• The KIPS Transactions:PartC
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• v.15C no.5
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• pp.419-428
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• 2008

IEEE 802.15.4 reserves transmission time to support real-time transport by sending GTS request packets to the PAN coordinator in advance. This paper introduces GTS-FAT technique to reduce the reservation time by giving a higher sending priority to GTS request packets than data packets. Differently from the conventional scheme where these two kinds of packets share a single transmission queue, GTS-FAT scheme allocates two queues with two different contention window sizes like IEEE 802.11e. This paper also proposes an analytical GTS delay model by combining the two legacy models for 802.15.4 and 802.11e to accurately predict the GTS-FAT delay over a given network topology. Our analysis shows that GTS-FAT reduces GTS service delay by up to 50% at the expense of the data delay by only up to 6.1% when GTS request packets four times outnumber data packets.

• Proceedings of the Korea Information Processing Society Conference
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• 2008.11a
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• pp.1215-1218
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• 2008

IEEE 802.15.4 기반의 무선 센서 네트워크는 다양한 종류의 센서들로 구성된다. 이러한 센서들은 각각 다양한 주기들로 중심 노드에게 데이터를 전송하고자 한다. 슈퍼프레임마다의 주기적인 전송을 위해 IEEE 802.15.4에서는 GTS(Guaranteed Time Slot) 메커니즘을 제공한다. 하지만 하나의 센서 네트워크에서 슈퍼프레임 길이는 모두 동일하기 때문에 이보다 긴 주기를 갖는 센서들은 GTS를 할당받고도 데이터를 전송하지 않는 경우가 발생할 수 있다. 때문에 IEEE 802.15.4의 GTS 메커니즘에서는 낮은 사용 효율의 문제가 발생한다. 본 논문은 이러한 문제를 보완하고자 주기적 GTS 할당 방법(PGTS: Periodic Guaranteed Time Slot)을 제안한다. 주기적 GTS 할당 방법에서는 단말들이 GTS 요청 시 자신의 데이터 전송 주기를 PAN 코디네이터에게 보고하고, PAN 코디네이터는 이를 고려하여 단말의 주기에 따른 슈퍼프레임에서만 GTS 구간을 할당한다. 이를 통해 주기적 GTS 할당 방법은 기존 GTS 할당 방법보다 대역의 낭비를 줄여 GTS를 효율적으로 사용가능하도록 하고 더 많은 수의 단말들에게 GTS를 배정할 수 있게 한다. 본 논문에서는 시뮬레이션 결과를 통해 주기적 GTS 할당 방법이 IEEE 802.15.4의 GTS 할당 방법보다 효율적이며 더 많은 수의 단말에게 GTS를 할당할 수 있음을 확인하였다.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.20 no.1 s.32
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• pp.169-176
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• 2007

Objectives : The purpose of this study was to investigate inhibitory effect of Gagamtongsung-San(GTS) on the cancer. Methods : This study estimated the cytotoxicity of GTS about L1210 and NIH3T3. We used GTS extract distilled with water, n-Hexane, Ethyl acetate and Butanol. The cytotoxicitys of GTS about cancer cells and normal cells were tested using a colorimetric tetrazoliun assay(MTT assay). Results : The results of this study were obtained as follow ; l. Cytotoxicity of water extract of GTS in L1210 cell lines was significantly increased, compared with NIH3T3. 2. n-Hexane fraction of GTS had similar cytotoxicity between L1210 and NIH3T3, and that have similar $IC_{50}$ of water extract of GTS at 276 ${\mu}g/ml$ 3. Ethyl acetate fraction of GTS had low degree cytotoxicity both L1210 and NIH3T3 cell lines. 4. Butanol fraction of GTS had cytotoxicity between L1210 and NIH3T3. Significantly, Cytotoxicity of GTS in L1210 cell lines was significant increased. 5. $H_2O$ fraction of GTS had no cytotoxicity both L1210 and NIH3T3.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• v.14 no.2
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• pp.89-111
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• 2001

