• Proceedings of the Korean Magnestics Society Conference
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• 2003.06a
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• pp.56-57
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• 2003

• Information and Communications Magazine
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• v.20 no.3
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• pp.78-92
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• 2003

본 고에서는 차세대 통합 네트워크를 위한 프로토콜들 중 소프트스위치(MGC)와 미디어 게이트웨이를 중심으로 사용될 수 있는 BICC, SIPT, Megaco/H.248 프로토콜과 VoIP용 프로토콜인 H.323, SIP 프로토콜 등의 표준화 내용에 대해서 살펴보고 차세대 등합 네트워크로 진화하는 중간 단계에서 필수적으로 이루어져야 할 기존망들간의 연동 기술들에 대한 표준화 내용을 다루고자 한다. 그리고 마지막으로 연동기술 동향으로써 MSF(Multiservice Switching Forum)에서 주관하고 있는 장비 간 상호운용성 시험인 GMI(Global MSF Interoperability)에 대해서 기술하도록 한다.

• Journal of Magnetics
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• v.11 no.1
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• pp.43-50
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• 2006

In this paper, the influences of microstructural and surface morphological developments on the soft magnetic properties and giant magneto-impedance (GMI) effect of the $Fe_{73.5-x}Cr_{x}Si_{13.5}B_{9}Nb_{3}Au_1$ (x = 1, 2, 3, 4, 5) alloys have been presented. It was found that the Cr addition slightly decreased the mean grain size of $\alpha-Fe(Si)$ grains. AFM results indicate a large variation of surface morphology of density and size of protrusions along the ribbon plane due to microstructural changes caused by thermal annealing with increasing Cr content. Ultrasoft magnetic properties of the nanocrystallized samples were noticeably enhanced by properly heat treatments at $T_a=540^{\circ}C$ such as an increase of the magnetic permeability and the decrease of coercivity, which is likely due to the formation of nanoscale $\alpha-Fe(Si)$ phase which reduced the magnetoelastic anisotropy of samples. Accordingly, the GMI effect was observed in the annealed samples. The correlation between the microstructure, surface morphology, and soft magnetic properties were explained by nucleation and growth model.

• BMB Reports
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• v.43 no.10
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• pp.704-709
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• 2010

The Swedish mutation (K595N/M596L) of amyloid precursor protein (APP-swe) has been known to increase abnormal cleavage of cellular APP by Beta-secretase (BACE), which causes tau protein hyperphosphorylation and early-onset Alzheimer's disease (AD). Here, we analyzed the effect of APP-swe in global gene expression using deep transcriptome sequencing technique. We found 283 genes were down-regulated and 348 genes were up-regulated in APP-swe expressing H4-swe cells compared to H4 wild-type cells from a total of approximately 74 million reads of 38 base pairs from each transcriptome. Two independent mechanisms such as kinase and phosphatase signaling cascades leading hyperphosphorylation of tau protein were regulated by the expression of APP-swe. Expressions of catalytic subunit as well as several regulatory subunits of protein phosphatases 2A were decreased. In contrast, expressions of tau-phosphorylating glycogen synthase kinase $3\beta$(GSK-3$\beta$), cyclin dependent kinase 5 (CDK5), and cAMP-dependent protein kinase A (PKA) catalytic subunit were increased. Moreover, the expression of AD-related Aquaporin 1 and presenilin 2 expression was regulated by APP-swe. Taken together, we propose that the expression of APP-swe modulates global gene expression directed to AD pathogenesis.

• Journal of Magnetics
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• v.9 no.2
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• pp.47-51
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• 2004

Giant magneto-impedance (GMI) effect in zero-magnetostrictive Co-based amorphous ribbons samples in their as-quenched and stress-released states as well as with intentionally induced magnetic anisotropy were investigated. Magnetic and impedance properties of the samples exhibiting different anisotropy were compared and the optimum operation conditions for the studied samples from the view-point of their utilization as a sensor element have been determined. A design of a model of magnetic field sensor and characteristics of the constructed prototype are presented.

