• Nuclear Engineering and Technology
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• 제50권7호
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• pp.1154-1159
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• 2018

Precise prediction of the radiation interaction position in scintillators plays an important role in medical and industrial imaging systems. In this research, the incident position of the gamma rays was predicted precisely in a plastic rod scintillator by using attenuation technique and multilayer perceptron (MLP) neural network, for the first time. Also, this procedure was performed using nonlinear regression (NLR) method. The experimental setup is comprised of a plastic rod scintillator (BC400) coupled with two PMTs at two sides, a $^{60}Co$ gamma source and two counters that record count rates. Using two proposed techniques (ANN and NLR), the radiation interaction position was predicted in a plastic rod scintillator with a mean relative error percentage less than 4.6% and 14.6%, respectively. The mean absolute error was measured less than 2.5 and 5.5. The correlation coefficient was calculated 0.998 and 0.984, respectively. Also, the ANN technique was confirmed by leave-one-out (LOO) method with 1% error. These results presented the superiority of the ANN method in comparison with NLR and the other methods. The technique and set up used are simpler and faster than other the previous position sensitive detectors. Thus, the time, cost and shielding and electronics requirements are minimized and optimized.

• 한국시뮬레이션학회논문지
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• 제28권3호
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• pp.83-89
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• 2019

본 연구는 회전 비행체(Magnus rotor)를 탑재한 분산탄두의 분산 균일도에 미치는 요인 분석과 성능지표를 도출하기 위해 모탄의 속도 V와 회전속도 ${\omega}$, 비행경로각(flight path angle) ${\gamma}$ 그리고 고도 h의 변화에 따른 해석 결과를 기술했으며, 이때 모탄의 회전속도와 속도의 비를 새로운 변수로 정의했다. 자탄의 분산 해석에는 풍동실험을 통해 획득한 공력계수를 사용한 6 자유도 운동방정식을 이용했으며, 분산도 분석을 위해 회귀분석과 결정계수를 구해 분산도를 평가했다. 해석결과 최적의 회전속도와 낙하속도의 비, 비행경로각(flight path angle)을 구할 수 있었으며, 방출고도는 분산도에 회전속도와 낙하속도의 비, 비행경로각(flight path angle)의 영향에 비해 영향은 크지 않고, 자탄의 분산반경에 영향이 큰 것을 확인했다.

• 대한교통학회지
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• 제34권6호
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• pp.560-569
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• 2016

운전자의 정신부하는 교통사고를 감소하는데 중요한 역할을 하는 것으로 선행연구에서 나타나고 있다. 본 연구에서는 도로 및 환경요소 뿐만 아니라 운전자의 알파파, 베타파, 감마파를 측정할 수 있는 운전시뮬레이터를 활용하여 분석자료를 확보하였다. 운전자의 운전부하와 감마파의 연관성을 분석하기 위한 방법으로 로지스틱모형을 적용하였다. 분석결과, 도로의 커브가 많을수록 운전자의 베타 영역은 증가하는 반면 알파와 감마 영역은 감소되는 것으로 나타났다. 그리고, 운전부하는 감마영역과 음의 상관관계를 지닌 것으로 나타났다. 결론적으로, 직선구간에서의 도로주행이 운전자의 스트레스를 줄이고 행복감을 높일 수 있을 것으로 판단된다.

• Journal of Nutrition and Health
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• 제39권8호
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• pp.773-785
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• 2006

Vitamin E in the body system plays an important role in preventing chronic diseases by decreasing the oxidative stress by free-radicals. However, there are not enough researches on analyzing the primary factors affecting vitamin E levels in the blood in Korean adults. Therefore, the purpose of this research was to examine blood tocopherol levels and the primary factors affecting the status. A complete lifestyle survey was performed on 314 Korean adult men and surveyed their smoking, drinking and exercising habits. The average plasma level of ${\alpha}-\;and\;{\gamma}-tocopherol$ showed similar mutual relations with plasma total cholesterol (TC), triglyceride (TG), or low density lipoprotein cholesterol (LDL-C) levels (p<0.001). Plasma ${\alpha}-tocopherol$ level of the subjects did not show any difference as smoking, drinking and exercising habits changed. However, ${\gamma}-tocopherol$ per TG showed much lower figure in smokers than non smokers (p < 0.05). Amongst diet factors, plasma ${\alpha}-tocopherol$ level showed negative correlations with Vitamin E intake, while ${\gamma}-tocopherol$ level showed positive correlations with Vitamin E intake. Erythrocyte superoxide dismutase (SOD) activity and plasma tocopherol showed negative correlations, and catalase activity and plasma ${\alpha}-tocopherol$ showed positive correlationship. The level of cell DNA damage of Iymphocyte and plasma ${\alpha}-\;or\;{\gamma}-tocopherol$ showed negative correlations. As a result of this research, the factors that affect Korean adult men's plasma ${\alpha}-tocopherol$ level are plasma TG, LDL-C and cell DNA damage in Iymphocyte, while the factors that affect ${\gamma}-tocopherol$ level are plasma TG, LDL-C and vitamin E intake based on multiple regression analysis. These findings implies that the level of different types of tocopherol depends on slightly different factors. A further research is needed on the factors involved in the differentiation of the types of tocopherol.

