• Asian Pacific Journal of Cancer Prevention
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• 제14권7호
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• pp.4071-4075
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• 2013

Expression changes of somatostatin receptor subtypes (SSTRs) including SSTR1, SSTR2, SSTR3, SSTR4 and SSTR5 in the development of gallbladder cancer were assessed with attention to relationships with clinical pathological characteristics. SSTRs in 29 gallbladder cancer and 25 normal gallbladder tissue specimens were examined by immunohistochemical staining. Differences between SSTRs expressions and clinical pathological parameters were analyzed by chi-square test. The five subtypes of SSTR were all expressed in gallbladder cancer tissues and SSTR3 presented the highest expression. SSTR5 expression was increased significantly in gallbladder cancer (P<0.05) compared with that in normal gallbladder tissue. SSTR3 expression in highly and moderately differentiated gallbladder cancer was significantly higher than that in poorly differentiated lesions (P<0.05). SSTR4 expression was lower in gallbladder cancer with lymph node metastasis than that in gallbladder cancer without lymph node metastasis (P<0.05). Therfore, these results indicated that SSRT5, SSTR3 and SSTR4 may play important roles in the formation and development of gallbladder cancer.

• 한국임상수의학회지
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• 제33권1호
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• pp.58-61
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• 2016

An 11-year-old, intact male Cocker Spaniel dog was presented with history of abdominal distension, dyspnea for 10 days and lethargy for 1 day. Abdominal radiographs showed decreased serosal detail with abdominal distension. Abdominal ultrasounds revealed gallbladder mucocele with generalized peritonitis showing stellate-like sludge in the gallbladder with echogenic fat degeneration of cranial abdomen and abdominal free fluid containing echogenic materials. Loss of gallbladder wall integrity was shown clearly on computed tomography but ambiguously on ultrasound. Ultrasound-guided abdominocentesis was performed and showed amount of yellowish-bloody peritoneal fluid with vegetable matter and mucoid substance. On peritoneal fluid analysis, bilirubin level was elevated over three times than those of the serum. On exploratory laparotomy, gallbladder rupture and generalized bile peritonitis with intestinal adhesions were confirmed and cholecystectomy with peritoneal lavage was performed. One day after operation, patient died. This report describes delayed clinical symptoms of gallbladder rupture by gallbladder mucocele. In addition, this is the first case report using computed tomography made a diagnosis gallbladder rupture in a dog. Computed tomography might be helpful to diagnose gallbladder rupture.

• Journal of Digestive Cancer Research
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• 제7권2호
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• pp.51-56
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• 2019

비록 국내에서 담낭암의 발생률은 비교적 낮지만, 한국은 전세계적으로 담낭암의 발생률이 상대적으로 높은 나라 중 하나이다. 담낭암은 진행된 상태에서 진단되는 경우가 많고, 치료 효과도 좋지 않은 암 중 하나이다. 담석은 담낭암의 주된 위험 인자이고, 많은 논문에서 담석과 담낭암의 관계를 보고하였지만, 담석이 담낭암을 일으키는 명확한 기전은 아직 밝혀지지 않았다. 이 종설에서는 현재까지 보고된 여러 본문을 근거로 담석과 담낭암의 관계를 정리해 보기로 한다. 또한, 다른 위험인자가 없는 담석 환자에서, 담낭암 발생을 막기 위한 예방적 담낭절제술이 필요한지에 대해서도 알아 보기로 한다.

• 대한한의학원전학회지
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• 제29권4호
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• pp.95-103
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• 2016

Objectives : This paper aims to study how 'All articulations are controlled by the gallbladder' as urged by Heoim in Chimgugyeongheombang was reflected in the clinical field, and look into the reason for his assertion. Methods : The paper looked into Chimgugyeongheombang and 1) found examples of how acupoints related to gallbladder were used to treat articulation-related diseases, and 2) investigated the relation between gallbladder and articulations through analyzing the acupoints used for treating articulation-related diseases. These are then compared with Zhenjiuzishengjing to see if the assertions made in 'All articulations are controlled by the gallbladder' were actually applied in clinical fields. Results & Conclusions : Heoim dealt with 20 points out of the 44 acupoints for gallbladder, and used 14 of them for treatments of articulation-related diseases. Gallbladder acupoints were used for ten illnesses, and four of them were related to articulation. Chimgujasaenggyeong showed a difference in that it did not utilize gallbladder acupoints to treat these illnesses. Out of 33 articulation-related illnesses, gallbladder meridians and acupoints were suggested as a means to treat them in 15 cases, and this is an increase in the usage of these points compared to Chimgugyeongheombang. In other words, Heoim actively utilized gallbladder meridian points in treating articulation-related illnesses. The reason Heoim drew a line between gallbladder and articulations is because gallbladder is categorized as a lesser yang pivot and articulations itself functions as a pivot by acting as a pivot for human body movement.

