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MR Imaging and Histological Findings of Experimental Cerebral Fat Embolism in Cats

  • Park Byung-Rae;Ko Seong-Jin;Kim Hwa-Gon
    • Biomedical Science Letters
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    • v.10 no.3
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    • pp.285-291
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    • 2004
  • To determine the magnetic resonance (MR) imaging findings and natural history of cerebral fat embolism in a cat model, and to correlate the MR imaging and histologic fmdings. Intemel carotid artery of 11 cats was injected with 0.1 ml of triolein. T2-weighted, T1-weighted and Gd-enhanced T1-weighted images were obtained serially for 2 hours, 1 days, 4 days, 1 week, 2 weeks and 3 weeks after embolization. Any abnormal signal intensity was evaluated. After MR imaging at 3 weeks, brain tissue was obtained for light microscopic (LM) examination using hematoxylin-eosin (HE) and Luxol fast blue staining, and for electron microscopic examination. The LM examination with HE staining revealed normal histological findings in the greater part of an embolized lesion. Cystic change was observed in the gray matter of 8 cats, while in the gray and white matter of 3 cats. At LM examination, Luxol fast blue, staining demonstrated demyelination around the cystic change occurring in the white matter, and EM examination of the embolized cortex revealed sporadic intracapillary fat vacuoles (n=11) and disruption of the blood-brain barrier (n=4). Most lesions were normal, however, and perivascular interstitial edema and cellular swelling were mild compared with the control side. The greater part of an embolized lesion showed reversible findings at MR and histological examination. Irreversible focal necrosis was, however, observed in gray and white matter at weeks 3.

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Characterization of PSCF3737 for intermediate temperature solid oxide fuel cell (IT-SOFC) (중.저온형 고체 산화물 연료전지의 공기극으로 사용되는 PSCF3737 물질의 특성에 관한 연구)

  • Park, Kwang-Jin;Bae, Joong-Myeon
    • 한국신재생에너지학회:학술대회논문집
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    • 2008.05a
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    • pp.61-64
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    • 2008
  • $Pr_{0.3}Sr_{0.7}Co_{0.3}Fe_{0.7}O_{3-\delta}$ (PSCF3737) was prepared and characterized as a cathode material for intermediate temperature-operating solid oxide fuel cell (IT-SOFC). X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), extended X-ray absorption fine structure (EXAFS), and electrical property measurement were carried out to study cathode performance of the material. XPS and EXAFS results proved that oxygen vacancy concentration was decreased and lattice constants of the perovskite structure material were increased by doping Fe up to 70 mol% at B-site of the crystal structure, which also extended the distance between oxygen and neighbor atoms. Thermal expansion coefficient (TEC) of PSCF3737 is smaller than that of $Pr_{0.3}Sr_{0.7}CoO_{3-\delta}$(PSC37) due to lower oxygen vacancy concentration. PSCF3737 showed better cathode performance than PSC37. It might be due good adhesion by a smaller difference of TEC between $Gd_{0.1}Ce_{0.9}O_2$ (CGO91) and electrode. Composite material PSCF3737-CGO91 showed better compatibility of TEC than PSCF3737. However, PSCF3737-CGO91 did not represent higher electrochemical property than PSCF3737 due to decreased reaction sites by CGO91.

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Inhibitory Effect of Disinfectants and Antibiotics on Rusty-root Symptoms in Panax Ginseng C. A. Meyer (소독제 및 항생제의 적변삼 발생 억제 효과)

  • Park, Hong-Woo;Lee, Eun-Jeong;Choi, Jae-Eul
    • Korean Journal of Medicinal Crop Science
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    • v.14 no.6
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    • pp.336-341
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    • 2006
  • The endophytic bacteria were isolated from the rusty-root ginseng. This isolated bacteria were occurred the rusty-root ginseng with artificial inoculation. For the suppressing of rusty-ginseng, disinfectants, antibiotics, kitosan, micro-organisms and metabolites were tested to isolated endophytic bacterium. All of the isolated bacteria strains were sensitive sodium hypochlorite, however, some of isolated bacteria lines were sensitive to other tested materials. For example, D (didecyl dimethyl ammonium bromide), CIO$_2$, ODDA (octyldecyl dimethyl ammonium chloride + diocyul dimethyl ammonium chloride + alkyl diethyl benzyl ammonium chloride), GD (glutaraldehyde + dimethy cocobenzyl ammonium chloride) suppressed some of bacteria strains. Otherwise, some of antibiotics (e.g. ampicillin, chloramphenicol, erythromycin, kanamycin, neomycin, rifampin, streptomycin, tetracycline) were sensitive to the isolated bacteria strains. All of isolated bacteria strainswere inhibitive to the mixed formation with neomycin and streptomycin, and neomycin and tetracycline. Both sodium hypochlorite and antibiotic mixing of neomycin and tetracycline were effective to prevention of rusty-root ginseng of sub-merging ginseng in the ginseng field.