• Proceedings of the Korean Magnestics Society Conference
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• 2002.12a
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• pp.210-211
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• 2002

The magnetic anisotropy of amorphous wires plays a decisive role in the giant magnetoimpedance(GMI) behavior. The magnetoelastic anisotropy caused by internal stress, that are frozen in during the fabrication process, results in an axial easy axis in the core region and in a circular easy axis in the shell region [1]. It leads to a simple domain structure consisting of circular domains in the shell and axial domains in the core. For a more realistic domain structure, it has been suggested that the helical anisotropy exists due to an internal helical stress [2]. (omitted)

• Proceedings of the Korean Magnestics Society Conference
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• 2002.12a
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• pp.208-209
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• 2002

Recently an asymmetric giant magnetoimpedance (GMI) profile has been observed in Co-based amorphous ribbons annealed at the weak field [1-4]. This phenomenon has attracted a large interest due to its practical application to sensitive magnetic sensors. It is known [5.6] that in magnetic materials, the magnetoimpedance is caused by the effect of the magnetic field on the transverse magnetic permeability of a near-surface layer. In consequence of it, the value of the magnetoimpedance depends strongly on near-surface magnetic properties of the sample. (omitted)

• Journal of Genetic Medicine
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• v.16 no.2
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• pp.67-70
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• 2019

Limb-girdle muscular dystrophy (LGMD) is a group of muscular dystrophies that has extremely heterogeneous clinical features and genetic background. The caveolin-3 gene (CAV3) is one of the causative genes. LGMD appears as a clinical continuum, from isolated skeletal muscle involvement to long QT syndrome. Here we report two patients without apparent muscle weakness in a family with CAV3 mutation. A 7-month-old Korean boy visited our muscle clinic because of an incidental finding of elevated serum creatine kinase (CK) concentration (680 IU/L, reference range, 20-270 IU/L) without clinical symptoms. The patient was born after an uneventful pregnancy and showed normal developmental milestones. He developed pseudohypertrophy of his calf muscle during the follow-up. We obtained a muscle biopsy at age 14 months, which showed size variations and degenerating/regenerating myofibers with endomysial fibrosis and immunohistochemical evidence of normal dystrophin. Under the impression of LGMD, we performed target panel sequencing and identified a heterozygous in-frame mutation of CAV3, c.307_312delGTGGTG (p.Val103_Val104del). Immunohistochemical staining of muscle indicated complete loss of caveolin-3 compared with normal control muscle, which supported the variant's pathogenicity. We performed segregation analysis and found that the patient's mother had the same variant with elevated serum CK level (972 IU/L). We report on autosomal dominant familial caveolinopathy caused by a pathogenic variant in CAV3, which was asymptomatic until the fourth decade. This case highlights the utility of next generation sequencing in the diagnosis of muscular dystrophies and the additive role of muscle biopsy to confirm the variants.

• Journal of Sensor Science and Technology
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• v.15 no.2
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• pp.77-83
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• 2006

A monitoring apparatus for pulse shapes of human heartbeats has been developed using an amorphous MI(Magnetic Impedance) sensor. The pulse shapes are successfully obtained from voltage signals due to the variations of magnetic impedance in the amorphous MI sensor, which is attached to a patient's wrist. This voltage signal was fed into a signal processing module to extract the pulse shapes of heartbeats. The signal processing module, which is proposed to detect a weak variations of impedance in MI sensor under a noisy measurement environment, consists of a high frequency current source, an amplifier stage and a synchronous detection circuit. To evaluate the characteristics of a newly developed apparatus, various experiments were performed. The experimental results show that the developed apparatus could be used as a diagnosis tool for traditional Korean medicine with further systematic clinical studies.

• Journal of Nutrition and Health
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• v.31 no.2
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• pp.159-165
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• 1998

This study was undertaken to examine relations between obesity and birthweight, parental weight and serum biochemical levels(lipids , glucose, insulin and aminotransferase) in elementary school children aged 10-12 . The weight of obese girls was higher than that of obese boys, while WHR was higher in obese boys than in obese girls. The birth weight of the obese children was significantly higher than that of the non-obese children(p<0.01), and was positively correlated with current weight. The concentrations of serum TG, LDL, VLDL, LDL-cholesterol, glucose, insulin and ALT in obese children were much higher than those in non-obese children . However, the serum HDL -cholesterol concentration of the obese children was significantly lower compared with that of the no-obese children. On the other hand, little differences in these levels were found between genders. The concentrations of PL, TC and AST in the groups showed no significant differences. In the obese children, serum concentrations of TG, LDL-cholesterol , glucose and ALT were more closely associated with GMI than with WHR. No significant correlation was found with serum insulin , glucose and TG levels. These data show that childhood obesity may be related to hyperlipidemia , atherosclerosis, hypertension, diabetes mellitus and fatty liver.