• Korean Journal of Head & Neck Oncology
• /
• v.15 no.2
• /
• pp.194-199
• /
• 1999

Introduction: Since 1996, Dr. James Norman has successfully performed mimimally invasive radio-guided parathyroidectomy(MIRP) using intraoperative nuclear mapping with $^{99m}Tc$ sestamibi scanning and radioactivity detection probe. Objectives: We aimed to introduce this new surgical technique and evaluate it's efficacy by our own experiences. Method: From May to October 1999, five consecutive patients with primary hyperparathyroidism underwent parathyroidectomy by using modified MIRP technique. $^{99m}Tc$ sestamibi scanning was performed 1.0 or 1.5 hour before operation. After intraoperative localization of the tumor under the guidance of quantitative gamma counting with a NEVIGATOR probe, an unilateral small skin incision(3.0-4.0cm) was placed. Without a skin flap, the strap muscle was directly divided with the use of a Harmonic scalpel. After careful dissection, the parathyroid tumor was removed. Result: In all patients, a single adenoma could be easily detected and removed by this new technique. Mean incision length was 3.2cm(3.0-4.0cm) and operative time ranged from 40 to 110minute. All the patients were discharged within 2 days of surgery without any complication. Conclusion: This new operative technique could become the most minimally invasive alternative to the standard operative procedure for parathyroid adenoma.

• Korean Journal of Metals and Materials
• /
• v.49 no.11
• /
• pp.882-892
• /
• 2011

The influence of rhenium (Re) and ruthenium (Ru) addition on the solidification and solute redistribution behaviors in advanced experimental Ni-base superalloys has been investigated. A series of model alloys with different levels of Re and Ru were designed based on the composition of Ni-6Al-8Ta and were prepared by vacuum arc melting of pure metallic elements. In order to identify the influence of Re and Ru addition on the thermo-physical properties, differential scanning calorimetry analyses were carried out. The results showed that Re addition marginally increases the liquidus temperature of the alloy. However, the ${\gamma}^{\prime}$ solvus was significantly increased at a rate of $8.2^{\circ}C/wt.%$ by the addition of Re. Ru addition, on the other hand, displayed a much weaker effect on the thermo-physical properties or even no effect at all. The microsegregation behavior of solute elements was also quantitatively estimated by an electron probe microanalysis on a sample quenched during directional solidification of primary ${\gamma}$ with the planar solid/liquid interface. It was found that increasing the Re content gradually increases the microsegregation tendency of Re into the dendritic core and ${\gamma}^{\prime}$ forming elements, such as Al and Ta, into the interdendritic area. The strongest effect of Ru addition was found to be Re segregation. Increasing the Ru content up to 6 wt.% significantly alleviated the microsegregation of Re, which resulted in a decrease of Re accumulation in the dendritic core. The influence of Ru on the microstructural stability toward the topologically close-packed phase formation was discussed based on Scheil type calculations with experimentally determined microsegregation results.

• Journal of the Institute of Electronics Engineers of Korea SC
• /
• v.48 no.6
• /
• pp.51-56
• /
• 2011

The surface of magnetic iron oxide nanoparticles (${\gamma}-Fe_2O_3$) is functionalized ($-NH_2$, -COOH) with bifunctional organic molecules and evaluated using FT-IR (Fourier transform infrared spectroscopy). We immobilize 21-base pair probe DNA and hybridize fluorescence-labeled (Cy5) target DNA onto the functionalized iron oxide nanoparticles. The fluorescence images obtained from a confocal microscopy show that the functionalized iron oxide nanoparticles should detect the hybridization of complementary and noncomplementary DNA.

• Journal of the Korean Institute of Telematics and Electronics
• /
• v.3 no.1
• /
• pp.18-23
• /
• 1966

An experimental study of a steel plate thickness gauge by means of the measurements of backscatered gamma-rays has been carried out. The difference between this and other methods is that this method does not include any shilding matterials in the detecting probe, because the primary radiations and the backscattered radiations are detected simultaneously by an NaI (TI) scintillating crystal, and the activity of the Co-60 source used is low enough. In this thickness gauge, the thickness of the steel plates can be read directly on the counting ratemeter scale. The optimum conditions in the source-to-detector distance, window width of the analyzer, energy and strength of the gamma-ray source were found experimentally. The results have shown that the accuracy of the gauge was about $\pm$3% in the range of 3 to 8mm thickness. This gauge can be used to detect the pits or corrosions on the inner walls of the steel pipes.

