• The Bulletin of The Korean Astronomical Society
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• v.35 no.2
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• pp.35.1-35.1
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• 2010

Unlike the initial mass function, the initial size distribution of globular cluster (GC) systems is not well known. We calculate the evolution of the mass function (MF), radial distribution (RD), and size distribution (SD) of the Galactic GC system. By comparing the results from this calculation and the present-day MF, RD, and SD of the Galactic GC system, we infer the initial SD of the GC system. We find that a Gaussian distribution of the half-mass radius and a Gaussian distribution of the half-mass to Jacobi radius ratio are the best-fit initial SDs of the Galactic GC system.

• Biomolecules & Therapeutics
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• v.8 no.2
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• pp.171-178
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• 2000

To evaluate the pharmacokinetic properties and tissue distribution of a newly developed recombinant human erythropoietin (GC-rhEPO), we analyzed the plasma and tissue levels of erythropoietin by an ELISA after intravenous (IV) and subcutaneous (SC) adminstration to the male rats at the doses of 20, 100, 500 or 2,500 unit/kg. After single IV bolus injection of GC-rhEPO, the plasma concentration was rapidly increased and decreased with two phases with half-lives of 13.4 min and 2.94 hours. AUC was increased dose- dependently but plasma half-lives remained constant regardless of GC-rhEPO doses. Following SC administration, the plasma concentration increased slowly with half-life of 9.2 hours and reached peak at 8 hours. Mean residence time and bioavailability were 18.2 hours and 44%, respectively. After single IV dose of 100 unit/kg, tissue GC-rhEPO level was higher in bone marrow and spleen, while the depletion rate was slower in liver and bone marrow, indicating the higher affinity of GC-rhEPO to bone marrow. Taken together, the experimental results indicate that GC-rhEPO contained the typical pharmacokinetic properties and the tissue distribution patterns inherent to human erythropoietin.

• The Bulletin of The Korean Astronomical Society
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• v.39 no.2
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• pp.62.1-62.1
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• 2014

Metallicity distribution of globular clusters (GCs) provides an important clue for star formation history of their host galaxy. With an assumption that GCs are generally old, GC colors have been used as a proxy of GC metallicities. Bimodal GC color distributions observed in most large galaxies have, for decades, been interpreted as bimodal metallicity distributions, indicating the presence of two populations within a galaxy. However, the conventional view has been challenged by a new theory that non-linear GC color-metallicity relations (CMRs) can cause a bimodal color distribution even from a single-peaked metallicity distribution. Using the photometric and spectroscopic data of NGC 5128 GCs in combination with stellar population simulation models, we examine the effect of non-linearity in GC CMRs on the transformation of GC color distributions into metallicity distributions. Although, in some colors, offsets are present between observations and models in the CMRs, their overall shape agrees well for various colors. After the offsets are corrected, the observed spectroscopic metallicity distribution is well reproduced via modeled CMRs from various color distributions having different morphologies. On the other hand, the linearly converted metallicity distributions from GC colors show a significant discrepancy with the observed spectroscopic metallicity distribution. We discuss the implications of our results.

• The Bulletin of The Korean Astronomical Society
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• v.40 no.2
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• pp.50.1-50.1
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• 2015

The origin of globular cluster (GC) color bimodality, which is one of the salient phenomena observed in most large galaxies, has not yet been fully resolved. The phenomenon has conventionally been interpreted as a bimodal metallicity distribution based on an assumption of linear GC color-metallicity relations (CMRs). Recent studies however suggest that nonlinear GC CMRs can cause a bimodal color distribution even from a single-peaked metallicity spread. Using photometric and spectroscopic data on GCs in NGC 5128 (Cen A) and NGC 4594 (Sombrero), we investigate the nonlinearity of GC CMRs and compare the observed GC CMRs with the predictions of stellar population simulation models. Our careful selection of old GCs effectively reduces the scatter and reveals the nonlinear nature of the GC CMRs for various colors. The overall shape of the observed CMRs agrees well with that of the modeled CMRs, while offsets are present for some colors. We discuss the implications of our results in terms of the GC color bimodality and GC formation in NGC 5128 and NGC 4594.

• YAKHAK HOEJI
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• v.46 no.2
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• pp.93-97
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• 2002

Methidathion is one of the organophosphorus pesticides commonly used for stamping out harmful pests in farming areas. This paper presents a fatality due to methidathion intoxication and describes the distribution of methidathion in postmortem blood and tissues obtained at autopsy. Qualitative identification of methidathion was achieved by TLC, GC and GC/MS, and quantitative analysis was performed by GC with thermionic specific detector (TSD). The analytes in postmortem specimens were extracted by liquid-liquid extraction (LLE) with ethylether. After the ethylether layer was evaporated, the residue was partitioned into hexane and acetonitrile, and the acetonitrile layer was used for analysis. Tissue specimens were homogenized with 4% perchloric acid and applied for LLE. After extraction, the extracts were reconstituted 100 $\mu\textrm{g}$ pyraclofos (IS, 100 $\mu\textrm{g}$/ml in methanol) for GC and GC/MS analysis. On analysis of postmortem specimens, methidathion was identified and quantitated. The methidathion concentrations were 2.0 $\mu$l/ml in blood, 24.4 $\mu\textrm{g}$/g in liver, 13.9 $\mu\textrm{g}$/g in lung, 21.8 $\mu\textrm{g}$/g in kidney, respectively.

