• Journal of Periodontal and Implant Science
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• 제49권5호
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• pp.299-309
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• 2019

Purpose: To analyze the ridge profile of the anterior maxilla using cone-beam computed tomography and to assess the clinical significance of the ridge profile by performing virtual implant placement. Methods: Thirty-two cone-beam computed tomography scans of anterior maxillae were included. For each tooth, a vertical line was made along the longitudinal axis, and 3 horizontal lines at 1-, 3-, and 5-mm levels below the labial bone crest were drawn perpendicularly to the vertical reference. At these levels, the thickness of the alveolar ridge (RT), and the labial (LT) and palatal bone plate (PT) were measured. Then, virtual implant placement using standard and tapered implants was performed. A generalized linear mixed model was used for statistical analysis. Results: The teeth were located labially based on the proportion of LT and PT with respect to RT. At the 1-mm level, the value of LT was between $1.0{\pm}0.4mm$ for central incisors and $1.3{\pm}0.6mm$ for canines. A large number of teeth had area(s) with less than 1-mm-thick labial bone between the 1- and 5-mm levels below the crest. The mean PT was generally thicker than the LT in all tooth types. The greatest mean value of labial concavity was observed for canines, compared to other tooth types. Men had a greater RT than did women, but had a comparable LT. Less apical fenestration was observed when tapered implants were used. Conclusions: Most teeth in the anterior maxilla had a thin labial bone plate, with no significant difference between sexes. Tapered implants may be advantageous for the anterior maxilla.

• Animal Bioscience
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• 제34권12호
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• pp.1886-1894
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• 2021

Objective: Growth hormone (GH) and insulin-like growth factor I (IGF-I) play a critical role in animal growth rates. We aimed to investigate the effect of GH and IGF-I genotypes on body weight (BW), dominance, and gene expression in slow-growing chickens at different ages. Methods: A total of 613 Korat chickens (KRs) were bred and divided into three groups by genotype - A1A1, A1A3, and A3A3 for GH and AA, AC, and CC for IGF-I. Chickens were weighed every two weeks, and liver and breast muscle tissues were collected at 10 weeks of age. Genetic parameters of KRs were estimated using ASReml software. The GH and IGF-I mRNA levels were measured by quantitative polymerase chain reaction. Significant differences between traits were analyzed using the generalized linear model. Results: A significant effect of GH genotypes on BW was found at most ages, and the A1A1 genotype had the highest value of BW. Compared with the A3A3 genotype, the A1A1 and A1A3 genotypes showed a higher dominance effect at 0 and 2 weeks, and genotype A1A1 had the highest value of dominance at 8 weeks of age. A difference in GH mRNA levels between genotypes was detected in breast muscle at 6 weeks and in the liver tissue at 2 weeks. In the case of IGF-I gene, the AA genotype had the highest BW at the beginning of life. Significant differences in BW dominance were found at 2 weeks. However, IGF-I mRNA levels were not different among genotypes in both breast muscles and liver tissues. Conclusion: Our results revealed that GH and IGF-I influence growth, but may not be involved in heterosis. GH can be used as a marker gene in selection programs for growth because the homozygous genotype (A1A1) had the highest BW at all ages. The IGF-I is not a useful marker gene for selection programs.

• 한방재활의학과학회지
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• 제29권3호
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• pp.87-101
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• 2019

Objectives The purpose of this study is to investigate characteristics of low back pain patients and trends of Korean medicine conservative treatment effects of low back pain patients by registry data. Methods A total of 78 patients were analyzed, statistical analysis was performed using a generalized linear model. The comparison between groups was performed using independent two samples t-test or Wilcoxon rank sum test according to the distribution of normality. Before and after the treatment effects, ANOVA and Kruskal-Wallis method were used for the comparison, Sheffe method was used for the post test. Results The average age of hospitalized patients was 31.8 years old and out-patient department (OPD) patients was 44.9 years old. Lots of OPD patients and hospitalized patients were classified to 'Lumbago due to Coexist Qu Stagnation and Bloos Stasis'. Both OPD patients and hospitalized patients classified to 'Lumbago due to Coexist Qu Stagnation and Bloos Stasis' showed statistically significant decrease in RMDQ (Roland-Morris disability questionnaire) and NRS (numeric rating scale) on 1 month and 3 month after clinical research start date. Comparing the treatment effects of Chuna manual therapy, both Chuna group and non-Chuna group showed statistically significant decrease in RMDQ and NRS on discharge date, 1 month and 3 month after clinical research start date. Conclusions We expect that a larger scale registry study will be carried out to provide a higher level of basis for the Korean medical treatment of low back pain.

