• The Journal of Internal Korean Medicine
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• v.41 no.4
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• pp.668-675
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• 2020

Objectives: The aim of this study was to compare the effects of Galkunhwanglyeonhwanggum-tang (GGT), and Sopunghwalhyeol-tang (SPT) on gene expression of MCP-1, ICAM-1, VCAM-1, and eNOS in human umbilical vein endothelial cells (HUVECs). Methods: HUVECs were treated with GGT and SPT at concentrations of 50, 100, and 200 ㎍/mL. Gene expression of MCP-1, ICAM-1, VCAM-1, and eNOS in HUVECs was analyzed by the polymerase chain reaction (PCR), and electrophoresis was performed to verify the gene expression level. Results: 1. MCP-1 gene expression was more strongly decreased by SPT than by GGT. 2. ICAM-1 and VCAM-1 gene expressions were more strongly decreased by SPT than by GGT 3. GGT significantly increased eNOS gene expression, but SPT did not. Conclusions: These findings suggest that GGT and SPT regulate gene expression related to anti-inflammatory effects in HUVECs. Clinical application of these Korean medicines to diseases related to dyslipidemia, such as cardiovascular disease, will require additional in vivo experiments to verify the anti-inflammatory effects of GGT and SPT.

• 대한상한금궤의학회지
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• v.11 no.1
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• pp.95-102
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• 2019

Objective : The purpose of this study was to report the improvement in a patient with cystitis by a herbal medication based on Shanghanlun disease pattern identification diagnostic system (DPIDS). Methods : A patient was diagnosed with cystitis according to DPIDS. The patient was treated with Galgunhwangryunhwanggum-tang. Results : The symptoms of cystitis disappeared after treatment and did not recur after 4 months. Conclusions : The herbal medication Galgunhwangryunhwanggum-tang is effective in this case of cystitis.