• Asian-Australasian Journal of Animal Sciences
• /
• v.29 no.5
• /
• pp.640-645
• /
• 2016

The objective of this study was to evaluate the present conventional selection program of a swine nucleus farm and compare it with a new selection strategy employing genomic enhanced breeding value (GEBV) as the selection criteria. The ZPLAN+ software was employed to calculate and compare the genetic gain, total cost, return and profit of each selection strategy. The first strategy reflected the current conventional breeding program, which was a progeny test system (CS). The second strategy was a selection scheme based strictly on genomic information (GS1). The third scenario was the same as GS1, but the selection by GEBV was further supplemented by the performance test (GS2). The last scenario was a mixture of genomic information and progeny tests (GS3). The results showed that the accuracy of the selection index of young boars of GS1 was 26% higher than that of CS. On the other hand, both GS2 and GS3 gave 31% higher accuracy than CS for young boars. The annual monetary genetic gain of GS1, GS2 and GS3 was 10%, 12%, and 11% higher, respectively, than that of CS. As expected, the discounted costs of genomic selection strategies were higher than those of CS. The costs of GS1, GS2 and GS3 were 35%, 73%, and 89% higher than those of CS, respectively, assuming a genotyping cost of $120. As a result, the discounted profit per animal of GS1 and GS2 was 8% and 2% higher, respectively, than that of CS while GS3 was 6% lower. Comparison among genomic breeding scenarios revealed that GS1 was more profitable than GS2 and GS3. The genomic selection schemes, especially GS1 and GS2, were clearly superior to the conventional scheme in terms of monetary genetic gain and profit.

• Microbiology and Biotechnology Letters
• /
• v.19 no.3
• /
• pp.259-264
• /
• 1991

Glutamine synthetase (GS) of Kkbsiellu pmumonzae was purified and identified it's properties. It was determined to be composed of 12 identical subunits and it's molecular weight was about 600,000. It's optimum pH and temperature were identified as pH 7.0 and $37^{\circ}C$ respectively, and also there was no considerable variation of activity between pH 5 and 8. When GS was incubated at $57^{\circ}C$ for 10 min, it's activity was decreased to half of maximum activity. It was observed that K. pneumoniae has adenylylation-deadenylylation system which regulates activity of GS according to the quality and quantity of nitrogen source like GS of E. coli Also it's GS was very similar to that of E. coli. in structure deduced from the immunodiffuslon experiment using anti-E. coli GS antibody.

• Journal of Food Hygiene and Safety
• /
• v.29 no.1
• /
• pp.67-72
• /
• 2014

This study investigated the antibacterial effects of GR ethanol extracts (GRE), sodium chlorate (SC) and a combination of GRE and SC (GS) on Brucella abortus (B. abortus). The antibacterial activities of GRE, SC and GS towards B. abortus were evaluated by incubating B. abortus with GRE, SC and GS. Following treatment with GRE, SC and GS, B. abortus survival and intracellular proliferation in macrophages were monitored. In the cellular cytotoxicity assay, GRE, SC and GS are not cytotoxic at concentrations less than $400{\mu}g/ml$, 15 mM and 0.6GS (1 of GS, GRE $1,000{\mu}g/ml$ + SC 30 mM), respectively. The viability of B. abortus was markedly decreased in a dose-dependent manner in all treatment groups. In addition, B. abortus intracellular proliferation within macrophages was significantly reduced in cells treated with GRE ($400{\mu}g/mL$), SC (15 mM) and 0.5GS (GRE $500{\mu}g/mL$ + SC 15 mM) after 48 hr-incubation (GRE, p < 0.01; SC and 0.5GS, p < 0.001). Especially, in the treatment of GS, the synergistic effect of GRE and SC treatment on B. abortus in macrophage was observed. In conclusion, GS is useful as an antibacterial candidate against B. abortus, and can be applied in the field of meat and milk hygiene.

• Journal of KIISE:Computer Systems and Theory
• /
• v.28 no.1_2
• /
• pp.73-79
• /
• 2001

단순 다각형 P에 대한 새로운 화량문제인 경비가능충분집합(Guard Sufficiency Set:GSS)에 대하여 소개하고 정의하였다. 집합 S P가 P의 경비가능집합이라는 의미는 P의 각 점들이 최소한 S에 있는 한 점으로부터 보인다는 것을 의미한다. 집합 G P가 P의 경비가능충분집합이라는 의미는 G를 경비 가능한 임의의 집합 S P가 P 역시 경비 가능하다는 것을 의미한다. 본 논문에서는 꼭지점에 대한 GSS가 다각형 전체에 대한 GSS가 되는 다각형 부류를 제시하고, 또한 에지에 대한 GSS가 다각형 전체에 대한 GSS가 되는 다각형 부류를 제시한다. 그리고, P의 꼭지점에 대한 GSS의 크기에 대한 하한과 상한을 제시하고, 기하학적 요소에 특정 제약조건을 주어 대체 GSS을 정의할 수 있음을 보인다. 이 외에도 다양한 GSS 문제들을 소개하고, 기하학적 요소에 제약을 가한 대체 GSS를 정의하고 그와 관련된 가설을 하나 제시한다.

