• 제목/요약/키워드: GOT/GPT

검색결과 850건 처리시간 0.027초

배합사료에 크릴, 켈프, 마늘 또는 감귤 분말 첨가가 넙치 육성어의 성장, 혈액 성상 및 지방산 조성에 미치는 영향 (Growth Performance, Hematological Parameter and Fatty Acid Composition of Growing Olive Flounder (Paralichthys olivaceus) to Dietary Inclusion of Kelp Meal, Krill Meal, Garlic Powder or Citrus Meal)

  • 서주영;김경덕;손맹현;이상민
    • 한국수산과학회지
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    • 제43권5호
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    • pp.557-561
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    • 2010
  • This feeding experiment was conducted to investigate the effects of dietary inclusion of some additives on growth performance, hematological parameter and fatty acid composition of growing flounder. Triplicate groups of fish (average weight 120 g) were fed one of five diets containing 5% kelp meal (Ke), 10% krill meal (Kr), 1% garlic powder (Ga), 1% citrus meal (Ci) or control diet (Con) without supplementation for 15 weeks. After the feeding experiment, survival was not significantly different among the groups fed the different diets. Weight gain of fish fed the Ci diet was significantly higher than that of fish fed the Kr diet, but not significantly different from Con, Ke and Ga treatments. Feed efficiency and protein efficiency ratio of fish fed the Ga diet were significantly higher than those of fish fed the other diets. Total protein, glucose, GOT, GPT and total cholesterol contents in the plasma were not affected by the dietary additives. Composition of C20:4n-6 in the dorsal muscle of fish fed the Con diet was significantly higher than that of fish fed the other diets. The results of this study suggest that the dietary inclusion of garlic meal at 1% may improve feed utilization of growing flounder.

대시호탕(大柴胡湯)이 alloxan으로 유발(誘發)된 고혈당(高血糖) 백서(白鼠)에 미치는 영향(影響) (Effects of Daesihotang and its component groups on diabetes, free radical and antioxidative defense system in alloxan induced diabetic rats)

  • 박선동;윤병국
    • 대한한의학방제학회지
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    • 제9권1호
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    • pp.289-317
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    • 2001
  • The purpose of this study was to reseach the effect of Daesihotang and its component groups on diabetes, free radical and antioxidative defense system in alloxan-induced diabetic rats. The experimental group was divided into three groups: Daesihotang (DS), Soyangyak (DS1), Yangmyungyak (DS2). The results were obtained as follows: The level of glucose, triglyceride, total cholesterol, creatinine in serum were considerablely reduced by Daesihotang. And the level of HDL cholesterol, albumin, total protein in serum were increased by Daesihotang significantly. And the level of BUN has some decreased, but with no significancy. In the study of Daesihotang on free radical scavenging effect in vitro, it has shown that Daesihotang and its components group have significant suppressing effect on peroxidation of linoleic acid on concentration. And in other experiments as scavenging effect of DPPH radical, inhibitory effect of superoxide in xanthine-xanthine oxidase system and inhibitory effect on lipid peroxidation reaction by hydroxy radical in $H_2O_2-Fe^{2+}$ system, Daesihatang have some activity, but with no significancy. In the study of Daesihotang on antioxidative defense system in vivo, the activity of GOT and GPT in serum were significantly increased; and the amounts of lipid peroxide in serum was reduced significantly but in liver no significancy. In hepatic catalase activity, Daesihotang has showed significant effect. In the level of hepatic glutathione, Daesihotang increased the amount of glutathione significantly. And in the activity of glutathione-s-transferase, Daesihotang has decreasing effect but has no significancy. These result suggest that Daesihotang has strong effect on diabetes and it is useful to prevent diabetes, but has less effect on peroxidative damage by free radical.

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인진(茵蔯)과 갈근(葛根)이 d-galactosamine, 급성(急性) alcohol중독(中毒) 및 $CCl_4$중독(中毒) 백서(白鼠)의 간손상(肝損傷)에 미치는 영향(影響) (Studies on the effects of PUERARIAE RADIX(葛根) and ARTEMISIAE HERBA(茵蔯) on experimental liver damages induced by alcohol, d-galactosamine and $CCl_4$)

