associated with a poor prognosis, often due to advanced disease at the time of diagnosis. However, if BE is diagnosed early, pharmacologic and endoscopic treatments can prevent progression to EAC. The current standard of care for BE surveillance utilizes the Seattle protocol. Unfortunately, a sizable proportion of early EAC and BE-related high-grade dysplasia (HGD) are missed due to poor adherence to the Seattle protocol and sampling errors. New modalities using artificial intelligence (AI) have been proposed to improve the detection of early EAC and BE-related HGD. This review will focus on AI technology and its application to various endoscopic modalities such as high-definition white light endoscopy, narrow-band imaging, and volumetric laser endomicroscopy.

• 대한예방한의학회지
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• 제18권2호
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• pp.11-30
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• 2014

Objective : To compare the differences in health behaviors by chronic diseases of middle-aged living in Seoul's low-income housing Method : Of the 1469 residents aged 35 to 60 living in low-income housing in Seoul's District A, 318 were equal probability of selection method selected. t-test, ANOVA, $x^2$, OR(95% CI, P-value) were selected to analyze the data, and the confidence interval was 5%. Results : There were no significant differences in all health behaviors by vascular and metabolic, But there was a statistically significant difference for gastrointestinal diseases caused by sleep hours(p=0.001), liver diseases caused by smoking, drinking and sleep hours(p=0.004, p=0.001, and p=0.033, respectively), musculoskeletal diseases caused by sleep hours and health exam(p=0.0000 and p=0.002, respectively). Also, statistically significant differences were found for tumors caused by sleep hours(p=0.004), depression by the sleep hours and health exam(p=0.001 and p=0.013, respectively), allergies by in sleep hours(p=0.004), thyroid diseases by smoking and health exam(p=0.013 and p=0.007, respectively). After adjusting for the confounding factors for diseases, OR was obtained for each health behavior. There were no statistically significant differences in all health behaviors for vascular, metabolic, and tumors. However, the OR for gastrointestinal diseases 4.10(1.63-10.36, 0.0028) and 2.96(1.05-8.41, 0.0041) at 5-7 and 7-9 sleep hours. The OR for liver diseases was 3.13(1.03-9.48, 0.0437) at 7-9 sleep hours, the OR values for musculoskeletal diseases were 2.91(1.23-6.88, 0.00149), and 4.46(1.68-11.86, 0.0027) at 5-7 and 7-9 sleep hours. OR for depression were 4.82(1.70-13.66, 0.0031) and 4.13(1.19-14.31, 0.0026) at 5-7 and 7-9 sleep hours. OR for allergy were 2.78(1.22-6.32, 0.0015) and 3.93(1.49-10.39, 0.0058) at 5-7 and 7-9 sleep hours. There were statistical significances for liver diseases for 1-2 times of health exam at 0.35(0.14-0.90, 0.00301), for liver diseases for 1-2 times of health exam at 0.35(0.14-0.90, 0.00301), for musculoskeletal diseases for 3-4 times of health exam at 0.26(0.09-0.79, 0.0175), for depression for 3-4 times of health exam at 0.17(0.04-0.66, 0.0106), for allergies for 1-2 times of health exam at 0.30(0.13-0.70, 0.0055), and for thyroid diseases for 1-2 times and annually of health exam at 0.07(0.01-0.60, 0.00154), 0.09(0.01-0.96, 0.0461). We known significant difference the health behaviors by the diseases. especially in sleep hours and health exam times Conclusion : Only sleep hours and health exam caused statistically significant differences in chronic diseases. but the sleep hours was postitively correlated with the risk of disease, while health exam were inversely related.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제14권2호
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• pp.130-136
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• 2011

Plain X-ray radiographs are the first line of investigation taken in the diagnosis of abdominal pathology and are considered an important diagnostic tool to provide guidelines for further imaging studies and comprehensive therapeutic management. Although most abdominal pathology demonstrates non-specific radiologic findings, the plain abdominal radiography is very useful in specific diseases, including certain gastrointestinal anomalies. This review provides image findings of normal plain abdominal radiography and some common abdominal pathology in infants and children.

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 1967년도 제6회 학술대회
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• pp.106.2-106.2
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• 1967

• Journal of Digestive Cancer Research
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• 제10권2호
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• pp.112-116
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• 2022

Idiopathic inflammatory myopathy (IIM) is known for its association with malignant diseases. Moreover, various solid organ malignancies, such as ovarian, breast, lung, esophageal, stomach, and colorectal cancers, have been reported to occur with IIM. Furthermore, its relationship with hematologic malignancies, including non-Hodgkin lymphoma, myeloma, and leukemia, has been reported. However, to date, IIM related to pancreatic cancer has scarcely been reported, particularly in patients with polymyositis (PM). Therefore, here we report a case of PM developed immediately after the diagnosis of pancreatic ductal adenocarcinoma.