• Journal of Digestive Cancer Research
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• 제4권2호
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• pp.83-87
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• 2016

Till now, two distinct epithelial lesions, dysplasia and adenoma, are currently recognized as premalignant stages of gallbladder (GB) carcinogenesis. In these two carcinogenesis pathways, GB stones and polyps are regarded as one of the most important risk factors of GB carcinoma respectively. Although there still remain controversies for the indication of prophylactic cholecystectomy for GB stones and polyps due to lack of high-level evidence, the present review demonstrated that patients who have GB stones with more than 3 cm size, chronic typhoid carriers, porcelain GB, or anomalous pancreaticobiliary ductal union and patients with more than 1 cm sized GB polyp would be recommended prophylactic cholecystectomy.

• 대한방사선기술학회지:방사선기술과학
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• 제30권4호
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• pp.391-397
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• 2007

목 적: 담낭 결석은 담도계의 가장 흔한 질환이며 우리나라에서 점차적으로 늘어나고 있는 추세이다. 이와 같은 변화는 서구화된 식이요인이 변화되었기 때문이다. 본 연구는 식이요인에 따른 담낭 운동성과 담낭결석과의 관계를 알아보고자 하였다. 대상 및 방법: 전라북도 위도에서 69명과 경기도 남양주시에서 60명 등 총 129명을 대상으로 하였다. 남양주 시에서 60명 중 9명(남: 2, 여: 7)에서 담석이 발견되었는데 9명을 담석증군으로 하였다. 위도에서 69명 중 단 한 명도 담석이 발견되지 않아 단순 무작위 표본추출로 18명(남: 6, 여: 12)을 담석이 없는 대조군으로 하였다. 담석 및 당뇨가 없는 20대 4명(남: 2, 여: 2)을 추가로 실험 대상자로 설정하여 각각 생선 섭취 후 담낭의 박출 계수와 육류 섭취 후 담낭의 박출 계수를 구하였다. 결 과: 생선과 육류 섭취 후 담낭의 박출 계수율이 차이가 있었다. 생선 섭취 후 120분에 담낭의 박출 계수율이 가장 높게 나타났으며 육류 섭취 후 210분에 담낭의 박출 계수율이 가장 높게 나타났다. 결 론: 생선 섭취 후 보다 육류 섭취 후 담낭 내 담즙이 오래 정체되어 담낭 결석이 형성된다. 본 연구의 결과 담낭의 운동성이 담낭 결석의 형성에 중요한 역할을 한다.

• Journal of Gastric Cancer
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• 제19권4호
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• pp.417-426
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• 2019

Purpose: Although an increased incidence of gallbladder (GB) stone formation after gastrectomy has been reported, its etiology remains uncertain. The goal of this study was to explore the incidence of gallstone formation after gastrectomy in gastric cancer patients and investigate the risk factors therein. Materials and Methods: Medical records of patients who underwent curative gastrectomy, performed by a single surgeon between August 2012 and December 2015 at the Asan Medical Center, were retrospectively reviewed. Baseline characteristics and surgical outcomes, including GB stone gallstone formation after gastrectomy, were analyzed. Results: Of 561 patients included in the study, 36 presented with GB stone formation after gastrectomy for gastric cancer. The incidence of gallstone formation was 6.4%. The mean interval between gallstone formation and gastrectomy was 21.9 months. In multivariate analyses, the incidence of gallstone formation increased in patients 63 years or older, with greater than 6.2 kg weight loss in the first 6 months after the procedure, a preoperative serum total bilirubin level greater than 0.5 mg/dL, and in patients who did not receive adjuvant chemotherapy. Conclusions: This study presented risk factors for GB stone formation after gastric cancer surgery, and special attention should be afforded to patients with such risk factors.

• Parasites, Hosts and Diseases
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• 제45권4호
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• pp.301-306
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• 2007

We attempted to identify parasite DNA in the biliary stones of humans via PCR and DNA sequencing. Genomic DNA was isolated from each of 15 common bile duct (CBD) stones and 5 gallbladder (GB) stones. The patients who had the CBD stones suffered from cholangitis, and the patients with GB stones showed acute cholecystitis, respectively. The 28S and 18S rDNA genes were amplified successfully from 3 and/or 1 common bile duct stone samples, and then cloned and sequenced. The 28S and 18S rDNA sequences were highly conserved among isolates. Identity of the obtained 28S D1 rDNA with that of Clonorchis sinensis was higher than 97.6%, and identity of the 18S rDNA with that of other Ascarididae was 97.9%. Almost no intra-specific variations were detected in the 28S and 18S rDNA with the exception of a few nucleotide variations, i.e., substitution and deletion. These findings suggest that C. sinensis and Ascaris lumbricoides may be related with the biliary stoneformation and development.