• Journal of Life Science
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• v.23 no.8
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• pp.1057-1063
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• 2013

Citri Pericarpium is one of the most commonly used traditional herbal medicines in Korea, China, and Japan. Its extracts have many properties including the treatment of indigestion and inflammatory respiratory syndromes such as bronchitis and asthma. However, the underlying molecular mechanisms of anti-cancer activity and molecular targets are not fully understood. In this work, we investigated the anti-proliferative activity of Citri Pericapium (EMCP) methanol extract on reactive oxygen species (ROS) production and the association of these effects with apoptotic cell death using U937 human leukemia cells in vitro. EMCP treatment decreased cell proliferation in a dose-dependent manner following an increase of the sub-G1 phase, the down-regulation of Bax proteins, the activation of caspases, the degradation of poly (ADP-ribose) polymerase proteins (PARP), and the induction of ROS generation. However, the quenching of ROS generation by N-acetyl-L-cysteine administration, a scavenger of ROS, reversed the EMCP-induced apoptosis effects. In addition, heme oxygenase-1 expression also recovered by inhibiting the nuclear translocation of phosphorylated NF-E2-related factor 2. Taken together, our data indicate that ROS are involved as key mediators in the early molecular events in the EMCP-induced apoptotic pathway.

• Korean Journal of Soil Science and Fertilizer
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• v.20 no.4
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• pp.351-357
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• 1987

A laboratory experiment was conducted to find out the effect of organic fertilizer as Bio-com$^{(R)}$ on the changes of pH and Eh values, gas evolution, ammonification and nitrification, and microbial population with farmer's compost and refused mushroom compost in submerged paddy condition. The results obtained are summarized as follows: 1. Application of compost and refused mushroom compost was increased the pH values than that of NPK alone. Organic fertilizer of Bio-com$^{(R)}$ showed the same results of the farmer's compost or refused mushroom compost. 2. Population of soil microbes as bacteria, actinomycetes and fungi was increased by application of compost, refused mushroom compost and Bio-com$^{(R)}$. Moreover, the results were pronounced more with the addition of NPK. 3. The application of Bio-com$^{(R)}$ was effected to the increase of the amount of $NO_3-N$ and the rate of nitrification than NPK, farmer's compost or refused mushroom compost. 4. The amounts of evolved gases as $CH_4$, $CO_2$, and $N_2O$ were not much differed with application of kinds of compost and NPK, but little increasing tendency was observed in application of NPK than that of NPK+kinds of compost.

• The Journal of Korean Institute of Electromagnetic Engineering and Science
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• v.17 no.3 s.106
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• pp.249-258
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• 2006

In this letter, we propose a novel printed helix antenna for RFID reader in UHF band. The printed strip line of the antenna is first wound up outside a polygonal shaped layer and then the winding continues on an inner layer to control the overall gain and the radiation pattern. In addition, the winding pitch angles on each layer have either negative or positive values resulting in the broad CP bandwidth. The detail structure of the antenna was optimized using Pareto genetic algorithm(GA), so as to obtain excellent performances for RFID reader antennas. The optimized two-layered polygonal helix was fabricated on the cardboard of a flexible substrate and the performances were measured and compared with the simulations. The fabricated antenna was made up of copper tape which can adhere to a flexible cardboard and had 21.4 % matching bandwidth, 31.9 % CP bandwidth, readable range of $5.5m^2$ with kr=3.2. Also based on the current distribution of the strip line of the antenna and sensitivity of the antenna bents points, we confirmed that the antenna has the quarter-wave transformer near the feed for the broad matching bandwidth and radiates the traveling wave for the broad CP bandwidth using the bent strip line.

• The Journal of the Petrological Society of Korea
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• v.24 no.1
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• pp.1-10
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• 2015

Neulgeori prehistoric site is located at Joong-ri Kwanin-myon Pocheon-si, Gyeonggi-do, where lots of stone artefacts were excavated. We investigated the petrological features of the artefacts through petrographical observation and modal analysis. In addition we estimated the provenance of the artefacts by means of the geological survey. The twelve stone artefacts used in this study are identified as ash tuff, lapilli tuff, granite porphyry, andesite and diorite porphyry. Various rocks were used for making flakes, whereas blades and debris were from the tuffaceous rocks. Lapilli tuff is considered to have been delivered from the Dongmakgol tuff in the Cheolwon basin, granite porphyry from the Cretaceous granite porphyry stocks cropped out at the southeastern Oksan-ri and eastern Yeoncheon areas. Andesite artefact would have been originated from the outcrops located at the northern part of the site, and diorite porphyry artefact from the southern part of the site. The stone artefacts investigated are estimated to have been transported from the area within 15 kilometers from the site.