In order to investigate the effects of GamiTakliSodocyum(GTS) on wound healing, migration of epidermis, formation of granulation tissue and number of capillary within the granulation tissue were measured in diabetic mice by local application and NZW rabbits by local application and prescription of medicine in vivo, and proliferation of human epidermal keratinocytes and human dermal fibroblasts and composition of extracellular matrix were measured in vitro. The results were summerized as follows. 1. $2\%,\;10\%$ GTS remarkably increased migration of epidermis in diabetic mice by local application. 2. $2\%,\;10\%$ GTS remarkably increased formation of granulation tissue, number of neovascularization within the granulation tissue in diabetic mice by local application. 3. 5\%,\;10\%$ GTS remarkably increased migration of epidermis in NZW rabbits by local application. 4. $5\%,\;10\%$ GTS remarkably increased fonnation of granulation tissue, number of neovascularization within the granulation tissue in NZW rabbits by local application. 5. $5\%,\;10\%$ GTS increased migration of epidennis in NZW rabbits by prescription of medicine. 6. $5\%,\;10\%$ GTS increased formation of granulation tissue, number of neovascularization within the granulation tissue in NZW rabbits by prescription of medicine. 7. GTS didn't show effect on the proliferation of human epidermal keratinocytes. 8. GTS increased the proliferation of cultured human dermal fibroblasts. 9. GTS increased the expression of procoliagen ${\alpha}1(I) mRNA in cultured human dermal fibroblasts. 10. GTS increased the expression of fibronectin mRNA in cultured human dennal fibroblasts according to dosage of GTS using northern blot hybridization but didn't increase, using RT-PCR. From the above results, it is conclude that GTS might use on wound healing.

• Animal cells and systems
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• v.16 no.5
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• pp.376-384
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• 2012

Although ginsenosides have a variety of physiologic or pharmacologic functions in various regions, there are only a few reports on the effects of transient receptor potential melastatin 7 (TRPM7) channels. Here, we showed evidence suggesting that TRPM7 channels play an important role in ginseng total saponin (GTS)-mediated cellular injury. The combination techniques of electrophysiology, pharmacological analysis, small interfering RNA (siRNA) method and cell death assays were used. GTS depolarized the resting membrane potentials and decreased the amplitude of pacemaker potentials in cultured interstitial cells of Cajal (ICCs) in gastrointestinal (GI) tract. The TRPM7-like currents in single ICCs and the overexpressing TRPM7 in HEK293 cells were inhibited by GTS. However, GTS had no effect on $Ca^{2+}$-activated $Cl^-$ conductance. GTS inhibited the survival of human gastric (AGS) and brea (MCF-7) adenocarcinoma cells. Also, GTS inhibited the TRPM7-like currents in AGS and MCF-7 cells. The GTS-mediated cytotoxicity was inhibited by TRPM7-specific siRNA. In addition, we showed that overexpression of TRPM7 channels in HEK293 cells was inhibited by GTS. Thus, TRPM7 channels are involved in GTS-mediated cell death in AGS and MCF-7 cells, and these channels may represent a novel target for physiological disorders where GTS plays an important role.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.47 no.9
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• pp.19-28
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• 2010

The GTS(Guaranteed Time Slot) of the IEEE 802.15.4 standard, which is the contention free access mechanism, is used for low-latency applications or applications requiring specific data bandwidth. But it has some problems such as delay of service due to FIFS(First In First Service) scheduling. In this paper, we proposes a weight based GTS allocation scheme for fair queuing in IEEE 802.15.4 LR-WPAN. The proposed scheme uses a weight that formed by how much more weight we give to the recent history than to the older history for a new GTS allocation. This scheme reduces service delay time and also guarantees transmission simultaneously within a limited time. The results of the performance analysis shows that our approach improves the performance as compared to the native explicit allocation mechanism defined in the IEEE 802.15.4 standard.

• The Journal of Internal Korean Medicine
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• v.31 no.3
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• pp.554-568
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• 2010

Objective : This study was examined to investigate the effect of Gamitongseong-san(GTS) extract on spontaneous hypertension. Methods : After administering GTS extract to SHR for 4 weeks, we measured anti-oxygen effects, weight of body, heart and kidney, blood pressure, heart rate, aldosterone, catecholamine, electrolyte, uric acid, and BUN. Results : 1. GTS increased 2,2-diphenyl-1-picrylhydrazyl(DPPH) scavenging activity and superoxide dismutase(SOD) similar activity depending on the concentration. 2. GTS significantly decreased heart weight in spontaneously hypertensive rat. 3. GTS significantly decreased blood pressure and heart rate in SHR. 4. GTS significantly decreased aldosterone. 5. GTS significantly decreased norepinephrine and epinephrine. 6. GTS significantly decreased $K^+$. 7. GTS significantly decreased BUN. Conclusions : These results suggest that GTS may be usefully applied for the treatment of hypertension.