• Asian Pacific Journal of Cancer Prevention
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• 제13권5호
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• pp.1829-1831
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• 2012

Background: The generalized gamma distribution statistics constitute an extensive family that contains nearly all of the most commonly used distributions including the exponential, Weibull and log normal. A saturated version of the model allows covariates having effects through all the parameters of survival time distribution. Accelerated failure-time models assume that only one parameter of the distribution depends on the covariates. Methods: We fitted both the conventional GG model and the saturated form for each of its members including the Weibull and lognormal distribution; and compared them using likelihood ratios. To compare the selected parameter distribution with log logistic distribution which is a famous distribution in survival analysis that is not included in generalized gamma family, we used the Akaike information criterion (AIC; r=l(b)-2p). All models were fitted using data for 369 women age 50 years or more, diagnosed with stage IV breast cancer in BC during 1990-1999 and followed to 2010. Results: In both conventional and saturated parametric models, the lognormal was the best candidate among the GG family members; also, the lognormal fitted better than log-logistic distribution. By the conventional GG model, the variables "surgery", "radiotherapy", "hormone therapy", "erposneg" and interaction between "hormone therapy" and "erposneg" are significant. In the AFT model, we estimated the relative time for these variables. By the saturated GG model, similar significant variables are selected. Estimating the relative times in different percentiles of extended model illustrate the pattern in which the relative survival time change during the time. Conclusions: The advantage of using the generalized gamma distribution is that it facilitates estimating a model with improved fit over the standard Weibull or lognormal distributions. Alternatively, the generalized F family of distributions might be considered, of which the generalized gamma distribution is a member and also includes the commonly used log-logistic distribution.

• 한국산림과학회지
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• 제13권1호
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• pp.79-84
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• 1971

대나무의 주산지(主産地)인 전남(全南) 담양지방(潭陽地方)의 왕죽림(王竹林)에 대(對)한 각종성장인자간(各種成長因子間)의 상관분석(相關分析) 및 회귀분석(回歸分析)의 결과(結果)를 요약(要約)하면 다음과 같다. 1. 간고(稈高)(y)와 안고주위(眼高周圍)(x) 및 절간장(節間長)(z)간(間)의 단순상관(單純相關) 또는 다원상관관계(多元相關關係)가 $r_{yx}=0.91$(유의적(有意的)), $r_{yz}=0.78$(유의적(有意的)), $r{yx{\cdot}z}=0.84$(유의적(有意的)), $r_{yz{\cdot}x}=0.55$(유의적(有意的)), $R_{y{\cdot}xz}=0.94$(유의적(有意的))등(等)으로 나타나 양성장인자(兩性長因子) 다같이 종속인자(從屬因子)인 간고(稈高)와 고도(高度)의 상관(相關)을 갖이고 있는데 상관도(相關度)의 강약(强弱)에 따라 안고주위(眼高周圍)가 절간장(節間長) 보다도 훨씬 간고(稈高)와 밀접(密接)한 관계(關係)를 갖이고 있는 지배적(支配的)인 인자(因子)임을 알수있다. 2. 회귀분석(回歸分析)의 결과(結果) 안고주위(眼高周圍)(x), 절간장(節間長)(z)에 관(關)한 간고(稈高)(y)의 회귀방정식(回歸方程式)(실험식(實驗式))으로서 y= -0.687+0.335x+0.206z를 얻었는데 이로써 현장(現場)에서 용역(容易)하게 얻을수 있는 안고주위(眼高周圍)(x)와 절간장(節間長)(z)에 의(依)해서 간고(稈高)(y)의 간접적(間接的)인 측정(測定)을 할수있다. 3. 조제(調製)된 간고(稈高)의 회귀방정식(回歸方程式)은 회귀성(回歸性)의 검정결과(檢定結果) 회귀계수(回歸係數) ${\beta}$, ${\gamma}$가 각각(各各) ${\beta}{\neq}O$, ${\gamma}{\neq}O$, ${\beta}{\neq}O{\neq}{\gamma}$로 되어 부분(部分) 또는 전회귀(全回歸)가 유의적(有意的)이었다. 따라서 본회귀방정식(本回歸方程式)은 안고주위(眼高周圍)x와 절간장(節間長)z에 의(依)해서 간고(稈高)y를 추정(推定)할수 있는 능력(能力)이 있음을 알수 있다. 4. 본회귀방정식(本回歸方程式)의 적합도(適合度)를 알기 위(爲)하여 추정(推定)의 표준오차(標準誤差) 또는 백분율오차(百分率誤差)를 산출(算出)하여 본바 $Sy{\cdot}xz=0.89$, $Sy{\cdot}xz(%)=8.14$로 되어 비교적(比較的) 정도(精度)가 높다는 것을 알았다.

