• The Korean Journal of Physiology and Pharmacology
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• v.28 no.1
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• pp.1-10
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• 2024

Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia and dyslipidemia. Carvacrol (CAR) has demonstrated the potential to mitigate dyslipidemia. This study aims to investigate whether CAR can modulate blood glucose and lipid levels in a T2DM rat model by regulating short-chain fatty acids (SCFAs) and the GPR41/43 pathway. The T2DM rat model was induced by a high-fat diet combined with low-dose streptozocin injection and treated with oral CAR and/or mixed antibiotics. Fasting blood glucose, oral glucose tolerance, and insulin tolerance tests were assessed. Serum lipid parameters, hepatic and renal function indicators, tissue morphology, and SCFAs were measured. In vitro, high glucose (HG)-induced IEC-6 cells were treated with CAR, and optimal CAR concentration was determined. HG-induced IEC-6 cells were treated with SCFAs or/and GPR41/43 agonists. CAR significantly reduced blood lipid and glucose levels, improved tissue damage, and increased SCFA levels in feces and GPR41/43 expression in colonic tissues of T2DM rats. CAR also attenuated HG-induced apoptosis of IEC-6 cells and enhanced GPR41/43 expression. Overall, these findings suggest that CAR alleviates blood lipid and glucose abnormalities in T2DM rats by modulating SCFAs and the GPR41/43 pathway.

• The Journal of Korean Society for Radiation Therapy
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• v.27 no.2
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• pp.167-174
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• 2015

Purpose : The pre-treatment QA using Portal dosimetry for Volumetric Arc Therapy To analyze whether maintaining the reproducibility depending on various factors. Materials and Methods : Test was used for TrueBeam STx$^{TM}$ (Ver.1.5, Varian, USA). Varian Eclipse Treatment planning system(TPS) was used for planning with total of seven patients include head and neck cancer, lung cancer, prostate cancer, and cervical cancer was established for a Portal dosimetry QA plan. In order to measure these plans, Portal Dosimetry application (Ver.10) (Varian) and Portal Vision aS1000 Imager was used. Each Points of QA was determined by dividing, before and after morning treatment, and the after afternoon treatment ended (after 4 hours). Calibration of EPID(Dark field correction, Flood field correction, Dose normalization) was implemented before Every QA measure points. MLC initialize was implemented after each QA points and QA was retried. Also before QA measurements, Beam Ouput at the each of QA points was measured using the Water Phantom and Ionization chamber(IBA dosimetry, Germany). Results : The mean values of the Gamma pass rate(GPR, 3%, 3mm) for every patients between morning, afternoon and evening was 97.3%, 96.1%, 95.4% and the patient's showing maximum difference was 95.7%, 94.2% 93.7%. The mean value of GPR before and after EPID calibration were 95.94%, 96.01%. The mean value of Beam Output were 100.45%, 100.46%, 100.59% at each QA points. The mean value of GPR before and after MLC initialization were 95.83%, 96.40%. Conclusion : Maintain the reproducibility of the Portal Dosimetry as a VMAT QA tool required management of the various factors that can affect the dosimetry.

• Korean Journal of Heritage: History & Science
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• v.43 no.3
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• pp.306-333
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• 2010

Previous studies on Wolseong fortress have focused on capital system of Silla Dynasty and on the recreation of Wolseong fortress due to the excavations in and around Wolseong moat. Since the report on the Geographical Survey of Wolseong fortress was published and GPR survey in Wolseong fortress was executed as a trial test in 2004, the academic interest in the site has now expanded to the inside of the fortress. From such context, the preliminary research on the fortress including geophysical survey had been commenced. GPR survey had been conducted for a year from March, 2007. The principal purpose of the recent 3D GPR survey was to provide visualization of subsurface images of the entire Wolseong fortress area. In order to obtain 3D GPR data, dense profile lines were laid in grid-form. The total area surveyed was $112,535m^2$. Depth slice was applied to analyse each level to examine how the layers of the remains had changed and overlapped over time. In addition, slice overlay analysis methodology was used to gather reflects of each depth on a single map. Isolated surface visualization, which is one of 3D analysis methods, was also employed to gain more in-depth understanding and more accurate interpretations of the remain The GPR survey has confirmed that there are building sites whose archaeological features can be classified into 14 different groups. Three interesting areas with huge public building arrangement have been found in Zone 2 in the far west, Zone 9 in the middle, and Zone 14 in the far east. It is recognized that such areas must had been used for important public functions. This research has displayed that 3D GPR survey can be effective for a vast area of archaeological remains and that slice overlay images can provide clearer image with high contrast for objects and remains buried the site.

• Magazine of the Korea Concrete Institute
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• v.12 no.3
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• pp.78-84
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• 2000

• Proceedings of the Korean Association of Geographic Inforamtion Studies Conference
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• 2003.04a
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• pp.83-87
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• 2003

• Geophysics and Geophysical Exploration
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• v.4 no.1
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• pp.8-18
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• 2001

To delineate the inhomogeneities including fractures and to estimate the freshness of rock borehole radar consisting of the reflection and tomography methods, and GPR surveys were conducted at a granite quarry mine. The borehole reflection survey using the direction finding antenna was also conducted to get the spatial orientations of reflectors. 20 MHz was adopted as the central frequency for the borehole radar reflection and tomography surveys and 100 MHz was for GPR. Through the interpretation of borehole reflection data using dipole and direction finding antenna as well as GPR images, which are good agreement with each other, we could determine the orientation of the major fractures in three dimensional way. Parts of travel time curves of tomography data showed the anisotropy, which is uncommon in granite quarry. By comparing the tomography data and TeleViewer images, the anisotropy effect in this area are closely related to fine fissures aligned in the same direction. The area confined by the two fractures, MF2 and MF5, might consist of the most fresh granite in the surveyed area, which was concluded from the borehole radar tomography, and GPR images as well as the distribution of anisotropy.