  • 우홍정;이장훈;김영철
    • 대한한의학회지
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    • 제18권1호
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    • pp.411-429
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    • 1997
  • Recent survey shows that chronic liver disease such as chronic hepatitis, liver cirrhosis and hepatoma is the third leading causes for death in Korea. In oriental medicine, viral hepatitis is related to Hwangdal(黃疸) and alcoholic liver disease is related to Joosang(酒傷). ARTEMISIAE HERBA and PUERARIAE RADIX have long been used in treating those symptoms. This study was done to evaluate the effect of AR1EMISIAE HERBA and PUERARIAE RADIX on viral and alcoholic hepatitis. ARTEMISIAE HERBA and PUERARIAE RADIX were decocted respectively with water and followed by vaccum evaporation. The solution was diluted to adequate concentration. Sprague-Dawley rats were used in this experiment. Each group was given PUERARIAE RADIX or ARTEMISIAE HERBA solution orally and CCl4, d-galactosamine or alcohol was given orally 30 minutes later. After 24 hours of starvation, blood samples were taken to check serum GOT, GPT, LDH and ALP activities, TC, TG, glucose and BUN levels. These results show that ARTEMISIAE HERBA has better effect on liver injury induced by d-Galactosamine than PUERARIAE RADIX and that both ARTEMISIAE HERBA and PUERARlAE RADIX have good effect on acute alcoholic liver disease while in the liver injury induced by $CCl_{4}$, PUERARIAE RADIX has better inhibitory effect on serum AST, ALT and ALP levels and ARTEMISIAE HERBA has better inhibitory effect on serum total cholesterol and triglyceride. And the result that high concentration group has better effect shows these effects are concentration-dependent. Further study on the mechanism of these herbs is still required.

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백화수오약침의 항산화작용에 관한 실험적 연구 (Experiment Study on Antioxidant Activites of Aqua-acupuncture of Cynanchum Wilfordii Hemsley)

  • 이종현;성락기;김성훈
    • 대한한의학회지
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    • 제18권1호
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    • pp.278-298
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    • 1997
  • This study was performed to prove the antioxidant activities of Cynanchum Wilfordii Hemsley(白何首烏) by way of aqua- acupuncture methods. After 10% & 20% concentrations of liquid extract of Cynanchum Wilfordii Hemsley were acupunctured on Joksamri(足三里) of rats with acute and chronic experimental oxidation by AAPH(2, 2'-azobis(aminoidinopropane), hydrochoride), various kinds of experiments were measured. The results were obtained as follows: 1. In acute antioxidant experiment, the amount of TBARS indicated irregular increase and decrease to over 68% in experiment group in comparison with normal group. 2. In the serum test of acute antioxident experiment, uric acid and total protein and albumin were significantly increased in experiment group in comparison with control group. 3. In chronic antioxident experiment, the change of body weight was significantly decreased in 20% experimental groups in comparison with control group, and only liver significantly increased in 10% & 20% experiment group. 4. In chronic antioxident experiment, total protein significantly increased in 10%, 20% experimental groups and creatinine and BUN were significantly decreased in 10% experiment group. 5. In the chronic antioxident experiment, serum GOT, GPT activity didn't show no significantly change, LDH activity was significantly increase in 10% experiment group in comparison with control group. 6. In the chronic antioxident experiment, the tolerance test with enzyme activities of erythrocyte membrane was significantly decreased in 10% & 20% experimental groups. 7. In the chronic antioxident experiment, the change of TBA was significantly decreased in 10% & 20% experimental group. 8. In the chronic antioxident experiment, the amount of cytochrome p-450 was significantly increased in 10% & 20% experimental groups in comparison with control group. 9. In the chronic antioxident experiment, the amount of cytochrome b5 was significantly increase in 20% experimental group in comparison with control group. 10. In the chronic antioxident experiment, the change of activity of superoxide dismutase, and catalase were significantly increased in 20% experiment group in comparison with control group. From the above result, it was concluded considers the liquid extract of Cynanchum Wilfordii Hemsley(白何首烏) could be used as antiaging drugs, because it delayed the aging process and retarded senility.

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은복과 한약재 복합물이 알콜 투여로 유발된 흰쥐의 고지혈증과 간 손상의 예방에 미치는 영향 (Effects of Water Extracts from Lagocephalus wheeleri with Several Herbs on Hyperlipemia and Liver Damage Induced by Alcohol)

  • 서부일;박지하;최홍식;김승모;구덕모;김미려;박진현
    • 대한본초학회지
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    • 제23권1호
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    • pp.9-15
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    • 2008
  • Objectives : This study was performed to investigate the effect of water extracts from Lagocephalus wheeled with several herbs(LW) on hyperlipemia and liver damage induced by alcohol. Methods : Except for the normal group, we fed rat on 25% alcohol for 55 days. And each extract was administrated for the same period. We measured the serum component in rat's blood, body weight and weight of liver. Results : At first, we observed effects of LW on hyperlipemia induced by alcohol. LW group didn't show significant increase of total cholesterol in comparison with those of the control group. LW group didn't show significant increase of HDL(High-Density lipoprotein) cholesterol in comparison with those of the control group. LW group showed significant decrease of triglyceride in comparison with those of the control group. LW group showed significant increase of body weight in comparison with those of the control group in 4weeks and 8weeks. LW group showed significant increase of liver weight in comparison with those of the control group. At second, we observed effects of LW on liver damage induced by alcohol. LW group showed significant decrease of ALP, GOT, GPT and LDH in comparison with those of the control group. Conclusions : Reviewing these experimental results, it appears that water extracts from Lagocephalus wheeleri with several herbs have pharmaceutical efficacy on hyperlipidemia and liver damage induced by alcohol. Therefore further additional study should be conducted to elucidate in depth the pharmaceutical efficacy of this.