• Tuberculosis and Respiratory Diseases
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• 제43권1호
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• pp.63-68
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• 1996

연구배경: 인터페론감마-(interferon-$\gamma$)는 항바이러스 효과, 암세포의 형증식 효과, 대식세포 및 B 림프구의 활성화, 주면역복합체(MHC) 항원 발현의 증가 등의 생물학적 효과를 나타낸다. 특히, 인터페론감마의 항암 효과는 이미 생체 내외에서 입증되어 실제 폐암 환자에 대한 임상 연구가 시도되고 있다. 그러나, 인터페론감마의 항암효과 기전은 여러가지 가설이 제시되기는 하고 있지만 아직 확립된 것이 없다. 세포의 괴사(necrosis)는 심한 외부의 스트레스에 의해서 발생하는 세포 사망의 형태로 잘 알려져 있다. 생명현상 중 괴사와는 전혀 다른 세포 사망의 과정으로 아포프토시스(apoptosis)가 있다. 아포프토시스는 조직의 항상성(homeostasis of tissue volume), 개체의 발생과정, 장기의 퇴행(regression), tolerance 등의 여러 생명 활동 과정에서 발생하는 세포 사망의 과정으로서, 세포질 및 핵이 분절화(fragmentation)되어 죽어가는 능동적 사망과정으로 알려져 있다. 아포프토시스에서는 수동적으로 죽어가는 괴사에서 볼 수 없는 DNA 분절화(DNA ladder pattern)가 특징적으로 관찰된다. 인터페론감마의 암세포에 대한 세포독성 기전을 연구하기 위해서 인터페론감마를 폐암세포주인 A549세 처치한 후 현미경(inverted microscope)로 A549의 변화를 관찰하였는데 A549세포가 분절화되면서 죽어가는 것을 관찰할 수 있었다. 저자들은 인터페론감마의 항암기전으로서 아포프토시스의 가능성을 평가하고자 본 연구를 시행하였다. 방법: 폐암세포주인 A549세포를 대상으로 하였다. A549세포에 여러 농도의 인터페론감마를 투여하고 24시간, 72시간, 120시간 후에 MTT(dimethylthiazolyl diphenyltetrazolium bromide) bioassay법으로 세포독성을 정량화하였다. 그리고, 100 unit/ml의 인터페론감마를 A549 세포에 120시간 처치 후, 광학 현미경으로 세포 사망의 양상을 관찰하였다. 또한, 100 unit/ml의 인터페론감마를 투여하고 120시간이 경과한 후 사망 세포의 DNA를 추출하여 1.5% agarose gel에서 전기 영동을 시행하고 ethidium bromide로 염색 후 DNA ladder pattern 유무를 관찰하였다. 결과: 1) 인터페론감마에 의한 A549 폐암세포주의 세포독성 효과는 24시간에는 거의 없다가 72시간부터 120시간 사이에 나타나기 시작하여 120시간에는 더 증가하였다. 2) 인터페론감마에 의한 A549 세포의 사망 양상은 광학현미경상 A549 세포들이 작은 분절로 나뉘면서 사망하였다. 3) 인터페론감마를 A549 폐암세포주에 처치 후 죽어기는 세포의 DNA를 추출하여 전기영동시킨 결과 아포프토시스(apoptosis)에서 특징적으로 보이는 DNA ladder pattern을 관찰할 수 있었다. 결론: 인터페론감마(interferon-$\gamma$)의 A549 폐암세포주에 대한 세포독성의 기전은 아포프토시스 과정을 통해서 일어난다.