• 한국지구물리탐사학회:학술대회논문집
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• 2001.09a
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• pp.122-140
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• 2001

We have applied the geophysical survey, mainly electric and electromagnetic (EM) methods, to a test site contaminated by hydrocarbon waste disposal and local spill. The multi-frequency, moving source & receiver EM survey along with ground penetrating radar (GPR) showed a fairly good performance in detection of buried metal pipes and objects. Magnetic survey measuring vertical and horizontal gradients were so sensitive to the small metallic objects spread over the surface that it's hard to discriminate the buried pipe. We chose electrical resistivity, EM and GPR survey to examine the soil contamination. Depth slices of resistivity distribution as the results of the inversion of resistivity and EM data coincided each other and closely matched the contaminated area determined by chemical analysis of the soil samples. GPR images did not show the reflection events related with contamination plume since there are no distinct spill in this site. We inferred the contamination using the penetration depth of the GPR energy, which could be used as auxiliary information to the resistivity and EM results. We summarized the applicability of each survey methods based on this results and proposed a desirable survey scheme for the determination of hydrocarbon contaminated site.

• Geophysics and Geophysical Exploration
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• v.8 no.1
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• pp.59-66
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• 2005

The main purpose of this paper is to describe a highly efficient common mid-point (CMP) data acquisition method for ground-penetrating radar (GPR) surveying, which is intended to widen the application of GPR. The most important innovation to increase the efficiency of CMP data acquisition is continuous monitoring of the GPR antenna positions, using a real-time kinematic Global Positioning System (RTK-GPS). Survey time efficiency is improved because the automatic antenna locating system that we propose frees us from the most time-consuming process-deployment of the antenna at specified positions. Numerical experiments predicted that the data density and the CMP fold would be increased by the increased efficiency of data acquisition, which results in improved signal-to-noise ratios in the resulting data. A field experiment confirmed this hypothesis. The proposed method makes GPR surveys using CMP method more practical and popular. Furthermore, the method has the potential to supply detailed groundwater information. This is because we can convert the spatially dense dielectric constant distribution, obtained by using the CMP method we describe, into a dense physical value distribution that is closely related to such groundwater properties as water saturation.

• Journal of Korean Tunnelling and Underground Space Association
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• v.21 no.5
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• pp.717-733
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• 2019

In this study, lining thickness distribution and its behind state (particularly, its void state) were analyzed using the GPR survey data performed on three currently operating NATM tunnels. Results of GPR analysis showed that void areas were mostly detected between concrete lining and primary support, particularly, near the crown of the tunnels. The lining thickness in the left-hand side of the tunnel was different from that of the right-hand side by 8.6~253.5 mm when measured in transverse direction. It was also found that longitudinal cracks were prevailed in the area lining thickness was sharply changed. Longitudinal thickness distribution at the crown was also studied and tested by performing 3 goodness-of-fit tests in order to find the most suitable thickness distribution. Normal distribution (or similar distribution) fit most suitably to the measured data if the measured average thickness was larger than designed one; Gamma and/or Inverse Gauss distribution fit to the measured data reasonably well if the measured average thickness was less than the designed value of thickness. Since actual lining thickness can be a potential index when assessing the state and safety of the unreinforced NATM tunnel lining, measuring of the lining thickness with GPR survey might be needed rather than assuming the thickness is always constant and same with the designed value.

• Journal of Korean Tunnelling and Underground Space Association
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• v.24 no.4
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• pp.341-353
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• 2022

Pipelines are buried in urban area, and the position (depth and orientation) of buried pipeline should be clearly identified before ground excavation. Although various geophysical methods can be used to detect the buried pipeline, it is not easy to identify the exact information of pipeline due to heterogeneous ground condition. Among various non-destructive geo-exploration methods, ground penetration radar (GPR) can explore the ground subsurface rapidly with relatively low cost compared to other exploration methods. However, the exploration data obtained from GPR requires considerable experiences because interpretation is not intuitive. Recently, researches on automated detection technology for GPR data using deep learning have been conducted. However, the lack of GPR data which is essential for training makes it difficult to build up the reliable detection model. To overcome this problem, we conducted a preliminary study to improve the performance of the detection model using finite difference time domain (FDTD)-based numerical analysis. Firstly, numerical analysis was performed with homogeneous soil media having single permittivity. In case of heterogeneous ground, numerical analysis was performed considering the ground heterogeneity using fractal technique. Secondly, deep learning was carried out using convolutional neural network. Detection Model-A is trained with data set obtained from homogeneous ground. And, detection Model-B is trained with data set obtained from homogeneous ground and heterogeneous ground. As a result, it is found that the detection Model-B which is trained including heterogeneous ground shows better performance than detection Model-A. It indicates the ground heterogeneity should be considered to increase the performance of automated detection model for GPR exploration.