• Korean Membrane Journal
• /
• v.1 no.1
• /
• pp.25-37
• /
• 1999

positron annihilation Lifetime Spectroscopy has been extensively applied in recent years to investigate the free volume in polymers owing to the capability of the electron-positron bound system (positronium) to probe the typical size of sub-nanometric cavities among the macromolecular chains. In this paper we show recent results obtained through this technique in some amorphous polymeric mem-branes(olyurethanes. PUs and polytrimethilsylilpropine PTMSP) after a brief survey of the general features of the annihilation process as well as of the experimental apparatus. Lifetime of o-ps decay({{{{ tau _3}}}}) in PUs increases going from sub {{{{ TAU _g}}}} to over {{{{ TAU _g}}}} temperatures following a sigmoid curve. The coefficient of dilatation of the free volume fraction is shown to be the sum of two contributes due to the variation with T of the number of holes and of their mean volume. PAL spectrum of PTMSP freshly prepared shows four lifetime components: {{{{ tau _3}}}} and {{{{ tau _4}}}}: only are useful for free volume study. Two kinds of holes of different equivalent radius are reported ({{{{ gamma _s}}}} 4.60 nm and {{{{ gamma _1}}}} 0.754) The equivalent volume does not change in a range of 100 K. however the physical aging increases density and decreases oxygen permeability while {{{{ gamma _s}}}} goes down to 0.374 and r1 to 0.735 The number of holes obtained from the intensities{{{{ IOTA _3}}}} and {{{{ IOTA _4}}}} of PAL spectra decreases with aging 21.7% and 3.5% for large and small holes respectively.

• Proceedings of the Korean Nuclear Society Conference
• /
• 1996.11a
• /
• pp.435-440
• /
• 1996

PHEBUS FPT0 노내실험의 핵연료 다발에 대한 실험후 비파괴 검사 및 파괴 검사 결과를 분석하여 노심손상 후기과정을 정alf 분석하였다. 분석한 비파괴 검사결과는 gamma scanning, radiography, tomographies 였으며 파괴 검사 결과는 정밀사진, metallography, Electron Probe Micro Analysis(EPMA)였다. 그 결과, PHEBUS-FPT0 실험에 사용한 핵연료다발은 기존에 수행된 어떤 다른 노내실험의 핵연료다발보다 많이 용융되었으며 용융 pool 및 피막충의 형성, 용융물 내부의 자연대류 열전달과 이에 따른 shroud 물질 손상, 핵연료다발 물질들간의 eutectic 형성 등을 보여주었다. 특히 Ag-In-Cd 제어봉 물질과 stainless-steel이 핵연료봉 물질과 반응하여 이들의 용융온도를 낮게하여 실험 예측값보다 많이 핵연료다발이 손상되어 기존 중대사고 해석 전산코드의 개선이 요구되었다.

• Biomolecules & Therapeutics
• /
• v.18 no.4
• /
• pp.411-419
• /
• 2010

Korean mistletoe has a variety of biological effects, such as immunoadjuvant activities. This study investigates the effects of Korean mistletoe lectin (Viscum album L. var. coloratum agglutinin, VCA) on human T lymphocytes to determine whether VCA acts as an immunomodulator. Purified human T-lymphocytes were cultured with VCA and RNA from each point was analyzed using Affymetrix human genome chips containing 22,500 probe sets which represents more than 18,000 transcripts derived from 14,500 human genes. As a result, there was a striking upregulation of genes coding for chemokines. Seventeen genes out of 50 coding for proteins with chemokine activity were upregulated including CXCL9 and IL-8 which are related to the treatment of cancer. In addition, 28 cytokine genes were upregulated including IL-1, IL-6, IL-8, IFN-$\gamma$, and TNF-$\alpha$. Taken together, the data suggest that Korean mistletoe lectin, in parallel with European mistletoe, has an ability to modulate human T cell function.