• The Korean Journal of Pain
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• 제9권2호
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• pp.349-353
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• 1996

Background: Although the paramedian approach for epidural blockade is useful in some clinical situation, the parameters which are correlated with the distance from skin to the epidural space has not been established. Methods: We studied in 143 patients having elective continuous epidural blocks for relief of postoperative pain. All blocks were performed using paramedian approach with Tuohy needle in the lumbar (group 1, n=100) and thoracic (group 2, n=45) area. We measured the distance from skin to the epidural space, body weight, height, and the angle between the shaft of the needle and the skin. Data were analyzed by linear regression. The relationships between parameters identified by the F-test with a P value of less than 0.05 were considered statistically significant. Results: The mean distance from skin to the lumbar epidural space was $4.4{\pm}0.7$ cm. significant correlation between the body weight and the depth of lumbar epidural space ($\gamma$ value : 0.492) was noted with regression equation of depth(cm)=2.293+0.034${\times}$body weight (kg). Also the significant correlation between the ponderal index (PI) and the depth of lumbar epidural space ($\gamma$ value : 0.539) was noted with regression equation of depth(cm)=1.703+0.07${\times}$PI, The mean distance from skin to the thoracic epidural space was $5.2{\pm}0.7cm$ which did not correlated with other anatomic measurements. Conclusion: We found that PI and body weight are the suitable predictors of the depth of the lumbar epidural space, but not the thoracic epidural space.

• Asian Pacific Journal of Cancer Prevention
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• 제16권5호
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• pp.2099-2102
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• 2015

Objective: To explore the expression of $laminin{\gamma}2$ in extrahepatic cholangiocarcinoma (EHCC) tissues and its influence on tumor invasion and metastasis. Materials and Methods: Paraffin embedding samples of cancer, para-cancer, lymph node metastatic and hepatic metastatic tissues from 79 patients undergoing EHCC resection were collected. Expression of $laminin{\gamma}2$ was detected by immunohistochemistry and its relationship with clinical pathological characteristics and the prognosis of EHCC patients were analyzed. Results: $Laminin{\gamma}2$ showed negative staining in para-cancer tissues, but demonstrated a 51.9% (41/79) positive expression rate in extracellular matrix (ECM) or cytoplasm of EHCC tissues. In lymph node metastatic and distant metastatic nidi, expression of $laminin{\gamma}2$ was significantly higher than in the primary nidi (${\chi}^2=7.4173$, P=0.0065; ${\chi}^2=4.0077$, P=0.0453). The expression was in obvious association with lymph node metastasis (P<0.01), but had no relevance with age, gender, tumor location, tumor stage, differentiation and distant metastasis in ECM (P>0.05), whereas it was in marked connection with lymph node and distant metastasis (P<0.05 or P<0.01), but had no relationship with age, gender, tumor location, tumor stage and differentiation in cytoplasm (P>0.05). However, the median survival time and median recurrent period of patients with positive expression of $laminin{\gamma}2$ in both cytoplasm and ECM of tumor cells, only in ECM and only in cytoplasm, were evidently lower than with negative expression of $laminin{\gamma}2$ in RCM and cytoplasm (P<0.05 or P<0.01). Further Cox regression analysis showed that the positive expression of $laminin{\gamma}2$ and the tumor differentiation were independent risk factors influencing the prognosis of EHCC patients. Conclusions: Abnormal expression of $laminin{\gamma}2$ may be closely associated with invasion and metastasis of tumor cells, and thus a potential molecular marker for prognosis of EHCC patients.

• Asian Pacific Journal of Cancer Prevention
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• 제15권8호
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• pp.3513-3518
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• 2014

The 14-3-3 protein has been shown to be involved in the cancer process. However, there is no understanding of the relationship between 14-3-$3{\gamma}$ (14-3-3 gamma) expression and prognosis in advanced non-small cell lung cancer. In this study, we therefore investigated the association between protein levels by immunohistochemistry and clinicopathological features of advanced NSCLC patients. Survival curves were estimated using the Kaplan-Meier method and tested by log-rank. Multivariate analysis was conducted with the Cox's regression model to determine independence of factors. p values less than 0.05 were considered significant. A total 153 patients were studied, with 54.3% being stage III and 45.8% stage IV. Fifty-one cases (33.3%) were squamous cell carcinomas, and 98 cases (64.1%) were adenocarcinomas. High 14-3-$3{\gamma}$ expression was seen in 59.5% and significantly correlated with lymph node metastasis (p=0.010) and distant metastasis (p=0.017). On Kaplan-Meier analysis, high 14-3-$3{\gamma}$ expression was associated with poorer survival with a marginal trend toward significance (p=0.055). On multivariate analysis, age, treatment, and 14-3-$3{\gamma}$ expression proved to be independent prognostic parameters. In vitro experiments indicated that 14-3-$3{\gamma}$ overexpression also played a potential role in cancer invasion. In conclusion, our data suggest that 14-3-$3{\gamma}$ overexpression is associated with invasion and a poor prognosis. Therefore, 14-3-$3{\gamma}$ may be a potential prognostic marker of advanced non-small cell lung cancer.