• Journal of the Korean Institute of Intelligent Systems
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• v.22 no.5
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• pp.540-548
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• 2012

The Weapon Target Allocation(WTA) problem is the NP-Complete problem. The WTA problem is that the threatful air targets are assigned by weapon of allies for killing the targets. A good solution of NP-complete problem is heuristic algorithms. Genetic algorithms are commonly used heuristic for global optimization, and it is good solution on the diverse problem domain. But there has been very little research done on the generation of their initial population. The initialization of population is one of the GA step, and it decide to initial value of individuals. In this paper, we propose to the population initialization method to improve a Genetic Algorithm. When it initializes population, the proposed algorithm reflects the characteristics of the WTA problem domain, and inherits the dominant gene. In addition, the search space widely spread in the problem space to find efficiently the good quality solution. In this paper, the proposed algorithm to verify performance examine that an analysis of various properties and the experimental results by analyzing the performance compare to other algorithms. The proposed algorithm compared to the other initialization methods and a general genetic algorithm. As a result, the proposed algorithm showed better performance in WTA problem than the other algorithms. In particular, the proposed algorithm is a good way to apply to the variety of situation WTA problem domain, because the proposed algorithm can be applied flexibly to WTA problem by the adjustment of RMI.

• Journal of the Korean Institute of Gas
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• v.21 no.2
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• pp.32-40
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• 2017

Safety Instrumented Systems (SIS) have wide application area. They are of vital importance at process plants to detect the onset of hazardous events, for instance, a release of some hazardous material, and for mitigating their consequences to humans, material assets, and the environment. The integrated safety systems, where electrical, electronic, and/or programmable electronic (E/E/PE) devices interact with mechanical, pneumatic, and hydraulic systems are governed by international safety standards like IEC 61508. IEC 61508 organises its requirements according to a Safety Life Cycle (SLC). Fulfilling these requirements following the SLC can be complex without the aid of SIS supporting tools. This paper presents simple SIS support tool which can greatly help the user to implement the design phase of the safety lifecycle. This tool is modelled in the form of Android application which can be integrated with a Web-based data reading and modifying system. This tool can reduce the computation time spent on the design phase of the SLC and reduce the possible errors which can arise in the process. In addition, this paper presents an optimization approach to SISs based on cost measures. The multi-objective genetic algorithm has been used for the optimization to search for the best combinations of solutions without enumeration of all the solution space.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.30 no.4
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• pp.49-61
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• 2017

Objectives : In order to find out the whitening effects of Leonuri Herba, this study was designed to identify the effects and the action mechanism of LHE(Leonuri Herba extract) on Malignant melanoma cell lines. Methods : After treating LHE on the B16F10 cell-Malignant melanoma cell line-, the cell survival rate, melanin biosynthesis rate, intra&extracellular tyrosinase activity rate, SOD-like activity, tyrosinase mRNA gene expression were investigated. The results were compared with control group without LHE treatment or with positive control group treated with whitening efficacy substance. Results : B16F10 cell survival rate, melanin biosynthesis rate, and intra&extracellular tyrosinase activity were significantly inhibited depending on the concentration of treated LHE. Melanin biosynthesis rate and tyrosinase activity rate were also decreased when ${\alpha}-MSH$ was combined with LHE. In addition, the SOD-like activity was increased in a concentration-dependent manner in the treatment with the LHE, indicating signigicant activity at high concentrations, and the tyrosinase mRNA gene expression was decreased in both the LHE-treated group, the LHE and ${\alpha}-MSH-treated$ group. Conclusions : LHE seems to inhibit melanin synthesis through inhibition of tyrosinase activity and inhibition of tyrosinase mRNA gene expression. It also has the effect of promoting SOD-like activity and may be used clinically as a skin whitening agent in the future.