• Asian Pacific Journal of Cancer Prevention
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• 제13권6호
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• pp.2511-2514
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• 2012

Objective: To evaluate the prognostic factors of gallbladder carcinoma. Methods: Presentation, operative data, complications, and survival outcome were examined for 132 gallbladder carcinoma patients who underwent gallbladder surgery in our unit during 2002-2007, and follow-up results were obtained from every patient for univariate and multivariate survival analysis. Results: The univariate analysis showed that gallbladder lesion history, tumor cell differentiation, Nevin staging, preoperative lymph node metastasis and the surgical approach significantly correlated with the prognosis of the patients (p<0.05). The results of the multivariate analysis (Cox regression) showed that gallbladder lesion history, Nevin staging and the surgical approach were independent predicators with relative risks of 6.9, 4.4, 2.8, respectively (p=0.002, 0.003, 0.008). Conclusion: Gallbladder lesion history, Nevin staging and the surgical approach are independent prognostic factors for gallbladder carcinoma, a rapidly fatal disease. Therefore, early diagnosis, anti-infective therapy and radical surgery are greatly needed to improve the prognosis of gallbladder carcinoma.

• 셀메드
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• 제12권5호
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• pp.2.1-2.3
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• 2022

Objective: A case report on the improvement of gallbladder polyps through Ortho-Cellular Nutrition Therapy Methods: On ultrasound, gallbladder polyps were detected in a 54-year-old male Korean patient. In addition to the polyps, there were also calcific tendonitis and various inflammatory conditions of the shoulder. Results: Ultrasound revealed the absence of gallbladder polyps 8 months after nutritional therapy. Conclusion: It is believed that nutritional therapy is beneficial for patients with gallbladder polyps who do not require surgical treatment and are under observation.

• 대한수의학회지
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• 제47권1호
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• pp.131-134
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• 2007

In 3 dogs with gallbladder mucocele, rupture of gallbladder was diagnosed and treated. Althoughthe diagnosis of gallbladder is challenging due to non-specific clinical signs and physical examinationfindings, mucoceles are ultrasonographically characterized by the appearance of the stellate or finely striatedbile paterns and difer from biliary sludge by the absence of gravity dependent bile movement. In thiscase, gallbladder rupture caused by mucocele can be diagnosed based on not only above characteristicsbut secondary lesion such as ascites around gallbladder and swollen hyperechoic mesentery.

• Journal of Trauma and Injury
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• 제34권3호
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• pp.208-211
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• 2021

Gallbladder injuries are rare in cases of blunt abdominal trauma and are usually associated with damage to other internal organs. If the physician does not suspect gallbladder injury and check imaging studies carefully, it may be difficult to distinguish a gallbladder injury from gallbladder stone, hematoma, or bleeding. Therefore, in order not to miss the diagnosis, the clinical findings and correlation should be confirmed. In the present case, a 60-year-old male presented to a local trauma center complaining of pain in the upper right quadrant and chest wall following a motor vehicle collision. Abdominal computed tomography (CT) showed a hepatic laceration and hematoma in the parenchyma in segments 4, 5, and 6 and active bleeding in the lumen of the gallbladder. Traumatic gallbladder injuries generally require surgery, but in this case, non-operative management was possible with cautious follow-up consisting of abdominal CT and angiography with repeated physical examinations and hemodynamic monitoring in the intensive care unit.

• Journal of Yeungnam Medical Science
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• 제23권2호
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• pp.152-161
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• 2006

담낭암은 조기에 진단되지 않아 예후가 아주 나쁜 소화기암 중의 하나로, 담낭암 발생의 위험성을 예견한 담낭절제술의 대상을 정확히 규명하는 것이 중요하다. 담낭 용종의 크기, 개수, 담석의 유무, 환자의 나이가 담낭암 발생과 관련된 인자이며, 용종 크기 1 cm 이상, 동반된 담석증, 50세 이상, 증상이 있을 때, 관찰 기간 중 급격한 크기 변화가 있을 때 수술을 권하는 것이 좋을 것으로 판단되며, 췌담관 합류 기형이 발견되면 담낭을 반드시 절제 하여야 하며 수술 전 및 수술중 담낭암의 존재 여부를 세밀히 조사하는 것이 좋겠다. 만성 담낭염에서 보이는 담낭 점막의 화생 변화는 전암 병변으로 생각이 되며, 담낭염의 변종으로 생기는 황색육아종성 담낭염, 도재담낭 및 담낭 장관루 등에서 고빈도로 담낭암이 발생하고 있어, 염증성 변화 및 이의 지속되는 기간과 암 발생과는 밀접한 관계가 있을 것으로 사료 된다.

• 대한방사선기술학회지:방사선기술과학
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• 제31권4호
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• pp.323-327
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• 2008

자기양담낭은 담낭 벽에 칼슘이 침착되는 드문 질환이며, 만성담낭염에 의해 벽에 석회화가 일어나거나 결석에 의해 담낭관이 폐색되면서 발생하는 것으로 보고 되고 있다. 자기양담낭은 일반적으로 담낭암을 동반하므로 담낭암을 예방하기 위해 일차적으로 담낭 절제술이 시행된다. 저자들은 증상이 없는 석회화된 담낭을 초음파 검사와 복부 단순방사선검사 및 복부 전산화단층검사를 통해 확인하였고 문헌고찰과 함께 보고하고자 한다.