• Fire Science and Engineering
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• v.31 no.6
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• pp.1-7
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• 2017

Currently, flammable liquids account for more than 87 wt% of the hazardous materials in circulation in Korea, and paint products are the most commonly used mixed hazardous materials. Therefore, one of the most urgent and important issues is that we have to secure the safety for manufacturing, storage and transport of paint products. In this study we investigated and analyzed the domestic hazardous materials safety management method, the international GHS test method and so forth. We tested risks for a variety of oil paints and found a relation between the results. Furthermore, the risk test method and criteria adapted for domestic situation was presented. Paints were classified as hazardous or non-hazardous according to the results of the flash point test, the amount of flammable liquid or the UN-combustion persistence test. It was revealed from the test results of 6 kind of oil-based paints using different resins that they were hazardous materials with very high risks and belonged to the Category 1 or the Category 2.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.24 no.1
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• pp.91-102
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• 2014

Objectives: This study was performed in order to devise a procedure for supplementing the Special Management Materials in the Occupational Safety and Health Act and recommend candidate materials. The results are expected to be used as fundamental data for classification and criteria necessary to manage Special Management Materials in workplaces. Also, they are expected to be used as a basis for selecting target materials to nominate as additional Special Management Material. Methods: We investigated the selection standards for candidates and review ranges of data sources to nominate Special Management Materials. The substances classified as GHS(Globally Harmonized System of classification and labeling of chemicals) category 1A(known to have carcinogenic potential and reproductive toxicity for humans) or 1B(presumed to have carcinogenic potential and reproductive toxicity for humans) carcinogens and reproductive toxicants among the Controlled Hazardous Substances of the Regulation on Occupational Safety and Health Standards and substances with OELs(Occupational Exposure Limits) were inspected as the candidates for Special Management Materials. Conclusions: A seven-step procedure for selecting candidates to designate as Special Management Materials was suggested, including the setting of target chemicals for evaluation, classification of CMR(Carcinogens, Mutagens or Reproductive toxicants) by GHS classification and criteria, suggestion and selection of the candidates, and more. This study recommends 58 chemicals as qualified candidates to supplement the Special Management Materials.

• Journal of the Korean Society of Safety
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• v.37 no.2
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• pp.10-17
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• 2022

Currently, in Korea, lower and upper tier qualifying quantities of the 97 substances requiring preparation for accidents have been designated. The information on the submission of chemical accident prevention management plan varies depending on whether the handling volume is above or below the lower or upper qualifying quantity. Because the criteria of the lower and upper qualifying quantities of substance requiring preparation for accidents are not stipulated in the Chemical Substances Control Act, this study attempted to establish a criterion through significance verification. In addition, the study investigated whether these qualifying quantities are related to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), toxic concentration endpoint, and National Fire Protection Association (NFPA). Finally, by comparing the risk categorization of the GHS, endpoint, and NFPA, it was evaluated whether the circulation-volume-based risk categorization of the substance requiring preparation for accidents that are in the top 13 is appropriate. The qualifying quantities of benzene, toluene, and sulfuric acid needed to be adjusted upward, while those of methyl alcohol and ammonia were adjusted downward from the current qualifying quantities. It is required to establish a quantified criterion that fully reflects the domestic situations in Korea and various indicators such as toxicity, physicochemical properties, and circulation volume for the qualified criterion of hazardous chemical substances. The study is expected to be helpful in establishing an efficient system by systematizing the criterion for qualifying quantity.

• Journal of Life Science
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• v.24 no.12
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• pp.1356-1363
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• 2014

Ghrelin is a 28 amino acid orexigenic peptide hormone that is secreted predominantly by tX/A cells in the stomach, and it plays a major role in energy homeostasis. Activated ghrelin has an n-octanoyl group covalently linked to the hydroxyl group of the Ser3 residue, which is critical for its binding to the G-protein coupled growth hormone secretagogue receptor-1a (GHS-R1a). According to recent reports, both ghrelin and its receptor, GHS-R1a, are expressed by a variety of immune cells, including T- and B-lymphocytes, monocytes, and dendritic cells, and ghrelin stimulation of leukocytes provides a potent immunomodulatory signal controlling systemic and age-associated inflammation and thymic involution. Here, we report that ghrelin protected murine thymocytes from dexamethasone (DEX)-induced cell death both in vivo and in vitro. Subsequently, we explored the molecular mechanisms of the antiapoptotic effect of ghrelin. According to our experiments, ghrelin inhibited the expression of proapoptotic proteins via the regulation of glucocorticoid receptor (GR) phosphorylation. As a result, ghrelin inhibited the proapoptotic activation of proteins, such as Caspase-3, PARP, and Bim. These data suggest that ghrelin, through GHS-R, inhibits the pathway to apoptosis by regulation of the proapoptotic protein activation signal pathway. They provide evidence that blocking apoptosis is an essential function of ghrelin during the development of thymocytes.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.1
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• pp.691-702
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• 2021

