• Polymer(Korea)
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• v.34 no.4
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• pp.333-340
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• 2010

Zaltoprofen, a propionic acid derivative non-steroidal anti-inflammatory drug (NSAID), is known to have powerful inhibitory effects on acute, subacute and chronic inflammation. We developed poly(lactide-co-glycolide)(PLGA) microspheres loaded with zaltoprofen for sustained controlled delivery using an oil-water solvent evaporation methods by varying PLGA molecular weight and cosurfactant contents. Physicochemical properties and morphology of zaltoprofen-loaded PLGA microspheres were investigated by scanning electron microscope, X-ray diffraction and differential scanning calorimeter. The size of microspheres increased with the molecular weight of PLGA and the content of cosurfactants. The increase of PLGA molecular weight and cosurfactant content decreased the porosity of microspheres, subsequently resulting in the slow drug release. The results demonstrated that the adjustment of PLGA molecular weight and the cosurfactant content allowed us to control the drug release profiles of drug-loaded microspheres.

• Journal of Pharmaceutical Investigation
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• v.41 no.6
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• pp.363-369
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• 2011

In this study, we demonstrated the release behavior of carvedilol with the content of polyvinylpyrrolidone K-30 (PVP K-30) and the effect of citric acid and fumaric acid as acidifiers on the release behavior of drug. In addition, it tries to inquire into the release behavior difference of the carvedilol according to the manufacturing method. The release behavior of the tablets was compared with Dilatrand$^{(R)}$ in the simulated gastric fluid (pH1.2). Differential scanning calorimeter (DSC), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FT-IR) were characterized for the physicochemical properties of the tablets. In case of mixing the carvedilol and PVP K-30, in case the ratio of the carvedilol and PVP K-30 was 1:5, the release behavior was the highest among. As well as the dissolution rate of tablets manufactured by lyophilization and rotary evaporator was higher than physical mixture. The dissolution rate of containing acidifiers was more improved. But, rather the excessive amount of the acidifier addition reduced the dissolution rate.

• Korean Journal of Microbiology
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• v.26 no.2
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• pp.82-87
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• 1988

The genetic analysis and characterization of protoplast fusion hybrids between complementary auxotrophic mutants of Candida pseudotropicalis were carried out. Nuclear fusion appeared to occur in fusion hybrids (e.g., F15 and F33), as strongly suggested by isolation of recombinants after mitotic segregation of parental genetic markers. This was confirmed by KNA content, nuclear staining and comparison of survival rate to UV light. After keeping fusion hybrids for approximately one year, the frequency of spontaneous mitotic segregation was $3.0\times 10^{-4}$ - $8.1\times 10^{-4}$ while that of induced mitotic segregation was $1.4\times 10^{-3}$- $1.7\times 10^{-3}$. These results suggested that they maintained stable karyogamy state. It was also found that the production of $\beta$-D-galactosidase from F15, F33 and F158 was somewhat increased when compared with that from either auxotrophic parents or wild type.

• KIPS Transactions on Computer and Communication Systems
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• v.2 no.1
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• pp.1-6
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• 2013

Variety of smart devices including smart phone have become and essential item in user's daily life. This means that smart devices are good mediators to get collecting user's behavior by sensors mounted on the devices. The information from smart devices is important clues to identify by analyzing the user's preferences and needs. Through this, the intelligent service which is fitted to the user is possible. This paper propose a smart service recommendation model based on user scenario using fusion context-awareness. The information for recommendation services is collected to make the scenario depending on time, location, action based on the Fusion process. The scenarios can help predict a user's situation and provide the services in advance. Also, content categories as well as the content types are determined depending on the scenario. The scenario is a method for providing the best service as well as a basis for the user's situation. Using this method, proposing a smart service model with the fusion context-awareness based on the hybrid sensing is the goal of this paper.

• Journal of Digital Convergence
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• v.13 no.7
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• pp.431-436
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• 2015

To determine fusion-complex activity of Camellia extract extracted hot water, this study was conducted. Special catechin was identified at this extract by analysis of catechin. In analysis of antioxidant activity, the extract was contained antioxidant material and flower among the other parts showed high antioxidant activity. flavonoid showed most high content of Camellia. Flavonoid content was found to be $223.29{\pm}0.005mg/g$ to measured most high to stem, a control group was measured Green tea new leaves $126.14{\pm}0.005mg/g$. Total polyphenol content exhibited most high content at new leaves and flavonoid showed most high content at stem. ${\gamma}$-Amino butyric acid (GAVA) among the free amino acid showed highly at all parts.