• Publications of The Korean Astronomical Society
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• v.30 no.2
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• pp.261-263
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• 2015

The metallicity distribution of globular clusters (GCs) provides a crucial clue for the star formation history of their host galaxy. With the assumption that GCs are generally old, GC colors have been used as a proxy for GC metallicities. Bimodal color distributions of GCs observed in most large galaxies have, for decades, been interpreted as bimodal metallicity distributions, indicating the presence of two populations within a galaxy. However, the conventional view has been challenged by a new theory that non-linear GC color-metallicity relations can cause a bimodal color distribution even from a single-peaked metallicity distribution. Using photometric and spectroscopic data of NGC 5128 GCs in combination with stellar population simulation models, we examine the effect of non-linearity in GC color-metallicity relations on transformation of the color distributions into the metallicity distributions. Although in some colors offsets are present between observations and models for the color-metallicity relations, their overall shape agrees well for various colors. After the offsets are corrected, the observed spectroscopic metallicity distribution is well reproduced via modeled color-metallicity relations from various color distributions having different morphologies. We discuss the implications of our results.

• Journal of Microbiology and Biotechnology
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• v.16 no.7
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• pp.1139-1143
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• 2006

Various techniques and strategies have been developed for the identification of intracellular metabolic conditions, and among them, isotope balance-based flux analysis with gas chromatography/mass spectrometry (GC/ MS) has recently become popular. Even though isotope balance-based flux analysis allows a more accurate estimation of intracellular fluxes, its application has been restricted to relatively small metabolic systems because of the limited number of measurable metabolites. In this paper, a strategy for incorporating isotope balance-based flux data obtained for a small network into metabolic flux analysis was examined as a feasible alternative allowing more accurate quantification of intracellular flux distribution in a large metabolic system. To impose GC/MS based data into a large metabolic network and obtain optimum flux distribution profile, data reconciliation procedure was applied. As a result, metabolic flux values of 308 intracellular reactions could be estimated from 29 GC/ MS based fluxes with higher accuracy.

• Journal of The Korean Astronomical Society
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• v.43 no.4
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• pp.105-113
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• 2010

We study the dynamical evolution of the M87 globular cluster (GC) system using the most advanced and realistic Fokker-Planck (FP) model.By comparing our FP models with both mass function (MF) and radial distribution (RD) of the observed GC system, we find the best-fit initial (at M87's age of 2-3 Gyr) MF and RD for three GC groups: all GCs, blue GCs, and red GCs. We estimate the initial total mass in GCs to be $1.8^{+0.3}_{-0.2}{\times}10^{10}M_{\bigodot}$, which is about 100 times larger than that of the Milky Way GC system. We also find that the fraction of the total mass currently in GCs is 34\%. When blue and red GCs are fitted separately, blue GCs initially have a larger total mass and a shallower radial distribution than red GCs. If one assumes that most of the significant major merger events of M87 have ended by the age of 2-3 Gyr, our finding that blue (metal-poor) GCs initially had a shallower radial distribution supports the major merger scenario for the origin of metallicity bimodality.

• The Bulletin of The Korean Astronomical Society
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• v.35 no.1
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• pp.55.2-55.2
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• 2010

We present a photometric and spectroscopic study of the globular clusters (GCs) in the giant elliptical galaxy NGC 4636 in the Virgo cluster. The photometry of the GCs is based on HST/WFPC2 images for the inner region and deep, wide field Washington $CT_1$ CCD images for the outer region. We investigated the color distribution, the radial number density profile, the spatial distribution, and the mean color of the bright blue GCs about the GCs in NGC 4636. We obtained spectra of the GC candidates in NGC 4636 using the Multi-Object Spectroscopy (MOS) mode of Faint Object Camera and Spectrograph (FOCAS) on the SUBARU 8.2m Telescope. We measured the velocities for 105 GCs in NGC 4636. Using the 238 GCs obtained from combining our results with data in the literature, we investigated the kinematics of the GC system of NGC 4636: the rotation, the velocity dispersion, the radial variation, and the orbit. We also investigated the distribution and the radial variation of the metallicities, ages, and alpha-elements of the GCs in NGC 4636 derived using the absorption lines. We compared the GC kinematics of NGC 4636 with those of other six gEs, finding that the kinematic properties of the GCs are diverse among gEs. We found several correlations between the kinematics of the GCs and the global parameters of their host galaxies. Finally we discuss the implication of the results for the formation models of the GC system in gEs, and suggest a mixture scenario for the origin of the GCs in gEs.

• Applied Chemistry for Engineering
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• v.9 no.3
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• pp.404-406
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• 1998

Analysis for the imidazoline type cationic surfactants was performed by the gas chromatography(GC) and high performance liquid chromatography(HPLC). The composition of the alkyl chain distribution was investigated by GC after base/Acid hydrolysis of the imidazoline ring. The distribution of total alkyl chain was separated clearly by a Bondclone C18/NOVA-Pak C18 HPLC column using 50% acetonitrile in methanol containing 0.1M sodium perchlorate as a mobile phase. Alkyl chain distribution and average molecular weight of imidazoline type cationic surfactants were obtained based on these analytical methods. The agreement of results from GC and HPLC was good. The detection limit of imidazoline by HPLC method was 10ng without pretreatment.