Development of Macrocyclic Ligands for Stable Radiometal Complexes (안정한 방사금속 착물을 위한 거대고리 리간드 개발)

  • Yoo, Jeong-Soo;Lee, Jae-Tae
    • The Korean Journal of Nuclear Medicine
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    • v.39 no.4
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    • pp.215-223
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    • 2005
  • Current interest in the regioselective N-functionalization of tetraazacycloalkanes (cyclen and cyclam) stems mainly from their complexes with radioactive metals for applications in diagnostic ($^{64}Cu,\;^{111}In,\;^{67}Ga$) and therapeutic ($^{90}Y$) medicine, and with paramagnetic ions for magnetic resonance imaging ($Gd^{+3}$). Selective methods for the N-substitution of cyclen and cyclam is a crucial step in most syntheses of cyclen and cyclam-based radiometal complexes and bifunctional chelating agents. In addition, mixing different pendent groups to give hetero-substituted cyclen derivatives would be advantageous in many applications for fine-tuning the compound's physical properties. So far, numerous approaches for the regioselective N-substitution of tetraazacycloalkanes and more specifically cyclen and cyclam are reported. Unfortunately, none of them are general and every strategy has its own strong points and drawbacks. Herein, we categorize numerous regioselective N-alkylation methods into three strategies, such as 1) direct substitution of the macrocycle, 2) introductiou of the functional groups prior to cyclization, and 3) protection/iunclionallrationideproteclion. Our discussion is also split into the methods of mono- and tri-functionalization and di-functionalizataion based on number of substituents. At the end, we describe new trials for the new macrocycles which iorm more stable metal complexes with various radiometals, and briefly mention the commercially available tetraazacycloalkanes which are used for the biconjugation of biomolecules.

Oxidation Behavior of Unirradiated and Irradiated $UO_2$ in hir at $150-375^\circ{C}$

  • Kim, Keon-Sik;You, Gil-Sung;Min, Duck-Kee;Ro, Seung-Gy;Kim, Eun-Ka
    • Nuclear Engineering and Technology
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    • v.29 no.2
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    • pp.93-98
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    • 1997
  • Air-oxidation experiments on unirradiated and irradiated UO$_2$ were performed at temperature from 150 to 375$^{\circ}C$ for investigating the long-term storage behavior of spent PWR fuel. The rate of oxidation was monitored by a thermogravimetric analyzer(TGA) and an X-ray diffraction(XRD). The correlation between the onset-time for U$_3$O$_{8}$ formation and temperature was given as follows, logt(hr) = -12.89+7650/T(K), 423$_2$ pellet, the oxidation rate of irradiated UO$_2$ increase more rapidly at the initial stage and shows a lower saturation point at the later Stage. The Oxidation rate of high bumup UO$_2$ and gadolinia-doped UO$_2$(Gd$_2$O$_3$-UO$_2$) were observed to be much slower than that of unirradiated UO$_2$ pellets.s.

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Fabrication of YSZ/GDC Bilayer Electrolyte Thin Film for Solid Oxide Fuel Cells

  • Yang, Seon-Ho;Choi, Hyung-Wook
    • Transactions on Electrical and Electronic Materials
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    • v.15 no.4
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    • pp.189-192
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    • 2014
  • Yttria-stablized zirconia (YSZ) is the most commonly used electrolyte material, but the reduction in working temperature leads to insufficient ionic conductivity. Ceria based electrolytes (GDC) are more attractive in terms of conductivity at low temperature, but these materials are well known to be reducible at very low oxygen partial pressure. The reduction of electrolyte resistivity is necessary to overcome cell performance losses. So, thin YSZ/GDC bilayer technology seems suitable for decreasing the electrolyte resistance at lower operating temperatures. Bilayer electrolytes composed of a galdolinium-doped $CeO_2$ ($Ce_{0.9}Gd_{0.1}O_{1.95}$, GDC) layer and yttria-stabilized $ZrO_2$ (YSZ) layer with various thicknesses were deposited by RF sputtering and E-beam evaporation. The bilayer electrolytes were deposited between porous Ni-GDC anode and LSM cathode for anode-supported single cells. Thin film structure and surface morphology were investigated by X-ray diffraction (XRD), using $CuK{\alpha}$-radiation in the range of 2ce morphol$^{\circ}C$. The XRD patterns exhibit a well-formed cubic fluorite structure, and sharp lines of XRD peaks can be observed, which indicate a single solid solution. The morphology and size of the prepared particles were investigated by field-emission scanning electron microscopy (FE-SEM). The performance of the cells was evaluated over $500{\sim}800^{\circ}C$, using humidified hydrogen as fuel, and air as oxidant.