• 보건행정학회지
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• 제30권4호
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• pp.479-492
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• 2020

Background: As the prevalence of hypertension is increasing in Korea, the government is seeking policy actions to manage patients with hypertension more efficiently. In this paper, we aimed to identify factors associated with the use of medical care at hospitals among outpatients with hypertension. Methods: We analyzed a total of 15,040 cases of 3,877 outpatients with hypertension obtained from the Korea Medical Panel database from 2010 to 2016. The dependent variable was whether a patient with hypertension visited a hospital or not; and independent variables were the patient's various socio-demographic, health-related, and heath-status characteristics. We conducted a generalized linear mixed model analysis with logit link for all the cases and then conducted it stratified by gender. Results: As a result of a multivariable analysis, women were less likely than to visit at a hospital (odds ratio [OR], 0.44; 95% confidence interval [CI], 0.32-0.61) and people aged 65 years and older than those aged less than 65 years (OR, 0.71; 95% CI, 0.57-0.89). Residents in Busan, Ulsan, and Gyeongnam were more likely than those in than Seoul, Gyeonggi, Incheon, and Jeju to visit a hospital (OR, 1.40; 95% CI, 1.05-1.86). The likelihood of visiting a hospital was high in people belonging to a group of: the highest level of annual household income (OR, 1.73; 95% CI, 1.30-2.29); Medical care aid recipients (OR, 1.94; 95% CI, 1.34-2.83); people having three or more complex chronic diseases (OR, 1.59; 95% CI, 1.19-2.11); people having diabetes (OR, 1.81; 95% CI, 1.41-2.32); or people having ischemic heart disease or cerebrovascular disease (OR, 6.80; 95% CI, 5.28-8.76). Also, we found that factors associated with the use of medical care at hospitals among outpatients with hypertension differed between genders. Conclusion: A variety of factors seem to be associated with the use of medical care at hospitals among outpatients with hypertension. Future research needs to find a way to help patients with hypertension visit an appropriate medical institution between clinics and hospitals.

• 산업융합연구
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• 제20권8호
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• pp.109-118
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• 2022

본 연구는 COVID-19 판데믹 기간 동안 라이프스타일 행동변화 정도, 일상생활 제한인식, 그리고 그 관계를 파악하고자 하였다. 2020년 지역사회건강조사를 이용하여, 한국 성인들이 판데믹 기간 동안 사회인구학적 특성 및 라이프스타일 행동 범주(신체적 활동, 수면기간, 음주, 흡연, 사회적 접촉, 대중교통수단 이용, 음식배달, 인스턴트음식 소비) 별로 일상생활의 제한인식 정도를 산출하였다. 일반화선형모형을 이용하여 행동변화와 제한인식간의 관계를 분석하였다. 총 227,808명의 조사대상자 중 56.70%가 판데믹 기간 동안 자신들의 일상생활이 절반이상 제한받았다고 응답하였다. 대부분의 응답자들은 신체적 활동, 사회적 접촉, 대중교통 이용을 감소시켰다(각각 52.71%, 89.70%, 63.74%). 신체적 활동, 수면시간, 사회적 접촉의 빈도를 줄이거나 음주빈도, 음식배달 및 인스턴트 식품섭취를 늘린 개인들은 그렇지 않은 사람들에 비해 일상생활에 대해서 보다 더 제한받았다고 인식하였다(p<0.001). 결론적으로 사회적 접촉과 신체적 활동의 감소 및 배달음식 이용 및 인스턴트 음식 소비의 증가는 판데믹 기간 중 일상생활에 대한 제한 인식의 증가와 유의한 관련성이 있었다. 판데믹 기간 동안 사람들이 느낄 일상생활에 대한 부정적인 심리적인 영향을 줄이기 위한 노력은 건강한 라이프스타일 행동을 증진하기 위한 노력을 수반해야 할 수 있다.

