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Immunotoxicological Evaluation of Pollen Intake Using Mice Model (실험동물을 이용한 화분섭취의 면역안전성 평가)

  • Park Hee Sung;Heo Young Jeu;Byun Jung-A;Heo Yong
    • Journal of Environmental Health Sciences
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    • v.31 no.4 s.85
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    • pp.287-293
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    • 2005
  • Pollen has been used for Prevention or treatment of certain diseases such as diabetes, arthritis, or cancer in traditional medicine. In addition, pollen is under investigation as a host cell for a gene expression. This study was undertaken to evaluate the immunologic safety of pollen intake. BALB/c mice were administered with 500, 50,5, or 0.5 mg/kg bw of lily pollen for five times a week for four weeks through gastric intubation. Comparing the control mice administered with distilled water, no significant changes were observed in body weight gain, weight of liver, spleen, lung, and his-topathological findings of liver and kidney of the mice groups administered with the pollen. Plasma level of IgG1, IgG2a, and IgE was not different among the groups. When splenic B lymphocytes were stimulated in vitro with lipopolysaccharides for 7 days, level of IgGl and IgGwa produced in the culture supernatants was not significantly different among the groups. Furthermore, no significant alteration was observed in IL-4 and $IFN{\gamma}$ producing ability with splenic T lymphocytes stimulated in vitro with phytohemagglutinins for 48 hours between the pollen-administered and the control mice. Overall, this study suggests that the lily pollen intake is Inducing no significant modulation of humoral and cell-mediated immunity in mice.

패키지 소프트웨어 품질평가모형 개발 및 적용에 관한 연구

  • 이국철;이성현
    • Proceedings of the Korea Database Society Conference
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    • 1999.10a
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    • pp.143-152
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    • 1999
  • 세계 소프트웨어 시장의 급속한 성장과 함께 선진국들은 자국에 유리한 소프트웨어 품질표준을 만들어 이를 국제 표준에 반영하고, 외국 소프트웨어에 대한 진입 규제의 수단으로 활용하고 있다. 또한 전자상거래의 발달로 인해 디지털 상품인 소프트웨어는 전자상거래를 통한 거래가 쉬운 이점을 가지고 있는 상황에서 아직 우리나라에서는 패키지 소프트웨어에 관한 품질모형 개발에 관한 연구가 다소 미흡한 실정이다. 본 연구에서는 기존 국내외 소프트웨어 품질평가모형을 도출하고, 그 평가모형을 바탕으로 전자상거래에서 활용 가능한 패키지 소프트웨어만을 대상으로 품질평가모형을 개발하였다. 그리고 평가모형을 적용하기에 앞서 소프트웨어 개발 업체를 대상으로 설문조사를 실시하여 품질평가모형에 대한 실증분석을 하였다. 실증분석은 현재 개발업체가 취급하고 있는 제품에 대한 종류와 개발업체에서 평가받기를 원하는 제품의 종류, 그리고 평가대상이 될 수 있는 패키지 소프트웨어 제품의 경쟁력 수준과 관련하여 선진국의 제품과 비교하여 5점 척도로 조사하였다. 그리고 소프트웨어 개발자 입장에서 품질평가 항목별로 중요도를 조사하였으며 분석결과를 토대로 품질평가모형의 적용 대상을 선정하였다. 적용대상 제품은 모두 14개로 각각의 제품들을 게임, OA, 통신, ERP, 4GL, OS 소프트웨어로 분류하고 제품에 대한 평가는 개발자(개발경력 3년 이상)와 일반사용자로 분류하여 평가를 실시하였다. 그리고 각 제품분야별로 평가항목에 대한 가중치를 전문가 집단에 의뢰하여 적용하였다. 평가방법은 각각의 제품에 대한 평가점수를 1점부터 5점까지 나누어 평가결과를 평균값으로 나타냈으며, 평가결과에 대해 여러 가지 방법으로 분석하였다. 첫째, 동종제품간 평가분석을 통하여 각각의 제품을 비교하였으며, 둘째 소프트웨어 종류별 평가로 제품을 응용소프트웨어, 응용개발도구, 시스템 소프트웨어로 분류하여 평균값으로 비교하였다. 셋째, 국내외 제품별 평가분석으로 전체 제품을 국내제품과 국외제품으로 분류하여 비교하였으며, 마지막으로 총괄분석을 통해 가중치를 적용하여 전 제품의 점수를 비교하였다. 여기에서는 각 제품의 평균점수에 대한 차이를 95%의 유의수준으로 T-Test를 실시하였다.