Fabrication and Current Transport Properties of TmBCO Coated Conductors (TmBCO Coated Conductors 제조 및 전류 전송 특성 평가)

  • Kwon, O-Jong;Ko, Rock-Kil;Bae, Sung-Hwan;Koo, Hyun;Jung, Myung-Jin;Oh, Sang-Soo;Park, Chan
    • Proceedings of the KIEE Conference
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    • 2009.07a
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    • pp.1307_1308
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    • 2009
  • 고온초전도체 REBCO(RE=rare earth) 선재는 높은 전류전송밀도를 가지고 있기 때문에 고용량의 전류가 요구되는 응용분야에 사용되어 전력기기 등의 성능을 높일 수 있을 것으로 기대되고 있다. 이전까지 대부분의 REBCO 선재 연구들은 GdBCO, NdBCO, YBCO 등 비교적 Tc값이 높은 고온초전도체에 집중되어 왔다. 반면에 TmBCO는 대부분의 REBCO 보다 Tc값이 낮기 때문에 선재 연구 분야에서 거의 주목받지 않았다. 하지만 본 연구 결과에 따르면 TmBCO 선재는 비교적 낮은 Tc(88K) 값에도 불구하고 우수한 전류전송밀도(Jc=2.3MA/$cm^2$) 특성을 나타내기 때문에 고온초전도 선재로서 활용이 가능하다. 또한 NdBCO 선재에 비해 낮은 기판온도에서 제조가 가능함으로써 공정상의 이점을 가질 수 있음을 확인하였다.

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Capacitance Swing and Capacitance Ratio of GaN-Based Metal-Semiconductor-Metal Two-Dimensional Electron Gas Varactor with Different Dielectric Films

  • Tien, Chu-Yeh;Kuei, Ping-Yu;Chang, Liann-Be;Hsu, Chien-Pin
    • Journal of Electrical Engineering and Technology
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    • v.10 no.4
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    • pp.1720-1725
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    • 2015
  • The performance of the AlGaN/GaN MSM-2DEG varactor with different dielectric films deposited by the E-beam deposition is investigated in detail. The capacitance swing and the capacitance ratio of the varactor without dielectric film as well as with, SiO2, Gd2O3, and Si3N4 films, respectively, are determined by electrodes of varying areas. The maximum capacitance, the minimum capacitance and the capacitance ratios are proportional to the increasing of the electrode areas. The capacitance ratio determined by the maximum and the minimum capacitance is found to be 18.35 (with Si3N4 dielectric film) and 149.51 (without dielectric film), respectively. The transition voltages of the fabricated varactors are almost the same for a bias voltage of about ±5 V and leakage current can be lower three orders of magnitude while the varactors with dielectric films. The tunability of the capacitance ratio makes the AlGaN/GaN MSM-2DEG varactor with a dielectric film highly useful in multirange applications of a surge free preamplier.

Optimization of Geometric Dimension & Tolerance Parameters of Front Suspension System for Vehicle Pulls Improvement (차량 쏠림 개선을 위한 전륜 현가시스템의 기하공차 최적화)

  • Kim, Yong-Suk;Jang, Dong-Young
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.33 no.9
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    • pp.903-912
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    • 2009
  • This study is focused on simulation-based dimensional tolerance optimization process (DTOP) to minimize vehicle pulls by reduction of dimensional variation in front suspension system. In previous studies, the effect of tires and wheel alignment sensitivity have mainly been investigated to eliminate vehicle pulls in nominal design condition without allocating optimal tolerance level for selected components, among various factors regarding vehicle pulls such as vehicle design parameters, vehicle weight balance, tires, and environmental factors. Unfortunately, there are wide variations in the real vehicle, and these have impacted actual vehicle pulls, especially wheel alignment effects from suspension geometry variation has not been considered in the previous studies. In the tolerance design of suspension, tolerance variables with the uncertainty such as parts dimensional variation, assembly process, datum position and direction, and assembly tool tolerance has a great influence on the variation of the suspension dimensional performances. This study introduces total vehicle pull prediction model in considering major key factors for vehicle pull sensitivity. The Monte Carlo-based tolerance analysis model using Taguchi robust method is developed to optimize dimensional tolerance parameters, satisfying on the target variation level.

A study on the fabrication of polymer-coated SAW sensors and their sensing properties for some toxic chemical compounds (SAW 센서의 제작 및 독성화학물질 감도특성 연구)

  • Lim, Y.R.;Park, B.H.;Choi, S.K.;Song, K.D;Lee, D.D.
    • Journal of Sensor Science and Technology
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    • v.17 no.2
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    • pp.143-146
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    • 2008
  • Polymer-coated film SAW sensors have been fabricated and their sensing properties for toxic chemicals have been extensively investigated. Four types of the toxic chemical compounds of hydrogen cyanide(AC), carbonyl dichloride(CG), pinacolyl methylfluorophosphonate(GD), 2,2'-dichlorodiethylthio ether(HD) were used as target gases. SAW sensors using five different kinds of polymers were used to detect toxic chemicals and their gas sensing characteristics were investigated. The polymers used as the sensing materials were polyisobutylene(PIB), polyepichlorohydrin(PECH), polydimethylsiloxane(PDMS), polybutadiene(PBD) and polyisoprene(PIP). The recommendable mixing ratio of PIB, PECH, PDMS, PBD and PIP to solvents were 1:30, 1:40, 1:10, 1:30 and 1:30, respectively. The sensing characteristics of the SAW sensors were measured by using E-5061A network analyzer.