• Journal of Nutrition and Health
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• 제56권2호
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• pp.217-230
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• 2023

본 연구는 성인영양지수 조사지를 바탕으로 북한이탈주민의 전반적인 식사의 질을 평가하고자 진행되었다. 특히 연령대별 식품 섭취 빈도와 식습관 및 식행동, 영양 지수의 차이를 분석하였다. 대상자는 서울 및 경기 일부 지역의 만 19-64세 성인 166명을 대상으로 진행되었으며 각 연령대별로 20대 41명, 30대 41명, 40대 41명, 50대이상 43명으로 연령대를 평준화하였다. 연령대가 낮을수록 라면, 패스트푸드, 과자 (초콜릿, 사탕 포함), 달거나 기름진 빵 (케이크, 도넛, 단팥빵 등), 가당 음료 등 고에너지 식품 섭취 빈도와 외식, 야식 섭취 비율이 높은 것으로 나타났다. 또한 20대 연령대에서 총점 NQ, 절제 영역 총 점수가 낮고 등급은 '하'로 판정된 비율이 높았다. 50대 연령대에서 절제영역의 점수가 높게 나타난 원인은 라면, 패스트푸드, 과자, 달거나 기름진 빵, 가당 음료 등과 같은 고에너지 식품 섭취 빈도도 낮기 때문인데, 이는 이 집단이 절제력있는 식사를 하고 있는 것으로 비춰질 수도 있으나 중년층에서 패스트푸드, 라면과 같은 식품의 기호도가 낮아 아예 섭취 고려 대상이 아니라는 점에 주목해야 한다. 본 연구에서 주목해야 할 점은 연령이 낮을수록 식사의 질이 매우 열악하게 나타나 식사의 질 개선을 위한 맞춤형 영양 교육 프로그램 개발 및 보급의 필요성을 시사한다. 이에 본 연구의 결과와 시사점이 북한이탈주민의 건강 증진을 위한 영양 교육과 이를 위한 정책 마련의 기초자료로 활용되기를 기대한다.

• 한국의학물리학회:학술대회논문집
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• 한국의학물리학회 2002년도 Proceedings
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• pp.53-60
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• 2002

Motion of lung tumors from respiration has been reported in the literature to be as large as of 1-2 cm. This motion requires an additional margin between the Clinical Target Volume (CTV) and the Planning Target Volume (PTV). While such a margin is necessary, it may not be sufficient to ensure proper delivery of Intensity Modulated Radiotherapy (IMRT) to the CTV during the simultaneous movement of the DMLC. Gated treatment has been proposed to improve normal tissues sparing as well as to ensure accurate dose coverage of the tumor volume. The following questions have not been addressed in the literature: a) what is the dose error to a target volume without gated IMRT treatment\ulcorner b) what is an acceptable gating window for such treatment. In this study, we address these questions by proposing a novel technique for calculating the 3D dose error that would result if a lung IMRT plan were delivered without gating. The method is also generalized for gated treatment with an arbitrary triggering window. IMRT plans for three patients with lung tumor were studied. The treatment plans were generated with HELIOS for delivery with 6 MV on a CL2100 Varian linear accelerator with a 26 pair MLC. A CTV to PTV margin of 1 cm was used. An IMRT planning system searches for an optimized fluence map ${\Phi}$ (x,y) for each port, which is then converted into a dynamic MLC file (DMLC). The DMLC file contains information about MLC subfield shapes and the fractional Monitor Units (MUs) to be delivered for each subfield. With a lung tumor, a CTV that executes a quasi periodic motion z(t) does not receive ${\Phi}$ (x,y), but rather an Effective Incident Fluence EIF(x,y). We numerically evaluate the EIF(x,y) from a given DMLC file by a coordinate transformation to the Target's Eye View (TEV). In the TEV coordinate system, the CTV itself is stationary, and the MLC is seen to execute a motion -z(t) that is superimposed on the DMLC motion. The resulting EIF(x,y)is inputted back into the dose calculation engine to estimate the 3D dose to a moving CTV. In this study, we model respiratory motion as a sinusoidal function with an amplitude of 10 mm in the superior-inferior direction, a period of 5 seconds, and an initial phase of zero.

