• Proceedings of the Korean Vacuum Society Conference
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• 2004.08a
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• pp.154-154
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• 2004

• Molecular & Cellular Toxicology
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• v.4 no.1
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• pp.78-84
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• 2008

EGFR has been intensively investigated as a target to block the signal transduction pathway which stimulates cancer growth and metastasis. Studies about structure-activity relationship for tricyclic azepine derivatives were performed with topomer-CoMFA. The derived topomer-CoMFA model with steric and electrostatic field parameters based on fragment units gave reasonable statistics ($q^2$=0.561, $r^2$=0.679). The model explains why a halogen atom at the meta position of aniline is important to increases inhibitory activity. This comes from an electrostatically negative groups are favored near this region. The model also shows that there are sterically favored regions around methoxy group extended from oxazepine derivatives. The findings about steric and electrostatic effects can be utilized for designing new inhibitors.

• Journal of Information Science Theory and Practice
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• v.10 no.spc
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• pp.154-163
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• 2022

The purpose of this paper is to illuminate the role and importance of National Research & Education Network (NREN) in the national research and education field and to establish the future strategy of KREONET in Korea. To this end, we first carefully analyze the footsteps of NREN in major overseas countries, KREONET achievements, and future demand for KREONET. The history of NREN's development is divided into the 2000s, 2010s, and present by era, and classified into network infrastructure, network service, and next-generation network technology by subject. KREONET achievements are divided into advanced research support, network backbone and operation, and network service. Future demand analysis of users who use KREONET was conducted through Korea Research International Incorporation, a survey company. This paper presents the future development strategy of KREONET by analyzing KREONET achievements and future demand.

• Journal of Aerospace System Engineering
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• v.10 no.3
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• pp.32-38
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• 2016

This paper explains space-technology startup-business support programs. MSIP (Ministry of Science, ICT and Future Planning) and KARI (Korea Aerospace Research Institute) began running startup-business support programs from 2013 according to a "space-technology industrialization plan." In addition, MSIP and KARI have been running startup academies and STAR-Exploration for future entrepreneurs and startup companies since 2015. From these programs, five startup companies were established and they are generating sales. This paper shows the results of the programs, and the program cases of the startup and venture companies are analyzed for both domestic and international audiences. The future direction of startup-business support programs that are based on space technology is also discussed.

• Proceedings of the Korean Vacuum Society Conference
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• 2003.08a
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• pp.165-165
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• 2003

• Proceedings of the Korean Vacuum Society Conference
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• 2003.08a
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• pp.73-73
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• 2003

• International Journal of Contents
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• v.13 no.4
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• pp.47-62
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• 2017

This paper analyzes how much the gap existed between the public group and expert group using future issues and future core technologies that are announced in government institutions based on ontology. We calculated gap with two groups' point of view, one is expert groups' ideas that are based on future hopeful technologies documents, and another is public people ideas that are based on documents of contest that is hosted by 'Ministry of Science, ICT and Future Planning (MSIP)', and 'Institute for Information & communications Technology Promotion (IITP)'. For calculating these, we suggested SDGM model. In the case of ETRI Meta-trend ICT Field, there is a little gap between expert group and public group, and another case that is XT (ETRI determined future technologies excluding ICT field) Field, the gap is increasing annually. Moreover, in the case of all ETRI Meta trend, the gap is bigger than ICT and XT field. We analyzed, also, KEIT's future issues for generalizing this model. The gap existed between two groups. Utilizing SDGM model of this paper, people can interpret easily how much the gap exists between future technologies and issues that are announced in institutions.

• Bulletin of the Korean Chemical Society
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• v.29 no.3
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• pp.647-655
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• 2008

Microsomal prostaglandin E2 synthase (mPGES-1) is a potent target for pain and inflammation. Various QSAR (quantitative structure activity relationship) analyses used to understand the factors affecting inhibitory potency for a series of MK886 analogues. We derived four QSAR models utilizing various quantum mechanical (QM) descriptors. These QM models indicate that steric, electrostatic and hydrophobic interaction can be important factors. Common pharmacophore hypotheses (CPHs) also have studied. The QSAR model derived by best-fitted CPHs considering hydrophobic, negative group and ring effect gave a reasonable result (q2 = 0.77, r2 = 0.97 and Rtestset = 0.90). The pharmacophore-derived molecular alignment subsequently used for 3D-QSAR. The CoMFA (Comparative Molecular Field Analysis) and CoMSIA (Comparative Molecular Similarity Indices Analysis) techniques employed on same series of mPGES-1 inhibitors which gives a statistically reasonable result (CoMFA; q2 = 0.90, r2 = 0.99. CoMSIA; q2 = 0.93, r2 = 1.00). All modeling results (QM-based QSAR, pharmacophore modeling and 3D-QSAR) imply steric, electrostatic and hydrophobic contribution to the inhibitory activity. CoMFA and CoMSIA models suggest the introduction of bulky group around ring B may enhance the inhibitory activity.

• Mass Spectrometry Letters
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• v.3 no.1
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• pp.4-9
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• 2012

• Proceedings of the Korean Vacuum Society Conference
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• 2009.02a
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• pp.108.1-108.1
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• 2009