• Advances in Traditional Medicine
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• v.7 no.5
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• pp.556-563
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• 2008

Peripheral nerve injuries are a commonly encountered clinical problem and often result in a chronic pain and severe functional deficits. The expression of c-Fos is sometimes used as a marker of increased neuronal activity. We have prepared the aqueous extract of amygdalin from Armeniacae semen for pain control. In the present study, we investigated the effects of amygdalin on the recovery rate of the locomotor function and on the expression of c-Fos in the ventrolateral periaqueductal gray (vlPAG) region following sciatic crushed nerve injury in rats. Walking track analysis for the evaluation of functional recovery and immunohistochemistry for the c-Fos expression were used in this study. In the present results, characteristic gait change with dropping of the sciatic function index (SFI) was observed and c-Fos expression in the vlPAG was suppressed following sciatic crushed nerve injury in rats. Amygdalin enhanced SFI value and restored c-Fos expression in the vlPAG to the control value. The present our study indicated that amygdalin activates neurons in the vlPAG, and it facilitates functional recovery following peripheral nerve injury.

• The Journal of Korean Physical Therapy
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• v.19 no.3
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• pp.1-9
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• 2007

Purpose: Previous studies have suggested that BDNF has a role in plasticity and survival following spinal cord injury and treadmill exercise increases BDNF levels in the normal brain and spinal cord. We attempted to determine whether swimming exercise improve motor function following experimental contusive spinal cord injury and whether motor outcome is associated with BDNF expression. Methods: Thirty six Sprague-Dawley rats (weight, 250 to 300 g) were divided into control (n=18) and experimental swimming group (n=18). Spinal cord injury was produced using NYU-spinal impactor at the eleven thoracic levels in both groups. Swimming exercise started $7^{th}$ day from SCI operation, lasted 5 min per day, 5 days a week for 4 weeks and then exercise times a day were increased in one number to each week. Motor functional recovery was determined by the Basso-Beattie-Bresnahan (BBB) locomotor rating scale, modified inclined board plane test, histological findings, H&E and BDNF expression observed at $1^{th}$, $3^{rd}$, $7^{th}$, $14^{th}$, $21^{st}$ and $28^{th}$day after injury. Results: 1. The BBB scores were higher in experimental group than control group at $14^{th}$, $21^{st}$ day (left hind limb) and at $21^{th}$ day (right hind limb) (p<0.05) after injury. 2. The inclined board plane test were significantly greater in experimental group than control group at $7^{th}$ day (p<0.05), $14^{th}$ and $28^{th}$ day (p<0.01) after injury. 3. The BDNF expression was severe revealed in experimental group than control group at $7^{th}$, $14^{th}$ and $28^{th}$ day after injury. Conclusion: This study suggests that swimming applied from the early phase after spinal cord injury be beneficial effects in motor functional recovery.

• International Journal of Stem Cells
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• v.11 no.2
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• pp.177-186
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• 2018

Background and Objectives: Glial scarring and inflammation after spinal cord injury (SCI) interfere with neural regeneration and functional recovery due to the inhibitory microenvironment of the injured spinal cord. Stem cell transplantation can improve functional recovery in experimental models of SCI, but many obstacles to clinical application remain due to concerns regarding the effectiveness and safety of stem cell transplantation for SCI patients. In this study, we investigated the effects of transplantation of human mesenchymal stem cells (hMSCs) that were genetically modified to express Olig2 in a rat model of SCI. Methods: Bone marrow-derived hMSCs were genetically modified to express Olig2 and transplanted one week after the induction of contusive SCI in a rat model. Spinal cords were harvested 7 weeks after transplantation. Results: Transplantation of Olig2-expressing hMSCs significantly improved functional recovery in a rat model of contusive SCI model compared to the control hMSC-transplanted group. Transplantation of Olig2-expressing hMSCs also attenuated glial scar formation in spinal cord lesions. Immunohistochemical analysis showed that transplanted Olig2-expressing hMSCs were partially differentiated into Olig1-positive oligodendrocyte-like cells in spinal cords. Furthermore, NF-M-positive axons were more abundant in the Olig2-expressing hMSC-transplanted group than in the control hMSC-transplanted group. Conclusions: We suggest that Olig2-expressing hMSCs are a safe and optimal cell source for treating SCI.

• The Journal of Korean Physical Therapy
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• v.14 no.4
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• pp.441-453
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• 2002

The purpose of this study was to characterize lesion development, neural plasticity, and motor learing after spinal cord injury. Facilitatory intervention such as weight bearing and locomotor training after SCI may be more effective than compensatory strategies at inducing neuroplasticity and motor recovery. Minimal tissue sparing has a profound impact on segmental systems and recovery of function Spinal animal could functional locomotion when subjected to repetitive stimulation. task-specific learning of isolated lumbar spinal could improve motor performance more then other task learning.