• Journal of the Korea Society of Computer and Information
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• v.16 no.11
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• pp.45-56
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• 2011

WBAN is short range wireless communication technology which is consists of several small devices close to, attached to or implanted into the human body. WBAN is classified into between medical and non-medical by applications based on technology and medical data with periodic characteristics is used the GTS method for transmitting data to guarantee the QoS. In this paper we proposed algorithm that resolve lack of GTSs while data transmit GTS method in superframe structure of WBAN. Coordinator dynamically allocates GTSs according to the data rate of devices and make devices share GTSs when lack of GTSs. We compared delay bounds, throughput for performance evaluation of the proposed algorithm. In other words, we proposed algorithm adaptive WFQ scheduling that GTS allocation support differential data rate in environments of WBAN. The experiment results show the throughput increased and the maximum delay decreased compared with Round Robin scheduling.

• Biomolecules & Therapeutics
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• v.5 no.1
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• pp.36-42
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• 1997

To investigate effects of ginseng total saponin (GTS) on the ethylcholine aziridnium ion (AF64A) -induced glutamatergic nervous system, rats were pretreated with the infusion of AF64A (3 nmole) into lateral ventricle and were posttreated with 50 mg/kg of GTS, i.p., for 1 week. Twenty four hours after the last administration, rats were sacrificed and the levels of glutamate and taurine, [$^3$H]dizocilpine ([$^3$H]MK801) binding sites and glutamine synthetase activity were assessed in striatum, hippocampus and frontal cortex. The levels of striatal glutamate after GTS treatment in rats were decreased. And the levels of glutamate were decreased in striatum and frontal cortex and increased in hippocampus by the infusion of AF64A. However, the AF64A-induced changes of glutamate were returned to the control level by the administration of GTS in striatum, frontal cortex and hippocampus. After the infusion of AF64A, the level of taurine was decreased in striatum and increased in hippocampus. GTS administrations in the AF64A-treated rats restored to the control level of taurine in the decreased striatal level of taurine, but not in the elevated level of hippocampal taurine. The specific [$^3$H]MK801 binding sites in hippocampus was significantly decreased but not in striatum and frontal cortex after the administration of AF64A. Although GTS itself did not affect the specific [$^3$H]MK801 binding sites, GTS administrations in the AF64A-treated rats did decrease the binding sites of (\`H)Mk801 in all examined regions. The activities of striatal glutamine synthetase were decreased after GTS treatment. The activities of striatal glutamine synthetase (GS) were decreased in AF64A-treated groups. However, the decreased striatal GS activities by AF64A were returned to the control level by GTS treatment. Furthermore, GTS administrations in the AF64A-treated rats increased the hippocampal GS activities. The results indicatethat GTS may adjust the levels of glutamate and taurine constantly and may induce increase in AF64A-induced decrease of GS activity. Thus, it suggests that GTS may antagonize changes in central glutamatergic nervous system induced by AF64A. Also it suggests that the actions of GTS may differently affect in the disease state.

• Journal of Ginseng Research
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• v.22 no.3
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• pp.200-205
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• 1998

Isolated rabbit jejunal segments were used to study the effects of ginseng total saponins (GTS) , protopanaxatriol saponins (PT) and protopanaxadiol saponins (PD) on intestinal contractility. GTS, PT and PD caused a dose-dependent decrease in intestinal spontaneous movements, and PT was the most efficacious of them. The effect of GTS, PT and PD were not blocked by pretreatment with phentolamine (10-6 M), yohimbine (10-6 M), d1-propranolol (10-6 M), naloxone(10-6∼10-5M), Nu-nitro-L-arginine methyl ester (10-4 M), methylene blue (10-5M), and N-ethylmaleimide (10-4 M). However, pretreatment with tetraethylammonium chloride (3-10 mM) antagonized the effect of GTS, PT and PD. Furthermore, 4-amlnopyridine (1 mM) also inhibited the effect of GTS, PT and PD. The results suggest that GTS, PT and PD inhibited the spontaneous movements in isolated rebait jejunum by causing hyperpolarization through an activation of K+ channels directly.