• Proceedings of the Korean Vacuum Society Conference
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• 2013.08a
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• pp.97-97
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• 2013

Recently, Cu2ZnSn(S,Se)4 (CZTSS), which is one of the In- and Ga- free absorber materials, has been attracted considerable attention as a new candidate for use as an absorber material in thin film solar cells. The CZTSS-based absorber material has outstanding characteristics such as band gap energy of 1.0 eV to 1.5 eV, high absorption coefficient on the order of 104 cm-1, and high theoretical conversion efficiency of 32.2% in thin film solar cells. Despite these promising characteristics, research into CZTSS based thin film solar cells is still incomprehensive and related reports are quite few compared to those for CIGS thin film solar cells, which show high efficiency of over 20%. I will briefly overview the recent technological development of CZTSS thin film solar cells and then introduce our research results mainly related to sputter based process. CZTSS thin film solar cells are prepared by sulfurization of stacked both metallic and sulfide precursors. Sulfurization process was performed in both furnace annealing system and rapid thermal processing system using S powder as well as 5% diluted H2S gas source at various annealing temperatures ranging from $520^{\circ}C$ to $580^{\circ}C$. Structural, optical, microstructural, and electrical properties of absorber layers were characterized using XRD, SEM, TEM, UV-Vis spectroscopy, Hall-measurement, TRPL, etc. The effects of processing parameters, such as composition ratio, sulfurization pressure, and sulfurization temperature on the properties of CZTSS absorber layers will be discussed in detail. CZTSS thin film solar cell fabricated using metallic precursors shows maximum cell efficiency of 6.9% with Jsc of 25.2 mA/cm2, Voc of 469 mV, and fill factor of 59.1% and CZTS thin film solar cell using sulfide precursors shows that of 4.5% with Jsc of 19.8 mA/cm2, Voc of 492 mV, and fill factor of 46.2%. In addition, other research activities in our lab related to the formation of CZTS absorber layers using solution based processes such as electro-deposition, chemical solution deposition, nano-particle formation will be introduced briefly.

• Fire Science and Engineering
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• v.31 no.5
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• pp.63-69
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• 2017

This study describes the development of a long-distance hose for ultra-high pressure operation, which can be used in conjunction with an ultra-high pressure pump and can be effectively applied to the fire suppression of high-rise buildings and a long, large tunnels. Also, it has phosphorescent properties, which can help to secure the withdrawal route of the fire-fighters when they are threatened by the fire. We developed an ultra-high pressure hose aiming at a pressure of 3 MPa and a flow rate of 2000 lpm and developed an ultra-high pressure fire hose that can withstand this very high pressure by using a double jacket, triple polyurethane coating and warf (Wp) of 52. In order to ensure the performance of the developed ultra-high pressure hose, its structure, appearance, leakage at high pressure, length and elongation were inspected by a certified certification agency, who also subjected it to a peeling test, friction test, breaking pressure test and free fall test. Also, it was studied in addition to the luminescent high-pressure hose for fire-fighting. In the phosphorescence test, the luminance measurement value was more than the reference value of the luminance test after 40 minutes, which confirmed that its performance was satisfactory for fire-fighting products. In the future, if such an ultra-high pressure fire hose were commercialized and applied in the field, it could contribute to securing improved fire suppression and safer exit from fires, as compared to the fire hoses currently used in the suppression of fires in skyscraper buildings and long tunnels.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.4
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• pp.599-607
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• 2017

Since 2015, small and medium domestic enterprises that treat more than a certain quantity of chemical substances in accordance with the Chemical Substance Control Act are obliged to submit an off-site impact assessment and risk management plan. In order to reduce the administrative and economic burden of the risk assessment, its impact was determined. Toxic leaks of nitric acid, methanol, and acetic acid were estimated and the correlations (between them?) were calculated. In addition, the correlations of this study were used to compare the KORA results according to the accident scenarios of the actual workplace and the extent of the damage as a function of distance in the case of toxic leaks. In this study, the correlation formula of the materials can be used to quickly determine the damage distance in the event of the accidental leakage of materials in the road or workplace, and to prepare emergency plans and respond to emergencies more quickly.