• Journal of Korean Institute of Industrial Engineers
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• v.14 no.2
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• pp.63-70
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• 1988

Recently a new regime, called "back school" is advocated for the purpose of rapidly and economically returning a patient to full functional fitness and normal occupational activities. Assuming that this functional and vocational restoration is a goal of a regabilitation program, it is apparent that early recovery and higher success rate are major concern. In this study, a mixture model is developed and used to evaluate the recovery process of low back pain (LBP) patients in a rehabilitation program. The model provides (1) the probability of being recovered, and (2) the rate of recovery. Patients with gradual onset, with higher education, or of young age tend to show better prognosis.

• Medical Lasers
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• v.9 no.2
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• pp.89-94
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• 2020

Photobiomodulation (PBM) therapy has been investigated to enhance and accelerate the recovery of injured peripheral nerves. Based on the wide range of benefits of PBM therapy and its clinical relevance, this study reviewed the efficacy of PBM in injured facial nerves. The search was performed in the PubMed database to find relevant articles published over the last 10 years. Four animal studies, two randomized controlled studies, one case series, and five case reports were reviewed. Despite the various parameters, functional analysis showed that PBM therapy using near-infrared irradiation has beneficial effects on the recovery of the acute phase of the damaged facial nerve, especially when related to faster functional improvement. There were no reported adverse effects of PBM therapy.

• The Journal of Korean Medicine
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• v.27 no.4
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• pp.116-124
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• 2006

Peripheral nerve injuries are a commonly encountered clinical problem and often result in chronic pain and severe functional deficits. At the Dept. of Oriental Rehab. Medicine, we have used for pain control a herbal bath containing the following herbs: Harpagophytum radix, Atractylodes japonica and Corydalis tuber. In the present study, we investigated the effects of this herbal bath on the recovery rate of the locomotor function and the expression of c-Fos in the ventrolateral periaqueductal gray (vIPAG) region of the brain following sciatic crushed nerve injury in rats. In the present study, characteristic gait change with decreasing of the sciatic function index (SFI) was observed and c-Fos expression in the vIPAG was suppressed following sciatic crushed nerve injury in rats. Immersion into herbal bath enhanced SFI value and restored c-Fos expression in the vIPAG to the control value. These results suggest the herbal bath might activate neurons in the vIPAG, and could facilitate functional recovery from peripheral nerve injury.

• Journal of the Korean Academy of Clinical Electrophysiology
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• v.8 no.1
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• pp.1-5
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• 2010

Purpose : This research inquires into the effect of applying microcurrent (MC) according to various frequency levels on the pain and functional recovery of patients with chronic back pain. Methods : Thirty participants with chronic lower back pain disease were divided equally into three experimenta l groups. The MC frequency used in the first experimental group was 0.5Hz, the second experimental group was 50Hz, and the third experimental group was 100Hz for 20 minute sessions. A hot pack and ultrasound were applied to all groups as the general physical therapy. Measurements were taken using the visual analogue scale (VAS), the face pain rating scale (FPRS), and the Oswestry disability index (001). The analysis used the paired t-test in order to compare pretest and posttest results. A one-way ANOVA was performed to make comparisons with regards to frequency levels. Results : VAS, FPRS, and 001 showed significant pain decrease in all groups except for the 001 measurement in the 0.5 Hz group. There were no significant differences according to frequency levels. Conclusion: For chronic pain and functional recovery, a microcurrent produces an effect after treatment. However, results did not show a significant difference in change obtained from differing frequency levels.

• Fashion & Textile Research Journal
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• v.2 no.3
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• pp.227-233
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• 2000

The purpose of this study was to develop the High Functional Covering machine and the Compound Twister to produce the high value added textile goods and to meet the consumer's needs. For the study, 8 yarns and 12 fabrics were made with two developed machines and the tensile characteristics of the samples were tested and analysed. The result indicated that the sample fabrics kept their elongation regardless of buffering process. Elongation of the sample yarns was higher than those of yarns made with a traditional covering method. Elastic recovery of the sample fabrics was more effected by the recovery rate than by the number of extension and the characteristics of the sample yarns and fabrics were comparable to the yarns and fabrics made with a traditional covering method in terms of the position of Spandex yarns in their yarn structure and buffering effect.

• Journal of Trauma and Injury
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• v.32 no.3
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• pp.187-193
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• 2019

Many techniques have been developed for reconstruction of the hand; however, less attention has been paid to foot reconstruction techniques. In particular, reconstruction of the forefoot and big toe has been considered a minor procedure despite the importance of these body parts for standing and walking. Most of the weight load on the foot is concentrated on the forefoot and big toe, whereas the other toes have a minor role in weight bearing. Moreover, the forefoot and big toe are important for maintaining balance and supporting the body when changing directions. Recently, attention has been focused on the aesthetic appearance and functional aspects of the body, which are important considerations in the field of reconstructive surgery. In patients for whom flap reconstruction in the forefoot and big toe is planned, clinicians should pay close attention to flap survival as well as functional and cosmetic outcomes of surgery. In particular, it is important to assess the ability of the flap to withstand functional weight bearing and maintain sufficient durability under shearing force. Recovery of protective sensation in the forefoot area can reduce the risk of flap loss and promote rapid rehabilitation and functional recovery. Here, we report our experience with two cases of successful reconstruction of the forefoot and big toe with a sensate anterolateral thigh flap, with a review of the relevant literature.