• Journal of KIISE:Databases
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• v.28 no.3
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• pp.406-417
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• 2001

With the advances in multimedia databases on the World Wide Web, it becomes more important to provide users with the search capability of distributed multimedia data. While there have been many studies about the database selection and the collection fusion for text databases. The multimedia databases on the Web have autonomous and heterogeneous properties and they use mainly the content based retrieval. The collection fusion problem of multimedia databases is concerned with the merging of results retrieved by content based retrieval from heterogeneous multimedia databases on the Web. This problem is crucial for the search in distributed multimedia databases, however, it has not been studied yet. This paper provides novel algorithms for processing the collection fusion of heterogeneous multimedia databases on the Web. We propose two heuristic algorithms for estimating the number of objects to be retrieved from local databases and an algorithm using the linear regression. Extensive experiments show the effectiveness and efficiency of these algorithms. These algorithms can provide the basis for the distributed content based retrieval algorithms for multimedia databases on the Web.

• Journal of Microbiology and Biotechnology
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• v.1 no.3
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• pp.151-156
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• 1991

In order to construct a yeast strain having high ethanol tolerance together with good lactose fermentation ability, the protoplast fusion using Saccharomyces cerevisiae STV 89 and Kluyveromyces fragilis CBS 397 was carried out. Auxotrophic mutants of K. fragilis were obtained as a selection marker by treatment of ethylmethane sulfonate. The best mutant for protoplast fusion was selected based on the capabilities of ${\beta}-galactosidase$ production and lactose fermentation. The protoplast fusion using polyethylene glycol and calcium chloride solution led to the fusion frequence of $3{\times}10^{-6}$ and a number of fusants were obtained. Among these fusants, a fusant F-3-19 showed the best results in terms of ethanol tolerance, ${\beta}-galactosidase$ activity and lactose fermentation. The performance of lactose fermentation and ethanol tolerance by this fusant were better than those of K. fragilis. Study on the ethanol tolerance having relation to fatty acid composition and intracellular ethanol concentration revealed that the fusant F-3-19 had a higher unsaturated fatty acids content and accumulated less amount of intracellular ethanol compared with a parent of K. fragilis.

• BMB Reports
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• v.50 no.7
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• pp.361-366
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• 2017

Tetraploidy, a potential precursor of cancer-associated aneuploidy, is produced either by cell fusion or failure of cytokinesis. In this study, low p53-expressing HeLa cells were used to address the fate of cancer cells after fusion. We found that massive cell death or growth arrest occurred a few days after fusion. Interestingly, cells with larger nuclei preferentially died after fusion, suggesting that a larger deviation of DNA content is a strong inducer of apoptosis. Notably, a fraction of cells escaped cell death. Also, the stability of survivin increased, and its localization changed preferentially to the cytosol in fused cells. Knockdown of survivin decreased the survival of fused cells, more than observed in unfused cells, showing increased dependency of fused cells on survivin. Collectively, after cancer cell fusion, some fused cells avoid the apoptotic crisis partly owing to survivin, and continue to proliferate, a process that contributes to human cancer progression.

• Proceedings of the Korea Information Processing Society Conference
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• 2022.11a
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• pp.656-658
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• 2022

The purpose of infrared and visible image fusion is to integrate images of different modes with different details into a result image with rich information, which is convenient for high-level computer vision task. Considering many deep networks only work in a single scale, this paper proposes a novel image fusion based on three-scale dense network to preserve the content and key target features from the input images in the fused image. It comprises an encoder, a three-scale block, a fused strategy and a decoder, which can capture incredibly rich background details and prominent target details. The encoder is used to extract three-scale dense features from the source images for the initial image fusion. Then, a fusion strategy called l₁-norm to fuse features of different scales. Finally, the fused image is reconstructed by decoding network. Compared with the existing methods, the proposed method can achieve state-of-the-art fusion performance in subjective observation.

• Journal of Information Management
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• v.38 no.1
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• pp.1-19
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• 2007

This study investigates the effect of data fusion on the retrieval effectiveness by performing an experiment combining multiple representations of Web documents. The types of document representation combined in the study include content terms, links, anchor text, and URL. The experimental results showed that the data fusion technique combining document representation methods in Web environment did not bring any significant improvement in retrieval effectiveness.