• The Korean Journal of Pain
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• 제36권1호
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• pp.113-127
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• 2023

Background: Resting-state functional connectivity (rs-FC) may aid in understanding the link between painmodulating brain regions and the descending pain modulatory system (DPMS) in fibromyalgia (FM). This study investigated whether the differences in rs-FC of the primary somatosensory cortex in responders and non-responders to the conditioned pain modulation test (CPM-test) are related to pain, sleep quality, central sensitization, and the impact of FM on quality of life. Methods: This cross-sectional study included 33 females with FM. rs-FC was assessed by functional magnetic resonance imaging. Change in the numerical pain scale during the CPM-test assessed the DPMS function. Subjects were classified either as non-responders (i.e., DPMS dysfunction, n = 13) or responders (n = 20) to CPM-test. A generalized linear model (GLM) and a receiver operating characteristic (ROC) curve analysis were performed to check the accuracy of the rs-FC to differentiate each group. Results: Non-responders showed a decreased rs-FC between the left somatosensory cortex (S1) and the periaqueductal gray (PAG) (P < 0.001). The GLM analysis revealed that the S1-PAG rs-FC in the left-brain hemisphere was positively correlated with a central sensitization symptom and negatively correlated with sleep quality and pain scores. ROC curve analysis showed that left S1-PAG rs-FC offers a sensitivity and specificity of 85% or higher (area under the curve, 0.78, 95% confidence interval, 0.63-0.94) to discriminate who does/does not respond to the CPM-test. Conclusions: These results support using the rs-FC patterns in the left S1-PAG as a marker for predicting CPM-test response, which may aid in treatment individualization in FM patients.

• 정신신체의학
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• 제31권2호
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• pp.79-88
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• 2023

연구목적 암 진단은 정서적 고통을 야기함과 동시에 외상 후 성장이라는 긍정적 변화도 일으킬 수 있다. 암환자의 외상 후 성장에 영향을 주는 요인을 분석하고자 이 연구를 수행하였다. 방 법 서울소재 일 대학병원에서 정신건강의학과 진료를 받은 암환자 52명의 의무기록을 조사하여 외상 후 성장과 회복탄력성, 불안취약 사고경향, 마음챙김 주의 알아차림, 수용태도 등의 요인 간 상관관계를 분석하였다. 결 과 다중 일반화 선형모델 결과 회복탄력성(B=1.45, p<0.0001), 마음챙김 주의 알아차림(B=0.58, p=0.0030), 수용태도(B=1.29, p=0.0003)는 양의 상관관계가 있었고, 불안취약 사고경향(B=-0.84, p<0.0001)은 음의 상관관계가 있었다. 결 론 암환자의 외상 후 성장을 촉진하는 요인은 회복탄력성, 마음챙김, 수용태도가 있었고, 저해하는 요인은 불안 취약 사고경향이 있었다. 암환자 진료 시 외상 후 성장에 영향을 미치는 요인들을 고려한 접근이 필요하다.

• 대한통합의학회지
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• 제12권1호
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• pp.27-39
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• 2024

Purpose : Smoking is a major factor in chronic obstructive pulmonary disease (COPD), but the effect of electrical cigarette smoking on COPD development is still uncertain. This study aimed to compare the functions of airways and lungs exposed to combustible cigarettes and electrical cigarettes based on the pulmonary function test (PFT) results from the Korean National Health and Nutrition Examination Survey (NHANES). Methods : This study used data from 8,942 participants with PFT results out of 47,309 total subjects from the 6th to 8th Korean NHANES (2014-2015, 2016-2018, and 2019, respectively). Individuals with diseases such as cancer, ex-smokers, and dual tobacco users were excluded. The PFT results were analyzed according to the COPD diagnostic criteria. After adjusting for confounding variables, a complex sample generalized linear model ANOVA test was performed to investigate the association between PFT results and combustible smoker or electrical cigarette user groups. Results : In an analysis based on the obstructive ventilatory disorders (forced expiratory volume in 1 second[FEV₁]/forced vital capacity[FVC]<.7), combustible cigarette smokers showed a 3.46 times higher risk of COPD compared to non-smokers, while electrical cigarette smokers exhibited no significant difference in terms of COPD-related risks compared to non-smokers. FEV₁ showed a negative relation with combustible cigarette smokers as reported elsewhere (B=-.07, p<.001). FEV₁/FVC was negatively related to both combustible cigarette smokers (B=-.03, p<.001) and electrical cigarette smokers (B=-.02, p<.001). Conclusion : FEV₁/FVC decreases were observed in the long-term exposure to both combustible and electrical cigarettes. The lower FEV₁ in the combustible cigarette group implies the worsening of the severity of COPD, suggesting more damage to the airways and lungs in the short term. Therefore, the temporary electrical cigarettes use for the transition period in order to smoking cessation potentially aids to reduce the harmful effect of combustible cigarettes in COPD development.