• Korean Journal of Veterinary Pathology
• /
• v.7 no.1
• /
• pp.1-4
• /
• 2003

Malignant catarrhal fever (MCF) is a systemic disease of ruminants caused by a gamma herpesvirus, ovine herpesvirus 2 (OvHV-2). Dot blot hybridization (DBH) protocols for detecting and differentiating this MCF virus were developed. OvHV-2 specific primer pairs, 556/555, were used for the amplification of target DNA. Then, the amplified DNA was labeled with incorporation of digoxigenin (DIG). The Dig-labeled probe was able to detect and differentiate specifically OvHV-2 DNA. This DBH technique can be applied to confirm the presence of MCF virus on clinical samples and to differentiate specifically between OvHV-2 infection and other viral infections.

• Journal of Microbiology and Biotechnology
• /
• v.11 no.6
• /
• pp.994-1001
• /
• 2001

An easier way of understanding the BNR system was proposed from the study on substrate, nutrient removal tendency, microbial community and its metabolic function by applying the municipal settled sewage. During the anaerobic period, the phosphorus release rate per VFACOD we varied depending on the phosphorus content in the sludge. When the phosphorus content in the sludge was $6\%$ VSS, according to influent VFACOD, the phosphorus release rate and PHA production were $0.35 gPO_4P/gVFACOD$ and 1.0 gPHA/gVFACOD, respectively. The $NO_3N$ requirement for the phosphorus uptake as an electron acceptor was about $0.5 gNO_3N/gPO_4P_{uptake}$ based on the proposed equation with PHA, biomass, production, and the concentration of phosphorus release/uptake. Bacterial-community analysis of the sludge, as determined by FISH and 16SrDNA characterization FISH, revealed that the beta-subclass proteobacteria were the most abundant group ($27.9\%$ of the proteobacteria-specific probe EUB338), and it was likely that representative of the beta-subclass played key roles in activated sludge. The next dominant group found was the gamma-protebacteria ($15.4\%$ of probe EUB338). 16S rDNA clone library analysis showed that the members of${\beta}$- and ${\gamma}$-proteobacteria were also the most abundant groups, and $21.5\%$ (PN2 and PN4) and $15.4\%$ (PN1 and PN5) of total clones were the genera of denitrifying bacteria and PAO, respectively. Prediction of the microbial community composition was made with phosphorus content (Pv, $\%$ P/VSS) in wasted sludge and profiles of COD, PHA, $PO_4P,\;and\;NO_3N$ in an anaerobic-anoxic SBR unit. Generally, the predicted microbial composition based upon metabolic function, i.e., as measured by stoichiometry, is fairly similar to that measure by the unculturable dependent method. In this study, a proposal was made on he microbial community composition that was more easily approached to analyze the reactor behavior.

• Journal of the Korean Geotechnical Society
• /
• v.30 no.3
• /
• pp.59-72
• /
• 2014

For circular rigid footings with a rough base on sand, combined vertical - moment loading capacity was studied by three-dimensional numerical modelling. Mohr-Coulomb plasticity model with the associated flow-rule was used for the soil. After comparing the results of the swipe loading method, which can construct the interaction diagram with smaller number of analyses, and those of the probe loading method, which can simulate the load-paths in the conventional load tests, it was found that both loading methods give similar results. Conventional methods based on the effective width or area concept and the results by eccentricity factor ($e_{\gamma}$) were reviewed. The results by numerical modelling of this study were compared with those of previous studies. The combined loading capacity for vertical (V) - moment (M) loading was barely affected by the internal friction angle. It was found that the effective width concept expressed in the form of eccentricity factor can be applied to circular footings. The numerical results of this study were smaller than the previous experimental results and the differences between them increased with the eccentricity and moment load. Discussions are made on the reason of the disparities between the numerical and experimental results, and the areas for further researches are mentioned.