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죽엽이 알콜 투여로 유발된 흰쥐의 고지혈증과 간 손상의 예방에 미치는 영향 (Effects of water extracts from Phyllostachys Folium on hyperlipidemia and liver damage induced by alcohol)

  • 이재만;서부일;박지하;노성수
    • 대한본초학회지
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    • 제26권3호
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    • pp.31-36
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    • 2011
  • Objectives : This study was performed to investigate the effect of water extracts from Phyllostachys Folium(PF) on hyperlipiderma and liver damage induced by alcohol. Methods : Except for the normal group, we fed rat on 25% alcohol for 55 days. And extract was administrated for the same period. We measured the serum component in rat's blood, body weight and weight of liver. Results : At first, we observed effects of PF on hyperlipidemia induced by alcohol. PF group didn't show significant change of total cholesterol in comparison with those of the control group. PF group showed significant increase of HDL(High-Density lipoprotein) cholesterol in comparison with those of the control group. PF group showed significant decrease of triglyceride in comparison with those of the control group. PF group showed significant increase of body weight in comparison with those of the control group at 4weeks and 8weeks. At second, I observed effects of PF group on liver damage induced by alcohol. PF group showed significant decrease of GOT, GPT, ALP and LDH in comparison with those of the control group. PF group showed significant increase of liver weight in comparison with those of the control group. Conclusions : Reviewing these experimental results, it appears that water extracts from Phyllostachys Folium(PF) have pharmaceutical efficacy on hyperlipidemia and liver damage induced by alcohol. Therefore further additional study should be conducted to elucidate in depth the pharmaceutical efficacy of these.

배합사료가 양식장 넙치의 성장 및 건강도 향상에 미치는 영향 (Effects of Extruded Pellet on Growth and Health Parameters in Farm Cultured Olive Flounder Paralichthys Olivaceus)

  • 김강웅;권문경;김경덕;김신권;박명애;손맹현
    • 수산해양교육연구
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    • 제22권4호
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    • pp.529-536
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    • 2010
  • This study was conducted to effect of extruded pellets (EPs) and moist pellet (MP) diet on growth and fish health parameters in farm cultured olive flounder Paralichthys olivaceus. Two replicate groups of 2,600 fish per each tank (initial weight of $30.1{\pm}0.2$ g) were fed one of the three EPs (EP1, EP2 and CEP) and one MP for 13 months. In field feeding experiment conducted in commercial flounder farm, survival, growth (30-600 g) and condition factor of fish fed experimental EP1 and EP2 were comparable to those of fish fed MP, but considerably higher feed efficiency and protein efficiency ratio were observed in fish fed experimental EPs. Viable cell counts from diet and water from MP diet were considerably higher than those from EP diet, and lysozyme activity from EP diet was higher than that from MP diet. GOT and GPT of fish fed the EP diet were considerably lower than those from MP group, but total protein and glucose concentration of fish fed the EP groups were not significantly different from that of fish fed the MP. Therefore, these results strongly suggest that EP diets could be developed to replace MP diet without adverse effects on growth performance and to enhance the immunity and protective ability of olive flounder against fish disease such as Vibro, Edwardsiella and Strptococcus.

편식하는 비만 아동의 식행동, 맛 선호도 및 영양 섭취 상태 (The Dietary Behaviors, Taste Preferences, and Nutrient Intakes of Obese Children Consuming Unbalanced Diets)