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Organizational Ostracism: A Potential Framework in Order to Deal with It

  • Mlika, Mona;Khelil, Mehdi Ben;Salem, Nidhal Haj
    • Safety and Health at Work
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    • v.8 no.4
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    • pp.398-401
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    • 2017
  • Background: Organizational ostracism is defined as a violation of norms that we are suggested to acknowledge at the workplace. It results in the exclusion of one person or multiple persons, and causes damage to our innate need to belong. This kind of behaviorism can be engaged through a hierarchical or nonhierarchical relationship. Three elements interact in the framework of organizational ostracism: the actor, the target, and the institution. Our aim was to describe the different factors interacting with every element in order to produce recommendations targeting to prevent the occurrence of such behaviorism in an institution and to help targets of such a violence in order to handle this situation and go forward. As psychological impact of ostracism has frequently been studied in the literature, we focused on its impact on professional tasks. Methods: We performed a questionnaire-based study about organizational ostracism. This questionnaire was established through an online platform (https://www.sondageonline.com) and made available through the following link: https://goo.gl/forms/KrkVXe3bMEc79cau2. A keyword was sent to all participants. We created a 23-interrogation questionnaire with open and short questions. Nonwritten consent was obtained from all participants. Results: The actor of ostracism engaged in ostracism, in most of the cases, with other persons without a real purpose. The actor of ostracism had an antecedent of problematic relationship at work in 82.9% of the cases. Of the participants, 58.5% were of the view that ostracism aimed to cause hurt and isolate them. Professional isolation was observed in 58.5% of the cases; 51.2% of the participants tried to improve their work potential and explained their reaction by an intrinsic motivation. The organization atmosphere was judged to be bad in most of the cases. Conclusion: Our study showed that ostracism was mainly observed in public practice.

Effects of Onchung-eum Administration along with Samhwangseze-gamibang on Treatment Atopic Dermatitis Development in NC/Nga Mice (온청음(溫淸飮)과 삼황세제가미방(三黃洗劑加味方) 병용이 NC/Nga 아토피 생쥐에 미치는 영향)

  • Hong, Chul-Hee;Seo, Eun-Sung;Weon, Young-Ho;Kim, Yeong-Geun;Hwang, Chung-Yeon
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.21 no.3
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    • pp.679-687
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    • 2007
  • The purpose of this study is to examine closely effect that Onchung-eum(OC) and Samhwangseze-gamibang(SG) used to atopic dermatitis disease patient get in atopy eruption control experimentally. Atopic dermatitis(AD) of molecular mechanism underlying it's effectiveness is unknown. We analyzed the expression the clinical severities in 13 and 16 weeks old NC/Nga mice, and the spleen weight of OC with SG treated NC/Nga mice, and mRNA expression levels of IL-4, IL-5, and CCR3 in the skin tissues of OC with SG treated NC/Nga mice, and IL-1${\beta}$, TNF-${\alpha}$, IL-6 express of gene, and Histological observation of the ear and skin tissues, and than IgE, IL-4, IL-5, IL-6, IgM, IgGl levels in the serum of OC with SG treated NC/Nga mouse group compared to the untreated control mouse group. Also, We examined cell toxicity that of OC is safety the strength of 10, 50, 100ppm and inflammatory RAW 264.7 in the serum of OC. Thus in these present study diverse immune responses in terms of chemical mediators related to AD were investigated using an atopic mouse model NC/Nga after OC along with 5G. At the result that OC along with SG treat is can effective use for the treatment of atopic dermatitis(AD).

