• 제목/요약/키워드: Fructus of Rubus coreanus $M_{IQ.}$

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마우스 천식모델에서 복분자 물추출물의 기도 과민반응 및 염증의 억제 효과 (Attenuation of airway hyperreactivity (AHR) and inflammation by water extract of Rubus coreanus $M_{IQ.}$ (WRCM))

  • 김경준;이호섭;조은희;박민철
    • 한방안이비인후피부과학회지
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    • 제20권1호통권32호
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    • pp.177-194
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    • 2007

  • Fructus of Rubus coreanus $M_{IQ.}$. (FRCM) has been used for stuttering urination, prostate gland disease, and impotence in Korean traditional medicine. Water extract of FRCM (WFRCM) treatment significantly attenuated airway hyperreactivity (AHR). Airway recruitment of leukocytes and eosinophils was also markedly reduced by WFRCM administration, suggesting that WFRCM can alleviate the airway inflammation. However, the level of cytokine (IL-4, IL-5, and IL-13) in bronchoalveolar lavage fluid (BALF) and lung was not different compared with positive control. WFRCM reduced the number of draining lymph node cells during OVA-induced allergic asthma. I further examined transcription level of cytokine in lung. WFRCM treatment reduced IL-4 and IL-13 mRNA in lung and inhibited IgE and IgG1 but not IgG2a. My data suggest that WFRCM attenuates OVA-induced allergic asthma through inhibition of Th2 cell response.

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