  • 최미경;이윤신
    • 동아시아식생활학회지
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    • 제18권1호
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    • pp.127-134
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    • 2008
  • This study was designed to evaluate the nutritional status and dietary problems of obese elementary students consuming unbalanced diets. Blood parameters, body-image perceptions, taste preferences, and nutrient intakes of 40 obese elementary students with unbalanced diets were compared to those of 40 additional obese elementary students as a control. The averages for age, height, weight, and obesity index were 11.5 years, 142.0 cm, 51.0 kg, and 35.4% in the study group and 11.8 years, 144.0 cm, 53.5 kg, and 36.3% in the control group, respectively. The major disliked foods by the students in the study group were vegetables (65%) particularly Kimchi (15%), as well as fish(15%), and pulses (10%). Mean serum cholesterol, blood glucose, GOT/GPT, and hemoglobin levels were 175.1 mg/dL, 89.2 mg/dL, 24.1/18.9 IU/L, and 14.3 g/dL in the study group and 182.8 mg/dL, 91.3 mg/dL, 28.3/33.9 IU/L, and 14.7 g/dL, in the control group, respectively. Approximately 60${\sim}$80% of the subjects responded that they eat a meal everyday, and the remainder skipped at least one meal. The preference for salty tasting foods was significantly lower in the study group, but the preference for hot tasting food was higher as compared to the obese control group(p<0.05, p<0.05). The daily energy intakes of the study and control groups were 1,768.3 kcal and 1,572.7 kcal, respectively, but there was no significant differences between them. Daily intakes of animal protein, fat, animal fat, and vitamin $B_2$ were significantly higher in the study group than in the control group. In conclusion, this study found that obese children consuming unbalanced diets strongly disliked vegetables, particularly Kimchi, as well as hot tasting foods; however, they preferred salty foods. Daily intakes of animal protein and fat were higher in the study group as compared to obese children not consuming unbalanced diets.

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신통축어탕(身痛逐瘀湯)이 난소적출(卵巢摘出) 백서(白鼠)의 골다공증(骨多孔症)에 미치는 영향(影響) (Effects of Sintongchukeatang on the Ovariectomized Rat Model of Postmenopausal Osteoporosis)

  • 박재웅;심호철;김송백;유심근
    • 대한한방부인과학회지
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    • 제19권1호
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    • pp.81-96
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    • 2006
  • Purpose : this study is to examine what are the effects of the Sintongchukeatang(SCT) on the ovariectomized rat model of postmenopausal osteoporosis. Methods : 12weeks Female Sprague-Dawley 30 rats of weighting 250-300g, were divided into three groups including the sham operation groups(10heads) and overiectomy groups(10heads). then we observed changes in the body weight serum metabolic products and femoral trabecular bone. Results : 1. The level of serum ALP activity in control group showed significant increase in comparison with sham, but that in SCT-treated was significantly decreased in comparison with control. 2. The level of serum GOT in control group showed no change in comparison with sham, but that in SCT-treated was significantly decreased in comparison with control. The level of serum GPT did not significant change among the three groups. 3. The level of serum estrogen in control group showed slightly decreased in comparison with sham, but that in SCT-treated showed no change in comparison with control. 4. Trabecular bone area as well as trabecular thickness in control group showed significant decrease in comparison with sham. Those in SCT-treated showed significant increase in comparison with control. 5. Trabecular separation only in SCT-treated showed significant decrease in comparison with control. 6. Osteoclast number and oseoblast surface in control group showed significant increase in comparison with sham. Those in SCT-treated showed significant decrease in comparison with control. Conclusion : SCT has shown to be capable of preventing and curing osteoporosis caused by old-aged and postmenopause.

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당뇨흰쥐의 콜라겐 감소 및 인간 피부 섬유아세포의 MMP-1 증가에 대한 목단피(牧丹皮)의 항피부노화 효과 (Anti-skin-aging effects of Paeonia Suffruticosa Andrews on maintaining skin collagen in STZ-induced diabetic rats and inhibiting MMP-1 systhesis in human skin fibroblasts)

  • 김경진;김경준
    • 한방안이비인후피부과학회지
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    • 제21권1호
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    • pp.1-15
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    • 2008
  • Objective : Skin aging is commonly observed in patients with diabetes mellitus, which can be accessed by the amount of skin collagen and matrix metalloproteinase-1 (MMP-1). In the present study, anti-skin-aging effects of Root Cortex of Paeonia Suffruticosa Andrews (PSA), which has been widely used to treat diabetes mellitus, are investigated. Methods : Streptozotocin (STZ) was intraperitoneally injected to rats to induce diabetes. Body weights, feed intake, organ weights, blood glucose, and other biochemical index are determined in both normal and diabetic rats. In order to study the effect of PSA on skin aging, the amount of skin collagen was measured in diabetic rats after PSA treatments. Also, MMP-1 synthesis in UVB-irradiated human skin fibroblasts was investigated. Results : 1. When PSA was administered to STZ-induced diabetic rats, feed intake was significantly increased and blood glucose and total cholesterol were decreased in a dose-dependent manner. However, there are no differences in individual organ weights, GOT, and GPT. 2. A decrease of skin collagen in diabetic rats was significantly suppressed when PSA was treated. 3. PSA also inhibited MMP-1 synthesis in UVB-irradiated normal human skin fibroblasts, similar to retinoid, a well-known effective anti-skin-aging substance. Conclusion: PSA suppressed a collagen decrease in diabetic rats and inhibited MMP-1 synthesis in UVB-irradiated human skin fibroblasts. Therefore, the treatment of PSA is very effective to slow down the skin aging process.

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