This study aimed to provide basic data for safety education by surveying the status of safety education and general safety awareness among high school students by gender and school type in Chungnam area. From July 16th to October 15th, 2015, 1214 copies collected from 16 schools were analyzed using SPSS ver 23.0. Regarding safety education, females and general high school students (GHS) responded more frequently that safety education was more necessary for school life compared to males and specialized high school students (SHS), whereas males were more interested in safety education content than females. Males and SHS lost interest when learning unfamiliar content compared to females and GHS, respectively. In terms of general safety awareness, males and GHS usually followed safety rules better than females and SHS, and males demonstrated greater knowledge of first aid. Males and SHS acted according to their beliefs towards safety rather than knowledge compared to females and GHS, respectively. This study found a significant difference in safety education and general safety awareness among high school students by gender and type of school, and the results suggest that differentiated safety education is necessary.

• Bulletin of Korea Environmental Preservation Association
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• v.30 s.373
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• pp.33-36
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• 2008

금년부터 국제기준(GHS)에 따른 새로운 화학물질 분류∙표시제가 시행이 되며, 실내공기질 관리대상이 확대되고 포름알데히드 기준이 강화된다. 또한 종전에는 폐기물적법처리시스템을 지정폐기물만을 전산입력토록 하였으나, 2008년 8월부터는 사업장일반폐기물까지 전산입력 대상이 확대된다. 폐수 배출허용기준 강화, 폐기물 수출∙입 신고제도 시행 등 2008년부터 달라지거나 새롭게 시행되는 제도를 분야별로 정리하였다.

• The Korean Journal of Pesticide Science
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• v.15 no.4
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• pp.383-388
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• 2011

We investigated methiozolin acute toxicity using with Sprague-Dawley rats. The results of acute oral toxicity using rats showed $LD_{50}$ value of over 2,000 mg/kg bw for methiozolin. The calculate acute dermal $LD_{50}$ value of methiozolin was over 4,000 mg/kg. The skin irritation test showed moderately irritation and weak response of eye irritation test was observed in this experimental condition. According to these results, We concluded that methiozolin was Category IV in GHS chemical classification for acute toxicity. Future, we need more chronic toxicity test for safety.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.15 no.6
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• pp.209-215
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• 2015

Following the semiconductor industry's growing, various types of toxic gases and caustic chemicals, HF(Hydrofluoric acid), HCI (Hydochloric acid), $H_2O_2$ (Hydrogen peroxide), $H_2SO_4$ (Sulfuric acid), and Piranha, were using on the semiconductor manufacturing process. Therefore many gas leakage accidents that produce huge losses of lives were caused by the processes. This research deeply considers two basic solutions that the necessity of MSDS education on university for reducing damage of lives and protecting life from chemical leak accidents such as a HF accident in Gumi, Korea and the use of GHS, REACH and the comprehension of propriety about using MSDS for keeping safety from conflagrations by released poison chemical materials.

• Journal of the Korean Institute of Gas
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• v.19 no.5
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• pp.61-68
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• 2015

This study develop accident response program for the hazardous materials(HAZMAT) transport vehicle with materials database and guidelines for accident response. Guidelines was developed by guideline develop processes of FEMA after identify hazards. Developed material database was applied the GHS. also database was optimized by removing data that can confuse to accident response. Finally, This study verify developed programs through case study.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.22 no.1
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• pp.82-90
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• 2012

Objectives: This study was performed to provide workplaces with political guidelines that apply international CMRs (Carcinogens, Mutagens, Reproductive toxins) information to Public Notice of TLVs (Threshold Limit Values). We analyzed information supply status about CMRs of international agencies and compared substances for which TLVs are set in KMoEL (Ministry of Employment and Labor in Korea). Methods: We referred to the reliable literature about classification criteria of CMRs corresponding to UN GHS (Globally Harmonized System of classification and Labeling of chemicals) and Public Notice No. 2009-68 'Standard for Classification, Labeling of Chemical Substance and Material Safety Data Sheet' in KMoEL. The classification system of CMRs in professional organizations (IARC, NTP, ACGIH, EU ECHA, KMoEL, etc.) was investigated through the internet and literature. Conclusions: 191 chemical substances among total 650 substances with TLVs are classified as carcinogens. Also, 43 substances classified as mutagens, and 44 as reproductive toxicants. These results suggest that the information of CMRs in Public Notice of TLV will be reorganized to 191 carcinogens, 43 mutagens, and 44 reproductive toxicants.