Antioxidant Activity of Goldenrod (Solidago virgaurea) Leaf and Stem Powder on Raw Ground Pork during Chilled Storage

  • Kim, Yong-Jae;Kim, Hack-Youn;Choe, Ju-Hui;Park, Jae-Hyun;Ham, Youn-Kyung;Yeo, Eui-Joo;Hwang, Ko-Eun;Kim, Cheon-Jei
    • Food Science of Animal Resources
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    • v.33 no.1
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    • pp.1-8
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    • 2013
  • The effects of adding goldenrod leaf powder (GLP) and goldenrod stem powder (GSP) (0.1% and 0.5%) to raw ground pork on antioxidant activity were examined. The following six treatment groups were used: Control (without antioxidant), GLP1 (with 0.1% GLP), GLP2 (with 0.5% GLP), GSP1 (with 0.1% GSP), GSP2 (with 0.5% GSP) and AS (with 0.05% ascorbic acid). The chemical compositions, pH values, instrumental color, conjugated diene (CD), free fatty acids (FFA) and thiobarbituric acid-reactive substance (TBARS) value were measured during 15 d of storage at chilled temperatures. The addition of GLP and GSP showed no effect on moisture, protein and fat contents of the samples. However, adding 0.5% GSP increased the ash contents of ground pork (p<0.05). The pH values of treated samples decreased until day 7, and then increased thereafter. The addition of GLP and GSP decreased the $L^*$ and $a^*$ values and increased the $b^*$ value (p<0.05). The CD, FFA and TBARS value of the control were higher (p<0.05) than samples containing GLP and GSP. The addition of GLP and GSP resulted in a significant decrease in CD, FFA and TBARS values. Overall, this study demonstrated that GL and GS could be used as an antioxidant of raw ground pork.

Image Identifier based on Local Feature's Histogram and Acceleration Technique using GPU (지역 특징 히스토그램 기반 영상식별자와 GPU 가속화)

  • Jeon, Hyeok-June;Seo, Yong-Seok;Hwang, Chi-Jung
    • Journal of KIISE:Computing Practices and Letters
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    • v.16 no.9
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    • pp.889-897
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    • 2010
  • Recently, a cutting-edge large-scale image database system has demanded these attributes: search with alarming speed, performs with high accuracy, archives efficiently and much more. An image identifier (descriptor) is for measuring the similarity of two images which plays an important role in this system. The extraction method of an image identifier can be roughly classified into two methods: a local and global method. In this paper, the proposed image identifier, LFH(Local Feature's Histogram), is obtained by a histogram of robust and distinctive local descriptors (features) constrained by a district sub-division of a local region. Furthermore, LFH has not only the properties of a local and global descriptor, but also can perform calculations at a magnificent clip to determine distance with pinpoint accuracy. Additionally, we suggested a way to extract LFH via GPU (OpenGL and GLSL). In this experiment, we have compared the LFH with SIFT (local method) and EHD (global method) via storage capacity, extraction and retrieval time along with accuracy.

Stability Evaluation of Floating Dock during Construction and Launching of Caisson for Breakwater (방파제용 대형 케이슨 제작/진수에 따른 부양식 독의 안정성 해석)

  • Seok, Jun;Park, Jong-Chun;Jeong, Se-Min;Kim, Sung-Yong;Kang, Heon-Yong;Kim, Moo-Hyun;Kang, Yoon-Koo
    • Journal of Ocean Engineering and Technology
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    • v.27 no.6
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    • pp.43-55
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    • 2013
  • In general, huge caissons for breakwaters have been constructed on land or a floating dock. In the case of the construction on a floating dock, a 4 step installation procedure is involved: i) construction on a floating dock, ii) transportation by the floating dock to an area near the target sea, iii) launching from the floating dock, and iv) transference by tug-boats to the installation site. It is especially important to pay attention to the dynamic stability of the floating dock against the conditions in the sea during steps i) and iii). In this paper, the static and dynamic stabilities of a caisson on a floating dock are evaluated based on IMO rules during the construction and launching of the caisson on a floating dock by using independent commercial S/Ws such as NAPA, WAMIT, and CHARM3D.

Formation and Progression of Intermetallic phase on Iron Base Alloy PTA weld overlay in Molten Zn Alloys (용융 Zn 합금에서 Fe합금의 PTA 오버레이 용접 금속간 상의 형성과 진행)