• 한국IT서비스학회:학술대회논문집
• /
• 2006.11a
• /
• pp.483-490
• /
• 2006

본 연구에서는 조직 구성원의 협업을 위하여 도입되는 그룹지원시스템(group support system; GSS)를 대상으로 GSS의 사용에 미치는 영향과 GSS의 사용으로 인한 개인의 성과의 관계에 대한 연구를 실시하였다. 본 연구를 위해 개인의 기술수용 요인에 대한 연구에서 보편적으로 널리 사용되어 온 기술수용모델(technology acceptance model; TAM)과 사용자의 과업과의 연관성을 고려한 과학기술적합(task-technology fit; TTF) 개념, 그리고 적응구조화이론(adaptive structuration theory; AST)을 통합하여 그룹 구성원들이 GSS의 도입의도에 맞게 사용하는 것이 개인과 조직의 성과를 향상시키는지 검증하였다. 연구결과, 높은 TTF는 사용자들이 GSS에 대하여 지각하는 유용성과 용이성에 영향을 미친다는 것을 검증하였다. 또한, TTF가 사용자들의 적절한 사용을 이끌고 있음을 검증하여 TTF 중심의 연구와 AST의 적절한 사용(faithfulness on appropriation; FOA)을 중심으로 하는 두 연구에 대한 통합 모델을 제시하였다.

• Journal of the Korean BIBLIA Society for library and Information Science
• /
• v.25 no.3
• /
• pp.215-234
• /
• 2014

The purpose of this study is to investigate whether Google Scholar (GS) can substitute Web of Science (WoS) for those who don't have access to the subscription-based indexing service and if users feel GS is useful for scholarly information. To achieve the research purpose, the study evaluates both quantitative and qualitative aspects of the two databases. The major results through statistical analysis show that GS indexes much more records and citations for LIS journals than WoS(p < .01), but users' feedback about GS is not better than those about WoS.

• Biomolecules & Therapeutics
• /
• v.5 no.3
• /
• pp.239-245
• /
• 1997

Trimetoquinol (TMQ) and its analogs are known to have thromboxane $A_2$ antagonistic action. We also reported that GS389, chemically similar to TMQ, has competitive antagonistic action in rat aorta and human platelets. In the present study, we investigated the pharmacological characteristics of GS283 and GS 386, analogs of GS389, using vascular smooth muscle, human platelets and rat brain homogenates. In isolated pig coronary artery (PCA), both of GS283 and GS386 relaxed U46619-contracted rings in concentration dependent manner. Pretreatment with several concentrations of GS283 and GS386 shifted the dose-response curves to the right, and reduced of maximum contration dose-dependently. Furthermore, GS283 and GS386 strongly inhibited $Ca^{2+}$ -induced contraction in the PCA. In human platelets, U46619- and A23187-induced platelet aggregation was inhibited by GS283 and GS386, concentration-dependently. Anti-platelet aggregation was related to the compound\`s ability to inhibit ATP release at each stimulation. In rat brain homogenates, receptor-binding assay resulted that both GS283 and GS386 have a relative affinity to $\alpha$-adrenergic receptor. Taken together. we concluded that the mechamism of action of GS283 and GS86 is not related with in TXA$_2$ receptor but concerned with calcium antagonistic action and a-blocking action.n.

• Journal of the korean academy of Pediatric Dentistry
• /
• v.32 no.2
• /
• pp.357-369
• /
• 2005

Streptococci are Gram-positive, facultative anaerobes and have no catalase activities. Among mutans streptococci containing ${\alpha}-type$ hemolytic activity, S. mutans is a causative agent for dental caries. As well as acid production yielding the demineralization of tooth enamel, adherence and colonization of S. mutans to the teeth are also important for its virulence. These early colonization are accomplished by the bacterial fibrillar protein, Antigen I/II (Ag I/II) and glucosyltransferase (GTF). Therefore, Ag I/II and GTF are reasonable targets for the development of vaccine against S. mutans GS-5. The ag I/II and gtfD genes from S. mutans GS-5 were cloned and sequenced. Sequence analyses showed the nucleotides sequence of cloned genes had high homology to the sequences previously reported. The sequence alignment of 280 nucleotides between the cloned Ag I/II and the available sequence of the corresponding S. mutans GS-5 showed the perfect match. Comparing with the sequence of gtfD from S. mutans UA159, the corresponding nucleotide sequence of S. mutans GS-5 showed some mismatches and the mismatches introduced changes in four residues out of 105 amino acids, yielding four missense mutations.

• Journal of Food Hygiene and Safety
• /
• v.21 no.2
• /
• pp.107-112
• /
• 2006

Guh Sung Y.L.S-95 (GS95) is a kind of polyacidic solution, which contains acetic acid as a main component. We investigated in the present study tile genetic toxicity of GS95 according to the standard operation procedure from Korean Institute of Toxicology. In the Salmonella typhimurium reverse mutation assay using TA1535, TA1537, TA98 and TA100, GS95 did not induce mutation up to $5,000{\mu}g/plate$. GS95 did not induce chromosome aberration in Chinese hamster lung fibroblast in the concentration range between 1.25 and 5 mg/mL. In the rodent micronucleus assay, the frequency of micronucleated polychromatic erythrocyte in GS95 treated mice were not increased up to 5,000 mg/kg compared to the vehicle treated mice. Taken all these data together, GS95 was proven to be nongenotoxic in the concentration ranges tested.

• Proceedings of the KIEE Conference
• /
• 1987.07b
• /
• pp.1398-1401
• /
• 1987