  • Zulkarnain, Zulkarnain;Baek, E.R.
    • Proceedings of the KWS Conference
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    • 2009.11a
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    • pp.95-95
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    • 2009
  • Zinc coatings provide the most effective and economical way of protecting steel against corrosion. There are three types of galvanizing lines typically used in production line in galvanizing industries,Galvanize (GI) coating (Zn-0.1-0.3%Al), Galfan coating (Zn-5%Al), Galvalume(GL) coating (45%Zn-Al). In continuous Galvanizing lines, the immersed bath hardware (e.g. bearings, sink, stabilizer, and corrector rolls, and also support roll arms and snout tip) are subjected to corrosion and wear failure. Understanding the reaction of these materials with the molten Zn alloy is becomes scientific and commercial interest. To investigate the reaction with molten Zn alloys, static immersion test performed for 4, 8, 16, and 24 Hr. Two different baths used for the static immersion, which are molten Zn and molten Zn-55%Al. Microstructures characterization of each of the materials and intermetallic layer formed in the reaction zone was performed using optical microscope, SEM and EDS. The thickness of the reaction layer is examined using image analysis to determine the kinetics of the reaction. The phase dominated by two distinct phase which are eutectic carbide and matrix. The morphology of the intermetallic phase formed by molten Zn is discrete phase showing high dissolution of the material, and the intermetallic phase formed by Zn-55wt%Al is continuous. Aluminum reacts readily with the materials compare to Zinc, forming iron aluminide intermetallic layer ($Fe_2Al_5$) at the interface and leaving zinc behind.

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A Study on Cementation Reaction Mechanism for Weathered Granite Soil and Microbial Mixtures (화강풍화토와 미생물 혼합물의 고결 반응 메카니즘)

  • Oh, Jongshin;Lee, Sungyeol;Kim, Jinyung;Kwon, Sungjin;Jung, Changsung;Lee, Jaesoo;Lee, Jeonghoon;Ko, Hwabin;Baek, Wonjin
    • Journal of The Korean Society of Agricultural Engineers
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    • v.61 no.6
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    • pp.103-110
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    • 2019
  • The purpose of this study is to investigate the reaction mechanism of soil and bacteria solution by various mixing ratios. For this purpose, in order to understand the reaction mechanisms of microorganisms and weathered granite soil, the tests were carried out under various mixing ratios additives such as soil, bacteria solution, $Ca(OH)_2$ and fixture. The test results from this study are summarized as follows. Firstly, the reaction between the bacteria solution and fixture produced a precipitate called vaterite, a type of silicate and calcium carbonate. Secondly, as a result of SEM analysis, the resulting precipitates generated from the test results using the specimens with various mixing ratios except SW condition and the irregular spherical microscopic shapes were formed in the size of $150{\mu}m$ to $20{\mu}m$. In addition, it can be seen that the bacteria solution and the fixture reacted between the granules to form an adsorbent material layer on the surface, and the microorganisms had a biological solidifying effect when the pores are combined into hard particles. Finally, The XRD analysis of the sediment resulting from the reaction between the microorganism and the deposit control agent confirmed the presence of a type of calcium carbonate ($CaCO_3$) vaterite, which affects soil strength formation, as well as silicate($SiO_2$).

Statistical bias indicators for the long-term displacement of steel-concrete composite beams

  • Moreno, Julian A.;Tamayo, Jorge L.P.;Morsch, Inacio B.;Miranda, Marcela P.;Reginato, Lucas H.
    • Computers and Concrete
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    • v.24 no.4
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    • pp.379-397
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    • 2019
  • Steel-concrete composite beams are widely employed in constructions and their performance at the serviceability stage is of concern among practitioners and design regulations. In this context, an accurate evaluation of long-term deflections via various rheological concrete models is needed. In this work, the performance and predict capability of some concrete creep and shrinkage models ACI, CEB, B3, FIB and GL2000 are ascertained, and compared by using statistical bias indicators. Ten steel-concrete composite beams with existing experimental and numerical results are then modeled for this purpose. The proposed modeling technique uses the finite element method, where the concrete slab and steel beam are modeled with shell finite elements. Concrete is considered as an aging viscoelastic material and cracking is treated with the common smeared approach. The results show that when the experimental ultimate shrinkage strain is used for calibration, all studied rheological models predict nearly similar deflections, which agree with the experimental data. In contrast, significance differences are encountered for some models, when none calibration is made prior to. A value between twenty and thirty times the cracking strain is recommended for the ultimate tensile strain in the tension stiffening model. Also, increasing the relative humidity and decreasing the ambient temperature can lead to a substantial reduction of slab cracking for beams under negative flexure. Finally, there is not a unique rheological model that clearly excels in all scenarios.